Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 77459815

GI number: 77459815

Start: 4060263

End: 4061519

Strand: Reverse

Name: icd [H]

Synonym: Pfl01_3593

Alternate gene names: 77459815

Gene position: 4061519-4060263 (Counterclockwise)

Preceding gene: 77459841

Following gene: 77459813

Centisome position: 63.08

GC content: 58.07

Gene sequence:

>1257_bases
ATGGGTTACAAGAAGATTCAGGTTCCAGCCGTCGGCGACAAAATCACCGTCAACGCAGACCATTCTCTCAATGTCCCTGA
TAACCCGATCATTCCCTTCATCGAAGGTGACGGCATTGGCGTCGACGTCAGCCCTGTGATGATCAAAGTGGTTGATGCTG
CCGTAGAGAAAGCCTACGGGGGTAAGCGCAAGATTTCCTGGATGGAGGTTTATGCTGGCGAAAAAGCAACTCAGGTCTAT
GACCAGGACACCTGGCTGCCCCAGGAAACCCTGGACGCGGTCAAGGATTACGTGGTCTCCATCAAAGGCCCGCTGACCAC
TCCGGTCGGTGGCGGCATCCGTTCCCTCAACGTCGCCCTGCGCCAACAGCTCGATCTCTATGTCTGCCTTCGCCCTGTGG
TGTGGTTCGAAGGTGTGCCGAGCCCGGTGAAAAAGCCTGGCGACGTCGACATGGTGATCTTCCGCGAGAACTCCGAAGAC
ATTTATGCCGGTATCGAATGGAAAGCCGGCTCCCCTGAGGCCACCAAGGTCATCAAATTCCTGAAAGAAGAAATGGGCGT
CACCAAGATCCGTTTCGACCAGGATTGCGGCATCGGCATCAAGCCGGTTTCCAAAGAAGGCACCAAGCGTCTGGTGCGCA
AGGCGCTGCAATACGTGGTGGACAACGACCGCAAGTCGCTGACCATCGTGCACAAGGGCAACATCATGAAATTCACCGAA
GGTGCCTTCAAGGACTGGGGCTACGAGGTGGCGAAGGAAGAATTCGGCGCCGAGCTGCTCGATGGCGGCCCATGGATGAA
ATTCAAGAACCCGAAAACCGGCCGCGAAGTCGTCGTCAAGGACGCCATCGCCGACGCCATGCTCCAGCAGATCCTGCTGC
GTCCGGCCGAATACGATGTGATCGCCACCCTCAACCTCAACGGTGACTACCTGTCCGACGCCCTGGCGGCGGAAGTGGGC
GGTATCGGTATCGCGCCGGGTGCCAACCTGTCCGACACCGTAGCCATGTTCGAGGCGACCCACGGTACTGCGCCGAAATA
TGCCGGCAAGGACCAGGTCAACCCGGGTTCGGTGATTTTGTCGGCGGAAATGATGCTGCGCCACCTGGGCTGGACCGAGG
CGGCCGACCTGATCATCAAGGGCACCAATGGCGCCATCAAGGCCAAGACCGTGACCTACGACTTCGAACGTCTGATGGAA
GGCGCCACACTGGTGTCTTCTTCGGGCTTCGGTGAAGCGCTGATCAAGCACATGTAA

Upstream 100 bases:

>100_bases
ACGAGATGTGGTCGCGCCCGGAACAGAGGGTTTGCGTGTTGATTCAACTGGGTTACGCTCGAACCAAGCCAGATGTTCAA
TCCAAACAATGGAGTTCAGC

Downstream 100 bases:

>100_bases
GAACGGCAGCTGCAACGAAACCGCCCGGCTCGAGTGATCGAGCCGGGCGGTTTGTTTTCTGGCAGGTGTTCGGGTTGCTT
CAGCTGGTCACTGACTGGTG

Product: isocitrate dehydrogenase (NADP)

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MGYKKIQVPAVGDKITVNADHSLNVPDNPIIPFIEGDGIGVDVSPVMIKVVDAAVEKAYGGKRKISWMEVYAGEKATQVY
DQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVVWFEGVPSPVKKPGDVDMVIFRENSED
IYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGIKPVSKEGTKRLVRKALQYVVDNDRKSLTIVHKGNIMKFTE
GAFKDWGYEVAKEEFGAELLDGGPWMKFKNPKTGREVVVKDAIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVG
GIGIAPGANLSDTVAMFEATHGTAPKYAGKDQVNPGSVILSAEMMLRHLGWTEAADLIIKGTNGAIKAKTVTYDFERLME
GATLVSSSGFGEALIKHM

Sequences:

>Translated_418_residues
MGYKKIQVPAVGDKITVNADHSLNVPDNPIIPFIEGDGIGVDVSPVMIKVVDAAVEKAYGGKRKISWMEVYAGEKATQVY
DQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVVWFEGVPSPVKKPGDVDMVIFRENSED
IYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGIKPVSKEGTKRLVRKALQYVVDNDRKSLTIVHKGNIMKFTE
GAFKDWGYEVAKEEFGAELLDGGPWMKFKNPKTGREVVVKDAIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVG
GIGIAPGANLSDTVAMFEATHGTAPKYAGKDQVNPGSVILSAEMMLRHLGWTEAADLIIKGTNGAIKAKTVTYDFERLME
GATLVSSSGFGEALIKHM
>Mature_417_residues
GYKKIQVPAVGDKITVNADHSLNVPDNPIIPFIEGDGIGVDVSPVMIKVVDAAVEKAYGGKRKISWMEVYAGEKATQVYD
QDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVVWFEGVPSPVKKPGDVDMVIFRENSEDI
YAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGIKPVSKEGTKRLVRKALQYVVDNDRKSLTIVHKGNIMKFTEG
AFKDWGYEVAKEEFGAELLDGGPWMKFKNPKTGREVVVKDAIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGG
IGIAPGANLSDTVAMFEATHGTAPKYAGKDQVNPGSVILSAEMMLRHLGWTEAADLIIKGTNGAIKAKTVTYDFERLMEG
ATLVSSSGFGEALIKHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=367, Percent_Identity=33.2425068119891, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.8409090909091, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.8409090909091, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI28178838, Length=368, Percent_Identity=27.7173913043478, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4758582, Length=356, Percent_Identity=28.3707865168539, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1787381, Length=414, Percent_Identity=75.8454106280193, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=345, Percent_Identity=29.8550724637681, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081683, Length=405, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=365, Percent_Identity=33.4246575342466, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=292, Percent_Identity=31.1643835616438, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=288, Percent_Identity=29.8611111111111, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=24.8554913294798, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=28.9002557544757, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322097, Length=375, Percent_Identity=29.6, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=372, Percent_Identity=27.1505376344086, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643268, Length=359, Percent_Identity=35.0974930362117, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24643270, Length=359, Percent_Identity=35.0974930362117, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=30.690537084399, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI161078635, Length=292, Percent_Identity=29.4520547945205, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078633, Length=292, Percent_Identity=29.4520547945205, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24650122, Length=292, Percent_Identity=29.4520547945205, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078637, Length=292, Percent_Identity=29.4520547945205, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078639, Length=292, Percent_Identity=29.4520547945205, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130355, Length=348, Percent_Identity=27.2988505747126, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281362242, Length=327, Percent_Identity=28.1345565749235, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648872, Length=327, Percent_Identity=28.1345565749235, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45523; Mature: 45392

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYKKIQVPAVGDKITVNADHSLNVPDNPIIPFIEGDGIGVDVSPVMIKVVDAAVEKAYG
CCCCEEECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHCC
GKRKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEECCCHHHEECCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RQQLDLYVCLRPVVWFEGVPSPVKKPGDVDMVIFRENSEDIYAGIEWKAGSPEATKVIKF
HHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHH
LKEEMGVTKIRFDQDCGIGIKPVSKEGTKRLVRKALQYVVDNDRKSLTIVHKGNIMKFTE
HHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFKDWGYEVAKEEFGAELLDGGPWMKFKNPKTGREVVVKDAIADAMLQQILLRPAEYDV
CHHHHCCHHHHHHHHCCHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYLSDALAAEVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDQVNPGSVIL
EEEEECCCHHHHHHHHHHHCCEECCCCCCCCHHHHEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHLGWTEAADLIIKGTNGAIKAKTVTYDFERLMEGATLVSSSGFGEALIKHM
EHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEECHHHHHCCCCEEECCCHHHHHHHCC
>Mature Secondary Structure 
GYKKIQVPAVGDKITVNADHSLNVPDNPIIPFIEGDGIGVDVSPVMIKVVDAAVEKAYG
CCCEEECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHCC
GKRKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEECCCHHHEECCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RQQLDLYVCLRPVVWFEGVPSPVKKPGDVDMVIFRENSEDIYAGIEWKAGSPEATKVIKF
HHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHHHHHH
LKEEMGVTKIRFDQDCGIGIKPVSKEGTKRLVRKALQYVVDNDRKSLTIVHKGNIMKFTE
HHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFKDWGYEVAKEEFGAELLDGGPWMKFKNPKTGREVVVKDAIADAMLQQILLRPAEYDV
CHHHHCCHHHHHHHHCCHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYLSDALAAEVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDQVNPGSVIL
EEEEECCCHHHHHHHHHHHCCEECCCCCCCCHHHHEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHLGWTEAADLIIKGTNGAIKAKTVTYDFERLMEGATLVSSSGFGEALIKHM
EHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEECHHHHHCCCCEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]