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The map label for this gene is arsA [H]

Identifier: 77454732

GI number: 77454732

Start: 158874

End: 160631

Strand: Direct

Name: arsA [H]

Synonym: pREL1_0165

Alternate gene names: 77454732

Gene position: 158874-160631 (Clockwise)

Preceding gene: 77454731

Following gene: 77454733

Centisome position: 58.5

GC content: 64.56

Gene sequence:

>1758_bases
ATGAAGTTCCTGAACGATGCACCCCGATTCCTGTTCTTCACCGGCAAAGGCGGTGTCGGAAAGACCTCCATCGCCTGCGC
GAGCGCGATCACCCTCGCCCGCGCCGGGAAGAAAGTGCTGCTCGTGAGCACCGATCCCGCCTCCAACGTCGGGCAGGTCT
TCGGCGTGAGCATCGGCAACACCATCACCGACATTCCCGCCGCTCCCGGATTGTCGGCGCTCGAGATCAACCCGGAACAA
GCCGCCGCCGCCTATCGCGAGCGGATCATCGGCCCCGTCCGCGGACTGCTCCCCGAGAAGGAGATCGCGGCGATCGCCGA
ACAGCTCTCTGGGTCCTGCACCACCGAAATAGCGTCGTTCAACGAGTTCACCGGACTGCTCTCCTGCCAAGGCGACATCA
CCGCCGACTTCGACCATGTCCTCTTCGACACCGCTCCGACGGGGCACACCATCCGGCTGCTGCAGCTTCCCGGATCGTGG
ACCGAGTTCCTCGACGACGGTAGGGGCGACGCATCGTGCCTGGGGCCGCTGTCCGGGCTCGAGAAGCAGCGAGCCATCTA
CGCTGACGCTGTTGCCGCGCTCGCAGATCCGCAGCGGACCCGCCTCGTCCTGGTCTCGCGCGCCCAGCGTTCGACGCTCG
CCGAAATTACCCGCACCCACCGCGAACTCGCCGACATCGGACTGACCCATCAGCATGTCGTGATCAACGGTGTCCTCCCG
GCACCGGGCGACGACACCGATCCACTCGCGACCGCGATCTACCGGCGTGAACAAGCCGCGATAGCCGGCCTGCCCGACGA
ATTGGCGCAGCTGCCCACCGATCAGGTCCCGCTCAAAGCGACCAATATCGTCGGCATCGACGCACTCGAAAGCCTCTTCA
CCCCCGACCTCAGCCCGGTATCCGCCGCCTCAGCGGACCCGGCCCTGCAGCTACCCAGTGCTCCGCTCTCATCCCTGATC
GACGAACTCGACACCGACGATCACGGCCTGATCATGTGCATGGGCAAAGGCGGAGTCGGCAAGACCACCATCGCAGCCGC
CATCGCTGTCGCCCTCGCCGAACGCGGCCACCAGGTGCACCTGACCACCACCGACCCGGCCGCACATCTGACAGAAACCT
TGAACGGGGAACTCGACAACCTCCAGGTCTCCCGAATCGACCCCGCCGAAGCCACCGAGCAGTACCGCACCCGGGTTCTG
ACCACCAAAGGCAAGAACCTCGACGAACGCGGACGCGCGAACCTCGCCGAAGACCTCCGATCACCCTGCACCGAGGAAGT
GGCGGTCTTTCAGGCGTTTTCGCGGGTGATTCACGAATCGAGCCGCAAATTCGTCGTCGTCGACACCGCCCCGACCGGGC
ACACTTTGTTGTTGCTCGACGCCACCGGCTCCTACCACCGGGAAATCGCCCGCCAAATGGGTGAGAACACGAACTTCACC
ACCCCGCTCATGCGGCTCCAGGACCCGAACGCCACGAAAGTCCTACTCGTGACCCTCGCTGAAACCACACCTGTCCTCGA
GGCCGCCGGTCTGCAAGCCGACCTGCAACGCGCAGGCATTCACCCTTGGGCGTGGGTGGTCAACAACTCCCTCGCGGCAG
CCGAACCGACCTCGACGCTCCTGCAGCAACGCGCAGCCGGAGAGATCACCGAAATCGACAGCATCACAAACAAATACAGC
CAGCGAACCGCCATCGTCCCGATGCTCGCCGAAGAACCCGTCGGCACAGATGCATTGGCGGCGTTGAGTAAGGCCTGA

Upstream 100 bases:

>100_bases
CCGGCCGGGATCGCCATGCTCGGACTCGCCGACGGCTCAGCATGCTGCTCCACCGACGACGCCGACTCCACCACCTGCTG
CTGAAAGCACCCACAACGCA

Downstream 100 bases:

>100_bases
CGGGAGTAGGAATCGACTTCTGGCTGGTCATTTTCGTTGGCTGGATATGGTGGCGACGGCTTCTCTCGCCGCGCTCCGGT
ATGCCGTGATCCGGGGTCGG

Product: arsenite-transporting ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MKFLNDAPRFLFFTGKGGVGKTSIACASAITLARAGKKVLLVSTDPASNVGQVFGVSIGNTITDIPAAPGLSALEINPEQ
AAAAYRERIIGPVRGLLPEKEIAAIAEQLSGSCTTEIASFNEFTGLLSCQGDITADFDHVLFDTAPTGHTIRLLQLPGSW
TEFLDDGRGDASCLGPLSGLEKQRAIYADAVAALADPQRTRLVLVSRAQRSTLAEITRTHRELADIGLTHQHVVINGVLP
APGDDTDPLATAIYRREQAAIAGLPDELAQLPTDQVPLKATNIVGIDALESLFTPDLSPVSAASADPALQLPSAPLSSLI
DELDTDDHGLIMCMGKGGVGKTTIAAAIAVALAERGHQVHLTTTDPAAHLTETLNGELDNLQVSRIDPAEATEQYRTRVL
TTKGKNLDERGRANLAEDLRSPCTEEVAVFQAFSRVIHESSRKFVVVDTAPTGHTLLLLDATGSYHREIARQMGENTNFT
TPLMRLQDPNATKVLLVTLAETTPVLEAAGLQADLQRAGIHPWAWVVNNSLAAAEPTSTLLQQRAAGEITEIDSITNKYS
QRTAIVPMLAEEPVGTDALAALSKA

Sequences:

>Translated_585_residues
MKFLNDAPRFLFFTGKGGVGKTSIACASAITLARAGKKVLLVSTDPASNVGQVFGVSIGNTITDIPAAPGLSALEINPEQ
AAAAYRERIIGPVRGLLPEKEIAAIAEQLSGSCTTEIASFNEFTGLLSCQGDITADFDHVLFDTAPTGHTIRLLQLPGSW
TEFLDDGRGDASCLGPLSGLEKQRAIYADAVAALADPQRTRLVLVSRAQRSTLAEITRTHRELADIGLTHQHVVINGVLP
APGDDTDPLATAIYRREQAAIAGLPDELAQLPTDQVPLKATNIVGIDALESLFTPDLSPVSAASADPALQLPSAPLSSLI
DELDTDDHGLIMCMGKGGVGKTTIAAAIAVALAERGHQVHLTTTDPAAHLTETLNGELDNLQVSRIDPAEATEQYRTRVL
TTKGKNLDERGRANLAEDLRSPCTEEVAVFQAFSRVIHESSRKFVVVDTAPTGHTLLLLDATGSYHREIARQMGENTNFT
TPLMRLQDPNATKVLLVTLAETTPVLEAAGLQADLQRAGIHPWAWVVNNSLAAAEPTSTLLQQRAAGEITEIDSITNKYS
QRTAIVPMLAEEPVGTDALAALSKA
>Mature_585_residues
MKFLNDAPRFLFFTGKGGVGKTSIACASAITLARAGKKVLLVSTDPASNVGQVFGVSIGNTITDIPAAPGLSALEINPEQ
AAAAYRERIIGPVRGLLPEKEIAAIAEQLSGSCTTEIASFNEFTGLLSCQGDITADFDHVLFDTAPTGHTIRLLQLPGSW
TEFLDDGRGDASCLGPLSGLEKQRAIYADAVAALADPQRTRLVLVSRAQRSTLAEITRTHRELADIGLTHQHVVINGVLP
APGDDTDPLATAIYRREQAAIAGLPDELAQLPTDQVPLKATNIVGIDALESLFTPDLSPVSAASADPALQLPSAPLSSLI
DELDTDDHGLIMCMGKGGVGKTTIAAAIAVALAERGHQVHLTTTDPAAHLTETLNGELDNLQVSRIDPAEATEQYRTRVL
TTKGKNLDERGRANLAEDLRSPCTEEVAVFQAFSRVIHESSRKFVVVDTAPTGHTLLLLDATGSYHREIARQMGENTNFT
TPLMRLQDPNATKVLLVTLAETTPVLEAAGLQADLQRAGIHPWAWVVNNSLAAAEPTSTLLQQRAAGEITEIDSITNKYS
QRTAIVPMLAEEPVGTDALAALSKA

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=318, Percent_Identity=26.1006289308176, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557003, Length=263, Percent_Identity=28.5171102661597, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320103, Length=294, Percent_Identity=24.8299319727891, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24586297, Length=313, Percent_Identity=24.2811501597444, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 62027; Mature: 62027

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLNDAPRFLFFTGKGGVGKTSIACASAITLARAGKKVLLVSTDPASNVGQVFGVSIGN
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEECCC
TITDIPAAPGLSALEINPEQAAAAYRERIIGPVRGLLPEKEIAAIAEQLSGSCTTEIASF
CCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
NEFTGLLSCQGDITADFDHVLFDTAPTGHTIRLLQLPGSWTEFLDDGRGDASCLGPLSGL
HHHCEEEEECCCCCCCCCHHEEECCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHH
EKQRAIYADAVAALADPQRTRLVLVSRAQRSTLAEITRTHRELADIGLTHQHVVINGVLP
HHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
APGDDTDPLATAIYRREQAAIAGLPDELAQLPTDQVPLKATNIVGIDALESLFTPDLSPV
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEECCEECHHHHHHHHCCCCCCC
SAASADPALQLPSAPLSSLIDELDTDDHGLIMCMGKGGVGKTTIAAAIAVALAERGHQVH
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEE
LTTTDPAAHLTETLNGELDNLQVSRIDPAEATEQYRTRVLTTKGKNLDERGRANLAEDLR
EEECCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHH
SPCTEEVAVFQAFSRVIHESSRKFVVVDTAPTGHTLLLLDATGSYHREIARQMGENTNFT
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
TPLMRLQDPNATKVLLVTLAETTPVLEAAGLQADLQRAGIHPWAWVVNNSLAAAEPTSTL
CCEEEECCCCCCEEEEEEECCCCCHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCHHHH
LQQRAAGEITEIDSITNKYSQRTAIVPMLAEEPVGTDALAALSKA
HHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKFLNDAPRFLFFTGKGGVGKTSIACASAITLARAGKKVLLVSTDPASNVGQVFGVSIGN
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEEEECCC
TITDIPAAPGLSALEINPEQAAAAYRERIIGPVRGLLPEKEIAAIAEQLSGSCTTEIASF
CCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
NEFTGLLSCQGDITADFDHVLFDTAPTGHTIRLLQLPGSWTEFLDDGRGDASCLGPLSGL
HHHCEEEEECCCCCCCCCHHEEECCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHH
EKQRAIYADAVAALADPQRTRLVLVSRAQRSTLAEITRTHRELADIGLTHQHVVINGVLP
HHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
APGDDTDPLATAIYRREQAAIAGLPDELAQLPTDQVPLKATNIVGIDALESLFTPDLSPV
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEECCEECHHHHHHHHCCCCCCC
SAASADPALQLPSAPLSSLIDELDTDDHGLIMCMGKGGVGKTTIAAAIAVALAERGHQVH
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEE
LTTTDPAAHLTETLNGELDNLQVSRIDPAEATEQYRTRVLTTKGKNLDERGRANLAEDLR
EEECCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHH
SPCTEEVAVFQAFSRVIHESSRKFVVVDTAPTGHTLLLLDATGSYHREIARQMGENTNFT
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
TPLMRLQDPNATKVLLVTLAETTPVLEAAGLQADLQRAGIHPWAWVVNNSLAAAEPTSTL
CCEEEECCCCCCEEEEEEECCCCCHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCHHHH
LQQRAAGEITEIDSITNKYSQRTAIVPMLAEEPVGTDALAALSKA
HHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3021763; 1704144 [H]