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The map label for this gene is cya [H]

Identifier: 77465538

GI number: 77465538

Start: 622498

End: 624168

Strand: Reverse

Name: cya [H]

Synonym: RSP_3539

Alternate gene names: 77465538

Gene position: 624168-622498 (Counterclockwise)

Preceding gene: 77465539

Following gene: 77465537

Centisome position: 66.19

GC content: 66.43

Gene sequence:

>1671_bases
ATGGTCGGGCTGAACCTCGAAGGCACCGACGGCGCCGATCTGCTCATCGGCTCGCGGGGCGCGGACGTGATCTCCGGCCG
GATGTTCAACGACACGCTGATGGGCGGGGCGGGCAACGACAGCCTCTACGGCAACGGTGACGACGACCGCCTCTACGTTA
ACGAGGGCAACGACAGCCTCTATGGCGAGGAGGGCAACGACTGGCTGCATGGCGGTCAGGGCGACGACCTGGTCGTGGGC
GGCGACGGCAACGACACGCTCGCGGGCGGTCTGGGCAACGACACCCTGCAGGGTGGCGCGGGCAACGACACGGCCAGCTA
CGAAACGGCCACCGAGGGCGTTACCGTCAGCCTCGCGCTGCAGGGCGAAGGCCAGTTCGTGAACGCGCAGGAAGGCAACG
ACCCGCTGACCTCGATCGAGAACCTGACGGGCAGCAATCACGACGACACGCTGATCGGGGACGAGGGCGACAACGTGCTC
TCGGGTCTCGCGGGCAACGACGTGCTGGTGGGCGGCGCGGGCAATGACACGCTGCTCGGCGGTGCCGGCAACGACATCGC
CGACTACGCCGCGGCGACGGGCGGGGTGACGGTCAATCTGGCGCGTGATGGGCAGGCGCAGATCATCGGCGCCGATCAGG
GCACCGATGTCCTGAGCTCGATCGAGGGTGTCATCGGCAGCGCCTTCAACGACATCCTGTCGGGCAGCGCGGTCGCCAAC
CTCATCTTCGGTGGGGACGGTGCCGACCTGGCCACCGGTGGCGCGGGCAACGACACCATCCTCGGCGGCGCCGGATCGGA
CAGCCTCTATGGCAACCTTGGGGATGACCTCCTCTTTGGTGACGTGGGCAACGACTGGATCCACGGCGGCCAGGGCAACG
ACACCGTCCTCGGCGGTTTCGGCGACGATACGCTGGCCGGCGGCGTCGGTGACGATGTGGTGGATGGCGGCGATGGGATC
GACACCGTCGAGTTCCAGACCGCAACCGCCGGTGTCACCGTGGATCTCTCGCTGCAGGGTCAGGCGCAGCGCATCAGTGC
CGAGGAAGGCACGGATACGCTGTTCTCGATCGAGAACATCCTCGGCAGCCGGTATGACGACCGCCTGCTGGGCGATGCGG
GCTCCAACTTGATCGACGGCAGTGCCGGCAACGACACTGCCATGGGTCAGGCGGGCGAGGACCTCATCTTCGGCGGGGAC
GGCAACGACAGCCTCTATGGCAACCAGGACAACGACACTCTGGTCGGCGGCAACGGCAACGACTGGTTGCACGGCGGTCA
GGGCAACGATCTCCTGGTGGGCGATGCCGGCAGCGACACCCTCAACGGCGGCGTGGGCGACGATGTGCTGGTCGGGGGTC
AGGGCTTCGACCTTCTGACGGGCGGCACCGGGGCGGACACTTTCGTCTTCGGCAGCCTCGACAGCGCGGATGCGGATCGG
ATCACCGATTTCGAGCAGGGCGTCGACCAGATCGTGATCGCCGACCAGCTGATGTGGGCGCTGGAGAATGCCGAGCTGAA
CCTCGCCGATCAGATCGTCTGGAATGCCGAGACCGGCATGCTCTCCATCGATCTCGACGCCGGGGAGGCGACCCGTCTGG
TGGATCTTGCTCAGATCGATCATGATGGAACGCTGAACATCACGATCGACGACTTCCAGTTCCTGCGCTGA

Upstream 100 bases:

>100_bases
CACGCTGAAACCGGCGGATGCAGGCCATGTCATCAGCGCCCGCATCACCTACACCGACGGTGAAGGCAACCTCGAGGTCA
TCAACGTCGATGGCCCCGCC

Downstream 100 bases:

