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The map label for this gene is codB [H]

Identifier: 77460000

GI number: 77460000

Start: 4273837

End: 4275108

Strand: Direct

Name: codB [H]

Synonym: Pfl01_3778

Alternate gene names: 77460000

Gene position: 4273837-4275108 (Clockwise)

Preceding gene: 77459998

Following gene: 77460001

Centisome position: 66.38

GC content: 63.84

Gene sequence:

>1272_bases
ATGACGCAAAACGATCCCGGCAACGATTACCCCCTCAGTGAAGTGCCGATGCACGCGCGCAAAGGCCTGGCCTCCACGGC
GATGGTGCTGCTGGGCTTCACCTTCTTCACCGCGACCATGTTTGCCGGCGGCAAGCTCGGCGTGGCGTTCAACTTCGGCG
AAATGCTCGCCGTCATCGTTATCGGCAATCTGCTGCTCGGTGTGTATGCCGCAGGCCTCGGCTACATCGCCTTCAAGAGC
GGGCTGAATTCGGTGCTGATGGGGCGCTTCTGTTTTGGCGAAGTCGGCAGCAAGCTCAGCGACCTGATCCTCGGGTTCAC
CCAGATCGGCTGGTACGCCTGGGGCACCGCGACGGCGGCGGTGGTGCTCGGCAAGTATTTCGACTTGAACGAAGCCACGG
TGCTGGGCCTGATGGTGCTGTTCGGCCTGGTGTTCTGCGCCACGGCGTATGTCGGTTATCGCGGGCTGGAGATTCTGTCG
TACATCGCAGTGCCGGCGATGATGTTGCTGCTGATGCTGTCGATGTGGGTCGCGACCGTGAAAGTCGGCGGCCTCGATGG
TTTGCTCAGCGTCGTACCGACGGGTTCGCTGGACTGGTCGACCGCCATCACACTGGTGTTCGGCACCTTCGTCAGCGGCG
CGACCCAGGCCACCAACTGGACGCGTTTTTCCCGTTCGGCGCGGGTCGCGGTGCTGGCCAGCCTGATCGGTTTTTTCATC
GGCAACGGCCTGATGGTGCTGATCGGCGCCTATGGCGCAATCGTCTACCAACAGCCCGACGTGGTCGAAGTGCTGCTGTT
GCAGGGCTTTGCCATGGCGGCGATGGCGATGCTGTTACTGAACATCTGGAGCACCCAGGACAACACCATCTACAACTTCG
CCGTCGCCGGCTGCAACCTGCTGCGCACCGGGCGCCGCAAGACCGTGACCCTGGCCGGCGCAGTGATCGGCACGGCGCTC
GCGTTGCTGGGCATGTACGACATGCTGGTGCCTTATCTGATCCTGCTCGGCACGGTGATCCCGCCGATTGGCGGGGTGAT
CATGGCGGACTTTTTCTTCCGCTGGCGCGGGCGTTATCCGCGTCTGGCCGACGCACGGTTACCGGCGTTCAACTGGCCGG
GGCTCGCGGCTTACGCGGCCGGAACCGTCGCCGCGTTCGGCTCGCCGTGGGTCGCGCCGCTGGTGGGGATCGCCGTTGCC
GCGTTAACGTATATCGCAGTGACCGGCCTGCTCGGCGCCCGCAACGCCGCCGCCCCTCTACAAGATCTATAA

Upstream 100 bases:

>100_bases
CAAATCCGCCACCTCGTCTATACATAACCCCGTCAATCCGTGACTGGCACGACCGCTGCAACCTCTTCGCGTCCTCCCCT
TTCCAGCAAGGAACGCCCCC

Downstream 100 bases:

>100_bases
AAGGATTCGCCCGATGCACATCATCAACGCCCGACTGCGCAACCAGGAAGGTCTGCACGAATTGCACCTCGAAGACGGCC
TGATCCGCAGCATCGCGCGC

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQNDPGNDYPLSEVPMHARKGLASTAMVLLGFTFFTATMFAGGKLGVAFNFGEMLAVIVIGNLLLGVYAAGLGYIAFKS
GLNSVLMGRFCFGEVGSKLSDLILGFTQIGWYAWGTATAAVVLGKYFDLNEATVLGLMVLFGLVFCATAYVGYRGLEILS
YIAVPAMMLLLMLSMWVATVKVGGLDGLLSVVPTGSLDWSTAITLVFGTFVSGATQATNWTRFSRSARVAVLASLIGFFI
GNGLMVLIGAYGAIVYQQPDVVEVLLLQGFAMAAMAMLLLNIWSTQDNTIYNFAVAGCNLLRTGRRKTVTLAGAVIGTAL
ALLGMYDMLVPYLILLGTVIPPIGGVIMADFFFRWRGRYPRLADARLPAFNWPGLAAYAAGTVAAFGSPWVAPLVGIAVA
ALTYIAVTGLLGARNAAAPLQDL

Sequences:

>Translated_423_residues
MTQNDPGNDYPLSEVPMHARKGLASTAMVLLGFTFFTATMFAGGKLGVAFNFGEMLAVIVIGNLLLGVYAAGLGYIAFKS
GLNSVLMGRFCFGEVGSKLSDLILGFTQIGWYAWGTATAAVVLGKYFDLNEATVLGLMVLFGLVFCATAYVGYRGLEILS
YIAVPAMMLLLMLSMWVATVKVGGLDGLLSVVPTGSLDWSTAITLVFGTFVSGATQATNWTRFSRSARVAVLASLIGFFI
GNGLMVLIGAYGAIVYQQPDVVEVLLLQGFAMAAMAMLLLNIWSTQDNTIYNFAVAGCNLLRTGRRKTVTLAGAVIGTAL
ALLGMYDMLVPYLILLGTVIPPIGGVIMADFFFRWRGRYPRLADARLPAFNWPGLAAYAAGTVAAFGSPWVAPLVGIAVA
ALTYIAVTGLLGARNAAAPLQDL
>Mature_422_residues
TQNDPGNDYPLSEVPMHARKGLASTAMVLLGFTFFTATMFAGGKLGVAFNFGEMLAVIVIGNLLLGVYAAGLGYIAFKSG
LNSVLMGRFCFGEVGSKLSDLILGFTQIGWYAWGTATAAVVLGKYFDLNEATVLGLMVLFGLVFCATAYVGYRGLEILSY
IAVPAMMLLLMLSMWVATVKVGGLDGLLSVVPTGSLDWSTAITLVFGTFVSGATQATNWTRFSRSARVAVLASLIGFFIG
NGLMVLIGAYGAIVYQQPDVVEVLLLQGFAMAAMAMLLLNIWSTQDNTIYNFAVAGCNLLRTGRRKTVTLAGAVIGTALA
LLGMYDMLVPYLILLGTVIPPIGGVIMADFFFRWRGRYPRLADARLPAFNWPGLAAYAAGTVAAFGSPWVAPLVGIAVAA
LTYIAVTGLLGARNAAAPLQDL

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=421, Percent_Identity=39.1923990498812, Blast_Score=264, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 44728; Mature: 44596

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
TQNDPGNDYPLSEVPMHARKGLASTAMVLLGFTFFTATMFAGGKLGVAFNFGEMLAVIV
CCCCCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHH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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]