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The map label for this gene is glcD [H]

Identifier: 73542475

GI number: 73542475

Start: 3060255

End: 3061775

Strand: Direct

Name: glcD [H]

Synonym: Reut_A2790

Alternate gene names: 73542475

Gene position: 3060255-3061775 (Clockwise)

Preceding gene: 73542474

Following gene: 73542476

Centisome position: 80.39

GC content: 67.13

Gene sequence:

>1521_bases
ATGAATGCCCCGCACGAAGCCCCACTGACCACCGGCGCCACACCCGCCGGTAACGGCGCCGCCGATGGCCGCCGCAGCGC
GCTGCTGGCGGGCCTTGCGCAGATCCTGCCGGACGCCGCATTGCTGTGGAAGCCGGAAGACACCGTCCCCTACGAGTGCG
ACGGCCTGGCCGCCTACCGCCAGGTGCCGATGGCCGTGGCCCTGCCCGATACCGAGGAACAGGTCTGCGCGATCCTGCGC
CTGTGCCACAGGCTCAGCGTGCCCGTGGTGCCGCGCGGCGCGGGGACGAGCCTGTCCGGCGGCGCCATGCCGATCGCCGA
AGGGCTGGTGCTGTCGCTGGCCAAGTTCAAGCGCATCCTGAAAGTTGACCCGCACTCACGCACCGCGGTGGTCCAGCCGG
GCGTGCGCAACCTGGCCATCTCCGACGCCGCCGCTCCCTTCAACCTGTATTACGCGCCCGATCCGTCGTCGCAGATCGCC
TGCACCATCGGCGGCAACGTCAGCGAAAATTCGGGCGGCGTGCACTGCCTGAAATACGGCCTGACCGTGCATAACGTGCT
GCGCGTGCGCGCGGTGACGATGGAAGGCGAGGTCGTCGTGTTCGGCTCCGAAGCCCCGGATTCGCCGGGCCTGGATCTGC
TCGCCGCAATGATCGGCTCCGAAGGCATGCTGGCCGTGGTAACCGAAGTCACCGTGCGCCTGATCCCGAAGCCCCAGCTT
GCGCAGGTGATCATGGCCTGCTTCGACGACGTGGAAAAAGGCGGCAACGCGGTGGCCGCGATCATCGCGGCCGGCATCAT
CCCGGCAGGCCTGGAGATGATGGACAAACCCGCCACGGCCGCCGTGGAAGAGTTCGTGCACGCTGGCTACGACCTCGACG
CCGCGGCCATCCTGCTATGCGAATCCGATGGCACGCCCGAGGAGGTCGCAGAGGAAATCGAGCGCATGAGCGCGGTGCTG
ACGGCTTCGGGGTGCACGCGCATCGTCGTCTCGCAGAACGAAGCCGAGCGCCTGCGTTTCTGGAGCGGCCGCAAGAACGC
GTTCCCGGCGGCGGGCCGCATCTCGCCTGACTATTACTGCATGGACGGCACTATCCCGCGCAAGCATATCGGCACACTGC
TGCGCCGCATCGAAGAGATGGAGCGCAAGTACGCGCTGCGCTGCATCAACGTGTTCCATGCCGGCGACGGCAATATGCAT
CCGCTGATCCTGTTCGATGGTGCGGACGAGGACCAGTGGCACCGTGCCGAGCTGTTTGGCTCGGACATCCTGGAAGCTTG
CGTGGAACTGGGCGGCACCGTCACCGGCGAACACGGCGTGGGCGTGGAGAAGCTCAACTCGATGTGCGTGCAGTTCTCGC
CGTCCGAGCGCGATGCCTTCTTTGGCGTCAAGGCTGCCTTCGACCCGGCGCGACTGCTGAACCCGGACAAGGCCATCCCG
ACGCTCGCGCGCTGCGCCGAATACGGCAAGATGCACGTCAAGAAGGGGCTGCTGCCCCACCCCGACCTGCCGCGCTTCTG
A

Upstream 100 bases:

>100_bases
TTCACGTACCGGGGCGTGCTGGCGGCGCAAGCGCTGCGCTATAGTCACCCGTCCCCTCCGGCCGCACGCCGGCCTCGCAG
ACAGGCACATAGGAGTCGCC

Downstream 100 bases:

>100_bases
ACGACGCGCCAGCCATGCCGCACCGCGAGACCAACCAGACCCTGCGCCAGCGCCTCGGCCGGCCCGAGACCGGCTGGCGC
GAGCGCTGGTACACGATCAT

Product: D-lactate dehydrogenase (cytochrome)

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNAPHEAPLTTGATPAGNGAADGRRSALLAGLAQILPDAALLWKPEDTVPYECDGLAAYRQVPMAVALPDTEEQVCAILR
LCHRLSVPVVPRGAGTSLSGGAMPIAEGLVLSLAKFKRILKVDPHSRTAVVQPGVRNLAISDAAAPFNLYYAPDPSSQIA
CTIGGNVSENSGGVHCLKYGLTVHNVLRVRAVTMEGEVVVFGSEAPDSPGLDLLAAMIGSEGMLAVVTEVTVRLIPKPQL
AQVIMACFDDVEKGGNAVAAIIAAGIIPAGLEMMDKPATAAVEEFVHAGYDLDAAAILLCESDGTPEEVAEEIERMSAVL
TASGCTRIVVSQNEAERLRFWSGRKNAFPAAGRISPDYYCMDGTIPRKHIGTLLRRIEEMERKYALRCINVFHAGDGNMH
PLILFDGADEDQWHRAELFGSDILEACVELGGTVTGEHGVGVEKLNSMCVQFSPSERDAFFGVKAAFDPARLLNPDKAIP
TLARCAEYGKMHVKKGLLPHPDLPRF

Sequences:

>Translated_506_residues
MNAPHEAPLTTGATPAGNGAADGRRSALLAGLAQILPDAALLWKPEDTVPYECDGLAAYRQVPMAVALPDTEEQVCAILR
LCHRLSVPVVPRGAGTSLSGGAMPIAEGLVLSLAKFKRILKVDPHSRTAVVQPGVRNLAISDAAAPFNLYYAPDPSSQIA
CTIGGNVSENSGGVHCLKYGLTVHNVLRVRAVTMEGEVVVFGSEAPDSPGLDLLAAMIGSEGMLAVVTEVTVRLIPKPQL
AQVIMACFDDVEKGGNAVAAIIAAGIIPAGLEMMDKPATAAVEEFVHAGYDLDAAAILLCESDGTPEEVAEEIERMSAVL
TASGCTRIVVSQNEAERLRFWSGRKNAFPAAGRISPDYYCMDGTIPRKHIGTLLRRIEEMERKYALRCINVFHAGDGNMH
PLILFDGADEDQWHRAELFGSDILEACVELGGTVTGEHGVGVEKLNSMCVQFSPSERDAFFGVKAAFDPARLLNPDKAIP
TLARCAEYGKMHVKKGLLPHPDLPRF
>Mature_506_residues
MNAPHEAPLTTGATPAGNGAADGRRSALLAGLAQILPDAALLWKPEDTVPYECDGLAAYRQVPMAVALPDTEEQVCAILR
LCHRLSVPVVPRGAGTSLSGGAMPIAEGLVLSLAKFKRILKVDPHSRTAVVQPGVRNLAISDAAAPFNLYYAPDPSSQIA
CTIGGNVSENSGGVHCLKYGLTVHNVLRVRAVTMEGEVVVFGSEAPDSPGLDLLAAMIGSEGMLAVVTEVTVRLIPKPQL
AQVIMACFDDVEKGGNAVAAIIAAGIIPAGLEMMDKPATAAVEEFVHAGYDLDAAAILLCESDGTPEEVAEEIERMSAVL
TASGCTRIVVSQNEAERLRFWSGRKNAFPAAGRISPDYYCMDGTIPRKHIGTLLRRIEEMERKYALRCINVFHAGDGNMH
PLILFDGADEDQWHRAELFGSDILEACVELGGTVTGEHGVGVEKLNSMCVQFSPSERDAFFGVKAAFDPARLLNPDKAIP
TLARCAEYGKMHVKKGLLPHPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=26.9503546099291, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=26.2331838565022, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI119964728, Length=487, Percent_Identity=26.2833675564682, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4501993, Length=235, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1789351, Length=485, Percent_Identity=60.8247422680412, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1787977, Length=513, Percent_Identity=22.2222222222222, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994907, Length=456, Percent_Identity=23.4649122807018, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=427, Percent_Identity=25.0585480093677, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534361, Length=447, Percent_Identity=26.6219239373602, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71992381, Length=427, Percent_Identity=23.6533957845433, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=23.3983286908078, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=463, Percent_Identity=21.5982721382289, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320023, Length=471, Percent_Identity=28.8747346072187, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320027, Length=435, Percent_Identity=26.4367816091954, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320764, Length=476, Percent_Identity=25.8403361344538, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18921117, Length=464, Percent_Identity=28.0172413793103, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24639277, Length=464, Percent_Identity=28.0172413793103, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24639275, Length=464, Percent_Identity=28.0172413793103, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24653753, Length=281, Percent_Identity=27.4021352313167, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 53877; Mature: 53877

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPHEAPLTTGATPAGNGAADGRRSALLAGLAQILPDAALLWKPEDTVPYECDGLAAYR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHH
QVPMAVALPDTEEQVCAILRLCHRLSVPVVPRGAGTSLSGGAMPIAEGLVLSLAKFKRIL
HCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KVDPHSRTAVVQPGVRNLAISDAAAPFNLYYAPDPSSQIACTIGGNVSENSGGVHCLKYG
CCCCCCCEEEECCCCHHEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEC
LTVHNVLRVRAVTMEGEVVVFGSEAPDSPGLDLLAAMIGSEGMLAVVTEVTVRLIPKPQL
CHHHHHHEEEEEEECCCEEEECCCCCCCCCHHHHHHHHCCCCCEEHEEHHHHHCCCCHHH
AQVIMACFDDVEKGGNAVAAIIAAGIIPAGLEMMDKPATAAVEEFVHAGYDLDAAAILLC
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEE
ESDGTPEEVAEEIERMSAVLTASGCTRIVVSQNEAERLRFWSGRKNAFPAAGRISPDYYC
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEE
MDGTIPRKHIGTLLRRIEEMERKYALRCINVFHAGDGNMHPLILFDGADEDQWHRAELFG
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHH
SDILEACVELGGTVTGEHGVGVEKLNSMCVQFSPSERDAFFGVKAAFDPARLLNPDKAIP
HHHHHHHHHHCCEEECCCCCCHHHHHCHHEEECCCCCCCEEEECCCCCHHHHCCCCHHHH
TLARCAEYGKMHVKKGLLPHPDLPRF
HHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNAPHEAPLTTGATPAGNGAADGRRSALLAGLAQILPDAALLWKPEDTVPYECDGLAAYR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHH
QVPMAVALPDTEEQVCAILRLCHRLSVPVVPRGAGTSLSGGAMPIAEGLVLSLAKFKRIL
HCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KVDPHSRTAVVQPGVRNLAISDAAAPFNLYYAPDPSSQIACTIGGNVSENSGGVHCLKYG
CCCCCCCEEEECCCCHHEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEC
LTVHNVLRVRAVTMEGEVVVFGSEAPDSPGLDLLAAMIGSEGMLAVVTEVTVRLIPKPQL
CHHHHHHEEEEEEECCCEEEECCCCCCCCCHHHHHHHHCCCCCEEHEEHHHHHCCCCHHH
AQVIMACFDDVEKGGNAVAAIIAAGIIPAGLEMMDKPATAAVEEFVHAGYDLDAAAILLC
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEE
ESDGTPEEVAEEIERMSAVLTASGCTRIVVSQNEAERLRFWSGRKNAFPAAGRISPDYYC
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEE
MDGTIPRKHIGTLLRRIEEMERKYALRCINVFHAGDGNMHPLILFDGADEDQWHRAELFG
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHH
SDILEACVELGGTVTGEHGVGVEKLNSMCVQFSPSERDAFFGVKAAFDPARLLNPDKAIP
HHHHHHHHHHCCEEECCCCCCHHHHHCHHEEECCCCCCCEEEECCCCCHHHHCCCCHHHH
TLARCAEYGKMHVKKGLLPHPDLPRF
HHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]