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The map label for this gene is dxr [H]

Identifier: 78047028

GI number: 78047028

Start: 1654940

End: 1656130

Strand: Reverse

Name: dxr [H]

Synonym: XCV1472

Alternate gene names: 78047028

Gene position: 1656130-1654940 (Counterclockwise)

Preceding gene: 78047029

Following gene: 78047027

Centisome position: 31.98

GC content: 69.1

Gene sequence:

>1191_bases
ATGGCTGGCTCCTCTCTCCGTCAGGTCGCCGTGTTCGGCGCCACCGGCTCGATCGGTGCATCGGCACTGGACGTGATCGC
GCGTCACCCCGAGCGGCTGCGCGCCAGCCTGCTGTCGGCCGGCAGCAAGGTCGATGAGCTGCTGGCGCTGTGCGCCACCC
ACCGGCCTGCGCATGCGGTGATTGCCGATGCAGCGCTGTATCCCGCGCTGCGCGATGGCCTGCGCGCGCTGGGCCTGGCG
ACCCAGGCGCACGCCGGCGCCGAGGCGTTGGACGCACTGGCGAGCGGCGATGTGTGCGACACCGTGGTGGCGGCGATCGT
GGGTGCGGCCGGGCTGCCGTCTACGCTGGCGGCAGCGCGCGCCGGCAAGCGTCTGTTGCTGGCCAACAAGGAATCGCTGG
TGCTGGCTGGCGAGCTGCTGACCCGCACCGCAGCCGCTGCCGGCGCTGAAATCATTCCGATCGACAGCGAACACAGCGCC
ATCTTCCAGTGCCTGCGCTCCTGCGACGCCAGCCGCGGCGTGCGCCGGGTCATCCTGACTGCCTCCGGTGGCCCGTTCCG
CGGCCGCGACCGCGCGGCACTTGCCGCAGTCACGCCCGCGCAGGCAGTGGCGCATCCCAAGTGGTCGATGGGCCCGAAGA
TCTCGGTGGATTCGGCAACCATGATGAACAAGGGCCTGGAAGTCATCGAGGCGCATCACCTGTTCGGACTGCCGGGCGAG
CAGATCGATGTGCTGGTGCATCCGCAGAGCCTGGTGCATTCGCTGGTGGAATTCGTCGACGGCTCCACGCTTGCCCAGCT
TGGCCTGCCGGACATGCGTACCACCCTGGCGGTGGGCTTGGCCTGGCCGGAGCGGGTCGACTCCGGCGTCGGCGGGCTGG
ACCTGCTTCGCCAGGGCCGGCTGGATTTCGAGGCCCCCGACACCGCCGCGTTCCCATGTCTGCGCCTGGCCTGGGACGCG
TTACGGGCCGGCGGCACCGCCCCGGCGATCCTGAACGCGGCCAATGAAGTGGCTGTTTCAGCCTTTCTTCAGGGCCAGGT
GGGTTTCCTAGCGATCCCTGCGTTGGTCGAACACACACTGACAACGCTCCCGCGGCACAATGCCGACTCCCTCGACACCC
TGCTTTTTGCCGATGCGCAAGCCCGGCAAATCACTGAACGCGCCCTCGCCCACCACGCCCTTCATGCCTGA

Upstream 100 bases:

>100_bases
CGCTGATTCCGGGCCATGGCGGCGTGCTGGACCGCATCGATGGCGTGCTCGCTGCCCTGCCGGTGTTCGCACTCGGCAAG
GAAATTCTCGGATTCTAGGC

Downstream 100 bases:

>100_bases
TCGTTCCACGCACGCGAGCTGCACACATGGGTGATTTCATCGGTTCGGTCTGGTGGATGATCGTCAGCCTGGGCGTGTTG
GTGACCTTTCACGAATTCGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAGSSLRQVAVFGATGSIGASALDVIARHPERLRASLLSAGSKVDELLALCATHRPAHAVIADAALYPALRDGLRALGLA
TQAHAGAEALDALASGDVCDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSA
IFQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATMMNKGLEVIEAHHLFGLPGE
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVDSGVGGLDLLRQGRLDFEAPDTAAFPCLRLAWDA
LRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLPRHNADSLDTLLFADAQARQITERALAHHALHA

Sequences:

>Translated_396_residues
MAGSSLRQVAVFGATGSIGASALDVIARHPERLRASLLSAGSKVDELLALCATHRPAHAVIADAALYPALRDGLRALGLA
TQAHAGAEALDALASGDVCDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSA
IFQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATMMNKGLEVIEAHHLFGLPGE
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVDSGVGGLDLLRQGRLDFEAPDTAAFPCLRLAWDA
LRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLPRHNADSLDTLLFADAQARQITERALAHHALHA
>Mature_395_residues
AGSSLRQVAVFGATGSIGASALDVIARHPERLRASLLSAGSKVDELLALCATHRPAHAVIADAALYPALRDGLRALGLAT
QAHAGAEALDALASGDVCDTVVAAIVGAAGLPSTLAAARAGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAI
FQCLRSCDASRGVRRVILTASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATMMNKGLEVIEAHHLFGLPGEQ
IDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVDSGVGGLDLLRQGRLDFEAPDTAAFPCLRLAWDAL
RAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTLTTLPRHNADSLDTLLFADAQARQITERALAHHALHA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=46.8193384223919, Blast_Score=323, Evalue=9e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40931; Mature: 40800

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSSLRQVAVFGATGSIGASALDVIARHPERLRASLLSAGSKVDELLALCATHRPAHAV
CCCCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
IADAALYPALRDGLRALGLATQAHAGAEALDALASGDVCDTVVAAIVGAAGLPSTLAAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
AGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAIFQCLRSCDASRGVRRVILT
CCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
ASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATMMNKGLEVIEAHHLFGLPGE
ECCCCCCCCCCHHEEECCCHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCC
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVDSGVGGLDLLRQGR
CEEEEECCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHCCC
LDFEAPDTAAFPCLRLAWDALRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTL
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TTLPRHNADSLDTLLFADAQARQITERALAHHALHA
HHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGSSLRQVAVFGATGSIGASALDVIARHPERLRASLLSAGSKVDELLALCATHRPAHAV
CCCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
IADAALYPALRDGLRALGLATQAHAGAEALDALASGDVCDTVVAAIVGAAGLPSTLAAAR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
AGKRLLLANKESLVLAGELLTRTAAAAGAEIIPIDSEHSAIFQCLRSCDASRGVRRVILT
CCCEEEEECCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
ASGGPFRGRDRAALAAVTPAQAVAHPKWSMGPKISVDSATMMNKGLEVIEAHHLFGLPGE
ECCCCCCCCCCHHEEECCCHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCCC
QIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTTLAVGLAWPERVDSGVGGLDLLRQGR
CEEEEECCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHCCC
LDFEAPDTAAFPCLRLAWDALRAGGTAPAILNAANEVAVSAFLQGQVGFLAIPALVEHTL
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TTLPRHNADSLDTLLFADAQARQITERALAHHALHA
HHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]