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The map label for this gene is qor [C]

Identifier: 77456894

GI number: 77456894

Start: 780277

End: 781290

Strand: Reverse

Name: qor [C]

Synonym: Pfl01_0666

Alternate gene names: 77456894

Gene position: 781290-780277 (Counterclockwise)

Preceding gene: 77456895

Following gene: 77456893

Centisome position: 12.13

GC content: 61.54

Gene sequence:

>1014_bases
ATGAAAGCTATCGCCTATTACGCCTCGCTCCCGATCAGCGACGAAAAATCCCTGCAAGACATCGAACTGCCGGAGCCGGT
TGCCGGCCCGCGCGACTTGCTCGTCGAAGTCAAAGCGATTTCGGTCAACCCGGTCGACACCAAGGTTCGCCAGAACGTCG
CGCCGGAAGGCGGCGCCGCCAAGGTGCTGGGTTGGGACGTGGCTGGTGTGGTCAAGTCGGTCGGCAGTGAAGTGACCCTG
TTCAAGGCCGGCGACAAGGTGTTCTACGCCGGCTCCATCGCCCGGGCCGGTGGCAACAGCGAATTGCACGTGGTGGATGA
GCGGATTGTCGGCCACATGCCGAAAACCCTCGGCTTCGCCGAAGCCGCCGCCCTGCCGCTGACTGCGATCACGGCCTGGG
AGCTGTTGTTTGAACGGCTACAGATTCGCGAAGGCAACACCGATGAAGACCAGAGCCTGCTGATCGTCGGCGCGGCCGGC
GGCGTCGGTTCGATCCTCACCCAACTGGCCAGCCAGTTGACCGGACTCAAGGTGATCGGCACCGCCTCCCGCCCGGAGAC
CCGTGACTGGGTGACGGAGCTGGGCGCTGATCTGGTGATCGATCACAGTCAGCCGCTGAGCGAGGAACTGAAACGCACCG
GTGTCACTCACGTGACCCATGTCGCCAGCCTGACCCAGACCGAACAACATCTGGATCAACTGGTCGAGGCCCTGGCGCCG
CAAGGCAAACTGGCGCTGATCGACGATCCGAAGGCGCTGGACGTGACCAAGCTCAAGCGCAAGAGCCTGTCGCTGCACTG
GGAGTTCATGTACACCCGCTCGCTGTTCGAAACGCCGGACATGATCGAGCAGCACAAACTGCTCAACCGGGTGGCCGGGC
TGATCGACAGCGGAACGTTGAAAACCACAGTCGGCGAACACTTCGGCACAATCAACGCAAGCAACCTGCGCCGTGCCCAT
GAATTGCTGGAAAGCGGCAAGGCCAAGGGGAAAATTGTTTTAGAAGGTTTCTAA

Upstream 100 bases:

>100_bases
CATTTCCGCAGCCAGGCCGAGGCGTTCCTCGAACACTTCGAACTCAAGCGTCTGCGCGTCATCGCCTGAAGCCTTCCTTT
ATTCACTTTCGGAGTTCTCC

Downstream 100 bases:

>100_bases
AACTCGCGAGACCGCAGCCTTCTCCAGCCTCCGATGTGGCTGGCTCGGGGGCTGCGGTCGCGTTTTGCCGTCAGTCAGAT
GCTTGACCCTTGTCACAATT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAIAYYASLPISDEKSLQDIELPEPVAGPRDLLVEVKAISVNPVDTKVRQNVAPEGGAAKVLGWDVAGVVKSVGSEVTL
FKAGDKVFYAGSIARAGGNSELHVVDERIVGHMPKTLGFAEAAALPLTAITAWELLFERLQIREGNTDEDQSLLIVGAAG
GVGSILTQLASQLTGLKVIGTASRPETRDWVTELGADLVIDHSQPLSEELKRTGVTHVTHVASLTQTEQHLDQLVEALAP
QGKLALIDDPKALDVTKLKRKSLSLHWEFMYTRSLFETPDMIEQHKLLNRVAGLIDSGTLKTTVGEHFGTINASNLRRAH
ELLESGKAKGKIVLEGF

Sequences:

>Translated_337_residues
MKAIAYYASLPISDEKSLQDIELPEPVAGPRDLLVEVKAISVNPVDTKVRQNVAPEGGAAKVLGWDVAGVVKSVGSEVTL
FKAGDKVFYAGSIARAGGNSELHVVDERIVGHMPKTLGFAEAAALPLTAITAWELLFERLQIREGNTDEDQSLLIVGAAG
GVGSILTQLASQLTGLKVIGTASRPETRDWVTELGADLVIDHSQPLSEELKRTGVTHVTHVASLTQTEQHLDQLVEALAP
QGKLALIDDPKALDVTKLKRKSLSLHWEFMYTRSLFETPDMIEQHKLLNRVAGLIDSGTLKTTVGEHFGTINASNLRRAH
ELLESGKAKGKIVLEGF
>Mature_337_residues
MKAIAYYASLPISDEKSLQDIELPEPVAGPRDLLVEVKAISVNPVDTKVRQNVAPEGGAAKVLGWDVAGVVKSVGSEVTL
FKAGDKVFYAGSIARAGGNSELHVVDERIVGHMPKTLGFAEAAALPLTAITAWELLFERLQIREGNTDEDQSLLIVGAAG
GVGSILTQLASQLTGLKVIGTASRPETRDWVTELGADLVIDHSQPLSEELKRTGVTHVTHVASLTQTEQHLDQLVEALAP
QGKLALIDDPKALDVTKLKRKSLSLHWEFMYTRSLFETPDMIEQHKLLNRVAGLIDSGTLKTTVGEHFGTINASNLRRAH
ELLESGKAKGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=346, Percent_Identity=28.0346820809249, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194239676, Length=190, Percent_Identity=34.2105263157895, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239674, Length=190, Percent_Identity=34.2105263157895, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI13236495, Length=190, Percent_Identity=34.2105263157895, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI24308257, Length=305, Percent_Identity=27.8688524590164, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1790485, Length=320, Percent_Identity=29.0625, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=240, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71987554, Length=179, Percent_Identity=32.9608938547486, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=324, Percent_Identity=27.1604938271605, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36313; Mature: 36313

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIAYYASLPISDEKSLQDIELPEPVAGPRDLLVEVKAISVNPVDTKVRQNVAPEGGAA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHCCCCCCCCE
KVLGWDVAGVVKSVGSEVTLFKAGDKVFYAGSIARAGGNSELHVVDERIVGHMPKTLGFA
EEECHHHHHHHHHCCCCEEEEECCCEEEEECCEEECCCCCCEEEEHHHHHHCCCHHHCHH
EAAALPLTAITAWELLFERLQIREGNTDEDQSLLIVGAAGGVGSILTQLASQLTGLKVIG
HHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETRDWVTELGADLVIDHSQPLSEELKRTGVTHVTHVASLTQTEQHLDQLVEALAP
CCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
QGKLALIDDPKALDVTKLKRKSLSLHWEFMYTRSLFETPDMIEQHKLLNRVAGLIDSGTL
CCCEEEECCCCCCCHHHHHHHHHCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCE
KTTVGEHFGTINASNLRRAHELLESGKAKGKIVLEGF
EHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAIAYYASLPISDEKSLQDIELPEPVAGPRDLLVEVKAISVNPVDTKVRQNVAPEGGAA
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHCCCCCCCCE
KVLGWDVAGVVKSVGSEVTLFKAGDKVFYAGSIARAGGNSELHVVDERIVGHMPKTLGFA
EEECHHHHHHHHHCCCCEEEEECCCEEEEECCEEECCCCCCEEEEHHHHHHCCCHHHCHH
EAAALPLTAITAWELLFERLQIREGNTDEDQSLLIVGAAGGVGSILTQLASQLTGLKVIG
HHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETRDWVTELGADLVIDHSQPLSEELKRTGVTHVTHVASLTQTEQHLDQLVEALAP
CCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
QGKLALIDDPKALDVTKLKRKSLSLHWEFMYTRSLFETPDMIEQHKLLNRVAGLIDSGTL
CCCEEEECCCCCCCHHHHHHHHHCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCCCCE
KTTVGEHFGTINASNLRRAHELLESGKAKGKIVLEGF
EHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA