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The map label for this gene is ycdW [C]

Identifier: 77457617

GI number: 77457617

Start: 1563497

End: 1564429

Strand: Direct

Name: ycdW [C]

Synonym: Pfl01_1390

Alternate gene names: 77457617

Gene position: 1563497-1564429 (Clockwise)

Preceding gene: 77457616

Following gene: 77457619

Centisome position: 24.28

GC content: 64.84

Gene sequence:

>933_bases
ATGCGCGTTCTGATTGCTGAACACGACCACGCGATATACGCCCGACTGCTGCGTCAGGCGGCCCCGGAGCTTGAAGTACT
GACCAGCGGCGACTCCGCCGAACTGGCCCGCCAGGCCGTCGATTGCCCGGTGTGGCTGGGCCAGCCGGATCTGCTGGCGA
CCCTTTTGCGTCAGGGTCATCAGCCCCAATGGCTGCAATCGACCTGGGCCGGGATCACGCCGCTGCTGGCCGACGGCCTG
CGCCGGGATTACCGCCTGACCCGGGCGGTCGGCATTTTCGGCCAGGTCATGGCTGAATACGTGCTGACCTACATGCTCGG
CCACGAACGCGAAGTACTGGCGCGGCTGGTCAGCCAGGTCGAGCGCAAGTGGGACAACCGCACCGGCCAGAGTCTGGTCG
GGCGCAAGGTGCTGATCGTCGGCACCGGTGACATCGGCCAGAGCGTGGCGCAGTTCCTGCTGCCGTTCGGCGTCGAGTTG
TACGGCATCGCCAGCAGCGCTCGCGAGCAGGCGCCGTTTGTCGAAGTCGGTTCGATGGCGGACTTGCCGCGTCTGGTGGG
CGAGGCGGATTACGTGGTCAACCTGCTGCCCAACACCGAGCACACCCACGACATTTACGATGCGGCGCTGTTCAAGCAAT
TCAAGCCGACCGGGTTGTTCATCAACGCCGGACGCGGTGTCGCAGTGGTCGATGCGGATCTGGTCGAAGCGTTGAAGGAA
GGTCATCTGGCGGGCGCGGTGATCGACGTCTGCCGTCAGGAACCGTTGCCGCAACGGCATCCGTTCTGGACTGCATGGGG
CTTGTTGCTGACCGGGCACAGCTCGGCGCCGACCTCGCCGCCGATGATGGTGCAGTTGTTTCTGGATAACGTGCGGGCGT
ATCAGGCGGGCGAAGCGTTGCGCGGGGAAGTGGATTTCGCACGCGGTTACTGA

Upstream 100 bases:

>100_bases
AGGCCCTGTCCTGGGCCTCTGGTAACCCCTGGAACGGTTTTTACGGCGACGGCTGCCACGAAGTGGACGGCCGCCTGCAC
GGTTTGCGAAAGGTTTGAAG

Downstream 100 bases:

>100_bases
CTAGAGATCGTTCCCACGCTCTGCGTGGGAATGCAGCCCGTGACGCTCCGCGTCACTGGACGCGGAGCGTCCCTTGAGGC
ATTCCCACGCAGAGCGTGGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRVLIAEHDHAIYARLLRQAAPELEVLTSGDSAELARQAVDCPVWLGQPDLLATLLRQGHQPQWLQSTWAGITPLLADGL
RRDYRLTRAVGIFGQVMAEYVLTYMLGHEREVLARLVSQVERKWDNRTGQSLVGRKVLIVGTGDIGQSVAQFLLPFGVEL
YGIASSAREQAPFVEVGSMADLPRLVGEADYVVNLLPNTEHTHDIYDAALFKQFKPTGLFINAGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVQLFLDNVRAYQAGEALRGEVDFARGY

Sequences:

>Translated_310_residues
MRVLIAEHDHAIYARLLRQAAPELEVLTSGDSAELARQAVDCPVWLGQPDLLATLLRQGHQPQWLQSTWAGITPLLADGL
RRDYRLTRAVGIFGQVMAEYVLTYMLGHEREVLARLVSQVERKWDNRTGQSLVGRKVLIVGTGDIGQSVAQFLLPFGVEL
YGIASSAREQAPFVEVGSMADLPRLVGEADYVVNLLPNTEHTHDIYDAALFKQFKPTGLFINAGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVQLFLDNVRAYQAGEALRGEVDFARGY
>Mature_310_residues
MRVLIAEHDHAIYARLLRQAAPELEVLTSGDSAELARQAVDCPVWLGQPDLLATLLRQGHQPQWLQSTWAGITPLLADGL
RRDYRLTRAVGIFGQVMAEYVLTYMLGHEREVLARLVSQVERKWDNRTGQSLVGRKVLIVGTGDIGQSVAQFLLPFGVEL
YGIASSAREQAPFVEVGSMADLPRLVGEADYVVNLLPNTEHTHDIYDAALFKQFKPTGLFINAGRGVAVVDADLVEALKE
GHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVQLFLDNVRAYQAGEALRGEVDFARGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=184, Percent_Identity=32.0652173913043, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081824, Length=219, Percent_Identity=30.5936073059361, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082289, Length=237, Percent_Identity=28.6919831223629, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=214, Percent_Identity=29.9065420560748, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571528, Length=182, Percent_Identity=29.6703296703297, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574286, Length=158, Percent_Identity=31.0126582278481, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=25.8964143426295, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=25.8964143426295, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34156; Mature: 34156

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIAEHDHAIYARLLRQAAPELEVLTSGDSAELARQAVDCPVWLGQPDLLATLLRQGH
CEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEECCCHHHHHHHHHCCC
QPQWLQSTWAGITPLLADGLRRDYRLTRAVGIFGQVMAEYVLTYMLGHEREVLARLVSQV
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERKWDNRTGQSLVGRKVLIVGTGDIGQSVAQFLLPFGVELYGIASSAREQAPFVEVGSMA
HHHHCCCCCHHHHCCEEEEEECCHHHHHHHHHHHHHCCHHEECHHHHHHCCCCEECCCHH
DLPRLVGEADYVVNLLPNTEHTHDIYDAALFKQFKPTGLFINAGRGVAVVDADLVEALKE
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHH
GHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVQLFLDNVRAYQAGEAL
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCHHH
RGEVDFARGY
HCCCHHCCCC
>Mature Secondary Structure
MRVLIAEHDHAIYARLLRQAAPELEVLTSGDSAELARQAVDCPVWLGQPDLLATLLRQGH
CEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCEECCCHHHHHHHHHCCC
QPQWLQSTWAGITPLLADGLRRDYRLTRAVGIFGQVMAEYVLTYMLGHEREVLARLVSQV
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ERKWDNRTGQSLVGRKVLIVGTGDIGQSVAQFLLPFGVELYGIASSAREQAPFVEVGSMA
HHHHCCCCCHHHHCCEEEEEECCHHHHHHHHHHHHHCCHHEECHHHHHHCCCCEECCCHH
DLPRLVGEADYVVNLLPNTEHTHDIYDAALFKQFKPTGLFINAGRGVAVVDADLVEALKE
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECHHHHHHHHH
GHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVQLFLDNVRAYQAGEAL
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCHHH
RGEVDFARGY
HCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]