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The map label for this gene is trxA [C]

Identifier: 75674250

GI number: 75674250

Start: 62959

End: 63279

Strand: Direct

Name: trxA [C]

Synonym: Nwi_0051

Alternate gene names: 75674250

Gene position: 62959-63279 (Clockwise)

Preceding gene: 75674249

Following gene: 75674262

Centisome position: 1.85

GC content: 60.75

Gene sequence:

>321_bases
ATGGCTGTTGGCAAGGTTTCGGACGCCAATTTCGAAGCGGAAGTGCTCAAGGCGACTGGCCCGGTCGTGGTTGATTTCTG
GGCGGAGTGGTGCGGCCCCTGCCGCATGATCGGCCCGGTGCTGGACGAAATCTCCAGCGCCATGGGCAGCAAGGTCAAGA
TCGTGAAGCTGAACGTCGACGAGAGCCCGAGGACGGCCTCGAAATACGGCGTGATGTCGATTCCCACTTTGATGATCTTC
AAGGACGGCGAACTGGCCTCGCGTCAGGTCGGCGCGGCGCCCAAGCAGAAACTTGAGCAATGGATCACCGCCACGGTGTG
A

Upstream 100 bases:

>100_bases
TGTGAGAAACCTTGACCCGGGAAGATCGCCTTCTTAACTACATCCGCAGTTTCAAGCGCATTCTTTCGTCGCGCATCTCA
TCGAGACAACGAGGTATTCC

Downstream 100 bases:

>100_bases
TCTTTCCGCATTGAGATTTTTTTTCAAGCGGCCGGCGTCAATTCGCCGGCCGTTTTTGTTTGGGTAAGGAGAACGTTGAG
GTCAGGGCGCACCCTCCCTT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAVGKVSDANFEAEVLKATGPVVVDFWAEWCGPCRMIGPVLDEISSAMGSKVKIVKLNVDESPRTASKYGVMSIPTLMIF
KDGELASRQVGAAPKQKLEQWITATV

Sequences:

>Translated_106_residues
MAVGKVSDANFEAEVLKATGPVVVDFWAEWCGPCRMIGPVLDEISSAMGSKVKIVKLNVDESPRTASKYGVMSIPTLMIF
KDGELASRQVGAAPKQKLEQWITATV
>Mature_105_residues
AVGKVSDANFEAEVLKATGPVVVDFWAEWCGPCRMIGPVLDEISSAMGSKVKIVKLNVDESPRTASKYGVMSIPTLMIFK
DGELASRQVGAAPKQKLEQWITATV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=34.4086021505376, Blast_Score=78, Evalue=1e-15,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=34.8837209302326, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=50, Blast_Score=125, Evalue=7e-31,
Organism=Escherichia coli, GI1788936, Length=114, Percent_Identity=36.8421052631579, Blast_Score=98, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=34.4444444444444, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=79, Percent_Identity=36.7088607594937, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=89, Percent_Identity=37.0786516853933, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=106, Percent_Identity=30.188679245283, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=36.5591397849462, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=45.2054794520548, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=38, Blast_Score=71, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=34.020618556701, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=39.622641509434, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=39.622641509434, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=40.2597402597403, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=32, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=44.2622950819672, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11427; Mature: 11296

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGKVSDANFEAEVLKATGPVVVDFWAEWCGPCRMIGPVLDEISSAMGSKVKIVKLNVD
CCCCCCCCCCCCCEEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
ESPRTASKYGVMSIPTLMIFKDGELASRQVGAAPKQKLEQWITATV
CCCCCCCCCCCEECCEEEEEECCCCCHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AVGKVSDANFEAEVLKATGPVVVDFWAEWCGPCRMIGPVLDEISSAMGSKVKIVKLNVD
CCCCCCCCCCCCEEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECC
ESPRTASKYGVMSIPTLMIFKDGELASRQVGAAPKQKLEQWITATV
CCCCCCCCCCCEECCEEEEEECCCCCHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]