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The map label for this gene is aceK [H]

Identifier: 77457646

GI number: 77457646

Start: 1590514

End: 1592235

Strand: Direct

Name: aceK [H]

Synonym: Pfl01_1419

Alternate gene names: 77457646

Gene position: 1590514-1592235 (Clockwise)

Preceding gene: 77457643

Following gene: 77457647

Centisome position: 24.7

GC content: 60.63

Gene sequence:

>1722_bases
ATGCCGCAGCAATGGCCAGCCACCGACATCGCCCGCCTGATCCTCGATGGGTTTGACGATTACCGCGAGCATTTCCGGCG
GATCACCGACGGCGCCCGGGAGCGCTTCGAGCAGGCCCGCTGGCAGGACACGCAAACCGCGTCGGCGGCGCGGATCAACC
TCTACGAAGAAAAGGTCGGTGAAACCGTCGCCCGTCTGCGCGAGTACTTCGAGCCGGACACCTTGATGGATGTCACCTGC
TGGCCACTGGTGAAAAGCGCCTACATCAGCATCATCGACCTGCGCTTCGACGATGAGCTGTCCGAGACCTGGTACAACTC
GATTTTCTGCAGCCTGTTCAGCCACGACCTGATCAGCGACGGCTGCATGTTCATCCACACCACGCGCCCGAGCCTGCGTC
GGGCACGGGCCGCGCAAACCCGCACCTACAAGCCCCAAGGGCAGATCTCGGGCATGCTTGCGAGCATCTTTGCCGATTAC
CGCTTCAGCGAGGCCTACGCCGATTTGCCCGGCGACTTGCTGCGTCTGGAAGCGCAACTGCGCGAGAACCTGCCGGACTG
GGTGTGCAAGGACCCGGAGCTGAGCGTCGAGCTGTTTTCCTCGGTGCTGTACCGCAACAAGGGCGCGTACCTGGTGGGGC
GCATCTACACCAACGACGATCAGTGGCCGTTGGTGATTCCGTTGCTGCACCGCGAAGGGCGCGGGATTCAGATCGACGCA
TTGATCACCGACGAAGCGGAGGTGTCGATCATCTTCTCCTTCACCCGTTCGTATTTCATGGTGGATGTGCCGGTGCCGGC
GGAGTTCATCGGTTTCCTCAAACGCATCCTGCCGGGCAAGCACATCGCCGAGCTGTACACCTCGATCGGTTTCTACAAGC
ACGGTAAATCGGAGTTCTACCGCGCCCTGATCAATCACCTGGCCAACACCGATGACCAGTTCATCATGGCGCCGGGCGTG
CGCGGCATGGTCATGAGCGTGTTCACGCTGCCGGGCTTCAACACCGTGTTCAAGATCATCAAGGACCGTTTCTCCCCATC
CAAAAACGTCGACCGCGCCACGGTGATCGAGAAGTACCGACTGGTGAAAAGCGTCGACCGCGTCGGGCGCATGGCCGATA
CCCAGGAATTCGCCGACTTTCGTTTTCCCCTGAGCAAATTCGAGCCGGCGTGCCTGGCGGAGCTGCTGGAAGTCGCGCCG
TCCACGGTGTCGCTGGAAGGCGAAACCGTGCTGATCCGCCACTGCTGGACCGAGCGCCGGATGACCCCGCTCAACCTGTA
TCTGGATAACGCCAACGAAGCCCAGGTGCGCGAAGCGCTGGAGGATTACGGCCTGGCGATCAAGCAACTGGCGGCGGCCA
ACATCTTTCCCGGCGACATGCTGCTGAAGAACTTCGGCGTCACCCGCCATGGCCGGGTGGTGTTCTACGACTACGACGAG
ATCTGCTTTCTCACCGAAGCCAACTTCCGCCACATTCCGGCACCGCGTACGCCGGAGGACGAAATGGCCTCCGAACCGTG
GTATTCGATCGGGCCACTGGATGTGTTTCCCGAGGAATTTCCGCCGTTCCTGTTTGCCGATGCAGCGCAGCGCAAGCTGT
TCGATCAGTTGCATGGCGAGTTGTACAACGCTGATTACTGGAAGGGGCTACAGGAAGCGATTCGGGCGGGGAAAGTCATT
GATGTCTTTCCGTATCGGCGCAAAGGCCTGGATAACGAATAA

Upstream 100 bases:

>100_bases
AAGAGGATTTGGCCGAAATTGCGCTTCTCCTGCAGCCGCTTCCGTGGCTAAGCTCAGGCCTTCGAGCACAGATTCTCCAA
TTCCCGCAGAGGTCTCATCT

Downstream 100 bases:

>100_bases
AGCAGCCGCAAGCCGCAAGCCGCAAGCAGCAAGCAGCAAGCTACAAGCAGCAAGCTACAAGCCTCAAGTCAAACGCCGCT
TTCAACTTGCGGCTTGTAGC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MPQQWPATDIARLILDGFDDYREHFRRITDGARERFEQARWQDTQTASAARINLYEEKVGETVARLREYFEPDTLMDVTC
WPLVKSAYISIIDLRFDDELSETWYNSIFCSLFSHDLISDGCMFIHTTRPSLRRARAAQTRTYKPQGQISGMLASIFADY
RFSEAYADLPGDLLRLEAQLRENLPDWVCKDPELSVELFSSVLYRNKGAYLVGRIYTNDDQWPLVIPLLHREGRGIQIDA
LITDEAEVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFYRALINHLANTDDQFIMAPGV
RGMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYRLVKSVDRVGRMADTQEFADFRFPLSKFEPACLAELLEVAP
STVSLEGETVLIRHCWTERRMTPLNLYLDNANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDE
ICFLTEANFRHIPAPRTPEDEMASEPWYSIGPLDVFPEEFPPFLFADAAQRKLFDQLHGELYNADYWKGLQEAIRAGKVI
DVFPYRRKGLDNE

Sequences:

>Translated_573_residues
MPQQWPATDIARLILDGFDDYREHFRRITDGARERFEQARWQDTQTASAARINLYEEKVGETVARLREYFEPDTLMDVTC
WPLVKSAYISIIDLRFDDELSETWYNSIFCSLFSHDLISDGCMFIHTTRPSLRRARAAQTRTYKPQGQISGMLASIFADY
RFSEAYADLPGDLLRLEAQLRENLPDWVCKDPELSVELFSSVLYRNKGAYLVGRIYTNDDQWPLVIPLLHREGRGIQIDA
LITDEAEVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFYRALINHLANTDDQFIMAPGV
RGMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYRLVKSVDRVGRMADTQEFADFRFPLSKFEPACLAELLEVAP
STVSLEGETVLIRHCWTERRMTPLNLYLDNANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDE
ICFLTEANFRHIPAPRTPEDEMASEPWYSIGPLDVFPEEFPPFLFADAAQRKLFDQLHGELYNADYWKGLQEAIRAGKVI
DVFPYRRKGLDNE
>Mature_572_residues
PQQWPATDIARLILDGFDDYREHFRRITDGARERFEQARWQDTQTASAARINLYEEKVGETVARLREYFEPDTLMDVTCW
PLVKSAYISIIDLRFDDELSETWYNSIFCSLFSHDLISDGCMFIHTTRPSLRRARAAQTRTYKPQGQISGMLASIFADYR
FSEAYADLPGDLLRLEAQLRENLPDWVCKDPELSVELFSSVLYRNKGAYLVGRIYTNDDQWPLVIPLLHREGRGIQIDAL
ITDEAEVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFYRALINHLANTDDQFIMAPGVR
GMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYRLVKSVDRVGRMADTQEFADFRFPLSKFEPACLAELLEVAPS
TVSLEGETVLIRHCWTERRMTPLNLYLDNANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDEI
CFLTEANFRHIPAPRTPEDEMASEPWYSIGPLDVFPEEFPPFLFADAAQRKLFDQLHGELYNADYWKGLQEAIRAGKVID
VFPYRRKGLDNE

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=562, Percent_Identity=46.085409252669, Blast_Score=489, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 66063; Mature: 65932

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQQWPATDIARLILDGFDDYREHFRRITDGARERFEQARWQDTQTASAARINLYEEKVG
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ETVARLREYFEPDTLMDVTCWPLVKSAYISIIDLRFDDELSETWYNSIFCSLFSHDLISD
HHHHHHHHHCCCCCEECCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GCMFIHTTRPSLRRARAAQTRTYKPQGQISGMLASIFADYRFSEAYADLPGDLLRLEAQL
CEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RENLPDWVCKDPELSVELFSSVLYRNKGAYLVGRIYTNDDQWPLVIPLLHREGRGIQIDA
HHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEE
LITDEAEVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFY
EEECCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
RALINHLANTDDQFIMAPGVRGMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYR
HHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LVKSVDRVGRMADTQEFADFRFPLSKFEPACLAELLEVAPSTVSLEGETVLIRHCWTERR
HHHHHHHHHHHHCHHHHHHHCCCHHHCCHHHHHHHHHHCCCCEEECCCEEEEEEHHHCCC
MTPLNLYLDNANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDE
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCC
ICFLTEANFRHIPAPRTPEDEMASEPWYSIGPLDVFPEEFPPFLFADAAQRKLFDQLHGE
EEEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LYNADYWKGLQEAIRAGKVIDVFPYRRKGLDNE
HCCCHHHHHHHHHHHCCCEEEECCCHHCCCCCC
>Mature Secondary Structure 
PQQWPATDIARLILDGFDDYREHFRRITDGARERFEQARWQDTQTASAARINLYEEKVG
CCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ETVARLREYFEPDTLMDVTCWPLVKSAYISIIDLRFDDELSETWYNSIFCSLFSHDLISD
HHHHHHHHHCCCCCEECCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GCMFIHTTRPSLRRARAAQTRTYKPQGQISGMLASIFADYRFSEAYADLPGDLLRLEAQL
CEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RENLPDWVCKDPELSVELFSSVLYRNKGAYLVGRIYTNDDQWPLVIPLLHREGRGIQIDA
HHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEE
LITDEAEVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFY
EEECCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
RALINHLANTDDQFIMAPGVRGMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYR
HHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LVKSVDRVGRMADTQEFADFRFPLSKFEPACLAELLEVAPSTVSLEGETVLIRHCWTERR
HHHHHHHHHHHHCHHHHHHHCCCHHHCCHHHHHHHHHHCCCCEEECCCEEEEEEHHHCCC
MTPLNLYLDNANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDE
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCC
ICFLTEANFRHIPAPRTPEDEMASEPWYSIGPLDVFPEEFPPFLFADAAQRKLFDQLHGE
EEEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LYNADYWKGLQEAIRAGKVIDVFPYRRKGLDNE
HCCCHHHHHHHHHHHCCCEEEECCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA