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The map label for this gene is 77457138

Identifier: 77457138

GI number: 77457138

Start: 1061579

End: 1062883

Strand: Direct

Name: 77457138

Synonym: Pfl01_0911

Alternate gene names: NA

Gene position: 1061579-1062883 (Clockwise)

Preceding gene: 77457137

Following gene: 77457139

Centisome position: 16.49

GC content: 64.75

Gene sequence:

>1305_bases
ATGACTCAGAATTCCATCACCCGCAGTTGGGTCGCCTCGGCCAACGGTCACGCGGATTTCCCATTGCAGAACCTGCCGCT
GGGCGTATTCAGCACCAACGGTTCGGCACCGCGCGCGGGCGTGGCGATTGGCGAACACATCTTCGATCTGCAAGTGGCGC
TGGAATCCGGTCTGTTCGACGGCGCCGCGCGCAGTGCAGTCGAAGCCATGCGCGGCGGTCAGTTGAACGCGTTCTTCGAA
CTCGGCCGCGACGCCCGCGCTGCCTTGCGCGAGCGTCTGCTGGAACTGTTCAGCGAAGGCAGCACTCACCGCGGCAACAT
TGAAGCCCAGGGCGCAAAACTGCTGCCACTGGCCGCCGATTGCCAGCTGCACCTGCCGGCGCGCATCAGTGACTACACCG
ACTTCTACGTCGGCATCGAACACGCGCAGAACGTCGGCAAACTGTTCCGTCCGGACAACCCGTTGCTGCCGAACTACAAA
CACGTGCCGATCGGCTACCACGGTCGCGCGTCCACTGTGCGCGCTTCCGGTGCCGACGTGCGCCGCCCTAAAGGCCAGAC
CCTGCCGGCCGGCGCAACCGAGCCGACCTTCGGCCCGTGCGCGCGGCTGGACTATGAGCTGGAACTGGGGATCTGGATCG
GTCAGGGCAACGAGATGGGCGAGCCGATCGCCATTGGTGATGCCGCCGAACACATCGCCGGTTTCTGCCTGCTCAACGAC
TGGTCGGCCCGTGACATCCAGGCCTGGGAATACCAGCCGCTCGGCCCGTTCCTGTCCAAGAGCTTCATCACCAGCGTCTC
GCCATGGGTGGTGACCGCCGAAGCGCTGGCGCCATTCCGTACCGCGCAGCCGGCGCGTCCGCAAGGTGACCCGCAGCCGC
TGCCGTACCTGCTCGACAAGCGCGATCAGGAGGGTGGTGGCTTTGACATCGAGCTGGAAGTGCTGCTGCTCACCGAGAAA
ATGCGCGAGCAGAACCTGCCGGCCCATCGCCTGACCCTGAGCAACACCCGTTACATGTACTGGACCGTCGCGCAAATGGT
CGCGCACCACAGCGTCAATGGCTGCCAGTTGCAGGCCGGTGACCTGTTCGGTTCGGGCACTTTGTCCGGCCCTGAGAACG
GTCAGTTCGGCAGCCTGCTGGAAATCACCGAGGGCGGCAAAAAGCCGATCGAACTGGCCTCCGGTGAGGTGCGCAAATTC
CTTGAGGACGGCGACGAAATCATCCTGCGCGCCCGCTGCGCCCGCGAAGGTTTTGCCTCCATCGGTTTCGGCGAATGCCG
TGGCACCGTGCTGGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
CCCAAGCCGCTTCGCCCTCGACTGCCCGCAATTGCAATCCACTTACGACGCCTGCTGGGCCACGCTGCCCGCCACGTTCG
ATCCGACCCGGAGATAACCC

Downstream 100 bases:

>100_bases
CAGGAGCGGCTCATGGATCTCTACACCTATTACCGTTCCACCTCGTCGTACCGGGTGCGGATTGCGCTGGCGCTCAAGGG
CCTCGACTATCAGGCGTTGC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTQNSITRSWVASANGHADFPLQNLPLGVFSTNGSAPRAGVAIGEHIFDLQVALESGLFDGAARSAVEAMRGGQLNAFFE
LGRDARAALRERLLELFSEGSTHRGNIEAQGAKLLPLAADCQLHLPARISDYTDFYVGIEHAQNVGKLFRPDNPLLPNYK
HVPIGYHGRASTVRASGADVRRPKGQTLPAGATEPTFGPCARLDYELELGIWIGQGNEMGEPIAIGDAAEHIAGFCLLND
WSARDIQAWEYQPLGPFLSKSFITSVSPWVVTAEALAPFRTAQPARPQGDPQPLPYLLDKRDQEGGGFDIELEVLLLTEK
MREQNLPAHRLTLSNTRYMYWTVAQMVAHHSVNGCQLQAGDLFGSGTLSGPENGQFGSLLEITEGGKKPIELASGEVRKF
LEDGDEIILRARCAREGFASIGFGECRGTVLAAR

Sequences:

>Translated_434_residues
MTQNSITRSWVASANGHADFPLQNLPLGVFSTNGSAPRAGVAIGEHIFDLQVALESGLFDGAARSAVEAMRGGQLNAFFE
LGRDARAALRERLLELFSEGSTHRGNIEAQGAKLLPLAADCQLHLPARISDYTDFYVGIEHAQNVGKLFRPDNPLLPNYK
HVPIGYHGRASTVRASGADVRRPKGQTLPAGATEPTFGPCARLDYELELGIWIGQGNEMGEPIAIGDAAEHIAGFCLLND
WSARDIQAWEYQPLGPFLSKSFITSVSPWVVTAEALAPFRTAQPARPQGDPQPLPYLLDKRDQEGGGFDIELEVLLLTEK
MREQNLPAHRLTLSNTRYMYWTVAQMVAHHSVNGCQLQAGDLFGSGTLSGPENGQFGSLLEITEGGKKPIELASGEVRKF
LEDGDEIILRARCAREGFASIGFGECRGTVLAAR
>Mature_433_residues
TQNSITRSWVASANGHADFPLQNLPLGVFSTNGSAPRAGVAIGEHIFDLQVALESGLFDGAARSAVEAMRGGQLNAFFEL
GRDARAALRERLLELFSEGSTHRGNIEAQGAKLLPLAADCQLHLPARISDYTDFYVGIEHAQNVGKLFRPDNPLLPNYKH
VPIGYHGRASTVRASGADVRRPKGQTLPAGATEPTFGPCARLDYELELGIWIGQGNEMGEPIAIGDAAEHIAGFCLLNDW
SARDIQAWEYQPLGPFLSKSFITSVSPWVVTAEALAPFRTAQPARPQGDPQPLPYLLDKRDQEGGGFDIELEVLLLTEKM
REQNLPAHRLTLSNTRYMYWTVAQMVAHHSVNGCQLQAGDLFGSGTLSGPENGQFGSLLEITEGGKKPIELASGEVRKFL
EDGDEIILRARCAREGFASIGFGECRGTVLAAR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=420, Percent_Identity=49.5238095238095, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17568863, Length=426, Percent_Identity=46.7136150234742, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24657182, Length=421, Percent_Identity=47.7434679334917, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47060; Mature: 46928

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNSITRSWVASANGHADFPLQNLPLGVFSTNGSAPRAGVAIGEHIFDLQVALESGLFD
CCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAARSAVEAMRGGQLNAFFELGRDARAALRERLLELFSEGSTHRGNIEAQGAKLLPLAAD
HHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECC
CQLHLPARISDYTDFYVGIEHAQNVGKLFRPDNPLLPNYKHVPIGYHGRASTVRASGADV
CEEECCCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEECCCCCC
RRPKGQTLPAGATEPTFGPCARLDYELELGIWIGQGNEMGEPIAIGDAAEHIAGFCLLND
CCCCCCCCCCCCCCCCCCCHHCCCEEEEEEEEEECCCCCCCCEEECCHHHHHEEEEEECC
WSARDIQAWEYQPLGPFLSKSFITSVSPWVVTAEALAPFRTAQPARPQGDPQPLPYLLDK
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCHHCCCCCCCCCCCCCCCHHHCC
RDQEGGGFDIELEVLLLTEKMREQNLPAHRLTLSNTRYMYWTVAQMVAHHSVNGCQLQAG
CCCCCCCEEEEEEEEEEEHHHHHCCCCCEEEEECCCEEEEHHHHHHHHHCCCCCCEEEEC
DLFGSGTLSGPENGQFGSLLEITEGGKKPIELASGEVRKFLEDGDEIILRARCAREGFAS
CEECCCCCCCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHCCCCEEEHHHHHHCCCCC
IGFGECRGTVLAAR
CCCCCCCCEEEECC
>Mature Secondary Structure 
TQNSITRSWVASANGHADFPLQNLPLGVFSTNGSAPRAGVAIGEHIFDLQVALESGLFD
CCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAARSAVEAMRGGQLNAFFELGRDARAALRERLLELFSEGSTHRGNIEAQGAKLLPLAAD
HHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECC
CQLHLPARISDYTDFYVGIEHAQNVGKLFRPDNPLLPNYKHVPIGYHGRASTVRASGADV
CEEECCCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEECCCCCC
RRPKGQTLPAGATEPTFGPCARLDYELELGIWIGQGNEMGEPIAIGDAAEHIAGFCLLND
CCCCCCCCCCCCCCCCCCCHHCCCEEEEEEEEEECCCCCCCCEEECCHHHHHEEEEEECC
WSARDIQAWEYQPLGPFLSKSFITSVSPWVVTAEALAPFRTAQPARPQGDPQPLPYLLDK
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCHHCCCCCCCCCCCCCCCHHHCC
RDQEGGGFDIELEVLLLTEKMREQNLPAHRLTLSNTRYMYWTVAQMVAHHSVNGCQLQAG
CCCCCCCEEEEEEEEEEEHHHHHCCCCCEEEEECCCEEEEHHHHHHHHHCCCCCCEEEEC
DLFGSGTLSGPENGQFGSLLEITEGGKKPIELASGEVRKFLEDGDEIILRARCAREGFAS
CEECCCCCCCCCCCCCCCEEEECCCCCCCHHHCCHHHHHHHHCCCCEEEHHHHHHCCCCC
IGFGECRGTVLAAR
CCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA