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The map label for this gene is pntAA [H]

Identifier: 73542508

GI number: 73542508

Start: 3094731

End: 3095852

Strand: Direct

Name: pntAA [H]

Synonym: Reut_A2823

Alternate gene names: 73542508

Gene position: 3094731-3095852 (Clockwise)

Preceding gene: 73542505

Following gene: 73542509

Centisome position: 81.3

GC content: 68.0

Gene sequence:

>1122_bases
ATGTACATCGGCATCCCGCAGGAGACGCGGGCCGGCGAGACTCGCGTCGCCGCCACCCCGGAGACCGTCAAGAAGTACGT
CGCACAAGGCCATAAGGTCGTGGTGCAGGCGGGCGCCGGTGTACGGGCCAGCCAGCCTGACAGCGCCTATGAGGCCGTTG
GCGCGACCATTGGCACCGCGGCCGACGCATTCGGCGCCGACCTGGTGCTGAAAGTGCGCGCCCCGGAAGCCGCGGAGCTG
GCGCTGATGAGGCCCGGCTCGGCACTGGTGGGCATGCTCAACCCGTTCGATGCAGAGAACAACGCGCGCATGGCCGCTGC
ATCGGTCACGGCCTTCGCGCTGGAAGCCGCGCCGCGCACCACGCGTGCGCAGAGCATGGACGTGCTGTCCTCGCAGGCAA
ACATCGCCGGCTACAAGGCCGTGCTGGTCGCCGCGCACCACTATCAGCGCTTCATGCCGATGCTGATGACCGCCGCGGGC
ACCGTCAAGGCCGCGCGCGTGCTGATCCTCGGCGCCGGTGTGGCGGGCCTGCAGGCCATCGCCACGGCCAAGCGCCTCGG
TGCGGTAATCGAAGCGTCAGACGTGCGCCCGGCGGTGAAGGAGCAGATCGAATCGCTCGGCGGCAAGTTCCTCGACGTGC
CGTTCGTCACCGACGAAGAGCGCGAGATTGCGCAGGGCGTGGGCGGCTATGCGCGCCCGATGCCGCCTGACTGGATGCGC
CGCCAGGCCGAACTGGTCCACGAGCGCGCCAAGCAGGCCGATATCATCATCACCACCGCACTGATCCCGGGCCGCAAGGC
ACCCGTGCTGCTGCAGGAAGAAACCGTGCAGCAGATGAAGCCGGGCTCGGTGGTGGTCGACCTTGCCGCCGCGCAAGGCG
GCAACTGCCCGCTGACCGTGGCCGACGAAGTGGTCGAGCGCCATGGCGTGATCTTCGTGGGCCATACGAACCTGGCCAGC
ATGGTCGCGGCAGACGCCTCGGCGCTGTACGCGCGCAACGTGCTGGACTTCCTCAAGCTGGTCATCGACAAGGACGGCAA
CTTCACGCTCAACCTGGAAGACGACATCGTCGCTGCCTGCCTGATGTGCAACGGCGGCGAAGTCGTGCGAAAGGCGGCGT
GA

Upstream 100 bases:

>100_bases
TGAAAAATTGTGCGCTGCGGCTGTTGGCAGTCGTAGCGAACAACGGGCCAGACGTCGGCTCGCCAACCAGATATGACGCC
AGCAAAAGGAGAAATTGACG

Downstream 100 bases:

>100_bases
GTCTTCCCGGCACCCGGGTCTAAGCGCATGACGGCCAGCCTGTGTCGGGATTCCGCAGCGAAGGCGGCACCATGGGGTGC
CCGCCTTGGCATGCGGTTCG

Product: NAD(P)(+) transhydrogenase (AB-specific)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MYIGIPQETRAGETRVAATPETVKKYVAQGHKVVVQAGAGVRASQPDSAYEAVGATIGTAADAFGADLVLKVRAPEAAEL
ALMRPGSALVGMLNPFDAENNARMAAASVTAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
RQAELVHERAKQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGNFTLNLEDDIVAACLMCNGGEVVRKAA

Sequences:

>Translated_373_residues
MYIGIPQETRAGETRVAATPETVKKYVAQGHKVVVQAGAGVRASQPDSAYEAVGATIGTAADAFGADLVLKVRAPEAAEL
ALMRPGSALVGMLNPFDAENNARMAAASVTAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
RQAELVHERAKQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGNFTLNLEDDIVAACLMCNGGEVVRKAA
>Mature_373_residues
MYIGIPQETRAGETRVAATPETVKKYVAQGHKVVVQAGAGVRASQPDSAYEAVGATIGTAADAFGADLVLKVRAPEAAEL
ALMRPGSALVGMLNPFDAENNARMAAASVTAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
RQAELVHERAKQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVIFVGHTNLAS
MVAADASALYARNVLDFLKLVIDKDGNFTLNLEDDIVAACLMCNGGEVVRKAA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=363, Percent_Identity=40.495867768595, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI122939153, Length=363, Percent_Identity=40.495867768595, Blast_Score=262, Evalue=4e-70,
Organism=Escherichia coli, GI1787887, Length=375, Percent_Identity=44, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=371, Percent_Identity=41.7789757412399, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39176; Mature: 39176

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIGIPQETRAGETRVAATPETVKKYVAQGHKVVVQAGAGVRASQPDSAYEAVGATIGTA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ADAFGADLVLKVRAPEAAELALMRPGSALVGMLNPFDAENNARMAAASVTAFALEAAPRT
HHHCCCCEEEEEECCCCHHEEEECCCHHHEECCCCCCCCCCCEEHHHHHHHHHHHCCCCC
TRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
HHHHHHHHHEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAELVHERAKQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCCCEEH
ADEVVERHGVIFVGHTNLASMVAADASALYARNVLDFLKLVIDKDGNFTLNLEDDIVAAC
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LMCNGGEVVRKAA
HHCCCCHHHHCCC
>Mature Secondary Structure
MYIGIPQETRAGETRVAATPETVKKYVAQGHKVVVQAGAGVRASQPDSAYEAVGATIGTA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
ADAFGADLVLKVRAPEAAELALMRPGSALVGMLNPFDAENNARMAAASVTAFALEAAPRT
HHHCCCCEEEEEECCCCHHEEEECCCHHHEECCCCCCCCCCCEEHHHHHHHHHHHCCCCC
TRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGGKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
HHHHHHHHHEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAELVHERAKQADIIITTALIPGRKAPVLLQEETVQQMKPGSVVVDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHCCCCCEEEEEECCCCCCCCEEH
ADEVVERHGVIFVGHTNLASMVAADASALYARNVLDFLKLVIDKDGNFTLNLEDDIVAAC
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LMCNGGEVVRKAA
HHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]