| Definition | Burkholderia pseudomallei 1710b chromosome chromosome II, complete sequence. |
|---|---|
| Accession | NC_007435 |
| Length | 3,181,762 |
Click here to switch to the map view.
The map label for this gene is pksL [H]
Identifier: 76819558
GI number: 76819558
Start: 15359
End: 20032
Strand: Direct
Name: pksL [H]
Synonym: BURPS1710b_A0002
Alternate gene names: 76819558
Gene position: 15359-20032 (Clockwise)
Preceding gene: 76817822
Following gene: 76818976
Centisome position: 0.48
GC content: 72.23
Gene sequence:
>4674_bases ATGCAAGCAACGTTTAACTCCGACGAGGTCGCGCTTGCCGGCGACGCCCGGCGCACGGACGGCGATGCCGATCGCGCGGC CGCGTCGCCGCACGGGTTTCGCTTCGTCGAGAAGGCGCGTATCGCCGACGAGCCCGGCCTGTCGGCGCGGCTCGCCGCGC GCAAGGGCGACGCGCATCAGGACGGCGTGTTTCTCGACCTGTGGCCGTCGATCTTCCTGTCGGACGAACACGGCGACCAC ATCCACGTGCTGCGGGATCGCGGCCTGCTGTTCGTCACGCGCTTCGTCGGCGCGCCGCAGCGCGAGGCCGCGCTGCTGAG CGCGCTGCTCGATCGCGCGCGCGGCGAGGGCCGCGCGCTCTGCTACCTGGACATGTCGAACCGGCGCAAGCCCGACATCG AGCGCGAGTGCGGGCTGCTGTCGACGCCGCTCGGCGTCGTGCAGACGATCGACGACATTCGCCGCTTCACGCTCGACGGG CCGCGGATGCGCAAGCTGCGTTACCTCGTGTCGAAGTTCGGGCGCGACCCGTCGTGCCGCGTCGTCGAATACACGGAGCC GGACCCCGCCGTCGACGGCGAGATCCGCGCGGTGATGGCGGCCTGGAGCCGCGAGAAAGGCGTCGTCAACAAGGTCGATG CGATTCTCGCGGACATGCGCGTCGGCAATCTGCTCAAGCGCTACCGCGTCTACCTGACCTATCTCGGCGACCGGCTGCAG AACGTCGTCGTGCTGAGCCACATCGGCGAAGGCTATATCACCGATCAAGAGTATTTCGTGCCGGACATGCCGCTCGGCGG GACCGAGTATGCATACGCGACGATCATCGAACGGCTCGCCGCAGAGGGGCACCGCAAATTCAGTCTCGGGTTGACGTGGG GCCTGTTCGAGCCCGAGGCGGGCTTCAGCGACGCCGAGGGCTGGACGCTCGTCAACCGCACGGAAGGGCAGCTCGCGCAG ATCTTCCGGCGCGGCGTGCAGAACCATCAGTACAAGAACAAGTACTGCCCGGCGGAATATCCGCTGTACCTGTACCGAAG CGCCGACAGCCGGCCGCAGATCATCAAGCAGTGCATGGGGCAGTTCTTTCGCAACGGGGTGCCGTACGACGAAATCGCGC GCCAGATCGAGGCGGACGACGCGCGGGCCTTGGCGGCGGCCGGCGCCGCGCCGCCGCGCGCGACGCACGGCGGCGACGAG GCCGAAGCGCGTTCGGCCCTCGGCGGCGCGCCCGACGATGCGCGCGCCGGCGCGCCCGACGATGCATCCTTCGACGCACC CGACGAAGCGCCCATCGAGGTATCCGACCACGCACCCGGCAGCACGCCGCCCCCGCGCGCCGCGCGCGACGAGCGCGGCG GCGAGCGCGACGACGGCAAGGGCGGCCAAGCCGGCCAAGCCGACAGAAGCGGCAAGCACGACCCAGCCGACGCCCGCGGC CGTGCCGCGTCCGGCACGCCGGACGCGGCGCGAGCGCCGGCGCTCGCCGACATTCCCGACGCGTTCTTCGATGCGACGCA GGCCGATCCGAACGCGATCCGGCTCGACCTCGTCAGCGATTCGTGGGCCCATCTCGGCTACCCGTTCATTCGCGAGCGGG CGCGCCGGCTGCTTGCCGGCCTCGCGTCGCCGCACGCCGATCCGGCCGCGCCGTGCGGTCTTTTCGGCGTCGATCACTGC GTGCTGACGACTTCCGGGCGCAATGCGGAGCGGGTGTTCTTCAATCTGTTTCCGGCCAAGCGCAAGACGATCCTGCAAAA CATCCCGTTCTTCTCGACCCGGCACAACGCGGCGAAAGCGGGATTCGCCTCGGTCGAGATTCCCGATCCGCGGATCTTCG ATCCGGATTGCCGCGAAATATTCCGCGGCGGCATCGATTTCGCGCGCCTGCGCGAGCAACTGGAGGCGCGGCCGGACGGC GTCGCAATGGTGCTGATCGAGCTGTGCAACAACGCGAGCGGCGGCTATCCGGTGCCGCTCGCGCAGATCGCCGACGTATC