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The map label for this gene is purC [H]

Identifier: 77457601

GI number: 77457601

Start: 1547120

End: 1547833

Strand: Direct

Name: purC [H]

Synonym: Pfl01_1374

Alternate gene names: 77457601

Gene position: 1547120-1547833 (Clockwise)

Preceding gene: 77457600

Following gene: 77457604

Centisome position: 24.03

GC content: 57.98

Gene sequence:

>714_bases
ATGGAAAAACGTGAAGAACTCTACCGCGGCAAAGCCAAATCGGTTTACAAGACCGACGACGCTGACCGCTTGATCCTGCT
GTTTCGCAACGACACTTCGGCGTTCGACGGCAAGCGCATCGAGCAGCTCGACCGCAAAGGCATGGTGAACAACAAGTTCA
ACGCCTTCATCATGCAGAAACTCGAAGCGGCCGGCATTCCGACCCAATTCGACAAACTGCTGGCCGACAACGAAGTGCTG
GTGAAAAAACTCGACATGATCCCGGTCGAGTGCGTCGTGCGTAACTACGCCGCCGGCAGCCTGGTCAAGCGTCTGGGCGT
CGAGGAGGGCATGAAGCTCAACCCGTACACCTTCGAACTGTTCCTGAAGGACGACGCCAAGGGCGATCCGTTCATCAACG
AATCCCACGTCGTGGCCTTCGGCTGGGGTACTGCCGAGCAACTGGCGCGCATGAAAGAACTGTCGCTCAAGGTCAACGAA
GTCCTGAGCAAACTGTTCGACGACGCCGGCCTGTTGCTGGTGGACTTCAAGCTTGAATTCGGCGTGTTCAGCGACGGCTC
CATCGTCCTGGGCGACGAGTTCAGCCCGGACGGCTGCCGTCTGTGGGACAAGGACACCAAGAAGAAGATGGACAAGGACC
GCTTCCGCCAGGGCCTCGGTGACGTCATCGAAGCCTACGAAGAAGTCGCCAACCGTCTGGGCGTACCGCTTTAA

Upstream 100 bases:

>100_bases
CTCGGGTGCGACCCGGACTGGCTGCAACTGGCCGATCAAGATTCAGGGCTCGACTGGCGCCACATCGCCTAGCCCATCTA
CTTAGCAAGCGGAGCCCATC

Downstream 100 bases:

>100_bases
TCGACGCAAGCATCTGATAGCACGGAAAAAATTTCGTCTGGGGGTTTCCCATTCAGCGAAAGTGTTGTTATGATGCGCGC
CGTTGGAGAGATGCCAGAGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLADNEVL
VKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNE
VLSKLFDDAGLLLVDFKLEFGVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL

Sequences:

>Translated_237_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLADNEVL
VKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNE
VLSKLFDDAGLLLVDFKLEFGVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
>Mature_237_residues
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEAAGIPTQFDKLLADNEVL
VKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFELFLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNE
VLSKLFDDAGLLLVDFKLEFGVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=246, Percent_Identity=34.1463414634146, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI5453539, Length=246, Percent_Identity=34.1463414634146, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI119220559, Length=253, Percent_Identity=32.8063241106719, Blast_Score=111, Evalue=5e-25,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=71.7299578059072, Blast_Score=344, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17531275, Length=244, Percent_Identity=31.1475409836066, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=34.0909090909091, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24583917, Length=212, Percent_Identity=33.4905660377358, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26872; Mature: 26872

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQK
CCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHH
LEAAGIPTQFDKLLADNEVLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFEL
HHHCCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEE
FLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNEVLSKLFDDAGLLLVDFKLEF
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
CEECCCCEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKREELYRGKAKSVYKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQK
CCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHH
LEAAGIPTQFDKLLADNEVLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGMKLNPYTFEL
HHHCCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEE
FLKDDAKGDPFINESHVVAFGWGTAEQLARMKELSLKVNEVLSKLFDDAGLLLVDFKLEF
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GVFSDGSIVLGDEFSPDGCRLWDKDTKKKMDKDRFRQGLGDVIEAYEEVANRLGVPL
CEECCCCEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA