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The map label for this gene is guaB [H]

Identifier: 78042653

GI number: 78042653

Start: 1047577

End: 1049028

Strand: Direct

Name: guaB [H]

Synonym: CHY_1176

Alternate gene names: 78042653

Gene position: 1047577-1049028 (Clockwise)

Preceding gene: 78043820

Following gene: 78044122

Centisome position: 43.62

GC content: 43.04

Gene sequence:

>1452_bases
ATGGAGTCAAAAATAGTTAAAGAAGGATTAACTTTTGATGATGTACTTTTGATTCCTGCAAAATCGGAAGTATTACCCAG
AGATGTGGATACTACTACGCGTTTTACGAAAAAGATCAAATTAAATATTCCCATAGTTAGTGCAGGTATGGATACGGTAA
CCGAAGCGCGGATGGCTATAGCTATGGCCCGGGAGGGAGGAATTGGGGTCATACATAAAAATATGTCTATTGAAGAGCAA
GCGATGGAGGTGGATAAAGTTAAACGGTCCGAACATGGAATTATTGCTGACCCAATATCGCTGTCGCCGGAGCATTTAAT
TAGAGATGCTTTGGAAATAATGGAACGGTACCATATTTCAGGAGTACCCATTACCGTTGAGGGAAAGCTGGTAGGAATCA
TAACCAATAGAGACTTACGCTTTGAATCGGATTACAGCAAAAAAATTGCTGATGTCATGACCAAAGATAATTTAATTACC
GCACCGGTAGGAACGAGTTTAAAAGAGGCGGAAAAAATACTGCAAAAGCATAAAATAGAAAAGTTACCTTTAGTAGATGA
AAATTTCCATTTAAAAGGCTTAATTACGATTAAAGATATTGAAAAAACCCGGAAATATCCTAATGCCGCAAAAGACGAAA
AAGGAAGGTTGCGGGTTGCAGCGGCGGTCGGGGTTAGTCGAGACATGATGGACAGGGTTAAGGCTTTAGTTGAGGCTAAA
GTCGATGCGATTGTGGTGGATACTGCGCACGGTCACTCCCGGGGTGTATTAGAGGCAGTATATAAAATCAAAAGCAAATA
TCCAGAAGTGGAATTAGTTGCCGGAAATGTGGCCACTGCTGAAGCTACCGAAGATTTAATCAAAGCCGGTGCCGATGCGG
TAAAGGTGGGCATTGGTCCAGGGTCAATTTGTACCACCCGGGTAGTGGCGGGGATTGGGGTTCCACAAATTACCGCCATT
CTTGATTGCGCTGAAGTTGCCATGAAGTATGATGTACCCATTATTGCCGATGGAGGTATTAAATATTCCGGGGATATCAC
CAAGGCATTAGCCGCGGGTGCTGATACAGTTATGCTGGGAAGTTTGTTGGCTGGAACCGAAGAAAGCCCCGGGGAAATTG
AAATCTGGCAAGGGCGGAGCTATAAAGTTTACCGCGGAATGGGTTCTTTAGGCGCGATGAAAGAGGGAAGCAAGGATAGA
TATTTCCAGGAAAACGAGCAAAAGTTGGTGCCGGAAGGAGTAGAGGGAAGAGTTCCCTTTAAAGGGCCTGTTTCGGAAAC
TATTTTTCAATTAATTGGTGGACTTCGGGCCGGAATGGGATACTGTGGTGTTCGCAATATTTATGAATTAAAAACCAAAA
CAAAATTTATCAAAATTACCCAGGCAGGGCTTAGAGAAAGTCATCCGCATGATGTAACCATTACAAAAGAAGCGCCCAAT
TACAGCTTGTAA

Upstream 100 bases:

>100_bases
TTATATTTTTTGTCAAATTAAAATAATTATTCGAACAATTATTGGGGTATAAGTATAAATTTTGCAAAATTGATAAAATA
ATGAAAGAGGAGGAATTAGA

Downstream 100 bases:

>100_bases
TTGGGCAGCTCTTTTTCTTTTACGTATTTTAAATCTTCCCAGTGCTTAAGTAACACGCCCAGGGTGGTATCCAGTACTTC
GGGATTTAATGAGGTTAAAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MESKIVKEGLTFDDVLLIPAKSEVLPRDVDTTTRFTKKIKLNIPIVSAGMDTVTEARMAIAMAREGGIGVIHKNMSIEEQ
AMEVDKVKRSEHGIIADPISLSPEHLIRDALEIMERYHISGVPITVEGKLVGIITNRDLRFESDYSKKIADVMTKDNLIT
APVGTSLKEAEKILQKHKIEKLPLVDENFHLKGLITIKDIEKTRKYPNAAKDEKGRLRVAAAVGVSRDMMDRVKALVEAK
VDAIVVDTAHGHSRGVLEAVYKIKSKYPEVELVAGNVATAEATEDLIKAGADAVKVGIGPGSICTTRVVAGIGVPQITAI
LDCAEVAMKYDVPIIADGGIKYSGDITKALAAGADTVMLGSLLAGTEESPGEIEIWQGRSYKVYRGMGSLGAMKEGSKDR
YFQENEQKLVPEGVEGRVPFKGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDVTITKEAPN
YSL

Sequences:

