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The map label for this gene is garR [H]

Identifier: 77457478

GI number: 77457478

Start: 1422874

End: 1423770

Strand: Direct

Name: garR [H]

Synonym: Pfl01_1251

Alternate gene names: 77457478

Gene position: 1422874-1423770 (Clockwise)

Preceding gene: 77457476

Following gene: 77457481

Centisome position: 22.1

GC content: 65.89

Gene sequence:

>897_bases
ATGATGTCAACGCGACCTTCGTTGGGGTTTGCCGGAATCGGTCTGATGGGCCTGCCGATGTGCCGCCGTCTGCTGGCCGC
CGGCTATCCGCTGGCCGTGTGGAACCGCAACCCGGCCAAGTGCGCGCCGCTGGTCGAGGCTGGCGCCCGGCAGGTGGCGA
CTCCCGCTGAACTCTGTGAACAGGCTGACGTGGTGATGCTGTGCCTGGCGGACACCGCGGTGGTTCGCGAAGTGGTGTTC
GGCCCGGCGGGCGTGGCCGAAGGGGCGAAACCCGGTCAGTTGCTGGTGGATTTTTCCAGCCTCGAACCGACGGCGACCCG
TGAGATGGCAGCCGAGCTGGCCGACAAGACGGGCATGGCCTGGCTCGATTCGCCGGTGTCCGGCGGGGTAGTCGGGGCCG
AGGCCGGCAGCCTGGCGATCATGGTCGGCGGTGCCGAGGCGGATCTGCAGCGAGTACGCCCGGTGCTGCTCGAACTCGGG
CAGCGGGTCACACACATGGGCGGCGTGGGCGCCGGTCAGGTGACCAAGGCCTGCAATCAGATGATCGTCGCCTGCAACGC
CTTGGTGATTGCCGAAGTGGTGGCGCTGGCCGAACAGGCCGGGGTCGATGCCAGCCTGATTGCCGAAGCGCTGGCCGGTG
GTTTTGCCGATTCCAGACCGTTGCAGATCCTCGCCCCGCAAATGGCCGAAAGCCGTTTCGAGCCGGTGAAGTGGCACGTG
CGCACGCTGCTGAAAGATCTGGATACCGCGGTCAAGTTTTCCCGGGAAACCGGCTCGGCCACGCCGATCAGCGGATTGGC
CGCACAACTGATGCGCCTGCATGGGGCACAAGGCTTTTTGCAGAAGGATCCAGCGACACTGGTGCAAATGTACCGCGCGC
CAGACTCAACGGATTGA

Upstream 100 bases:

>100_bases
GTGCGTCAGGGTTATGGCCTGAGTGTCGCGCGGGGGAATCCTTTCCTGATTGATGATGGATCGGCCATTATTCGGCGATC
TTTAATCAAAAGGAGGCTAA

Downstream 100 bases:

>100_bases
CCGCGTGCGCGTGTTTGCGCTGATTGATTTCCTCCAGCACCGGACGCAGTTCGGCCAGTGGCACCGGGCGGCTGAGCAGG
TAACCCTGAATGAAGTCGCA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MMSTRPSLGFAGIGLMGLPMCRRLLAAGYPLAVWNRNPAKCAPLVEAGARQVATPAELCEQADVVMLCLADTAVVREVVF
GPAGVAEGAKPGQLLVDFSSLEPTATREMAAELADKTGMAWLDSPVSGGVVGAEAGSLAIMVGGAEADLQRVRPVLLELG
QRVTHMGGVGAGQVTKACNQMIVACNALVIAEVVALAEQAGVDASLIAEALAGGFADSRPLQILAPQMAESRFEPVKWHV
RTLLKDLDTAVKFSRETGSATPISGLAAQLMRLHGAQGFLQKDPATLVQMYRAPDSTD

Sequences:

>Translated_298_residues
MMSTRPSLGFAGIGLMGLPMCRRLLAAGYPLAVWNRNPAKCAPLVEAGARQVATPAELCEQADVVMLCLADTAVVREVVF
GPAGVAEGAKPGQLLVDFSSLEPTATREMAAELADKTGMAWLDSPVSGGVVGAEAGSLAIMVGGAEADLQRVRPVLLELG
QRVTHMGGVGAGQVTKACNQMIVACNALVIAEVVALAEQAGVDASLIAEALAGGFADSRPLQILAPQMAESRFEPVKWHV
RTLLKDLDTAVKFSRETGSATPISGLAAQLMRLHGAQGFLQKDPATLVQMYRAPDSTD
>Mature_298_residues
MMSTRPSLGFAGIGLMGLPMCRRLLAAGYPLAVWNRNPAKCAPLVEAGARQVATPAELCEQADVVMLCLADTAVVREVVF
GPAGVAEGAKPGQLLVDFSSLEPTATREMAAELADKTGMAWLDSPVSGGVVGAEAGSLAIMVGGAEADLQRVRPVLLELG
QRVTHMGGVGAGQVTKACNQMIVACNALVIAEVVALAEQAGVDASLIAEALAGGFADSRPLQILAPQMAESRFEPVKWHV
RTLLKDLDTAVKFSRETGSATPISGLAAQLMRLHGAQGFLQKDPATLVQMYRAPDSTD

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=301, Percent_Identity=31.2292358803987, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI40556376, Length=295, Percent_Identity=27.4576271186441, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=38.5964912280702, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=37.1024734982332, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=27.7397260273973, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=26.3888888888889, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=298, Percent_Identity=29.8657718120805, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24655230, Length=300, Percent_Identity=29.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19922568, Length=300, Percent_Identity=29.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574115, Length=287, Percent_Identity=22.9965156794425, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31001; Mature: 31001

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTRPSLGFAGIGLMGLPMCRRLLAAGYPLAVWNRNPAKCAPLVEAGARQVATPAELCE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHC
QADVVMLCLADTAVVREVVFGPAGVAEGAKPGQLLVDFSSLEPTATREMAAELADKTGMA
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCH
WLDSPVSGGVVGAEAGSLAIMVGGAEADLQRVRPVLLELGQRVTHMGGVGAGQVTKACNQ
HCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MIVACNALVIAEVVALAEQAGVDASLIAEALAGGFADSRPLQILAPQMAESRFEPVKWHV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCHHHHHH
RTLLKDLDTAVKFSRETGSATPISGLAAQLMRLHGAQGFLQKDPATLVQMYRAPDSTD
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMSTRPSLGFAGIGLMGLPMCRRLLAAGYPLAVWNRNPAKCAPLVEAGARQVATPAELCE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHC
QADVVMLCLADTAVVREVVFGPAGVAEGAKPGQLLVDFSSLEPTATREMAAELADKTGMA
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCH
WLDSPVSGGVVGAEAGSLAIMVGGAEADLQRVRPVLLELGQRVTHMGGVGAGQVTKACNQ
HCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MIVACNALVIAEVVALAEQAGVDASLIAEALAGGFADSRPLQILAPQMAESRFEPVKWHV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCHHHHHH
RTLLKDLDTAVKFSRETGSATPISGLAAQLMRLHGAQGFLQKDPATLVQMYRAPDSTD
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]