Click here to switch to the map view.

The map label for this gene is 78047201

Identifier: 78047201

GI number: 78047201

Start: 1858193

End: 1858723

Strand: Reverse

Name: 78047201

Synonym: XCV1645

Alternate gene names: NA

Gene position: 1858723-1858193 (Counterclockwise)

Preceding gene: 78047202

Following gene: 78047200

Centisome position: 35.89

GC content: 62.9

Gene sequence:

>531_bases
ATGCTGATCCCGCCGATCAACCTGCACGCCTGGATCGAGGAACACCGCCATCTGCTCAAACCGCCGGTGGGCAACAAGTG
CATCCAGCAGGATGGCTTCATCATCATGGTGGTCGGCGGGCCGAACGCGCGCACCGACTATCACTACGACGAAGGCCCGG
AGTGGTTCTTCCAGCTCGAAGGCGAAATGGTGCTGAAGGTGCAGGACGAGGGCGTGGCGCGCGACATTCCGATCCGTGCC
GGCGAAGTCTTTCTGCTGCCGCCCAAGGTGCCGCACTCGCCGCAACGCGCGGCCGGCTCGATCGGCCTGGTGATCGAACG
CGAGCGCCTGCCCAACGAGCAGGACGGCCTGCAATGGTATTGCCCGCAGTGCAATCACAAGTTGTATGAAGCGATGTTTC
CGCTGAAGAACATCGAAACCGACTTCCCGCCGGTGTTCGATCGCTTCTACCGTTCGCTGGCGCTGCGCACCTGTTCGCAG
TGCGGGCATCTGCATCCTGCGCCCGAGCGCTATGCCACGGTCGAGGACTGA

Upstream 100 bases:

>100_bases
GCGCCGAGCGCTGAGCCGCACGCACACCTGGCCGGCCGCAGCGTCCATCGGACGTAGGCGGCCGGCTGAGCCGGATACCT
TACTTTGCCGAGGAACGTCG

Downstream 100 bases:

>100_bases
CAGCGCGATGGCATGCGGCTGCGCGCAGCAGGTTTGCCGCTCGCATGCTCTGAAACCGGCACCATGCTGCGCGCACTGAT
CGACCTCAAACCGCGCGACG

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRAAGSIGLVIERERLPNEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSLALRTCSQ
CGHLHPAPERYATVED

Sequences:

>Translated_176_residues
MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRAAGSIGLVIERERLPNEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSLALRTCSQ
CGHLHPAPERYATVED
>Mature_176_residues
MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRAAGSIGLVIERERLPNEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSLALRTCSQ
CGHLHPAPERYATVED

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=152, Percent_Identity=47.3684210526316, Blast_Score=156, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17562218, Length=155, Percent_Identity=43.8709677419355, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322485, Length=167, Percent_Identity=42.5149700598802, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 20210; Mature: 20210

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLE
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEC
GEMVLKVQDEGVARDIPIRAGEVFLLPPKVPHSPQRAAGSIGLVIERERLPNEQDGLQWY
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCEEE
CPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSLALRTCSQCGHLHPAPERYATVED
CCCCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLE
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEC
GEMVLKVQDEGVARDIPIRAGEVFLLPPKVPHSPQRAAGSIGLVIERERLPNEQDGLQWY
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHCCCCCCCCEEE
CPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSLALRTCSQCGHLHPAPERYATVED
CCCCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]