>Translated_483_residues
MESKIVKEGLTFDDVLLIPAKSEVLPRDVDTTTRFTKKIKLNIPIVSAGMDTVTEARMAIAMAREGGIGVIHKNMSIEEQ
AMEVDKVKRSEHGIIADPISLSPEHLIRDALEIMERYHISGVPITVEGKLVGIITNRDLRFESDYSKKIADVMTKDNLIT
APVGTSLKEAEKILQKHKIEKLPLVDENFHLKGLITIKDIEKTRKYPNAAKDEKGRLRVAAAVGVSRDMMDRVKALVEAK
VDAIVVDTAHGHSRGVLEAVYKIKSKYPEVELVAGNVATAEATEDLIKAGADAVKVGIGPGSICTTRVVAGIGVPQITAI
LDCAEVAMKYDVPIIADGGIKYSGDITKALAAGADTVMLGSLLAGTEESPGEIEIWQGRSYKVYRGMGSLGAMKEGSKDR
YFQENEQKLVPEGVEGRVPFKGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDVTITKEAPN
YSL
>Mature_483_residues
MESKIVKEGLTFDDVLLIPAKSEVLPRDVDTTTRFTKKIKLNIPIVSAGMDTVTEARMAIAMAREGGIGVIHKNMSIEEQ
AMEVDKVKRSEHGIIADPISLSPEHLIRDALEIMERYHISGVPITVEGKLVGIITNRDLRFESDYSKKIADVMTKDNLIT
APVGTSLKEAEKILQKHKIEKLPLVDENFHLKGLITIKDIEKTRKYPNAAKDEKGRLRVAAAVGVSRDMMDRVKALVEAK
VDAIVVDTAHGHSRGVLEAVYKIKSKYPEVELVAGNVATAEATEDLIKAGADAVKVGIGPGSICTTRVVAGIGVPQITAI
LDCAEVAMKYDVPIIADGGIKYSGDITKALAAGADTVMLGSLLAGTEESPGEIEIWQGRSYKVYRGMGSLGAMKEGSKDR
YFQENEQKLVPEGVEGRVPFKGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDVTITKEAPN
YSL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=477, Percent_Identity=44.8637316561845, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI156616279, Length=477, Percent_Identity=44.8637316561845, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI34328930, Length=454, Percent_Identity=45.8149779735683, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=45.8149779735683, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=43.8413361169102, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=45.7589285714286, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI217035148, Length=477, Percent_Identity=44.0251572327044, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI217035150, Length=477, Percent_Identity=41.7190775681342, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=41.4634146341463, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=41.4634146341463, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=41.4634146341463, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.4634146341463, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=40.080971659919, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=56.4049586776859, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786293, Length=246, Percent_Identity=38.2113821138211, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=38.7368421052632, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=39.7163120567376, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17560440, Length=248, Percent_Identity=37.9032258064516, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322012, Length=470, Percent_Identity=41.2765957446808, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323585, Length=454, Percent_Identity=42.2907488986784, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=470, Percent_Identity=41.7021276595745, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=40.7514450867052, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=43.3333333333333, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=41.3361169102296, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=41.3361169102296, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=41.8764302059497, Blast_Score=314, Evalue=1e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52517; Mature: 52517

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKIVKEGLTFDDVLLIPAKSEVLPRDVDTTTRFTKKIKLNIPIVSAGMDTVTEARMAI
CCCCHHHCCCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEEECEEEECCCHHHHHHHHHH
AMAREGGIGVIHKNMSIEEQAMEVDKVKRSEHGIIADPISLSPEHLIRDALEIMERYHIS
HHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
GVPITVEGKLVGIITNRDLRFESDYSKKIADVMTKDNLITAPVGTSLKEAEKILQKHKIE
CCCEEECCEEEEEEECCCEEECCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCC
KLPLVDENFHLKGLITIKDIEKTRKYPNAAKDEKGRLRVAAAVGVSRDMMDRVKALVEAK
CCCCCCCCCEEEEEEEEEEHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHC
VDAIVVDTAHGHSRGVLEAVYKIKSKYPEVELVAGNVATAEATEDLIKAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGIGVPQITAILDCAEVAMKYDVPIIADGGIKYSGDITKALAAGADTVMLG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCHHHHH
SLLAGTEESPGEIEIWQGRSYKVYRGMGSLGAMKEGSKDRYFQENEQKLVPEGVEGRVPF
HHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDVTITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEEHHHCCCCCCCCEEEEECCCC
YSL
CCC
>Mature Secondary Structure
MESKIVKEGLTFDDVLLIPAKSEVLPRDVDTTTRFTKKIKLNIPIVSAGMDTVTEARMAI
CCCCHHHCCCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEEECEEEECCCHHHHHHHHHH
AMAREGGIGVIHKNMSIEEQAMEVDKVKRSEHGIIADPISLSPEHLIRDALEIMERYHIS
HHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
GVPITVEGKLVGIITNRDLRFESDYSKKIADVMTKDNLITAPVGTSLKEAEKILQKHKIE
CCCEEECCEEEEEEECCCEEECCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCC
KLPLVDENFHLKGLITIKDIEKTRKYPNAAKDEKGRLRVAAAVGVSRDMMDRVKALVEAK
CCCCCCCCCEEEEEEEEEEHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHC
VDAIVVDTAHGHSRGVLEAVYKIKSKYPEVELVAGNVATAEATEDLIKAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGIGVPQITAILDCAEVAMKYDVPIIADGGIKYSGDITKALAAGADTVMLG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCHHHHH
SLLAGTEESPGEIEIWQGRSYKVYRGMGSLGAMKEGSKDRYFQENEQKLVPEGVEGRVPF
HHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDVTITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEEHHHCCCCCCCCEEEEECCCC
YSL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]