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The map label for this gene is arpR [H]

Identifier: 77457508

GI number: 77457508

Start: 1457594

End: 1458226

Strand: Direct

Name: arpR [H]

Synonym: Pfl01_1281

Alternate gene names: 77457508

Gene position: 1457594-1458226 (Clockwise)

Preceding gene: 77457502

Following gene: 77457512

Centisome position: 22.64

GC content: 59.72

Gene sequence:

>633_bases
ATGGTTCGTCGTACCAAAGAGGAAGCTCAGGAAACGCGCAGCCAGATTCTCGAAGCGGCCGAGAAAGCCTTCTATGAGCG
GGGCGTGGCCCGCACGACCCTGTCGGACATCGCTACCTTGGCCGGGGTGACGCGCGGTGCGATCTACTGGCACTTCAGCA
ACAAGGCCGATCTGCTGCAGGCCATGCTCGATACCCTGCATGAGCCGCTGGACGAACTGGCCAAGGCCAGCGAAAGCGAG
GACGAACCCGATCCGCTGGGTTGCATGCGCAAATTGCTGATTCATTTGTTTCATCAAGTTGCGCTGGATCCGAAGACCCG
GCGTATCAACGAAATTCTGTTTCATAAGTGCGAGTTCACCGATGAAATGTGCGACCTGCGCCAGCAGCGCCGGACCGCCA
GCCTCGATTGCAATGTGCGGATCGCGCTGACACTGAGTAATGCGATCAATCGTGGGCAGTTGCCGGCAGACCTCGACACT
GCCCGGGCAGCCATCAGCATTCACGCCTATATCGACGGCCTCCTTTATGGATGGCTATTGGCGCCGGACAGCTTCGAGCT
GTACGCCGAGGCCGAACGCTGGGTCGATACCGGGCTGGACATGCTGCGCCTGAGCCCCAGCCTGCGCAAATGA

Upstream 100 bases:

>100_bases
GAAATTGTAGGCCGGGGATCCGATCCGCGAGAGATCAACCCTTTTTTATTCAGCGGATATTCAGCCATCCCTGAAACATC
CTGTTTGAGGTTTTACTGCC

Downstream 100 bases:

>100_bases
AACAAAATTCGTTGTTGGATCAGTTTGTGTCAATGACGGAGGAGGGTGAAGATCCCTGTTCACTCGCCCCGCTGCAATGG
GATGCTTTTATATACCTCTG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MVRRTKEEAQETRSQILEAAEKAFYERGVARTTLSDIATLAGVTRGAIYWHFSNKADLLQAMLDTLHEPLDELAKASESE
DEPDPLGCMRKLLIHLFHQVALDPKTRRINEILFHKCEFTDEMCDLRQQRRTASLDCNVRIALTLSNAINRGQLPADLDT
ARAAISIHAYIDGLLYGWLLAPDSFELYAEAERWVDTGLDMLRLSPSLRK

Sequences:

>Translated_210_residues
MVRRTKEEAQETRSQILEAAEKAFYERGVARTTLSDIATLAGVTRGAIYWHFSNKADLLQAMLDTLHEPLDELAKASESE
DEPDPLGCMRKLLIHLFHQVALDPKTRRINEILFHKCEFTDEMCDLRQQRRTASLDCNVRIALTLSNAINRGQLPADLDT
ARAAISIHAYIDGLLYGWLLAPDSFELYAEAERWVDTGLDMLRLSPSLRK
>Mature_210_residues
MVRRTKEEAQETRSQILEAAEKAFYERGVARTTLSDIATLAGVTRGAIYWHFSNKADLLQAMLDTLHEPLDELAKASESE
DEPDPLGCMRKLLIHLFHQVALDPKTRRINEILFHKCEFTDEMCDLRQQRRTASLDCNVRIALTLSNAINRGQLPADLDT
ARAAISIHAYIDGLLYGWLLAPDSFELYAEAERWVDTGLDMLRLSPSLRK

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=209, Percent_Identity=44.4976076555024, Blast_Score=181, Evalue=3e-47,
Organism=Escherichia coli, GI1789664, Length=212, Percent_Identity=35.377358490566, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23856; Mature: 23856

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEAQETRSQILEAAEKAFYERGVARTTLSDIATLAGVTRGAIYWHFSNKADLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
AMLDTLHEPLDELAKASESEDEPDPLGCMRKLLIHLFHQVALDPKTRRINEILFHKCEFT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DEMCDLRQQRRTASLDCNVRIALTLSNAINRGQLPADLDTARAAISIHAYIDGLLYGWLL
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
APDSFELYAEAERWVDTGLDMLRLSPSLRK
CCCCHHHHHHHHHHHHHCHHHHHCCCCCCC
>Mature Secondary Structure
MVRRTKEEAQETRSQILEAAEKAFYERGVARTTLSDIATLAGVTRGAIYWHFSNKADLLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
AMLDTLHEPLDELAKASESEDEPDPLGCMRKLLIHLFHQVALDPKTRRINEILFHKCEFT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DEMCDLRQQRRTASLDCNVRIALTLSNAINRGQLPADLDTARAAISIHAYIDGLLYGWLL
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
APDSFELYAEAERWVDTGLDMLRLSPSLRK
CCCCHHHHHHHHHHHHHCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]