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The map label for this gene is pip [H]

Identifier: 77456599

GI number: 77456599

Start: 423951

End: 424922

Strand: Direct

Name: pip [H]

Synonym: Pfl01_0371

Alternate gene names: 77456599

Gene position: 423951-424922 (Clockwise)

Preceding gene: 77456598

Following gene: 77456600

Centisome position: 6.58

GC content: 63.99

Gene sequence:

>972_bases
ATGCAGACTTTGTTTCCGCAGATCAAACCTCACGCACGGCACGATCTGGCCGTCGATGACACCCATACGCTGTACGTCGA
CGAAAGCGGTTCACCGGAGGGTTTGCCGGTGGTGTTCATCCACGGAGGTCCCGGCGCCGGGTGCGACGCCCAGAGTCGCC
GTTACTTCGATCCGAATCTGTATCGCATTGTCACCTTCGACCAGCGCGGCTGCGGTCGCTCCACGCCCCACGCCAGTCTG
GAAAACAACACCACCTGGGATCTGGTCGAAGACCTCGAGCGCATCCGTAAACATCTGGGCATCGACAAATGGGTGCTGTT
CGGCGGTTCCTGGGGTTCGACCCTGGCGCTGGCCTACGCGCAGACCCATCCGGAGCGCGTACATGGCCTGATCCTGCGCG
GGATCTTTCTCTGCCGTCCGCAGGAAATCGAATGGTTCTACCAGGCCGGCGCCAGCCGTCTGTTCCCCGATTACTGGCAG
GACTACCTCGCGCCGATTCCGCTGGACGAGCGCGACGACCTGCTCAGCGCGTTCCACAAACGCCTGACCGGCAACGACCA
GATCGCCCAGATGCACGCGGCCAAGGCCTGGTCGACCTGGGAAGGGCGCACCGCGACCCTGCGGCCGAATCCGCTGGTGG
TCGACCGTTTCTCCGAGCCGCAGCGCGCCTTGTCGATCGCGCGGATCGAATGCCACTACTTCACCAACAATGCGTTCCTT
GAGCCGAACCAGCTGATCCGCGACATGGGCAAGATCGCCCATCTGCCGGGCGTGATCATCCACGGCCGCTACGACGTGAT
CTGCCCGCTCGACAACGCCTGGGAACTGCATCAGGCCTGGCCGAACAGCGAGCTGCAGGTGATCCGCGATGCCGGCCACG
CCGCGTCCGAACCGGGCATCACCGATGCACTGGTGCGCGCCGCCAGCAAAATGGCCCGTCGTCTGCTCGACCTGCCGCCC
GAAGAAGCATGA

Upstream 100 bases:

>100_bases
GCACGGGCATGCTCATTGACGTAAATCGGGTTTATGATGCCGAACGGCAGAATAATAGAAGTCCCCCCAGGGATGACCTC
GACCCCTTACGGAGCGCGCA

Downstream 100 bases:

>100_bases
AGGGTCTGTTGCAGCGCGTGAAAGGCGCGCGGGTCGAAGTGGCGGGCGAGGTGGTTGGCAGTGTCGATCAGGGTTTGCTG
GTGCTGGTGGCGGTAGAACC

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQTLFPQIKPHARHDLAVDDTHTLYVDESGSPEGLPVVFIHGGPGAGCDAQSRRYFDPNLYRIVTFDQRGCGRSTPHASL
ENNTTWDLVEDLERIRKHLGIDKWVLFGGSWGSTLALAYAQTHPERVHGLILRGIFLCRPQEIEWFYQAGASRLFPDYWQ
DYLAPIPLDERDDLLSAFHKRLTGNDQIAQMHAAKAWSTWEGRTATLRPNPLVVDRFSEPQRALSIARIECHYFTNNAFL
EPNQLIRDMGKIAHLPGVIIHGRYDVICPLDNAWELHQAWPNSELQVIRDAGHAASEPGITDALVRAASKMARRLLDLPP
EEA

Sequences:

>Translated_323_residues
MQTLFPQIKPHARHDLAVDDTHTLYVDESGSPEGLPVVFIHGGPGAGCDAQSRRYFDPNLYRIVTFDQRGCGRSTPHASL
ENNTTWDLVEDLERIRKHLGIDKWVLFGGSWGSTLALAYAQTHPERVHGLILRGIFLCRPQEIEWFYQAGASRLFPDYWQ
DYLAPIPLDERDDLLSAFHKRLTGNDQIAQMHAAKAWSTWEGRTATLRPNPLVVDRFSEPQRALSIARIECHYFTNNAFL
EPNQLIRDMGKIAHLPGVIIHGRYDVICPLDNAWELHQAWPNSELQVIRDAGHAASEPGITDALVRAASKMARRLLDLPP
EEA
>Mature_323_residues
MQTLFPQIKPHARHDLAVDDTHTLYVDESGSPEGLPVVFIHGGPGAGCDAQSRRYFDPNLYRIVTFDQRGCGRSTPHASL
ENNTTWDLVEDLERIRKHLGIDKWVLFGGSWGSTLALAYAQTHPERVHGLILRGIFLCRPQEIEWFYQAGASRLFPDYWQ
DYLAPIPLDERDDLLSAFHKRLTGNDQIAQMHAAKAWSTWEGRTATLRPNPLVVDRFSEPQRALSIARIECHYFTNNAFL
EPNQLIRDMGKIAHLPGVIIHGRYDVICPLDNAWELHQAWPNSELQVIRDAGHAASEPGITDALVRAASKMARRLLDLPP
EEA

Specific function: May be involved in proline metabolism and sensitivity to ascamycin. Has ascamycin dealanylating activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36538; Mature: 36538

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLFPQIKPHARHDLAVDDTHTLYVDESGSPEGLPVVFIHGGPGAGCDAQSRRYFDPNL
CCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCE
YRIVTFDQRGCGRSTPHASLENNTTWDLVEDLERIRKHLGIDKWVLFGGSWGSTLALAYA
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEHH
QTHPERVHGLILRGIFLCRPQEIEWFYQAGASRLFPDYWQDYLAPIPLDERDDLLSAFHK
HCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
RLTGNDQIAQMHAAKAWSTWEGRTATLRPNPLVVDRFSEPQRALSIARIECHYFTNNAFL
HCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCHHHHHHEEEEEEEEECCCCEE
EPNQLIRDMGKIAHLPGVIIHGRYDVICPLDNAWELHQAWPNSELQVIRDAGHAASEPGI
CHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCHHHHHCCCCCHHHHEECCCCCCCCCCH
TDALVRAASKMARRLLDLPPEEA
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTLFPQIKPHARHDLAVDDTHTLYVDESGSPEGLPVVFIHGGPGAGCDAQSRRYFDPNL
CCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCE
YRIVTFDQRGCGRSTPHASLENNTTWDLVEDLERIRKHLGIDKWVLFGGSWGSTLALAYA
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEHH
QTHPERVHGLILRGIFLCRPQEIEWFYQAGASRLFPDYWQDYLAPIPLDERDDLLSAFHK
HCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
RLTGNDQIAQMHAAKAWSTWEGRTATLRPNPLVVDRFSEPQRALSIARIECHYFTNNAFL
HCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCHHHHHHEEEEEEEEECCCCEE
EPNQLIRDMGKIAHLPGVIIHGRYDVICPLDNAWELHQAWPNSELQVIRDAGHAASEPGI
CHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCHHHHHCCCCCHHHHEECCCCCCCCCCH
TDALVRAASKMARRLLDLPPEEA
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8885412; 8870654 [H]