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The map label for this gene is dcp [H]

Identifier: 78047069

GI number: 78047069

Start: 1706144

End: 1708294

Strand: Reverse

Name: dcp [H]

Synonym: XCV1513

Alternate gene names: 78047069

Gene position: 1708294-1706144 (Counterclockwise)

Preceding gene: 78047071

Following gene: 78047065

Centisome position: 32.99

GC content: 62.11

Gene sequence:

>2151_bases
ATGCCGTCCTACAGCATCGCCGCCCCCGCTGCCACGCAGGCCGCCACCCAAGCCAATCCCTTTTTTGCCGACAGCACGCT
GCCGCTGCATTACCCGCAGTTCGACAAAATTAAGGACAGCGATTTCGCACCTGCCTTCGATGCCGGCATGGCCGAACAGT
TGAAGGAAGTGGAAAAAATCGCCAACCAGAAAGCCAAGCCCAGCTTCGACAACACCATCATCGCGCTGGAAAAGAGCGGC
GCCACGCTCGACCGCGCCACCACGGTGTTCTTCAATCTGGTGGGCGCAGACACCAACGACGCACGCAAGAAGTTGCAGGC
CGACTATTCGGCGAAGTTCGCAGCGCACCGCGATGCGATTTCGCTCAACGGCAAGCTGTTCGCACGCATCCAGACCTTGT
ACGACCAACGCGCCACGCTGGGGCTGGATGCGCAAGGCGTGCGCCTGGTCGAGAAGTACTACAGCGACTTCGTGCGCGAC
GGCGCCAAGCTCTCCGACGTCGACAAGACCACGCTCAAGGCCATGAATGCCGAGCTGGCCAACCTGGGCACCACCTTCAG
CCAGAACGTGCTGGCCGAAGTGAATGCTGCCGCTGTGGTCGTGGACGACGTCAGGCAGCTGGACGGTTTGTCGCAGGAGC
AGATTGCCGCCGCCGCCGAAGCGGCCAAGGCGCGCAAGCTCGATGGCAAGTACGTCATTGCCTTGCTCAACACCACCGGC
CAGCCGCCGCTGACCCAGCTGAAGAATCGCGAGCTGCGCAAGAGGATCTACGACGCCTCGGTGTCGCGCGGCAGCCACGG
CGGCCAGTACGACAACACCGCGCTGGTGTCGCGCATCATGAAGCTGCGCGCCGACAAGGCCAAGCTGCTGGGCTTCCCCA
CCTATGCCGCCTACTCGCTGGAAAACCAGACCGCCAAGACGCCCGAAGCGGTCAACGCGATGCTGGGCAAACTGGCGCCG
GCCGCGGTGGCCAATGCCAAGCGCGAAGCCGCCGATCTGCAGGCCATGATCGACAAGGAACAAAAGGCTGCGCGCAAGCC
GACGTTCAAGCTGGAAGCCTGGGATTGGGCCTACTACAGCGAGAAGGTGCGCCAGGCCAAGTACAACTTCGACGAATCCC
AGCTCAAGCCGTACTTCGAACTGAAGAACGTGCTGGAAAATGGCGTGTTCTATGCGGCCAATCAGGAATATGGCCTGACC
TTCAAACAGCGCACCGACCTGCCGACCTACCGCGACGACATCACCGTCTACGACGTGTTCGACGCGGACGGCAAGCAGCT
GGCGATCTTCATTGCCGACATGTATGCGCGCGAATCCAAGCGCGGTGGCGCATGGATGAACTCCTATGTGTCGCAGTCGG
AGCTGACCGGCTTCAAGCCGGTGGTGGCCAATCACCTCAACATTCCCAAGCCGCCGGCCGGCCAGCCGACGCTGCTGACC
TGGGATGAGGTGACCACCATGTTCCATGAGTTCGGGCATGCGCTGCACGGCATGTTCTCCGACGTCAAATACCCGTATTT
CTCCGGTACCAGCGTACCGCGCGACTTCGTCGAGTTCCCCTCGCAGGTCAACGAAATGTGGGCCGACGAACCATCCATCC
TGAAGAACTACGCCAAGCATTACCAGAACGGCACCCCGATGCCGCAGGCATTGCTGGACAAGGTGATTGCCGCATCCAAG
TTCAACCAGGGCTTTGCCACCACTGAATACCTGGGTGCGGCGATGCTGGATCAGAACTGGCACCAGGTCAGCGCCAGCCA
GGTACCGGACGCCGCCGGCGTGATGGCATTCGAAGCCAAGGCGCTGCAGCAGGACGGCATTGCCTACGCGCCGGTGCCGC
CGCGCTACAAGACCCCGTATTTCAGCCACATCATGGGCGGTTACGCGGCAGGCTACTACGCCTACATCTGGTCGGAAGTG
CTGGACGCCAACACCCAGCAGTGGTTCAAGCAGCACGGTGGCCTGAGCCGCGCCAATGGCGATCGTTTCCGCAAGACCCT
GCTTTCGCGCGGCGGTAGCGTGGATGCGATGGAGCTGTTCCAGAACTTTGCCGGGCATGCGCCGCAGATCGAGCCGCTGC
TCGAAAAGCGCGGTCTCAGCGCGCAAGGCGGCGATGGTGCCACTCCGGAATCGCCGCAGTCCAAGCCGTAG

