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The map label for this gene is alsR [H]

Identifier: 77465438

GI number: 77465438

Start: 506714

End: 507595

Strand: Reverse

Name: alsR [H]

Synonym: RSP_3436

Alternate gene names: 77465438

Gene position: 507595-506714 (Counterclockwise)

Preceding gene: 77465445

Following gene: 77465436

Centisome position: 53.83

GC content: 72.56

Gene sequence:

>882_bases
ATGGACATCCGCTTTCTCGAGAGCTTCGTGGCGGTCGCCGATTGCGGCTCCATCGCCGAGGCCGCGCGGCGGCTGAACCT
GACGCCTGCGGCCCTGTCGCAGCGGCTGCGCACGCTCGAGCAGGATCTGGGCCATTCCCTCGTGATGCGCGCGGGGCGGC
GGGTGCGGCCCACGGCCTCGGGGCTGGCCGTGCTCGACCATGCCCGCGCGCTGATCGAGGGCGCGCGCGATCTCCGCGCC
ATCGCGGCGCAGGACGAGCCCGCGGGTCAGCTGCGCCTCGGCGCCATCGCCACCTCGCTGACCGGGCTTCTGCCCGGCAT
CGTCGCCCGGCTGCGCGCGCGCCATCCGCGGATCGAATATCACATCCGGCCGGATTCCTCGGTGAACCTCTATCACGGGG
TGATTGCGGGCGATCTCGATGCGGCGGTGATCGTGCGCCCGCAGTTTCCGGTGCCGAAATCGACCGGCTGGCTCACGCTG
CGCGAGGAACCGCTGGTGCTTCTGGTGCCCGAGGAGGCGCCGGGCACCGATCCGCTCGCCATCCTCCAGAGCCATCCGTT
CATCCGCTACGACCGCAACCAGTGGGGCGGGCAGATCGTCGACCGCTACCTGCGCCAGAACACGCTGAAGGTCCGCGAGT
GGCTGGAGCTCGATGCGCTCGATGCCATCGCGGGCCTCGTGAGCCGGGGCCTCGGCGTGGCCATCGTGCCGGATTGGGCG
CCGCCCTGGCCCGAGGGGCTGAGGCTGCGCAAGATCGCCCTGCCGGATGCGGGCGGGCGGCAGACGGGGGTGCTGTGGAA
CCTCTCGGGCGCGCGCATCGCGGCCATGCAGGCCTTCGTCGAGGCCTGCCGCGCGCGCGGCGCGCCGGCGCCGGGGCCTT
AA

Upstream 100 bases:

>100_bases
GGCCCTCGCTTCGGGCATGGTCTACGCCGGGTGAGGCGAAAGAAAAAATGGCTTTTTGTTATTTGAGAAGATAGGAAAGC
CGTGGGTCACGGAGGGCGCC

Downstream 100 bases:

>100_bases
GGCCGGGCAGGGCCGGCGAACTGGCAGCCCGTTCTCCGGCAGTGAAGACGGCTTCCGCCGCCTCGCGATGCCCCCCGGAG
ACGGTGTCACTTCAGCGGAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDIRFLESFVAVADCGSIAEAARRLNLTPAALSQRLRTLEQDLGHSLVMRAGRRVRPTASGLAVLDHARALIEGARDLRA
IAAQDEPAGQLRLGAIATSLTGLLPGIVARLRARHPRIEYHIRPDSSVNLYHGVIAGDLDAAVIVRPQFPVPKSTGWLTL
REEPLVLLVPEEAPGTDPLAILQSHPFIRYDRNQWGGQIVDRYLRQNTLKVREWLELDALDAIAGLVSRGLGVAIVPDWA
PPWPEGLRLRKIALPDAGGRQTGVLWNLSGARIAAMQAFVEACRARGAPAPGP

Sequences:

>Translated_293_residues
MDIRFLESFVAVADCGSIAEAARRLNLTPAALSQRLRTLEQDLGHSLVMRAGRRVRPTASGLAVLDHARALIEGARDLRA
IAAQDEPAGQLRLGAIATSLTGLLPGIVARLRARHPRIEYHIRPDSSVNLYHGVIAGDLDAAVIVRPQFPVPKSTGWLTL
REEPLVLLVPEEAPGTDPLAILQSHPFIRYDRNQWGGQIVDRYLRQNTLKVREWLELDALDAIAGLVSRGLGVAIVPDWA
PPWPEGLRLRKIALPDAGGRQTGVLWNLSGARIAAMQAFVEACRARGAPAPGP
>Mature_293_residues
MDIRFLESFVAVADCGSIAEAARRLNLTPAALSQRLRTLEQDLGHSLVMRAGRRVRPTASGLAVLDHARALIEGARDLRA
IAAQDEPAGQLRLGAIATSLTGLLPGIVARLRARHPRIEYHIRPDSSVNLYHGVIAGDLDAAVIVRPQFPVPKSTGWLTL
REEPLVLLVPEEAPGTDPLAILQSHPFIRYDRNQWGGQIVDRYLRQNTLKVREWLELDALDAIAGLVSRGLGVAIVPDWA
PPWPEGLRLRKIALPDAGGRQTGVLWNLSGARIAAMQAFVEACRARGAPAPGP

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=237, Percent_Identity=27.4261603375527, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=30.0813008130081, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790208, Length=245, Percent_Identity=25.7142857142857, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790399, Length=302, Percent_Identity=26.158940397351, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=29.6747967479675, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788887, Length=256, Percent_Identity=26.953125, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693105, Length=246, Percent_Identity=26.0162601626016, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=240, Percent_Identity=28.75, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=173, Percent_Identity=28.3236994219653, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=287, Percent_Identity=23.3449477351916, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=25.1028806584362, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI157672245, Length=298, Percent_Identity=26.1744966442953, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=252, Percent_Identity=24.6031746031746, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=253, Percent_Identity=26.4822134387352, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31811; Mature: 31811

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRFLESFVAVADCGSIAEAARRLNLTPAALSQRLRTLEQDLGHSLVMRAGRRVRPTAS
CCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLAVLDHARALIEGARDLRAIAAQDEPAGQLRLGAIATSLTGLLPGIVARLRARHPRIEY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
HIRPDSSVNLYHGVIAGDLDAAVIVRPQFPVPKSTGWLTLREEPLVLLVPEEAPGTDPLA
EECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHH
ILQSHPFIRYDRNQWGGQIVDRYLRQNTLKVREWLELDALDAIAGLVSRGLGVAIVPDWA
HHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PPWPEGLRLRKIALPDAGGRQTGVLWNLSGARIAAMQAFVEACRARGAPAPGP
CCCCCCCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDIRFLESFVAVADCGSIAEAARRLNLTPAALSQRLRTLEQDLGHSLVMRAGRRVRPTAS
CCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLAVLDHARALIEGARDLRAIAAQDEPAGQLRLGAIATSLTGLLPGIVARLRARHPRIEY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
HIRPDSSVNLYHGVIAGDLDAAVIVRPQFPVPKSTGWLTLREEPLVLLVPEEAPGTDPLA
EECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHH
ILQSHPFIRYDRNQWGGQIVDRYLRQNTLKVREWLELDALDAIAGLVSRGLGVAIVPDWA
HHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PPWPEGLRLRKIALPDAGGRQTGVLWNLSGARIAAMQAFVEACRARGAPAPGP
CCCCCCCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]