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The map label for this gene is ldc [H]

Identifier: 77457028

GI number: 77457028

Start: 944694

End: 945857

Strand: Reverse

Name: ldc [H]

Synonym: Pfl01_0801

Alternate gene names: 77457028

Gene position: 945857-944694 (Counterclockwise)

Preceding gene: 77457030

Following gene: 77457025

Centisome position: 14.69

GC content: 58.42

Gene sequence:

>1164_bases
ATGTCGATCCAGGTCGAAGACTATTTCGCGCGCGAAACCTTTCAGAAAATGAAGGCGTTCGCCGACAAACAGGAAACCCC
GTTCGTGGTGATCGACACCGCGATGATCGCCCAGGCTTACGATGACCTGCGCGCCGGTTTCGAATTCGCCAAGGTCTACT
ACGCGGTCAAGGCCAACCCGGCCGTCGAGATCATCGACCTGCTCAAAGAGAAGGGTTCGAGCTTCGACATCGCCTCGATC
TATGAGCTGGACAAAGTGCTGAGCCGTGGCGTCAGCGCGGATCAGATCAGCTACGGCAACACCATCAAGAAATCCAAGGA
CATTCGCTACTTCTATGAGAAGGGCGTGCGTCTGTTCGCCACCGACTCGGAAGCCGACCTGCGCAACATCGCCAAGGCCG
CACCGGGCGCCAAAGTCTATGTGCGCATCCTGACCGAAGGCTCGACCACGGCCGACTGGCCACTGTCGCGCAAATTCGGC
TGCCAGACCGACATGGCCATGGACCTGCTGATCCTCGCCCGTGACCTGGGCCTGGTGCCGTACGGCATCTCGTTCCACGT
CGGTTCGCAACAGCGTGACATCAGCGTCTGGGACGCGGCGATCGCCAAGGTCAAAGTGATTTTCGAGCGCCTGAAAGAAG
AAGACGGCATCCACCTGAAGCTGATCAACATGGGCGGAGGCTTCCCGGCCAACTACATCACCCGCACCAACAGCCTGGAA
ACCTACGCTGAAGAAATCATCCGCTTCCTCAAGGAAGACTTCGGTGATGACCTGCCGGAAATCATTCTGGAGCCAGGCCG
TTCGCTGATCGCCAACGCCGGTATCCTGGTCAGTGAAGTGGTGCTGGTCGCCCGTAAATCCCGCACCGCCGTCGAGCGTT
GGGTTTATACCGATGTGGGCAAGTTCTCGGGCCTGATCGAAACCATGGACGAAGCGATCAAGTTCCCGATCTGGACCGAG
AAGAAAGGCGAGATGGAAGAAGTCGTGATCGCTGGCCCGACCTGCGACAGCGCCGACATCATGTACGAAAACTACAAGTA
CGGCCTGCCGCTGAACCTGGCGATCGGTGATCGCCTGTACTGGCTGTCGACCGGTGCGTACACCACCAGCTACAGCGCCG
TCGAGTTCAATGGCTTTCCGCCGCTGAAGTCGTTCTACGTGTAA

Upstream 100 bases:

>100_bases
CGGCGACATGCCTTGGGAAGTAGGCGAACCAAAGTGGGGATACGGAGGACGTTCATTTGCACCCATTGATTAACGACGTT
TGCCACTAGGAGTCCCAAGT

Downstream 100 bases:

>100_bases
GCGATGCTGGCGTAATGCAAAAAGCCCATGACGTGTCATGGGCTTTTTTGTGGCTGCGATTCAGGTGTTCTGTAACTCGG
CGCAACGACGAGCGTAGGCC

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSIQVEDYFARETFQKMKAFADKQETPFVVIDTAMIAQAYDDLRAGFEFAKVYYAVKANPAVEIIDLLKEKGSSFDIASI
YELDKVLSRGVSADQISYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFG
CQTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIHLKLINMGGGFPANYITRTNSLE
TYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTE
KKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRLYWLSTGAYTTSYSAVEFNGFPPLKSFYV

Sequences:

>Translated_387_residues
MSIQVEDYFARETFQKMKAFADKQETPFVVIDTAMIAQAYDDLRAGFEFAKVYYAVKANPAVEIIDLLKEKGSSFDIASI
YELDKVLSRGVSADQISYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFG
CQTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIHLKLINMGGGFPANYITRTNSLE
TYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTE
KKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRLYWLSTGAYTTSYSAVEFNGFPPLKSFYV
>Mature_386_residues
SIQVEDYFARETFQKMKAFADKQETPFVVIDTAMIAQAYDDLRAGFEFAKVYYAVKANPAVEIIDLLKEKGSSFDIASIY
ELDKVLSRGVSADQISYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGC
QTDMAMDLLILARDLGLVPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIHLKLINMGGGFPANYITRTNSLET
YAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYTDVGKFSGLIETMDEAIKFPIWTEK
KGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRLYWLSTGAYTTSYSAVEFNGFPPLKSFYV

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=357, Percent_Identity=31.9327731092437, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI16506287, Length=393, Percent_Identity=26.972010178117, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI22538418, Length=373, Percent_Identity=26.0053619302949, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI21361583, Length=373, Percent_Identity=26.0053619302949, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562780, Length=379, Percent_Identity=31.3984168865435, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322664, Length=388, Percent_Identity=30.9278350515464, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24586472, Length=353, Percent_Identity=30.028328611898, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24586474, Length=336, Percent_Identity=29.7619047619048, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43401; Mature: 43270

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQVEDYFARETFQKMKAFADKQETPFVVIDTAMIAQAYDDLRAGFEFAKVYYAVKANP
CCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHEEHEEEEEECCC
AVEIIDLLKEKGSSFDIASIYELDKVLSRGVSADQISYGNTIKKSKDIRYFYEKGVRLFA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEE
TDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARDLGLVP
ECCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
YGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIHLKLINMGGGFPANYITRTNSLE
ECEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHEECCCCHH
TYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYTDVG
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFSGLIETMDEAIKFPIWTEKKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRLY
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECEECCCEEEEEECCEEE
WLSTGAYTTSYSAVEFNGFPPLKSFYV
EEECCCEEEEECEEEECCCCCHHHCCC
>Mature Secondary Structure 
SIQVEDYFARETFQKMKAFADKQETPFVVIDTAMIAQAYDDLRAGFEFAKVYYAVKANP
CEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHEEHEEEEEECCC
AVEIIDLLKEKGSSFDIASIYELDKVLSRGVSADQISYGNTIKKSKDIRYFYEKGVRLFA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEE
TDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARDLGLVP
ECCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE
YGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIHLKLINMGGGFPANYITRTNSLE
ECEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHEECCCCHH
TYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYTDVG
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KFSGLIETMDEAIKFPIWTEKKGEMEEVVIAGPTCDSADIMYENYKYGLPLNLAIGDRLY
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECEECCCEEEEEECCEEE
WLSTGAYTTSYSAVEFNGFPPLKSFYV
EEECCCEEEEECEEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]