Upstream 100 bases:

>100_bases
TGTCCCGACGGGCTGGGTTAGCCTCGGCGGTTCGAACTTTGGAGCAACTCTCTTGACCACCCGTCTCGCTTTTGCCCTGG
CCGCCTCCCTGGGACTTGCC

Downstream 100 bases:

>100_bases
ATCGGCTGCACGACCTGCGCGCGATCATCGGGCCGCGTGCTTGGCAACAGGATCGGCATGTCCCCTGCGGGCATGCCGAT
CTCGAACACCAGACGCGACA

Product: peptidyl-dipeptidase

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 716; Mature: 715

Protein sequence:

>716_residues
MPSYSIAAPAATQAATQANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAEQLKEVEKIANQKAKPSFDNTIIALEKSG
ATLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAISLNGKLFARIQTLYDQRATLGLDAQGVRLVEKYYSDFVRD
GAKLSDVDKTTLKAMNAELANLGTTFSQNVLAEVNAAAVVVDDVRQLDGLSQEQIAAAAEAAKARKLDGKYVIALLNTTG
QPPLTQLKNRELRKRIYDASVSRGSHGGQYDNTALVSRIMKLRADKAKLLGFPTYAAYSLENQTAKTPEAVNAMLGKLAP
AAVANAKREAADLQAMIDKEQKAARKPTFKLEAWDWAYYSEKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLT
FKQRTDLPTYRDDITVYDVFDADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLT
WDEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKHYQNGTPMPQALLDKVIAASK
FNQGFATTEYLGAAMLDQNWHQVSASQVPDAAGVMAFEAKALQQDGIAYAPVPPRYKTPYFSHIMGGYAAGYYAYIWSEV
LDANTQQWFKQHGGLSRANGDRFRKTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPESPQSKP

Sequences:

>Translated_716_residues
MPSYSIAAPAATQAATQANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAEQLKEVEKIANQKAKPSFDNTIIALEKSG
ATLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAISLNGKLFARIQTLYDQRATLGLDAQGVRLVEKYYSDFVRD
GAKLSDVDKTTLKAMNAELANLGTTFSQNVLAEVNAAAVVVDDVRQLDGLSQEQIAAAAEAAKARKLDGKYVIALLNTTG
QPPLTQLKNRELRKRIYDASVSRGSHGGQYDNTALVSRIMKLRADKAKLLGFPTYAAYSLENQTAKTPEAVNAMLGKLAP
AAVANAKREAADLQAMIDKEQKAARKPTFKLEAWDWAYYSEKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLT
FKQRTDLPTYRDDITVYDVFDADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLT
WDEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKHYQNGTPMPQALLDKVIAASK
FNQGFATTEYLGAAMLDQNWHQVSASQVPDAAGVMAFEAKALQQDGIAYAPVPPRYKTPYFSHIMGGYAAGYYAYIWSEV
LDANTQQWFKQHGGLSRANGDRFRKTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPESPQSKP
>Mature_715_residues
PSYSIAAPAATQAATQANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAEQLKEVEKIANQKAKPSFDNTIIALEKSGA
TLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAISLNGKLFARIQTLYDQRATLGLDAQGVRLVEKYYSDFVRDG
AKLSDVDKTTLKAMNAELANLGTTFSQNVLAEVNAAAVVVDDVRQLDGLSQEQIAAAAEAAKARKLDGKYVIALLNTTGQ
PPLTQLKNRELRKRIYDASVSRGSHGGQYDNTALVSRIMKLRADKAKLLGFPTYAAYSLENQTAKTPEAVNAMLGKLAPA
AVANAKREAADLQAMIDKEQKAARKPTFKLEAWDWAYYSEKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLTF
KQRTDLPTYRDDITVYDVFDADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLTW
DEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKHYQNGTPMPQALLDKVIAASKF
NQGFATTEYLGAAMLDQNWHQVSASQVPDAAGVMAFEAKALQQDGIAYAPVPPRYKTPYFSHIMGGYAAGYYAYIWSEVL
DANTQQWFKQHGGLSRANGDRFRKTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPESPQSKP

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=593, Percent_Identity=29.1736930860034, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI14149738, Length=593, Percent_Identity=30.5227655986509, Blast_Score=233, Evalue=7e-61,
Organism=Homo sapiens, GI156105687, Length=602, Percent_Identity=24.4186046511628, Blast_Score=158, Evalue=2e-38,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=46.5014577259475, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=682, Percent_Identity=32.8445747800587, Blast_Score=335, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI32565901, Length=553, Percent_Identity=19.5298372513562, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319793, Length=593, Percent_Identity=26.1382799325464, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322715, Length=503, Percent_Identity=25.6461232604374, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129717, Length=412, Percent_Identity=27.4271844660194, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21356111, Length=588, Percent_Identity=23.8095238095238, Blast_Score=152, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 79016; Mature: 78884

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSYSIAAPAATQAATQANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAEQLKEVEKI
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ANQKAKPSFDNTIIALEKSGATLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAI
HCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCE
SLNGKLFARIQTLYDQRATLGLDAQGVRLVEKYYSDFVRDGAKLSDVDKTTLKAMNAELA
ECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NLGTTFSQNVLAEVNAAAVVVDDVRQLDGLSQEQIAAAAEAAKARKLDGKYVIALLNTTG
HHCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
QPPLTQLKNRELRKRIYDASVSRGSHGGQYDNTALVSRIMKLRADKAKLLGFPTYAAYSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHEEEC
ENQTAKTPEAVNAMLGKLAPAAVANAKREAADLQAMIDKEQKAARKPTFKLEAWDWAYYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
EKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLTFKQRTDLPTYRDDITVYDVF
HHHHHHHCCCCHHHCCHHHHHHHHHHCCEEEEECCCCCCEECCCCCCCCCCCCEEEEEEE
DADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLT
CCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEE
WDEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
YQNGTPMPQALLDKVIAASKFNQGFATTEYLGAAMLDQNWHQVSASQVPDAAGVMAFEAK
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
ALQQDGIAYAPVPPRYKTPYFSHIMGGYAAGYYAYIWSEVLDANTQQWFKQHGGLSRANG
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
DRFRKTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPESPQSKP
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSYSIAAPAATQAATQANPFFADSTLPLHYPQFDKIKDSDFAPAFDAGMAEQLKEVEKI
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ANQKAKPSFDNTIIALEKSGATLDRATTVFFNLVGADTNDARKKLQADYSAKFAAHRDAI
HCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCE
SLNGKLFARIQTLYDQRATLGLDAQGVRLVEKYYSDFVRDGAKLSDVDKTTLKAMNAELA
ECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NLGTTFSQNVLAEVNAAAVVVDDVRQLDGLSQEQIAAAAEAAKARKLDGKYVIALLNTTG
HHCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
QPPLTQLKNRELRKRIYDASVSRGSHGGQYDNTALVSRIMKLRADKAKLLGFPTYAAYSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHEEEC
ENQTAKTPEAVNAMLGKLAPAAVANAKREAADLQAMIDKEQKAARKPTFKLEAWDWAYYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
EKVRQAKYNFDESQLKPYFELKNVLENGVFYAANQEYGLTFKQRTDLPTYRDDITVYDVF
HHHHHHHCCCCHHHCCHHHHHHHHHHCCEEEEECCCCCCEECCCCCCCCCCCCEEEEEEE
DADGKQLAIFIADMYARESKRGGAWMNSYVSQSELTGFKPVVANHLNIPKPPAGQPTLLT
CCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEE
WDEVTTMFHEFGHALHGMFSDVKYPYFSGTSVPRDFVEFPSQVNEMWADEPSILKNYAKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
YQNGTPMPQALLDKVIAASKFNQGFATTEYLGAAMLDQNWHQVSASQVPDAAGVMAFEAK
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
ALQQDGIAYAPVPPRYKTPYFSHIMGGYAAGYYAYIWSEVLDANTQQWFKQHGGLSRANG
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
DRFRKTLLSRGGSVDAMELFQNFAGHAPQIEPLLEKRGLSAQGGDGATPESPQSKP
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]