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The map label for this gene is hemB [H]

Identifier: 77461686

GI number: 77461686

Start: 6133040

End: 6134107

Strand: Reverse

Name: hemB [H]

Synonym: Pfl01_5465

Alternate gene names: 77461686

Gene position: 6134107-6133040 (Counterclockwise)

Preceding gene: 77461688

Following gene: 77461685

Centisome position: 95.27

GC content: 61.42

Gene sequence:

>1068_bases
ATGGCCATCTATAACTGTCACGCTCGCCCGTTTGCGCGGGCTCAGGAGTCTGCCGTGAGCTTTACCCCAGCCAACCGTCT
GTTCCCTGCCACCCGCCTGCGTCGCAATCGCCGTGATGATTTTTCCCGGCGGCTGGTGCGTGAGAATGTGTTGACGGTCG
ATGACCTGATCCTGCCAGTGTTCGTGCTCGACGGTGAAAATCGCCGCGAAGCTGTGGCTTCGATGCCGGGTGTCGAGCGC
CTGACCATCGATCTGCTGCTTGAAGAAGCCGCCAAATGGGTCGAGCTGGGAATTCCGGCGCTGGCGCTGTTCCCGGTCAC
CCCGCCTGAACTCAAATCCCTCGATGCCGCCGAAGCGTGGAATCCCGAAGGTATCGCCCAGCGCGCCACCCGTGCGCTGC
GTGACCGATTCCCCGAGCTGGGCGTGATCACCGACGTCGCCCTCGACCCGTTCACCACTCACGGTCAGGACGGCATTCTC
GATGAAGAAGGCTATGTGCAGAACGACATCACCGTCGACGCACTGGTCAAACAAGCCTTGTCCCACGCCGCTGCGGGCGC
CCAGGTGGTTGCCCCGTCGGACATGATGGACGGCCGCATCCAGGCGATCCGCGAAGCGCTGGAGCTGGCCGGTCACGTCA
ACGTGCGGATCATGGCCTACTCGGCCAAATACGCCAGCGCCTATTACGGCCCGTTCCGCGATGCCGTGGGTTCGGCGGCG
AACCTGGGCAAGGCGAACAAGGCCTCCTATCAGATGGACCCGGCCAACAGCGACGAAGCCCTGCACGAAGTGGGCGCGGA
CTTGTCTGAAGGCGCGGACATGGTCATGGTCAAGCCCGGCATGCCGTACCTGGATATTTTGTTCCGGGTAAAAGATGCCT
TCAAAGTGCCGACCTTCGTCTATCAGGTCAGCGGCGAATACGCCATGCACATGGCGGCGATCCAGAATGGCTGGTTGAGC
GAAGGCGTGATCCTCGAATCCCTGACCGCCTTTAAACGTGCCGGCGCTGATGGCATCCTGACTTACTTTGCTGTCCGTGC
CGCTCAATTGTTACGAGAGCAGAAATAG

Upstream 100 bases:

>100_bases
AAAGTGTCGAAATGTGTCTCGACGTGAACATTTCCTACACGGACAATGGAAAGCGACTACCTGTCGCAGGGGTGCACATA
ACTGTCATACGACCGTCATA

Downstream 100 bases:

>100_bases
CCCTCCCAGGAACATTCGATGAATACCGAAGGACTCACTGAAGTTGCCGTAAAAGACGCTCAACCCGTGGTCGAGCAGAT
TACCGAAACCCCGCCGGAAC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MAIYNCHARPFARAQESAVSFTPANRLFPATRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGENRREAVASMPGVER
LTIDLLLEEAAKWVELGIPALALFPVTPPELKSLDAAEAWNPEGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGIL
DEEGYVQNDITVDALVKQALSHAAAGAQVVAPSDMMDGRIQAIREALELAGHVNVRIMAYSAKYASAYYGPFRDAVGSAA
NLGKANKASYQMDPANSDEALHEVGADLSEGADMVMVKPGMPYLDILFRVKDAFKVPTFVYQVSGEYAMHMAAIQNGWLS
EGVILESLTAFKRAGADGILTYFAVRAAQLLREQK

Sequences:

>Translated_355_residues
MAIYNCHARPFARAQESAVSFTPANRLFPATRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGENRREAVASMPGVER
LTIDLLLEEAAKWVELGIPALALFPVTPPELKSLDAAEAWNPEGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGIL
DEEGYVQNDITVDALVKQALSHAAAGAQVVAPSDMMDGRIQAIREALELAGHVNVRIMAYSAKYASAYYGPFRDAVGSAA
NLGKANKASYQMDPANSDEALHEVGADLSEGADMVMVKPGMPYLDILFRVKDAFKVPTFVYQVSGEYAMHMAAIQNGWLS
EGVILESLTAFKRAGADGILTYFAVRAAQLLREQK
>Mature_354_residues
AIYNCHARPFARAQESAVSFTPANRLFPATRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGENRREAVASMPGVERL
TIDLLLEEAAKWVELGIPALALFPVTPPELKSLDAAEAWNPEGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILD
EEGYVQNDITVDALVKQALSHAAAGAQVVAPSDMMDGRIQAIREALELAGHVNVRIMAYSAKYASAYYGPFRDAVGSAAN
LGKANKASYQMDPANSDEALHEVGADLSEGADMVMVKPGMPYLDILFRVKDAFKVPTFVYQVSGEYAMHMAAIQNGWLSE
GVILESLTAFKRAGADGILTYFAVRAAQLLREQK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=309, Percent_Identity=44.0129449838188, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=42.3197492163009, Blast_Score=229, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321398, Length=317, Percent_Identity=36.2776025236593, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=40.5498281786942, Blast_Score=221, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38922; Mature: 38791

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYNCHARPFARAQESAVSFTPANRLFPATRLRRNRRDDFSRRLVRENVLTVDDLILPV
CCEEECCCCCHHHHHHHHCEECCCHHCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHEEE
FVLDGENRREAVASMPGVERLTIDLLLEEAAKWVELGIPALALFPVTPPELKSLDAAEAW
EEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCHHHCC
NPEGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQAL
CCHHHHHHHHHHHHHCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
SHAAAGAQVVAPSDMMDGRIQAIREALELAGHVNVRIMAYSAKYASAYYGPFRDAVGSAA
HHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHCCHHHHHHCCHH
NLGKANKASYQMDPANSDEALHEVGADLSEGADMVMVKPGMPYLDILFRVKDAFKVPTFV
HCCCCCCCCEEECCCCCHHHHHHHCCCHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEE
YQVSGEYAMHMAAIQNGWLSEGVILESLTAFKRAGADGILTYFAVRAAQLLREQK
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIYNCHARPFARAQESAVSFTPANRLFPATRLRRNRRDDFSRRLVRENVLTVDDLILPV
CEEECCCCCHHHHHHHHCEECCCHHCCCHHHHHHCCHHHHHHHHHHHHCCCHHHHHEEE
FVLDGENRREAVASMPGVERLTIDLLLEEAAKWVELGIPALALFPVTPPELKSLDAAEAW
EEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCHHHCC
NPEGIAQRATRALRDRFPELGVITDVALDPFTTHGQDGILDEEGYVQNDITVDALVKQAL
CCHHHHHHHHHHHHHCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
SHAAAGAQVVAPSDMMDGRIQAIREALELAGHVNVRIMAYSAKYASAYYGPFRDAVGSAA
HHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHCCHHHHHHCCHH
NLGKANKASYQMDPANSDEALHEVGADLSEGADMVMVKPGMPYLDILFRVKDAFKVPTFV
HCCCCCCCCEEECCCCCHHHHHHHCCCHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEE
YQVSGEYAMHMAAIQNGWLSEGVILESLTAFKRAGADGILTYFAVRAAQLLREQK
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]