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The map label for this gene is macB [H]

Identifier: 77465375

GI number: 77465375

Start: 437761

End: 438966

Strand: Reverse

Name: macB [H]

Synonym: RSP_3373

Alternate gene names: 77465375

Gene position: 438966-437761 (Counterclockwise)

Preceding gene: 77465376

Following gene: 77465374

Centisome position: 46.55

GC content: 68.66

Gene sequence:

>1206_bases
ATGCTGTGGGAGACGATCCGCCTCGCCTTCATCGCCATCGTGCGGAACAAGCTGCGCTCGTTCCTGACCGTGCTCGGCGT
GGTGATCGGGGTGGCGGCGGTCATCGCCATGGTGACGGTGGGGCAGGGCTCGTCGGCGCAGGTTTCGGCCAATGTGGCGA
GCCTCGGGACCAACGTGCTGATCCTGCGGCCGGGCAAGCGGATGATGGGGCCCGGGACGCGCGACACCTCGCCTGCCTTC
ACGCTGCGCGACGTGGAGGCGCTCGAGGAGCTGCCGGTGATCCGGGCGGTCTCGCCCAACACCTCGGCCTCGCAGACGGT
GGTCTATGGCAATGCCAATGCCACAACCTCGATCACCGGCACCACGGCCGCCTATCTCACCGTGGCCAACTGGGTGCTGG
CGGGCGGCCGCGTCTTCACGCAGGCCGAGGAGCGGCAGGGGGCGGCAGTCTGCATTCTGGGTGAGACGGTGCGCCAGAAG
CTGTTCGGCGCGGCCGACCCGTTGGGCCAGACGGTGCGGATCAAGTCGATCTCGTGTCTGGTGGTGGGGCTGCTCGAGGC
CAAGGGCGCGGGCTCGTTCGGGCAGGATCAGGACGATCTGGTGCTGATGCCCATCCGCACCGTGCAGCGGAGGCTGGTGG
GCAATCAGGATGTCTCGGGCATGTCGGTGGCGCTTCAGGACGGCGTCTCGGCCACGCGCGGCATCCGCGACATCAGCGCG
CTCCTGCGCGAGCGGCGGCGGATCGGGCCTGCCGACGAGGAAAACTTCTCAGTGACGGACATGAAGGAGATCGCCTCGAT
GCTGAGCTCGATCAACACCGTCCTCGCGGGGCTGCTCTCCTCGGTCGCGGCGGTGAGCCTTCTGGTCGGCGGCATCGGGA
TCATGAACATCATGCTGGTCTCGGTCACCGAGCGCACGCGCGAGATCGGCATCCGGCTTGCGGTGGGGGCGACGGCGGGG
CAGGTGCTGACGCAGTTCCTCGTCGAGGCGGTGGTGCTGTCGGTGCTGGGCGGCATGATCGGCATCGCCCTCGGGCTCGC
GCTGGCGCTGGTCGCCTCGCGCTACATGCTCATTCCCTTCACGCCCGATCCGCTGGTGGTGCTGATGGCCTTCGGATTTT
CGGCGGTCGTGGGGGTGATCTTCGGCTATTTCCCCGCCCGCCGGGCCGCCCGGCTCGACCCGATCGAGGCGCTGCGCCAC
CAGTAG

Upstream 100 bases:

>100_bases
GTCACCCACGAAGAGGATATCGCGGCCTATGCCGGGCGGCTCGTCGTCTTCACCGACGGCCATCTCACGCGGGACGAGCC
GGTGAAGGCGAGGGCCTGAG

Downstream 100 bases:

>100_bases
GATGGAAGGGAGAGGGGTCGGTTTCACCGGCGGGCGCAGAGGCGGCCCGGCGCCGTTTCCGTAGCGTCACCTCATCCGAA
ACGACAAGAGGCGCCGGAAA

Product: ABC efflux transporter, inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLWETIRLAFIAIVRNKLRSFLTVLGVVIGVAAVIAMVTVGQGSSAQVSANVASLGTNVLILRPGKRMMGPGTRDTSPAF
TLRDVEALEELPVIRAVSPNTSASQTVVYGNANATTSITGTTAAYLTVANWVLAGGRVFTQAEERQGAAVCILGETVRQK
LFGAADPLGQTVRIKSISCLVVGLLEAKGAGSFGQDQDDLVLMPIRTVQRRLVGNQDVSGMSVALQDGVSATRGIRDISA
LLRERRRIGPADEENFSVTDMKEIASMLSSINTVLAGLLSSVAAVSLLVGGIGIMNIMLVSVTERTREIGIRLAVGATAG
QVLTQFLVEAVVLSVLGGMIGIALGLALALVASRYMLIPFTPDPLVVLMAFGFSAVVGVIFGYFPARRAARLDPIEALRH
Q

Sequences:

>Translated_401_residues
MLWETIRLAFIAIVRNKLRSFLTVLGVVIGVAAVIAMVTVGQGSSAQVSANVASLGTNVLILRPGKRMMGPGTRDTSPAF
TLRDVEALEELPVIRAVSPNTSASQTVVYGNANATTSITGTTAAYLTVANWVLAGGRVFTQAEERQGAAVCILGETVRQK
LFGAADPLGQTVRIKSISCLVVGLLEAKGAGSFGQDQDDLVLMPIRTVQRRLVGNQDVSGMSVALQDGVSATRGIRDISA
LLRERRRIGPADEENFSVTDMKEIASMLSSINTVLAGLLSSVAAVSLLVGGIGIMNIMLVSVTERTREIGIRLAVGATAG
QVLTQFLVEAVVLSVLGGMIGIALGLALALVASRYMLIPFTPDPLVVLMAFGFSAVVGVIFGYFPARRAARLDPIEALRH
Q
>Mature_401_residues
MLWETIRLAFIAIVRNKLRSFLTVLGVVIGVAAVIAMVTVGQGSSAQVSANVASLGTNVLILRPGKRMMGPGTRDTSPAF
TLRDVEALEELPVIRAVSPNTSASQTVVYGNANATTSITGTTAAYLTVANWVLAGGRVFTQAEERQGAAVCILGETVRQK
LFGAADPLGQTVRIKSISCLVVGLLEAKGAGSFGQDQDDLVLMPIRTVQRRLVGNQDVSGMSVALQDGVSATRGIRDISA
LLRERRRIGPADEENFSVTDMKEIASMLSSINTVLAGLLSSVAAVSLLVGGIGIMNIMLVSVTERTREIGIRLAVGATAG
QVLTQFLVEAVVLSVLGGMIGIALGLALALVASRYMLIPFTPDPLVVLMAFGFSAVVGVIFGYFPARRAARLDPIEALRH
Q

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=399, Percent_Identity=35.3383458646617, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 42158; Mature: 42158

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWETIRLAFIAIVRNKLRSFLTVLGVVIGVAAVIAMVTVGQGSSAQVSANVASLGTNVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCEE
ILRPGKRMMGPGTRDTSPAFTLRDVEALEELPVIRAVSPNTSASQTVVYGNANATTSITG
EECCCCHHCCCCCCCCCCCEEHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCEEECC
TTAAYLTVANWVLAGGRVFTQAEERQGAAVCILGETVRQKLFGAADPLGQTVRIKSISCL
HHHHHHHHHHHHHHCCCCEECHHHCCCCEEEEECHHHHHHHHCCCCCCCCEEEEEHHHHH
VVGLLEAKGAGSFGQDQDDLVLMPIRTVQRRLVGNQDVSGMSVALQDGVSATRGIRDISA
HHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHH
LLRERRRIGPADEENFSVTDMKEIASMLSSINTVLAGLLSSVAAVSLLVGGIGIMNIMLV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVTERTREIGIRLAVGATAGQVLTQFLVEAVVLSVLGGMIGIALGLALALVASRYMLIPF
HHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TPDPLVVLMAFGFSAVVGVIFGYFPARRAARLDPIEALRHQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MLWETIRLAFIAIVRNKLRSFLTVLGVVIGVAAVIAMVTVGQGSSAQVSANVASLGTNVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHCCCCEE
ILRPGKRMMGPGTRDTSPAFTLRDVEALEELPVIRAVSPNTSASQTVVYGNANATTSITG
EECCCCHHCCCCCCCCCCCEEHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCCEEECC
TTAAYLTVANWVLAGGRVFTQAEERQGAAVCILGETVRQKLFGAADPLGQTVRIKSISCL
HHHHHHHHHHHHHHCCCCEECHHHCCCCEEEEECHHHHHHHHCCCCCCCCEEEEEHHHHH
VVGLLEAKGAGSFGQDQDDLVLMPIRTVQRRLVGNQDVSGMSVALQDGVSATRGIRDISA
HHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHH
LLRERRRIGPADEENFSVTDMKEIASMLSSINTVLAGLLSSVAAVSLLVGGIGIMNIMLV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVTERTREIGIRLAVGATAGQVLTQFLVEAVVLSVLGGMIGIALGLALALVASRYMLIPF
HHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TPDPLVVLMAFGFSAVVGVIFGYFPARRAARLDPIEALRHQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500908 [H]