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The map label for this gene is murB

Identifier: 73542446

GI number: 73542446

Start: 3029839

End: 3030849

Strand: Direct

Name: murB

Synonym: Reut_A2761

Alternate gene names: 73542446

Gene position: 3029839-3030849 (Clockwise)

Preceding gene: 73542444

Following gene: 73542449

Centisome position: 79.6

GC content: 66.37

Gene sequence:

>1011_bases
ATGGCAGATTTCCACGAATTTTATCCCCTGCGCCGCCACAATACATTCGGATTCGACGTCCGGGCGCGATATGCATCCCA
CATCCGCAGCGAAGCCGACCTTCTCGCCGCGCTGAATGACCCGCGTGCCGTCGGACTGCCGCTGGTGGTGCTCGGCGGCG
GCAGTAATGTGGTGCTGACCGGCGATCTCGACGCGCTGGTTCTGCTGATGGAGATTCCGGGCTTTCGCGTTGGCACGGCG
CCAGATGCCTGGCTGGTCACGGCGGGCGCTGGCGAAAACTGGCATGGGCTGGTCTGCCGCACCATCGCGGAGGGCCTCCC
TGGCCTCGAAAACCTTGCCCTGATTCCCGGCACCGTCGGGGCGGCGCCTATCCAGAACATCGGCGCGTATGGCGTCGAAC
TGCGCGAGCGTTTTGCGAGCGTGCGGGCGCTCGACCGCCAGACGATGCGTTTCGTGGACCTCGACCTGGAACAGTGCGCG
TTCAGCTACCGCGACAGCCTGTTCAAGCAGGCTGGTCGCGACCGTTACATCATCACGGCAGTGACGCTGCGCCTGTCGCG
CGACTGGCAGCCGGTGCTGGCCTATGGCGAGCTGGCACGCGAAGTGGAAGGCAATGCCGCGCCTGACGCGGCGGCGATCC
GCGATGCGGTGATCGCCATCCGCTCGCGCAAGCTGCCCGATCCCGCGCAGATCGGCAATGCGGGCAGCTTCTTCAAGAAT
CCGCTGGTCAGTGCAGAGCAACGCGACGTGCTGCTGGCGAGCCACCCCGATCTGGTCAGCTATGCCCAGCCCGACGGCTC
GTTCAAGCTAGCCGCGGGCTGGCTGATCGACCGCTGCGGATTCAAGGGACTCAACGACGGCCCGGTGGGCGTCTATGGCA
AGCAGGCGCTGGTGCTGGTACACCACGGTGGCGGCACCGGCGCAGCACTGCTGGCGCTGGCCGGGCGTATCGCCGATACG
GTGCAGGCCCGCTTCGGCGTGCGGATCGAACCGGAACCGGTCGTGCTGTAA

Upstream 100 bases:

>100_bases
ACCCGGGCGGTCCGCGCCGGTACTTCCGTATAATCCAGCCTGCCTCGCGCTCCACGGAGCACCCGGCCGCGCAGCGGCGG
CCGCATCACCTCTAGCTTGC

Downstream 100 bases:

>100_bases
TGGGCTCCGCGGCTGAGATCAGCCGTTCTGGTCAGCCAAAGTGGCAGACGTAGTCCAGGGTTTCCTGGACTTCAATGTCA
AAGCTGCTGTTGCCCGGCAC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MADFHEFYPLRRHNTFGFDVRARYASHIRSEADLLAALNDPRAVGLPLVVLGGGSNVVLTGDLDALVLLMEIPGFRVGTA
PDAWLVTAGAGENWHGLVCRTIAEGLPGLENLALIPGTVGAAPIQNIGAYGVELRERFASVRALDRQTMRFVDLDLEQCA
FSYRDSLFKQAGRDRYIITAVTLRLSRDWQPVLAYGELAREVEGNAAPDAAAIRDAVIAIRSRKLPDPAQIGNAGSFFKN
PLVSAEQRDVLLASHPDLVSYAQPDGSFKLAAGWLIDRCGFKGLNDGPVGVYGKQALVLVHHGGGTGAALLALAGRIADT
VQARFGVRIEPEPVVL

Sequences:

>Translated_336_residues
MADFHEFYPLRRHNTFGFDVRARYASHIRSEADLLAALNDPRAVGLPLVVLGGGSNVVLTGDLDALVLLMEIPGFRVGTA
PDAWLVTAGAGENWHGLVCRTIAEGLPGLENLALIPGTVGAAPIQNIGAYGVELRERFASVRALDRQTMRFVDLDLEQCA
FSYRDSLFKQAGRDRYIITAVTLRLSRDWQPVLAYGELAREVEGNAAPDAAAIRDAVIAIRSRKLPDPAQIGNAGSFFKN
PLVSAEQRDVLLASHPDLVSYAQPDGSFKLAAGWLIDRCGFKGLNDGPVGVYGKQALVLVHHGGGTGAALLALAGRIADT
VQARFGVRIEPEPVVL
>Mature_335_residues
ADFHEFYPLRRHNTFGFDVRARYASHIRSEADLLAALNDPRAVGLPLVVLGGGSNVVLTGDLDALVLLMEIPGFRVGTAP
DAWLVTAGAGENWHGLVCRTIAEGLPGLENLALIPGTVGAAPIQNIGAYGVELRERFASVRALDRQTMRFVDLDLEQCAF
SYRDSLFKQAGRDRYIITAVTLRLSRDWQPVLAYGELAREVEGNAAPDAAAIRDAVIAIRSRKLPDPAQIGNAGSFFKNP
LVSAEQRDVLLASHPDLVSYAQPDGSFKLAAGWLIDRCGFKGLNDGPVGVYGKQALVLVHHGGGTGAALLALAGRIADTV
QARFGVRIEPEPVVL

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=325, Percent_Identity=47.0769230769231, Blast_Score=293, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CUPPJ (Q46XL1)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296966.1
- ProteinModelPortal:   Q46XL1
- SMR:   Q46XL1
- GeneID:   3612331
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2761
- NMPDR:   fig|264198.3.peg.2193
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   REUT264198:REUT_A2761-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 36069; Mature: 35937

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 164-164 ACT_SITE 236-236 ACT_SITE 332-332

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFHEFYPLRRHNTFGFDVRARYASHIRSEADLLAALNDPRAVGLPLVVLGGGSNVVLT
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEE
GDLDALVLLMEIPGFRVGTAPDAWLVTAGAGENWHGLVCRTIAEGLPGLENLALIPGTVG
CCHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC
AAPIQNIGAYGVELRERFASVRALDRQTMRFVDLDLEQCAFSYRDSLFKQAGRDRYIITA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEE
VTLRLSRDWQPVLAYGELAREVEGNAAPDAAAIRDAVIAIRSRKLPDPAQIGNAGSFFKN
EEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHC
PLVSAEQRDVLLASHPDLVSYAQPDGSFKLAAGWLIDRCGFKGLNDGPVGVYGKQALVLV
CCCCCCCCCEEEECCCCHHEECCCCCCEEEEHHHHHHHCCCCCCCCCCCCEECCEEEEEE
HHGGGTGAALLALAGRIADTVQARFGVRIEPEPVVL
ECCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCC
>Mature Secondary Structure 
ADFHEFYPLRRHNTFGFDVRARYASHIRSEADLLAALNDPRAVGLPLVVLGGGSNVVLT
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEE
GDLDALVLLMEIPGFRVGTAPDAWLVTAGAGENWHGLVCRTIAEGLPGLENLALIPGTVG
CCHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC
AAPIQNIGAYGVELRERFASVRALDRQTMRFVDLDLEQCAFSYRDSLFKQAGRDRYIITA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEE
VTLRLSRDWQPVLAYGELAREVEGNAAPDAAAIRDAVIAIRSRKLPDPAQIGNAGSFFKN
EEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHC
PLVSAEQRDVLLASHPDLVSYAQPDGSFKLAAGWLIDRCGFKGLNDGPVGVYGKQALVLV
CCCCCCCCCEEEECCCCHHEECCCCCCEEEEHHHHHHHCCCCCCCCCCCCEECCEEEEEE
HHGGGTGAALLALAGRIADTVQARFGVRIEPEPVVL
ECCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA