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The map label for this gene is tpx [H]

Identifier: 73542554

GI number: 73542554

Start: 3143259

End: 3143759

Strand: Direct

Name: tpx [H]

Synonym: Reut_A2869

Alternate gene names: 73542554

Gene position: 3143259-3143759 (Clockwise)

Preceding gene: 73542553

Following gene: 73542555

Centisome position: 82.58

GC content: 64.87

Gene sequence:

>501_bases
ATGAGCAACGTGACCCTCGGCGGCAACGCTATCGAAGTGGCAGGCAAGTTCCCGCAACCTGGCGACAAGGCCGCCGATTT
CAAGCTGGTCGGCAAGGACCTGAAGGACGTGACGCTGGCCGACTTCGCCGGCAAGCGCAAAGTGCTCAATATCGTACCGA
GCCTGGATACCCCGGTGTGCCAGGCGTCGACGCGCAAGTTCAACGAGGCCGCCAGCGGCCTGGCCAACACTGTCGTGCTG
ACCATCTCGGCCGACCTGCCGTTCGCCATGGGCCGGTTCTGCAGCGCTGAAGGCCTGGACAACGTGGTGCCGCTGTCGAC
CATGCGCGGCGCCGAGTTCAAGGGCAACTACGGCGTGGACATCAAGTCCGGCCCGCTGGCCGGCGTGACCGCGCGTGCCG
TGGTGGTGCTCGACGAAAACAACGTCGTCAAGTACAGCCAGCTGGTGCCCGAGATCAAGACCGAGCCCGACTACGACGCC
GCGCTGGCCGCACTGAAGTAA

Upstream 100 bases:

>100_bases
TGAACGCCTCCTGGAATCCGCAGGCTTGCCGCCGAAGACCGAATCGAGTCCGGCTGCAAGCTGCGCCCCCCCCGAAGATC
CTGAACAGGAAGGAGCAGAG

Downstream 100 bases:

>100_bases
GCTGCCCCGGCAATCCGCACCGGCCGCCTGCATTCCCGGGGCGGCCGCTTCTGTTTTCCGAACCCCCCGGGCTGTATGCG
TGCAAGCAGCCCGACCATCC

Product: thiol peroxidase (atypical 2-Cys peroxiredoxin)

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSNVTLGGNAIEVAGKFPQPGDKAADFKLVGKDLKDVTLADFAGKRKVLNIVPSLDTPVCQASTRKFNEAASGLANTVVL
TISADLPFAMGRFCSAEGLDNVVPLSTMRGAEFKGNYGVDIKSGPLAGVTARAVVVLDENNVVKYSQLVPEIKTEPDYDA
ALAALK

Sequences:

>Translated_166_residues
MSNVTLGGNAIEVAGKFPQPGDKAADFKLVGKDLKDVTLADFAGKRKVLNIVPSLDTPVCQASTRKFNEAASGLANTVVL
TISADLPFAMGRFCSAEGLDNVVPLSTMRGAEFKGNYGVDIKSGPLAGVTARAVVVLDENNVVKYSQLVPEIKTEPDYDA
ALAALK
>Mature_165_residues
SNVTLGGNAIEVAGKFPQPGDKAADFKLVGKDLKDVTLADFAGKRKVLNIVPSLDTPVCQASTRKFNEAASGLANTVVLT
ISADLPFAMGRFCSAEGLDNVVPLSTMRGAEFKGNYGVDIKSGPLAGVTARAVVVLDENNVVKYSQLVPEIKTEPDYDAA
LAALK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=163, Percent_Identity=65.6441717791411, Blast_Score=210, Evalue=4e-56,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17400; Mature: 17269

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVTLGGNAIEVAGKFPQPGDKAADFKLVGKDLKDVTLADFAGKRKVLNIVPSLDTPVC
CCCEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCEEHHHHCCCCEEEEECCCCCCCCH
QASTRKFNEAASGLANTVVLTISADLPFAMGRFCSAEGLDNVVPLSTMRGAEFKGNYGVD
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
IKSGPLAGVTARAVVVLDENNVVKYSQLVPEIKTEPDYDAALAALK
ECCCCCCCEEEEEEEEECCCCEEEHHHHCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
SNVTLGGNAIEVAGKFPQPGDKAADFKLVGKDLKDVTLADFAGKRKVLNIVPSLDTPVC
CCEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCEEHHHHCCCCEEEEECCCCCCCCH
QASTRKFNEAASGLANTVVLTISADLPFAMGRFCSAEGLDNVVPLSTMRGAEFKGNYGVD
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
IKSGPLAGVTARAVVVLDENNVVKYSQLVPEIKTEPDYDAALAALK
ECCCCCCCEEEEEEEEECCCCEEEHHHHCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]