CGCGCTGTGCCGCGCGCGCGGCGTGCCGTTCGTGATGGACGTCACGCGCATCGTCAGGAACGCGGAGCTGATCCGGCGTC ACGAGCCCGGCTGCGCGAACGTCGGGCTCTGGGACACCGTCGCCCGGATCGTCGCCCATGCGGACGTCGTGTTCGGCAGC CTCTGCAAGGATTTCGGCGTGAGCGCGGGCGGCATCGTCGCGGCGAACGACGGGCGGCTGATCGGCAAGGCGCGGCGCTA CGCGGAAATCGAGGGCGCGCTGCTCGACCACGTGCAGACGCAGGTGGTGTGCGCGTCGCTCGGCGAGCGCGACGCGCTCG AGCGGGGCGTCGCGGCGCAGCTCGATGTCGCGCGGCGCGTGAGCGACGCGCTCGACGCGCGGCGGATTCCGGCGCTGCTG CCCGTGGTCGGGCATTGCGCGCTGGTGCGCGCGGCCGACATGCCGGGCTATGCCGGCCGCCGGTATCCGCGCGAATCGCT GCTGCGCGCGCTGCTCGAGCGGCACGGCGTGCGCGCCGGCATCCATCTCGCGGGCAGCGGCGCGGAGCGCGTCATCGACC GGTGCATCCGCATCGCGCTGCCGATCGGCCTGGACGACGCGCGGCTCGCATCCGGGCTCGCCGACGCGCTGGCCGGAACC GCGCCGGGCGCAACGGATGCGCCCGCCGCGCTGCCCGACCTGCTGCATGCGCGCGCCCCCGGTGCCGCGGACACGGCCGA CACCGTCGACACGGTCGATACCGTCGATACGGCTGATACGGCCGATACGGCTGATACGGCCGCGCAAGCCGGCGCCCGTC GCGGCGAGGCGCACGCGTCACGCGCGCCGATGCGGGCGAGCGACGACGATGCGATCGCGATCGTCGGCATGGCGGGCCGC TACCCCGGCGCCGACGATCTGTCCGCGTTCTGGCGCAACCTCGTCGACGGCGTGAACGCGATCACGGAAATCCCGGCCGA GCGCTGGGACTGGCGCGCGCATTACCACCCCGATCCCGAGCAGGCGGCGCGGCTGCGCAAGTCGTACGGCAAGTGGGGCG GCTTTCTCGGCGAGTTCGACTGTTTCGATCCGCTGTTCTTCTGGATGGCGCCGCGCCGCATCGCGATGATCGATCCGCAG GAGCGGCTGTTCCTCGAGGAGTGCTGGAAGGCGCTCGAGGATGCGGGCTACCCGCCGTCCCGCCTCGGCGACGCGCTGCG CGAGCGCACGGGCGTGTTCGGCGGGCTGTCGAAGCACGGCTTCAGCCTGTATGCGTCGCAGTATGCGGGCACCCAGCCGC ATACGTCGCCCGCGTCGATGGTCGGCCGCGTGTCGCACTTCTTCGATCTGAAGGGCCCGAGCGTGGCGATCGACAACCAT TGCGCGTCGTCGCTCGTCGCCGTTCACGAGGCCTGCGAATACCTGCGGCGGGGCGACGGCGATCTCGCGATCGCGGGCGG CGTCAGCCTGTGCCTGCACCCGTCGAGCTATGTGCAGCTCTCGCTCGTGCGGATGCTCTCGCGCGACGCGCACTGCGCGG CGTTCGACGAGGGCGGCGCGGGCTACGTGCCGGGCGAGGGGGTGGGCGTCGTCGTGCTCAAGCGGCTCGCGCAGGCGCGC GCGCACGGCGATCCGATCCACGCGGTGATCCGCTCCGGCGCGGTCAATCACAACGGCCGCATGCGCTACTACGGCCAGCC CGATCAGGCGGGCCAGCAGGCCGCCATCCGGGCCGCGCTCGCGCGCGCGCGGATCGATCCGCGCTCGATCAGCTACATCG AGGCGGCCGCGAGCGGCGTCGAGACGACGGACGCGGTCGAGATGGCCGCGCTGACCGAGGTGTTCGGCGATCGGGCGGGC GCCGCGGGCGCCTACACGATCGGTACGGTCAAGCCGGCGATCGGGCACGGCGAGGCCGCGTCGGGCATGTCGCAACTGAT GCGCGTCGCGCTGTCGCTCAAGCACGCGACGCTCACGCCGACCCGGCTGCCACGGCGGCCGAGCCCGCTGATCGATTTCG ATCGGCTGCCGTTCCGGCTCGCGGCCGAGGCGGCGCCGTGGGCGCCGGTGAGCGTCGACGGCCGGCCGGTGCCGCGGCGC GCCGGGGTCACCGCGATCGGCAACGGCGTCAACGCGCATCTGGTGCTCGAGGAATGGCCGGGCGCGCCCGCCGACGATTC CGCCGCCGCGCCGCGCGAGCCGCAGGTGTTCGTGCTGTCCGCGCAGGACGGCGAGCGGCTCGCGGCATACGTCGAGCGAT GGATCGCGTTCCTCGCGAGCGGCGCGACGCCCGATTTCGGGCGGATGCTGCGCACGCTGCAGATCGCGCGCGAGCCGATG CCCGCGCGGCTCGCGCTCGTCGCCTCCGATCGCGACGACTTGCTGCGCGCGTTGCGCGCGTGGCGCGACGGCGGCGCGTC GTCGCGCGTGCATCGCGGCGACGCCCGCCGGCGCGCCGGGCAGGCCGCGCTGGCGGAGCAGGCGTGCGATCCGCGCGCGT GCGCGCCCGACGAGGCGGCCGCGGCCTGGGTGCAAGGGCGCACGGTGCGCTGGGAGGCGCTTCACCGAGGCGGGCCGTGG CGGCGCGTCGGCGGTCTGCCGGCCTATCCGTTCGCGCGCGAGCGGTACTGGATCGCGGACGCGGCATCCGGCGCGCCGGC AGGCAGGGAGGAAGCATCGGCGCGGCCCGATTGA
Upstream 100 bases:
>100_bases GAGCTGGGCAGCCTGCCGAAGACGCTGTTCTTCGAGCACGAAACGATCGAGGAACTGGGCGAGTACCTGCTGGAGCGGCA AGGACAAGAGAGGGCGTGCC
Downstream 100 bases:
>100_bases CGGGCCGCGTGCCGACAGGTTGCCCGCCGGATTTCCCGACGGGTTCATTGACGAAGATTCGACAACAGGCTGGAGAAATA CGATGAGCAACAATCAGGTC
Product: putative polyketide synthase
Products: Indole; ammonia; Pyruvate [C]
Alternate protein names: PKS [H]
Number of amino acids: Translated: 1557; Mature: 1557
Protein sequence:
>1557_residues MQATFNSDEVALAGDARRTDGDADRAAASPHGFRFVEKARIADEPGLSARLAARKGDAHQDGVFLDLWPSIFLSDEHGDH IHVLRDRGLLFVTRFVGAPQREAALLSALLDRARGEGRALCYLDMSNRRKPDIERECGLLSTPLGVVQTIDDIRRFTLDG PRMRKLRYLVSKFGRDPSCRVVEYTEPDPAVDGEIRAVMAAWSREKGVVNKVDAILADMRVGNLLKRYRVYLTYLGDRLQ NVVVLSHIGEGYITDQEYFVPDMPLGGTEYAYATIIERLAAEGHRKFSLGLTWGLFEPEAGFSDAEGWTLVNRTEGQLAQ IFRRGVQNHQYKNKYCPAEYPLYLYRSADSRPQIIKQCMGQFFRNGVPYDEIARQIEADDARALAAAGAAPPRATHGGDE AEARSALGGAPDDARAGAPDDASFDAPDEAPIEVSDHAPGSTPPPRAARDERGGERDDGKGGQAGQADRSGKHDPADARG RAASGTPDAARAPALADIPDAFFDATQADPNAIRLDLVSDSWAHLGYPFIRERARRLLAGLASPHADPAAPCGLFGVDHC VLTTSGRNAERVFFNLFPAKRKTILQNIPFFSTRHNAAKAGFASVEIPDPRIFDPDCREIFRGGIDFARLREQLEARPDG VAMVLIELCNNASGGYPVPLAQIADVSALCRARGVPFVMDVTRIVRNAELIRRHEPGCANVGLWDTVARIVAHADVVFGS LCKDFGVSAGGIVAANDGRLIGKARRYAEIEGALLDHVQTQVVCASLGERDALERGVAAQLDVARRVSDALDARRIPALL PVVGHCALVRAADMPGYAGRRYPRESLLRALLERHGVRAGIHLAGSGAERVIDRCIRIALPIGLDDARLASGLADALAGT APGATDAPAALPDLLHARAPGAADTADTVDTVDTVDTADTADTADTAAQAGARRGEAHASRAPMRASDDDAIAIVGMAGR YPGADDLSAFWRNLVDGVNAITEIPAERWDWRAHYHPDPEQAARLRKSYGKWGGFLGEFDCFDPLFFWMAPRRIAMIDPQ ERLFLEECWKALEDAGYPPSRLGDALRERTGVFGGLSKHGFSLYASQYAGTQPHTSPASMVGRVSHFFDLKGPSVAIDNH CASSLVAVHEACEYLRRGDGDLAIAGGVSLCLHPSSYVQLSLVRMLSRDAHCAAFDEGGAGYVPGEGVGVVVLKRLAQAR AHGDPIHAVIRSGAVNHNGRMRYYGQPDQAGQQAAIRAALARARIDPRSISYIEAAASGVETTDAVEMAALTEVFGDRAG AAGAYTIGTVKPAIGHGEAASGMSQLMRVALSLKHATLTPTRLPRRPSPLIDFDRLPFRLAAEAAPWAPVSVDGRPVPRR AGVTAIGNGVNAHLVLEEWPGAPADDSAAAPREPQVFVLSAQDGERLAAYVERWIAFLASGATPDFGRMLRTLQIAREPM PARLALVASDRDDLLRALRAWRDGGASSRVHRGDARRRAGQAALAEQACDPRACAPDEAAAAWVQGRTVRWEALHRGGPW RRVGGLPAYPFARERYWIADAASGAPAGREEASARPD
Sequences:
