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The map label for this gene is yjcE [H]

Identifier: 77457322

GI number: 77457322

Start: 1266506

End: 1268137

Strand: Direct

Name: yjcE [H]

Synonym: Pfl01_1095

Alternate gene names: 77457322

Gene position: 1266506-1268137 (Clockwise)

Preceding gene: 77457317

Following gene: 77457328

Centisome position: 19.67

GC content: 63.79

Gene sequence:

>1632_bases
ATGCAAACTGCTTATACCGTCCTGATCCTGCTGATGCTGGTCAGTGTCTCGCGCCTGGTGGGACGGGTGATTCCGCTGCC
GCTGCCACTGGTGCAGATTGCCGCCGGTGCCTTGCTGGCCTGGCCGACTCTCGGCCTGCACGTGGCCCTCGATCCCGAAC
TGTTCCTGTTTCTGTTCCTGCCGCCGCTGCTGTTTTCCGATGGCTGGCGCATGCCCAAGCGCGAATTGTGGCGCCTGCGC
GGGCCGGTGCTGACGCTGGCGGTGGGTTTGGTGCTGTTTACCGTGGTCGGTGCCGGCTACTTCATTCACTGGCTGCTGCC
GACGATTCCTTTGCCGGTGGCCTTTGCGCTGGCGGCGGTGCTGTCGCCGACGGATGCTGTTGCAGTCTCGGCCATCTCAC
AGAACCGCCTGCCGACGCCGTTGATGCACATGTTGCAGGGCGAGGCGTTGATGAACGACGCCTCGGGTCTGGTGACGTTC
AAGTTCGCGCTGGTCGCGGCGGTGACCGGTGCGTTTTCCCTGGCCAATGCCAGCCTGACCTTCGTGCTGGTGGCCGTCGG
CGGGCTGGCGGTCGGCGTGGCGCTGAGCTGGCTGGTCGGAAGGTTGCGCGCCTGGATGATTGCCCGGGGCTGGGACGATC
CGGCGACCCACGTGGTGTTCATGTTGCTGCTGCCATTCGCCGCTTACGTGCTGGCCGAGCGGCTTGGCGCGTCGGGCATT
CTTTCGGCAGTGGCGGCGGGGATGATGCAGAGCTGGCTCGATCTGCTGCCGCGCCAGACCAGCACCCGGTTGCTCAACCG
CAGCGTCTGGTCGTTGCTGGAGTTTGCCTTCAACGGTTTGATCTTCCTGCTGCTCGGCCTGCAACTTCCGGACATCGTTA
AAGCGGTGGTCAGCCACGAGACATCGTTATGGCCGACCCTGTTCTATCGCTGTCTCGATGTGGTGGCGATTTTTCTGGCG
CTGGTGTTGTTGCGCTTCATCTGGGTGCAGAGCATCTGGCGGCTGTCGGTGCTGCTGCGTCGCTTGCGCGGCAAGGGTGA
TCTGACGCAGGTGCCGACCGCCCGTTCCTGCTGGCTGCTGACCGTCGGCGGCGTGCGCGGTGCGGTGACCCTGGCGGGCG
TGATGTCGGTGCCAATGCTGATGGGGAGCGAGGCGTTCCCCGAGCGCGATCTGCTGATCTTCATCGCCGCCGGGGTGATT
CTGTTATCGCTGGTGGCGGCCTGTATTGCGCTGCCGTTGCTGTTGCGCGGTATCGAAAAAAGTCCGGACGACAAGCGTCG
TCAGGAAGTGCGCGACGCCTGGCGCAAGACGGCGGAAGCGGCGATCCATGCGCTGGAAACCGAAGAGGTCAACCCGCAGG
ACGCCGCGCAAGCCGCGCTGGCAGCGGAGCTCAAGGCGCGGATCATGTCCGAGTATCGCCATCAACTGGAGGTCTTCAAC
GATTCGGCCGAAGCCCAGGCGCTGGCGTTCCAGATGGATCTGCTCGAACGCCGCTTGCGCCTCAAGGCACTGCGCGCGCA
ACGCCTTGAGTTATACAGCCTCAGTCGTCAGCACCAGATTGGCGATGACGTTCTGCGTGAAGTGTTGGGCGAACTGGACT
TGAGTGAGGCGAATCTGGGGTCGGTCAAATAA

Upstream 100 bases:

>100_bases
CTTTTGCTGAGCGGGCTGCGACATAGGTGCAACGGTCACGCACAGCCTAAGCGGCTAATATGGCAGTTCAACGCTGTCGA
TTGTCCGGGATTTCCGCTTT

Downstream 100 bases:

>100_bases
TGGCGTCACGTTGGTCCGAATGGGTTACTCCGCTTGTTCAGCAGGGTAGGGGTAGGCTTTCGACATGAACGTCTTGTCCT
TTTCACTGAGCTCCAGATTC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MQTAYTVLILLMLVSVSRLVGRVIPLPLPLVQIAAGALLAWPTLGLHVALDPELFLFLFLPPLLFSDGWRMPKRELWRLR
GPVLTLAVGLVLFTVVGAGYFIHWLLPTIPLPVAFALAAVLSPTDAVAVSAISQNRLPTPLMHMLQGEALMNDASGLVTF
KFALVAAVTGAFSLANASLTFVLVAVGGLAVGVALSWLVGRLRAWMIARGWDDPATHVVFMLLLPFAAYVLAERLGASGI
LSAVAAGMMQSWLDLLPRQTSTRLLNRSVWSLLEFAFNGLIFLLLGLQLPDIVKAVVSHETSLWPTLFYRCLDVVAIFLA
LVLLRFIWVQSIWRLSVLLRRLRGKGDLTQVPTARSCWLLTVGGVRGAVTLAGVMSVPMLMGSEAFPERDLLIFIAAGVI
LLSLVAACIALPLLLRGIEKSPDDKRRQEVRDAWRKTAEAAIHALETEEVNPQDAAQAALAAELKARIMSEYRHQLEVFN
DSAEAQALAFQMDLLERRLRLKALRAQRLELYSLSRQHQIGDDVLREVLGELDLSEANLGSVK

Sequences:

>Translated_543_residues
MQTAYTVLILLMLVSVSRLVGRVIPLPLPLVQIAAGALLAWPTLGLHVALDPELFLFLFLPPLLFSDGWRMPKRELWRLR
GPVLTLAVGLVLFTVVGAGYFIHWLLPTIPLPVAFALAAVLSPTDAVAVSAISQNRLPTPLMHMLQGEALMNDASGLVTF
KFALVAAVTGAFSLANASLTFVLVAVGGLAVGVALSWLVGRLRAWMIARGWDDPATHVVFMLLLPFAAYVLAERLGASGI
LSAVAAGMMQSWLDLLPRQTSTRLLNRSVWSLLEFAFNGLIFLLLGLQLPDIVKAVVSHETSLWPTLFYRCLDVVAIFLA
LVLLRFIWVQSIWRLSVLLRRLRGKGDLTQVPTARSCWLLTVGGVRGAVTLAGVMSVPMLMGSEAFPERDLLIFIAAGVI
LLSLVAACIALPLLLRGIEKSPDDKRRQEVRDAWRKTAEAAIHALETEEVNPQDAAQAALAAELKARIMSEYRHQLEVFN
DSAEAQALAFQMDLLERRLRLKALRAQRLELYSLSRQHQIGDDVLREVLGELDLSEANLGSVK
>Mature_543_residues
MQTAYTVLILLMLVSVSRLVGRVIPLPLPLVQIAAGALLAWPTLGLHVALDPELFLFLFLPPLLFSDGWRMPKRELWRLR
GPVLTLAVGLVLFTVVGAGYFIHWLLPTIPLPVAFALAAVLSPTDAVAVSAISQNRLPTPLMHMLQGEALMNDASGLVTF
KFALVAAVTGAFSLANASLTFVLVAVGGLAVGVALSWLVGRLRAWMIARGWDDPATHVVFMLLLPFAAYVLAERLGASGI
LSAVAAGMMQSWLDLLPRQTSTRLLNRSVWSLLEFAFNGLIFLLLGLQLPDIVKAVVSHETSLWPTLFYRCLDVVAIFLA
LVLLRFIWVQSIWRLSVLLRRLRGKGDLTQVPTARSCWLLTVGGVRGAVTLAGVMSVPMLMGSEAFPERDLLIFIAAGVI
LLSLVAACIALPLLLRGIEKSPDDKRRQEVRDAWRKTAEAAIHALETEEVNPQDAAQAALAAELKARIMSEYRHQLEVFN
DSAEAQALAFQMDLLERRLRLKALRAQRLELYSLSRQHQIGDDVLREVLGELDLSEANLGSVK

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=349, Percent_Identity=23.2091690544413, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI15529998, Length=399, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI294997330, Length=361, Percent_Identity=24.3767313019391, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI110227626, Length=361, Percent_Identity=24.3767313019391, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI5454070, Length=361, Percent_Identity=24.3767313019391, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI41872703, Length=417, Percent_Identity=22.7817745803357, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI14211919, Length=278, Percent_Identity=25.1798561151079, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI148727259, Length=454, Percent_Identity=21.8061674008811, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=552, Percent_Identity=45.4710144927536, Blast_Score=407, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71980847, Length=491, Percent_Identity=22.6069246435845, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71990932, Length=387, Percent_Identity=24.5478036175711, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=425, Percent_Identity=26.1176470588235, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999819, Length=425, Percent_Identity=26.1176470588235, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990924, Length=428, Percent_Identity=24.0654205607477, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999821, Length=425, Percent_Identity=26.1176470588235, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=424, Percent_Identity=25.2358490566038, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987535, Length=424, Percent_Identity=25.2358490566038, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=311, Percent_Identity=27.0096463022508, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=311, Percent_Identity=27.0096463022508, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=253, Percent_Identity=19.7628458498024, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=253, Percent_Identity=19.7628458498024, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=24.317617866005, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=24.317617866005, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510732, Length=398, Percent_Identity=24.6231155778894, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510736, Length=398, Percent_Identity=24.6231155778894, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585580, Length=398, Percent_Identity=24.6231155778894, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585578, Length=398, Percent_Identity=24.6231155778894, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221510740, Length=398, Percent_Identity=24.6231155778894, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281364513, Length=267, Percent_Identity=24.3445692883895, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360447, Length=402, Percent_Identity=24.6268656716418, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473212, Length=267, Percent_Identity=24.3445692883895, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473222, Length=267, Percent_Identity=24.3445692883895, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221473215, Length=267, Percent_Identity=24.3445692883895, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59494; Mature: 59494

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]