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The map label for this gene is coaBC [H]

Identifier: 73542432

GI number: 73542432

Start: 3017085

End: 3018287

Strand: Direct

Name: coaBC [H]

Synonym: Reut_A2747

Alternate gene names: 73542432

Gene position: 3017085-3018287 (Clockwise)

Preceding gene: 73542431

Following gene: 73542433

Centisome position: 79.26

GC content: 68.0

Gene sequence:

>1203_bases
ATGGATTTGCGCGGCAAGCACATCGTTCTCGGCCTGACCGGCGGCATCGCCTGCTACAAGTCGGCCGAACTGGTCCGCCT
GCTGACCAAGGCCGGCGCCACGGTTCAAGTGGCGATGACCGAGGCGGCGACCCATTTCATCACCCCGGTCACGATGCAGG
CCCTGTCGGGCCGCCCGGTGTTCCTGTCGCAGTGGGATGCGCGCGTCGACAACAACATGGCGCACATCGATCTCTCGCGC
GAGGCCGATGTCATCGTGATCGCGCCAGCATCGACGGACTTCCTCGCCAAGCTGGCCAACGGGCTCTGCGACGATTTGCT
GACCACGCTGTGCATTGCGCGCGACTGTCCGCTTCTCGTGGCACCGGCCATGAACCGCCAGATGTGGGCCGCTGCGCCGA
CGCAACGCAATGCGGCGCAACTCCGTGCCGATGGCGTCGTCATCCTCGGCCCCGGCAGCGGCGATCAGGCCTGCGGCGAA
GTCGGCGACGGCCGCATGCTGGAGCCCGAAGAGCTGGTCGACGACATCATCGCGTTCTTCCAGCCCAAGCCGCTGGCAGG
CAAGCGCGTTCTGATCACCGCGGGCCCGACGTTCGAAGCGATCGACCCGGTACGCGGCATCACCAACCTGTCGTCGGGCA
AGATGGGCTTTTCGATCGCGCGCGCCGCGCGCGAAGCCGGTGCCGACGTGCGGCTGGTCTCCGGCCCGACTGGCCTGCCC
ACGCCGCGCGGCGTAGTGCGCAGCGATGTGCGCAGCGCCCAGCAGATGCATGACTCGGTGCTGGCCCAGTTGCACGACGT
CGACGTGTTCATCGCGGTCGCCGCCGTGGCCGACTGGCGCCCCGCCGAGGTCGCCCAGCAGAAGCTCAAGAAGGTCAACG
ATACCGACACCCCGACGCTGCAGTTCGTGCAGAACCCGGATATCCTCGCCACCGTGGCGGCGCGCGCCGATGCGCCCTAC
TGCGTCGGCTTTGCCGCCGAGAGCGAGAACCTTGAGCAATACGGCGAGCAGAAGCGCCAGCGCAAGGGCGTGCCGCTGCT
GGTTGGCAATATCGGCCACCATACCTTCGGGCTCGACGACAACGAGATCGTGCTGTTCGATGCCGCGGGCATGACGCGAC
TGCCGCGCGCCGACAAGCTGACGCTGGCGCGGCAGCTTGTGGCCGCCATCGGTCAGCGCCTGCCGGGCCGTGCCCACCCC
TGA

Upstream 100 bases:

>100_bases
CGTCGACGAGCTGCGGCGCGTGCGCAAGCACTAAGCCGCCGCCGGCAGCCTGCGCAGGCTGCCGGTATCATGCCGAAACC
CAATCTCTGACGAGCCTTCC

Downstream 100 bases:

>100_bases
CGCGCATGACTGCGAACCGACCCCGGCTGCGCCTGTCCGTGCTCGACCAGAGCCCGGTGATCGCCGGCCATACCGCGCGT
GACGCGCTTGCTGCCACCAT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDLRGKHIVLGLTGGIACYKSAELVRLLTKAGATVQVAMTEAATHFITPVTMQALSGRPVFLSQWDARVDNNMAHIDLSR
EADVIVIAPASTDFLAKLANGLCDDLLTTLCIARDCPLLVAPAMNRQMWAAAPTQRNAAQLRADGVVILGPGSGDQACGE
VGDGRMLEPEELVDDIIAFFQPKPLAGKRVLITAGPTFEAIDPVRGITNLSSGKMGFSIARAAREAGADVRLVSGPTGLP
TPRGVVRSDVRSAQQMHDSVLAQLHDVDVFIAVAAVADWRPAEVAQQKLKKVNDTDTPTLQFVQNPDILATVAARADAPY
CVGFAAESENLEQYGEQKRQRKGVPLLVGNIGHHTFGLDDNEIVLFDAAGMTRLPRADKLTLARQLVAAIGQRLPGRAHP

Sequences:

>Translated_400_residues
MDLRGKHIVLGLTGGIACYKSAELVRLLTKAGATVQVAMTEAATHFITPVTMQALSGRPVFLSQWDARVDNNMAHIDLSR
EADVIVIAPASTDFLAKLANGLCDDLLTTLCIARDCPLLVAPAMNRQMWAAAPTQRNAAQLRADGVVILGPGSGDQACGE
VGDGRMLEPEELVDDIIAFFQPKPLAGKRVLITAGPTFEAIDPVRGITNLSSGKMGFSIARAAREAGADVRLVSGPTGLP
TPRGVVRSDVRSAQQMHDSVLAQLHDVDVFIAVAAVADWRPAEVAQQKLKKVNDTDTPTLQFVQNPDILATVAARADAPY
CVGFAAESENLEQYGEQKRQRKGVPLLVGNIGHHTFGLDDNEIVLFDAAGMTRLPRADKLTLARQLVAAIGQRLPGRAHP
>Mature_400_residues
MDLRGKHIVLGLTGGIACYKSAELVRLLTKAGATVQVAMTEAATHFITPVTMQALSGRPVFLSQWDARVDNNMAHIDLSR
EADVIVIAPASTDFLAKLANGLCDDLLTTLCIARDCPLLVAPAMNRQMWAAAPTQRNAAQLRADGVVILGPGSGDQACGE
VGDGRMLEPEELVDDIIAFFQPKPLAGKRVLITAGPTFEAIDPVRGITNLSSGKMGFSIARAAREAGADVRLVSGPTGLP
TPRGVVRSDVRSAQQMHDSVLAQLHDVDVFIAVAAVADWRPAEVAQQKLKKVNDTDTPTLQFVQNPDILATVAARADAPY
CVGFAAESENLEQYGEQKRQRKGVPLLVGNIGHHTFGLDDNEIVLFDAAGMTRLPRADKLTLARQLVAAIGQRLPGRAHP

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=37.7777777777778, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=49.3734335839599, Blast_Score=335, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=35.195530726257, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=31.7708333333333, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=32.8042328042328, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42680; Mature: 42680

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRGKHIVLGLTGGIACYKSAELVRLLTKAGATVQVAMTEAATHFITPVTMQALSGRPV
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCE
FLSQWDARVDNNMAHIDLSREADVIVIAPASTDFLAKLANGLCDDLLTTLCIARDCPLLV
EEECCCHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNRQMWAAAPTQRNAAQLRADGVVILGPGSGDQACGEVGDGRMLEPEELVDDIIAFF
ECCCCCCEEECCCCCCCHHHHHHCCEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
QPKPLAGKRVLITAGPTFEAIDPVRGITNLSSGKMGFSIARAAREAGADVRLVSGPTGLP
CCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
TPRGVVRSDVRSAQQMHDSVLAQLHDVDVFIAVAAVADWRPAEVAQQKLKKVNDTDTPTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCHHHHHHHHHHHCCCCCCCEE
QFVQNPDILATVAARADAPYCVGFAAESENLEQYGEQKRQRKGVPLLVGNIGHHTFGLDD
EEECCCCCEEEEHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEECCCCC
NEIVLFDAAGMTRLPRADKLTLARQLVAAIGQRLPGRAHP
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLRGKHIVLGLTGGIACYKSAELVRLLTKAGATVQVAMTEAATHFITPVTMQALSGRPV
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCE
FLSQWDARVDNNMAHIDLSREADVIVIAPASTDFLAKLANGLCDDLLTTLCIARDCPLLV
EEECCCHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNRQMWAAAPTQRNAAQLRADGVVILGPGSGDQACGEVGDGRMLEPEELVDDIIAFF
ECCCCCCEEECCCCCCCHHHHHHCCEEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
QPKPLAGKRVLITAGPTFEAIDPVRGITNLSSGKMGFSIARAAREAGADVRLVSGPTGLP
CCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
TPRGVVRSDVRSAQQMHDSVLAQLHDVDVFIAVAAVADWRPAEVAQQKLKKVNDTDTPTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCHHHHHHHHHHHCCCCCCCEE
QFVQNPDILATVAARADAPYCVGFAAESENLEQYGEQKRQRKGVPLLVGNIGHHTFGLDD
EEECCCCCEEEEHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEECCCCC
NEIVLFDAAGMTRLPRADKLTLARQLVAAIGQRLPGRAHP
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]