>Translated_1557_residues MQATFNSDEVALAGDARRTDGDADRAAASPHGFRFVEKARIADEPGLSARLAARKGDAHQDGVFLDLWPSIFLSDEHGDH IHVLRDRGLLFVTRFVGAPQREAALLSALLDRARGEGRALCYLDMSNRRKPDIERECGLLSTPLGVVQTIDDIRRFTLDG PRMRKLRYLVSKFGRDPSCRVVEYTEPDPAVDGEIRAVMAAWSREKGVVNKVDAILADMRVGNLLKRYRVYLTYLGDRLQ NVVVLSHIGEGYITDQEYFVPDMPLGGTEYAYATIIERLAAEGHRKFSLGLTWGLFEPEAGFSDAEGWTLVNRTEGQLAQ IFRRGVQNHQYKNKYCPAEYPLYLYRSADSRPQIIKQCMGQFFRNGVPYDEIARQIEADDARALAAAGAAPPRATHGGDE AEARSALGGAPDDARAGAPDDASFDAPDEAPIEVSDHAPGSTPPPRAARDERGGERDDGKGGQAGQADRSGKHDPADARG RAASGTPDAARAPALADIPDAFFDATQADPNAIRLDLVSDSWAHLGYPFIRERARRLLAGLASPHADPAAPCGLFGVDHC VLTTSGRNAERVFFNLFPAKRKTILQNIPFFSTRHNAAKAGFASVEIPDPRIFDPDCREIFRGGIDFARLREQLEARPDG VAMVLIELCNNASGGYPVPLAQIADVSALCRARGVPFVMDVTRIVRNAELIRRHEPGCANVGLWDTVARIVAHADVVFGS LCKDFGVSAGGIVAANDGRLIGKARRYAEIEGALLDHVQTQVVCASLGERDALERGVAAQLDVARRVSDALDARRIPALL PVVGHCALVRAADMPGYAGRRYPRESLLRALLERHGVRAGIHLAGSGAERVIDRCIRIALPIGLDDARLASGLADALAGT APGATDAPAALPDLLHARAPGAADTADTVDTVDTVDTADTADTADTAAQAGARRGEAHASRAPMRASDDDAIAIVGMAGR YPGADDLSAFWRNLVDGVNAITEIPAERWDWRAHYHPDPEQAARLRKSYGKWGGFLGEFDCFDPLFFWMAPRRIAMIDPQ ERLFLEECWKALEDAGYPPSRLGDALRERTGVFGGLSKHGFSLYASQYAGTQPHTSPASMVGRVSHFFDLKGPSVAIDNH CASSLVAVHEACEYLRRGDGDLAIAGGVSLCLHPSSYVQLSLVRMLSRDAHCAAFDEGGAGYVPGEGVGVVVLKRLAQAR AHGDPIHAVIRSGAVNHNGRMRYYGQPDQAGQQAAIRAALARARIDPRSISYIEAAASGVETTDAVEMAALTEVFGDRAG AAGAYTIGTVKPAIGHGEAASGMSQLMRVALSLKHATLTPTRLPRRPSPLIDFDRLPFRLAAEAAPWAPVSVDGRPVPRR AGVTAIGNGVNAHLVLEEWPGAPADDSAAAPREPQVFVLSAQDGERLAAYVERWIAFLASGATPDFGRMLRTLQIAREPM PARLALVASDRDDLLRALRAWRDGGASSRVHRGDARRRAGQAALAEQACDPRACAPDEAAAAWVQGRTVRWEALHRGGPW RRVGGLPAYPFARERYWIADAASGAPAGREEASARPD >Mature_1557_residues MQATFNSDEVALAGDARRTDGDADRAAASPHGFRFVEKARIADEPGLSARLAARKGDAHQDGVFLDLWPSIFLSDEHGDH IHVLRDRGLLFVTRFVGAPQREAALLSALLDRARGEGRALCYLDMSNRRKPDIERECGLLSTPLGVVQTIDDIRRFTLDG PRMRKLRYLVSKFGRDPSCRVVEYTEPDPAVDGEIRAVMAAWSREKGVVNKVDAILADMRVGNLLKRYRVYLTYLGDRLQ NVVVLSHIGEGYITDQEYFVPDMPLGGTEYAYATIIERLAAEGHRKFSLGLTWGLFEPEAGFSDAEGWTLVNRTEGQLAQ IFRRGVQNHQYKNKYCPAEYPLYLYRSADSRPQIIKQCMGQFFRNGVPYDEIARQIEADDARALAAAGAAPPRATHGGDE AEARSALGGAPDDARAGAPDDASFDAPDEAPIEVSDHAPGSTPPPRAARDERGGERDDGKGGQAGQADRSGKHDPADARG RAASGTPDAARAPALADIPDAFFDATQADPNAIRLDLVSDSWAHLGYPFIRERARRLLAGLASPHADPAAPCGLFGVDHC VLTTSGRNAERVFFNLFPAKRKTILQNIPFFSTRHNAAKAGFASVEIPDPRIFDPDCREIFRGGIDFARLREQLEARPDG VAMVLIELCNNASGGYPVPLAQIADVSALCRARGVPFVMDVTRIVRNAELIRRHEPGCANVGLWDTVARIVAHADVVFGS LCKDFGVSAGGIVAANDGRLIGKARRYAEIEGALLDHVQTQVVCASLGERDALERGVAAQLDVARRVSDALDARRIPALL PVVGHCALVRAADMPGYAGRRYPRESLLRALLERHGVRAGIHLAGSGAERVIDRCIRIALPIGLDDARLASGLADALAGT APGATDAPAALPDLLHARAPGAADTADTVDTVDTVDTADTADTADTAAQAGARRGEAHASRAPMRASDDDAIAIVGMAGR YPGADDLSAFWRNLVDGVNAITEIPAERWDWRAHYHPDPEQAARLRKSYGKWGGFLGEFDCFDPLFFWMAPRRIAMIDPQ ERLFLEECWKALEDAGYPPSRLGDALRERTGVFGGLSKHGFSLYASQYAGTQPHTSPASMVGRVSHFFDLKGPSVAIDNH CASSLVAVHEACEYLRRGDGDLAIAGGVSLCLHPSSYVQLSLVRMLSRDAHCAAFDEGGAGYVPGEGVGVVVLKRLAQAR AHGDPIHAVIRSGAVNHNGRMRYYGQPDQAGQQAAIRAALARARIDPRSISYIEAAASGVETTDAVEMAALTEVFGDRAG AAGAYTIGTVKPAIGHGEAASGMSQLMRVALSLKHATLTPTRLPRRPSPLIDFDRLPFRLAAEAAPWAPVSVDGRPVPRR AGVTAIGNGVNAHLVLEEWPGAPADDSAAAPREPQVFVLSAQDGERLAAYVERWIAFLASGATPDFGRMLRTLQIAREPM PARLALVASDRDDLLRALRAWRDGGASSRVHRGDARRRAGQAALAEQACDPRACAPDEAAAAWVQGRTVRWEALHRGGPW RRVGGLPAYPFARERYWIADAASGAPAGREEASARPD
Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism [H]
COG id: COG3321
COG function: function code Q; Polyketide synthase modules and related proteins
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 5 acyl carrier domains [H]
Homologues:
Organism=Homo sapiens, GI41872631, Length=448, Percent_Identity=31.4732142857143, Blast_Score=194, Evalue=7e-49, Organism=Homo sapiens, GI8923559, Length=305, Percent_Identity=27.8688524590164, Blast_Score=99, Evalue=4e-20, Organism=Escherichia coli, GI87082323, Length=399, Percent_Identity=23.0576441102757, Blast_Score=70, Evalue=9e-13, Organism=Escherichia coli, GI1787337, Length=401, Percent_Identity=22.1945137157107, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI212642053, Length=525, Percent_Identity=28.7619047619048, Blast_Score=187, Evalue=4e-47, Organism=Caenorhabditis elegans, GI17550940, Length=387, Percent_Identity=27.6485788113695, Blast_Score=147, Evalue=4e-35, Organism=Caenorhabditis elegans, GI71983541, Length=283, Percent_Identity=26.1484098939929, Blast_Score=79, Evalue=2e-14, Organism=Caenorhabditis elegans, GI71983535, Length=275, Percent_Identity=26.1818181818182, Blast_Score=77, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6320904, Length=457, Percent_Identity=23.6323851203501, Blast_Score=86, Evalue=6e-17, Organism=Drosophila melanogaster, GI221330659, Length=480, Percent_Identity=29.1666666666667, Blast_Score=178, Evalue=2e-44, Organism=Drosophila melanogaster, GI19920632, Length=480, Percent_Identity=29.1666666666667, Blast_Score=178, Evalue=3e-44, Organism=Drosophila melanogaster, GI24581345, Length=468, Percent_Identity=28.4188034188034, Blast_Score=175, Evalue=2e-43, Organism=Drosophila melanogaster, GI24644341, Length=392, Percent_Identity=26.0204081632653, Blast_Score=102, Evalue=2e-21,
Paralogues:
None
Copy number: 7160 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 460 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009081 - InterPro: IPR000794 - InterPro: IPR018201 - InterPro: IPR014031 - InterPro: IPR014030 - InterPro: IPR016040 - InterPro: IPR006163 - InterPro: IPR020842 - InterPro: IPR020841 - InterPro: IPR020807 - InterPro: IPR013968 - InterPro: IPR020806 - InterPro: IPR006162 - InterPro: IPR011254 - InterPro: IPR016039 - InterPro: IPR016038 [H]
Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]
EC number: 4.1.99.1 [C]
Molecular weight: Translated: 167738; Mature: 167738
Theoretical pI: Translated: 6.68; Mature: 6.68
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQATFNSDEVALAGDARRTDGDADRAAASPHGFRFVEKARIADEPGLSARLAARKGDAHQ CCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC DGVFLDLWPSIFLSDEHGDHIHVLRDRGLLFVTRFVGAPQREAALLSALLDRARGEGRAL CCEEEEECCCEEECCCCCCEEEEEECCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCCEE CYLDMSNRRKPDIERECGLLSTPLGVVQTIDDIRRFTLDGPRMRKLRYLVSKFGRDPSCR EEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCE VVEYTEPDPAVDGEIRAVMAAWSREKGVVNKVDAILADMRVGNLLKRYRVYLTYLGDRLQ EEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NVVVLSHIGEGYITDQEYFVPDMPLGGTEYAYATIIERLAAEGHRKFSLGLTWGLFEPEA HEEHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC GFSDAEGWTLVNRTEGQLAQIFRRGVQNHQYKNKYCPAEYPLYLYRSADSRPQIIKQCMG CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH QFFRNGVPYDEIARQIEADDARALAAAGAAPPRATHGGDEAEARSALGGAPDDARAGAPD HHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCC DASFDAPDEAPIEVSDHAPGSTPPPRAARDERGGERDDGKGGQAGQADRSGKHDPADARG CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC RAASGTPDAARAPALADIPDAFFDATQADPNAIRLDLVSDSWAHLGYPFIRERARRLLAG CCCCCCCCHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHHHHHH LASPHADPAAPCGLFGVDHCVLTTSGRNAERVFFNLFPAKRKTILQNIPFFSTRHNAAKA HCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHC GFASVEIPDPRIFDPDCREIFRGGIDFARLREQLEARPDGVAMVLIELCNNASGGYPVPL CCCEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCH AQIADVSALCRARGVPFVMDVTRIVRNAELIRRHEPGCANVGLWDTVARIVAHADVVFGS HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH LCKDFGVSAGGIVAANDGRLIGKARRYAEIEGALLDHVQTQVVCASLGERDALERGVAAQ HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH LDVARRVSDALDARRIPALLPVVGHCALVRAADMPGYAGRRYPRESLLRALLERHGVRAG HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE IHLAGSGAERVIDRCIRIALPIGLDDARLASGLADALAGTAPGATDAPAALPDLLHARAP EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC GAADTADTVDTVDTVDTADTADTADTAAQAGARRGEAHASRAPMRASDDDAIAIVGMAGR CCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEEECCC YPGADDLSAFWRNLVDGVNAITEIPAERWDWRAHYHPDPEQAARLRKSYGKWGGFLGEFD CCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC CFDPLFFWMAPRRIAMIDPQERLFLEECWKALEDAGYPPSRLGDALRERTGVFGGLSKHG HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCC FSLYASQYAGTQPHTSPASMVGRVSHFFDLKGPSVAIDNHCASSLVAVHEACEYLRRGDG HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCC DLAIAGGVSLCLHPSSYVQLSLVRMLSRDAHCAAFDEGGAGYVPGEGVGVVVLKRLAQAR CEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH AHGDPIHAVIRSGAVNHNGRMRYYGQPDQAGQQAAIRAALARARIDPRSISYIEAAASGV CCCCHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC ETTDAVEMAALTEVFGDRAGAAGAYTIGTVKPAIGHGEAASGMSQLMRVALSLKHATLTP CHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH TRLPRRPSPLIDFDRLPFRLAAEAAPWAPVSVDGRPVPRRAGVTAIGNGVNAHLVLEEWP HHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHCCCEEECCCCEEEEEEECCC GAPADDSAAAPREPQVFVLSAQDGERLAAYVERWIAFLASGATPDFGRMLRTLQIAREPM CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC PARLALVASDRDDLLRALRAWRDGGASSRVHRGDARRRAGQAALAEQACDPRACAPDEAA CCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHH AAWVQGRTVRWEALHRGGPWRRVGGLPAYPFARERYWIADAASGAPAGREEASARPD HHHHCCCCEEEHHHHCCCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC >Mature Secondary Structure MQATFNSDEVALAGDARRTDGDADRAAASPHGFRFVEKARIADEPGLSARLAARKGDAHQ CCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC DGVFLDLWPSIFLSDEHGDHIHVLRDRGLLFVTRFVGAPQREAALLSALLDRARGEGRAL CCEEEEECCCEEECCCCCCEEEEEECCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCCEE CYLDMSNRRKPDIERECGLLSTPLGVVQTIDDIRRFTLDGPRMRKLRYLVSKFGRDPSCR EEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCE VVEYTEPDPAVDGEIRAVMAAWSREKGVVNKVDAILADMRVGNLLKRYRVYLTYLGDRLQ EEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NVVVLSHIGEGYITDQEYFVPDMPLGGTEYAYATIIERLAAEGHRKFSLGLTWGLFEPEA HEEHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCC GFSDAEGWTLVNRTEGQLAQIFRRGVQNHQYKNKYCPAEYPLYLYRSADSRPQIIKQCMG CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH QFFRNGVPYDEIARQIEADDARALAAAGAAPPRATHGGDEAEARSALGGAPDDARAGAPD HHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCC DASFDAPDEAPIEVSDHAPGSTPPPRAARDERGGERDDGKGGQAGQADRSGKHDPADARG CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC RAASGTPDAARAPALADIPDAFFDATQADPNAIRLDLVSDSWAHLGYPFIRERARRLLAG CCCCCCCCHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHCCCHHHHHHHHHHHHH LASPHADPAAPCGLFGVDHCVLTTSGRNAERVFFNLFPAKRKTILQNIPFFSTRHNAAKA HCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHC GFASVEIPDPRIFDPDCREIFRGGIDFARLREQLEARPDGVAMVLIELCNNASGGYPVPL CCCEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCH AQIADVSALCRARGVPFVMDVTRIVRNAELIRRHEPGCANVGLWDTVARIVAHADVVFGS HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH LCKDFGVSAGGIVAANDGRLIGKARRYAEIEGALLDHVQTQVVCASLGERDALERGVAAQ HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH LDVARRVSDALDARRIPALLPVVGHCALVRAADMPGYAGRRYPRESLLRALLERHGVRAG HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEE IHLAGSGAERVIDRCIRIALPIGLDDARLASGLADALAGTAPGATDAPAALPDLLHARAP EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC GAADTADTVDTVDTVDTADTADTADTAAQAGARRGEAHASRAPMRASDDDAIAIVGMAGR CCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEEECCC YPGADDLSAFWRNLVDGVNAITEIPAERWDWRAHYHPDPEQAARLRKSYGKWGGFLGEFD CCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC CFDPLFFWMAPRRIAMIDPQERLFLEECWKALEDAGYPPSRLGDALRERTGVFGGLSKHG HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCC FSLYASQYAGTQPHTSPASMVGRVSHFFDLKGPSVAIDNHCASSLVAVHEACEYLRRGDG HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCC DLAIAGGVSLCLHPSSYVQLSLVRMLSRDAHCAAFDEGGAGYVPGEGVGVVVLKRLAQAR CEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH AHGDPIHAVIRSGAVNHNGRMRYYGQPDQAGQQAAIRAALARARIDPRSISYIEAAASGV CCCCHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC ETTDAVEMAALTEVFGDRAGAAGAYTIGTVKPAIGHGEAASGMSQLMRVALSLKHATLTP CHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH TRLPRRPSPLIDFDRLPFRLAAEAAPWAPVSVDGRPVPRRAGVTAIGNGVNAHLVLEEWP HHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHCCCEEECCCCEEEEEEECCC GAPADDSAAAPREPQVFVLSAQDGERLAAYVERWIAFLASGATPDFGRMLRTLQIAREPM CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC PARLALVASDRDDLLRALRAWRDGGASSRVHRGDARRRAGQAALAEQACDPRACAPDEAA CCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHH AAWVQGRTVRWEALHRGGPWRRVGGLPAYPFARERYWIADAASGAPAGREEASARPD HHHHCCCCEEEHHHHCCCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: pyridoxal 5'-phosphate [C]
Metal ions: Cs+; K+; Li+; Na+; NH4+; Rb+; Tl+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 11 {Cys}} 0.06 {S-o-nitrophenyl-L-Cys}} 0.019 {indole}} 12 {S-methyl-L-Cys}} 1.2 {beta-chloroalanine}} 160 {L-Ser}} 0.6 {alpha,beta-diaminopropionic} 70 {pyruvate}} 110 {cysteine} 0.067 {S-benzylcysteine}} 0.065 {S-benzylcyste
Substrates: H2O; L-Tryptophan [C]
Specific reaction: H2O + L-Tryptophan <==> Indole + ammonia + Pyruvate [C]
General reaction: Elimination (alphabeta-position of amino acidreplacement and beta-position of amino acid) [C]
Inhibitor: 4-phenyl -2-aminobutyrate; Ala; beta-phenyl lactate; beta-phenyl serine; ethionine; indole acrylate; indole propionate; indole pyruvate; L-Trp; Met; oxindolyl -L-Ala; Phe [C]
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8344529; 9384377; 10568751 [H]