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The map label for this gene is pdxA [H]

Identifier: 78043939

GI number: 78043939

Start: 1122719

End: 1123726

Strand: Direct

Name: pdxA [H]

Synonym: CHY_1259

Alternate gene names: 78043939

Gene position: 1122719-1123726 (Clockwise)

Preceding gene: 78042917

Following gene: 78044423

Centisome position: 46.75

GC content: 38.39

Gene sequence:

>1008_bases
ATGTCAAGACCGGTAATCGGAATTACTATGGGAGATGCAGCAGGAGTAGGGCCAGAGATAATAATGAAGGCGCTACGCGA
TCCTGAAATTTATGCAATCTGTAAACCATTGGTTATAGGCGATGCAAAGATACTGCAACGGGCTGAAACTATTATCCATA
CTGGACTTCATATTAAACCGATTCAGAGTATCGATGAAGCAGAATTTAAATTTGGGATAGTTGAGTGTTTGGATCTTAAT
TTACTTCCTCCTGATATTCCCTTTGGACAAGTTTCAGCAAAAGCTGGAGATGCAGCTTTTCGCTATTTAGAAAAAGCTAT
TGAACTAGCAAAAGAAGGTAAAATTGATGCTATTTGTACAGCACCACTAAATAAAGAAGCACTGCATAAAGCAGGTCATA
TGTATCCTGGGCATACTGAGATATTGGCAGAGCTAACAAACACAAAAGATTTTGCAATGATCCTATCTGCACCCAAATTA
AAAGTCATACACGTAACAACACATGTGGGATTAAAAGATGCTATAGATATGATTAACCCGAATCGGGTATACAAAGTTAT
AAAACTTGCTCATGATACCTTAAAAAAAGCTGGTTATTCGAATCCCAGAATTGCGGTTTGTGGAATAAACCCGCATGCTG
GCGAAAATGGATTATTTGGCTACAGAGAAGAAGAAGAAAAAATTATCCCAGCGATTAAAAAAGCTCAACAAGAAGGAATA
AATGCGATTGGTCCTTTGCCAGCAGATACGGTATTTTACAGAGCTATCAGAGGCGATTTTGATATTGCTGTTGCTATGTA
CCATGATCAAGGCCATACTCCTGTCAAAGTATTGGGGTTAGAAGTCGGGGTTAATATTACTGCAGGCCTTCCTTTTGTCA
GGACAAGTGTTGACCATGGCACTGCCTTTGACATTGCTGGAAAAGGAACTGCAAATGAATTAAGTATGAAAGAAGCAATC
CGCCAAGCTGTTGAATTGACTTCCAAAAAAAATTTAGATAAAAATTAA

Upstream 100 bases:

>100_bases
ATTGGCTTTGGTAATTTGTTGGCAATTACGAAAGCCGGTGCTTTTGGAACAGAAAGAACTCTTATTAATGCAGTACACTT
TTTGAAAGGAGATAGGTGAT

Downstream 100 bases:

>100_bases
TATCAATTTGCCAATCTCCTCGAAAACGATATTTCGCTAATACAATGAAATTGGCTCTTCGCTAAGTAGCATGGGTAAAT
GTCTCTAATGATTATATTAG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSRPVIGITMGDAAGVGPEIIMKALRDPEIYAICKPLVIGDAKILQRAETIIHTGLHIKPIQSIDEAEFKFGIVECLDLN
LLPPDIPFGQVSAKAGDAAFRYLEKAIELAKEGKIDAICTAPLNKEALHKAGHMYPGHTEILAELTNTKDFAMILSAPKL
KVIHVTTHVGLKDAIDMINPNRVYKVIKLAHDTLKKAGYSNPRIAVCGINPHAGENGLFGYREEEEKIIPAIKKAQQEGI
NAIGPLPADTVFYRAIRGDFDIAVAMYHDQGHTPVKVLGLEVGVNITAGLPFVRTSVDHGTAFDIAGKGTANELSMKEAI
RQAVELTSKKNLDKN

Sequences:

>Translated_335_residues
MSRPVIGITMGDAAGVGPEIIMKALRDPEIYAICKPLVIGDAKILQRAETIIHTGLHIKPIQSIDEAEFKFGIVECLDLN
LLPPDIPFGQVSAKAGDAAFRYLEKAIELAKEGKIDAICTAPLNKEALHKAGHMYPGHTEILAELTNTKDFAMILSAPKL
KVIHVTTHVGLKDAIDMINPNRVYKVIKLAHDTLKKAGYSNPRIAVCGINPHAGENGLFGYREEEEKIIPAIKKAQQEGI
NAIGPLPADTVFYRAIRGDFDIAVAMYHDQGHTPVKVLGLEVGVNITAGLPFVRTSVDHGTAFDIAGKGTANELSMKEAI
RQAVELTSKKNLDKN
>Mature_334_residues
SRPVIGITMGDAAGVGPEIIMKALRDPEIYAICKPLVIGDAKILQRAETIIHTGLHIKPIQSIDEAEFKFGIVECLDLNL
LPPDIPFGQVSAKAGDAAFRYLEKAIELAKEGKIDAICTAPLNKEALHKAGHMYPGHTEILAELTNTKDFAMILSAPKLK
VIHVTTHVGLKDAIDMINPNRVYKVIKLAHDTLKKAGYSNPRIAVCGINPHAGENGLFGYREEEEKIIPAIKKAQQEGIN
AIGPLPADTVFYRAIRGDFDIAVAMYHDQGHTPVKVLGLEVGVNITAGLPFVRTSVDHGTAFDIAGKGTANELSMKEAIR
QAVELTSKKNLDKN

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=322, Percent_Identity=37.2670807453416, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 36289; Mature: 36157

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPVIGITMGDAAGVGPEIIMKALRDPEIYAICKPLVIGDAKILQRAETIIHTGLHIKP
CCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEC
IQSIDEAEFKFGIVECLDLNLLPPDIPFGQVSAKAGDAAFRYLEKAIELAKEGKIDAICT
CCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
APLNKEALHKAGHMYPGHTEILAELTNTKDFAMILSAPKLKVIHVTTHVGLKDAIDMINP
CCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCHHHHHHHCCC
NRVYKVIKLAHDTLKKAGYSNPRIAVCGINPHAGENGLFGYREEEEKIIPAIKKAQQEGI
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAIGPLPADTVFYRAIRGDFDIAVAMYHDQGHTPVKVLGLEVGVNITAGLPFVRTSVDHG
CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEECCEEECCCCCEEECCCCC
TAFDIAGKGTANELSMKEAIRQAVELTSKKNLDKN
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRPVIGITMGDAAGVGPEIIMKALRDPEIYAICKPLVIGDAKILQRAETIIHTGLHIKP
CCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCEECCHHHHHHHHHHHHCCCCEEC
IQSIDEAEFKFGIVECLDLNLLPPDIPFGQVSAKAGDAAFRYLEKAIELAKEGKIDAICT
CCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
APLNKEALHKAGHMYPGHTEILAELTNTKDFAMILSAPKLKVIHVTTHVGLKDAIDMINP
CCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCHHHHHHHCCC
NRVYKVIKLAHDTLKKAGYSNPRIAVCGINPHAGENGLFGYREEEEKIIPAIKKAQQEGI
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAIGPLPADTVFYRAIRGDFDIAVAMYHDQGHTPVKVLGLEVGVNITAGLPFVRTSVDHG
CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEECCEEECCCCCEEECCCCC
TAFDIAGKGTANELSMKEAIRQAVELTSKKNLDKN
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]