>100_bases
GAACCCTGCCGGCTTCGGCCCGGCAGCCTCCGGCACCAGAAAAGGGCGGCGTCCGAAAGGGCGCCGTTTCGCATGATGAG
CATGATCGACCACGGACCCG

Product: hemolysin-type calcium-binding region, RTX

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MVGLNLEGTDGADLLIGSRGADVISGRMFNDTLMGGAGNDSLYGNGDDDRLYVNEGNDSLYGEEGNDWLHGGQGDDLVVG
GDGNDTLAGGLGNDTLQGGAGNDTASYETATEGVTVSLALQGEGQFVNAQEGNDPLTSIENLTGSNHDDTLIGDEGDNVL
SGLAGNDVLVGGAGNDTLLGGAGNDIADYAAATGGVTVNLARDGQAQIIGADQGTDVLSSIEGVIGSAFNDILSGSAVAN
LIFGGDGADLATGGAGNDTILGGAGSDSLYGNLGDDLLFGDVGNDWIHGGQGNDTVLGGFGDDTLAGGVGDDVVDGGDGI
DTVEFQTATAGVTVDLSLQGQAQRISAEEGTDTLFSIENILGSRYDDRLLGDAGSNLIDGSAGNDTAMGQAGEDLIFGGD
GNDSLYGNQDNDTLVGGNGNDWLHGGQGNDLLVGDAGSDTLNGGVGDDVLVGGQGFDLLTGGTGADTFVFGSLDSADADR
ITDFEQGVDQIVIADQLMWALENAELNLADQIVWNAETGMLSIDLDAGEATRLVDLAQIDHDGTLNITIDDFQFLR

Sequences:

>Translated_556_residues
MVGLNLEGTDGADLLIGSRGADVISGRMFNDTLMGGAGNDSLYGNGDDDRLYVNEGNDSLYGEEGNDWLHGGQGDDLVVG
GDGNDTLAGGLGNDTLQGGAGNDTASYETATEGVTVSLALQGEGQFVNAQEGNDPLTSIENLTGSNHDDTLIGDEGDNVL
SGLAGNDVLVGGAGNDTLLGGAGNDIADYAAATGGVTVNLARDGQAQIIGADQGTDVLSSIEGVIGSAFNDILSGSAVAN
LIFGGDGADLATGGAGNDTILGGAGSDSLYGNLGDDLLFGDVGNDWIHGGQGNDTVLGGFGDDTLAGGVGDDVVDGGDGI
DTVEFQTATAGVTVDLSLQGQAQRISAEEGTDTLFSIENILGSRYDDRLLGDAGSNLIDGSAGNDTAMGQAGEDLIFGGD
GNDSLYGNQDNDTLVGGNGNDWLHGGQGNDLLVGDAGSDTLNGGVGDDVLVGGQGFDLLTGGTGADTFVFGSLDSADADR
ITDFEQGVDQIVIADQLMWALENAELNLADQIVWNAETGMLSIDLDAGEATRLVDLAQIDHDGTLNITIDDFQFLR
>Mature_556_residues
MVGLNLEGTDGADLLIGSRGADVISGRMFNDTLMGGAGNDSLYGNGDDDRLYVNEGNDSLYGEEGNDWLHGGQGDDLVVG
GDGNDTLAGGLGNDTLQGGAGNDTASYETATEGVTVSLALQGEGQFVNAQEGNDPLTSIENLTGSNHDDTLIGDEGDNVL
SGLAGNDVLVGGAGNDTLLGGAGNDIADYAAATGGVTVNLARDGQAQIIGADQGTDVLSSIEGVIGSAFNDILSGSAVAN
LIFGGDGADLATGGAGNDTILGGAGSDSLYGNLGDDLLFGDVGNDWIHGGQGNDTVLGGFGDDTLAGGVGDDVVDGGDGI
DTVEFQTATAGVTVDLSLQGQAQRISAEEGTDTLFSIENILGSRYDDRLLGDAGSNLIDGSAGNDTAMGQAGEDLIFGGD
GNDSLYGNQDNDTLVGGNGNDWLHGGQGNDLLVGDAGSDTLNGGVGDDVLVGGQGFDLLTGGTGADTFVFGSLDSADADR
ITDFEQGVDQIVIADQLMWALENAELNLADQIVWNAETGMLSIDLDAGEATRLVDLAQIDHDGTLNITIDDFQFLR

