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The map label for this gene is nadC [H]

Identifier: 78044712

GI number: 78044712

Start: 1136583

End: 1137422

Strand: Direct

Name: nadC [H]

Synonym: CHY_1276

Alternate gene names: 78044712

Gene position: 1136583-1137422 (Clockwise)

Preceding gene: 78043099

Following gene: 78044017

Centisome position: 47.33

GC content: 38.69

Gene sequence:

>840_bases
ATGAATTTCAATAACTCTGGAGATATTCGCGATATCTTATTTTCTAAAATAATGCAAAAGCATTTCACAGCTCAGATTAA
AGCTGAAAATGGCGGGATTATTGCTGGTGCCCAAAATGCATATAATGCTTTGAAACAACTTGGTTTAGAAATCGAATATT
TTGTTTATGACGGAACGGAAGTCCAGCCGGAAACAGTTATTGCCCGTTTTAAAGGAAATCCCAAACAAATTGCGCAAGCG
GAAGAAGTAGTAATGGGTTATTTAATGAAAACTTCCGGGATTGCTACTGCCACCCGGAGGGCGATTAATTTAGCCGAAGG
CAAGATCAGGATTGTTTCCGGGGCATGGAAAAAGATGCCTTCCGAAATGAAGCAATTAGTAAGGGAAGCGATTGCTGTTG
GTGGCGGAGCTTTTCGCATACTTGATGTTCCCTTTGTTTATTTGGACAAGAATTATATTCGCATGTTTGGAAGTATCGTT
GAAGCATTAAAGAGTGCCCAGGTATTTGGTGATAGGTATAAAGTAGTTCAGTTAAGAGGCGAAATGAAAGACATTAAAGA
GGAAGCAATTGAAGCGGCTACAAATGGAGCTTATGTGCTCATGGTAGATACAGGCAAAATTTCTGACGTTAAAATTGTTA
ATAGTACGTTGGAAGAGCTTGGGCTAAGAAAAGAAAAGCTTGTAGCTTTTGCAGGAGGAGTAAAAATTAATGCTATTCCT
AGTTATATTGGTTTAGGGATAGATATTCTCGATATAGGATCCGAAATAGTTGATGCGCCACTAATGGATATGAAATTAGA
TGTAATAAGCGAAGGAAAGGAGGGAGAGGATGGAACTTAA

Upstream 100 bases:

>100_bases
TTTAAAAAAGGTGCTCCTTTCTGTTTTAAGCACCTAATGGCGGGTTAAAAAATGCAGAAAGGAGCACCTCCATTTTTAAA
ATTGGATTGTGGAGGCAAAT

Downstream 100 bases:

>100_bases
CCTTTTAGAAAAGACAGAACTGTGGATTGAAAATATCAAATTACAAAATGCTAATTTATCAACAATTGCCGAAGTTGTGG
CCGATGTTCTTGAAATCCCG

Product: putative nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNFNNSGDIRDILFSKIMQKHFTAQIKAENGGIIAGAQNAYNALKQLGLEIEYFVYDGTEVQPETVIARFKGNPKQIAQA
EEVVMGYLMKTSGIATATRRAINLAEGKIRIVSGAWKKMPSEMKQLVREAIAVGGGAFRILDVPFVYLDKNYIRMFGSIV
EALKSAQVFGDRYKVVQLRGEMKDIKEEAIEAATNGAYVLMVDTGKISDVKIVNSTLEELGLRKEKLVAFAGGVKINAIP
SYIGLGIDILDIGSEIVDAPLMDMKLDVISEGKEGEDGT

Sequences:

>Translated_279_residues
MNFNNSGDIRDILFSKIMQKHFTAQIKAENGGIIAGAQNAYNALKQLGLEIEYFVYDGTEVQPETVIARFKGNPKQIAQA
EEVVMGYLMKTSGIATATRRAINLAEGKIRIVSGAWKKMPSEMKQLVREAIAVGGGAFRILDVPFVYLDKNYIRMFGSIV
EALKSAQVFGDRYKVVQLRGEMKDIKEEAIEAATNGAYVLMVDTGKISDVKIVNSTLEELGLRKEKLVAFAGGVKINAIP
SYIGLGIDILDIGSEIVDAPLMDMKLDVISEGKEGEDGT
>Mature_279_residues
MNFNNSGDIRDILFSKIMQKHFTAQIKAENGGIIAGAQNAYNALKQLGLEIEYFVYDGTEVQPETVIARFKGNPKQIAQA
EEVVMGYLMKTSGIATATRRAINLAEGKIRIVSGAWKKMPSEMKQLVREAIAVGGGAFRILDVPFVYLDKNYIRMFGSIV
EALKSAQVFGDRYKVVQLRGEMKDIKEEAIEAATNGAYVLMVDTGKISDVKIVNSTLEELGLRKEKLVAFAGGVKINAIP
SYIGLGIDILDIGSEIVDAPLMDMKLDVISEGKEGEDGT

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=252, Percent_Identity=25, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321162, Length=253, Percent_Identity=28.0632411067194, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30490; Mature: 30490

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNNSGDIRDILFSKIMQKHFTAQIKAENGGIIAGAQNAYNALKQLGLEIEYFVYDGTE
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHCCEEEEEEECCCC
VQPETVIARFKGNPKQIAQAEEVVMGYLMKTSGIATATRRAINLAEGKIRIVSGAWKKMP
CCHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCEEEEEECHHHHCH
SEMKQLVREAIAVGGGAFRILDVPFVYLDKNYIRMFGSIVEALKSAQVFGDRYKVVQLRG
HHHHHHHHHHHHCCCCEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHH
EMKDIKEEAIEAATNGAYVLMVDTGKISDVKIVNSTLEELGLRKEKLVAFAGGVKINAIP
HHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHEEECCEEEEECH
SYIGLGIDILDIGSEIVDAPLMDMKLDVISEGKEGEDGT
HHHHCCCCHHHCCHHHHCCCHHHEEEHHHCCCCCCCCCC
>Mature Secondary Structure
MNFNNSGDIRDILFSKIMQKHFTAQIKAENGGIIAGAQNAYNALKQLGLEIEYFVYDGTE
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHCCEEEEEEECCCC
VQPETVIARFKGNPKQIAQAEEVVMGYLMKTSGIATATRRAINLAEGKIRIVSGAWKKMP
CCHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCEEEEEECHHHHCH
SEMKQLVREAIAVGGGAFRILDVPFVYLDKNYIRMFGSIVEALKSAQVFGDRYKVVQLRG
HHHHHHHHHHHHCCCCEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHH
EMKDIKEEAIEAATNGAYVLMVDTGKISDVKIVNSTLEELGLRKEKLVAFAGGVKINAIP
HHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHEEECCEEEEECH
SYIGLGIDILDIGSEIVDAPLMDMKLDVISEGKEGEDGT
HHHHCCCCHHHCCHHHHCCCHHHEEEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]