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 55957; Mature: 55957

Theoretical pI: Translated: 3.21; Mature: 3.21

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGLNLEGTDGADLLIGSRGADVISGRMFNDTLMGGAGNDSLYGNGDDDRLYVNEGNDSL
CEEECCCCCCCCEEEEECCCCCEEECEEECCEEECCCCCCCCCCCCCCCEEEEECCCCCC
YGEEGNDWLHGGQGDDLVVGGDGNDTLAGGLGNDTLQGGAGNDTASYETATEGVTVSLAL
CCCCCCCCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCEECCCCEEEEEEE
QGEGQFVNAQEGNDPLTSIENLTGSNHDDTLIGDEGDNVLSGLAGNDVLVGGAGNDTLLG
ECCCCEEECCCCCCHHHHHHHCCCCCCCCCEECCCCCHHHHCCCCCCEEEECCCCCEEEC
GAGNDIADYAAATGGVTVNLARDGQAQIIGADQGTDVLSSIEGVIGSAFNDILSGSAVAN
CCCCCHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LIFGGDGADLATGGAGNDTILGGAGSDSLYGNLGDDLLFGDVGNDWIHGGQGNDTVLGGF
EEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCCCCEEEECC
GDDTLAGGVGDDVVDGGDGIDTVEFQTATAGVTVDLSLQGQAQRISAEEGTDTLFSIENI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEECCCCCCCHHHHHHHH
LGSRYDDRLLGDAGSNLIDGSAGNDTAMGQAGEDLIFGGDGNDSLYGNQDNDTLVGGNGN
HCCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCC
DWLHGGQGNDLLVGDAGSDTLNGGVGDDVLVGGQGFDLLTGGTGADTFVFGSLDSADADR
CCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCEEEECCCCCCEEEEECCCCCCCHH
ITDFEQGVDQIVIADQLMWALENAELNLADQIVWNAETGMLSIDLDAGEATRLVDLAQID
HHHHHHCHHHEEHHHHHHHHHCCCCCEEEHEEEEECCCCEEEEEECCCCCEEEEEEEECC
HDGTLNITIDDFQFLR
CCCEEEEEECCCEECC
>Mature Secondary Structure
MVGLNLEGTDGADLLIGSRGADVISGRMFNDTLMGGAGNDSLYGNGDDDRLYVNEGNDSL
CEEECCCCCCCCEEEEECCCCCEEECEEECCEEECCCCCCCCCCCCCCCEEEEECCCCCC
YGEEGNDWLHGGQGDDLVVGGDGNDTLAGGLGNDTLQGGAGNDTASYETATEGVTVSLAL
CCCCCCCCCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCEECCCCEEEEEEE
QGEGQFVNAQEGNDPLTSIENLTGSNHDDTLIGDEGDNVLSGLAGNDVLVGGAGNDTLLG
ECCCCEEECCCCCCHHHHHHHCCCCCCCCCEECCCCCHHHHCCCCCCEEEECCCCCEEEC
GAGNDIADYAAATGGVTVNLARDGQAQIIGADQGTDVLSSIEGVIGSAFNDILSGSAVAN
CCCCCHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LIFGGDGADLATGGAGNDTILGGAGSDSLYGNLGDDLLFGDVGNDWIHGGQGNDTVLGGF
EEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCCCCEEEECC
GDDTLAGGVGDDVVDGGDGIDTVEFQTATAGVTVDLSLQGQAQRISAEEGTDTLFSIENI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEECCCCCCCHHHHHHHH
LGSRYDDRLLGDAGSNLIDGSAGNDTAMGQAGEDLIFGGDGNDSLYGNQDNDTLVGGNGN
HCCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCC
DWLHGGQGNDLLVGDAGSDTLNGGVGDDVLVGGQGFDLLTGGTGADTFVFGSLDSADADR
CCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCCEEEECCCCCCEEEEECCCCCCCHH
ITDFEQGVDQIVIADQLMWALENAELNLADQIVWNAETGMLSIDLDAGEATRLVDLAQID
HHHHHHCHHHEEHHHHHHHHHCCCCCEEEHEEEEECCCCEEEEEECCCCCEEEEEEEECC
HDGTLNITIDDFQFLR
CCCEEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]