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The map label for this gene is glxR [H]

Identifier: 73542386

GI number: 73542386

Start: 2964248

End: 2965126

Strand: Direct

Name: glxR [H]

Synonym: Reut_A2701

Alternate gene names: 73542386

Gene position: 2964248-2965126 (Clockwise)

Preceding gene: 73542385

Following gene: 73542388

Centisome position: 77.87

GC content: 68.6

Gene sequence:

>879_bases
ATGACTGCAACGCAATCGACTACCGTCGCCTTCATCGGCCTGGGCGCCATGGGCTCGCACATGGTCCGCCACCTGCTGGC
CGCGGGCCACACGGTGCGCGCATTCGTGCGCCGCCCTGAGGCGGCCGAAGCCGCCCGCGCGCTCGGCGCCGAACCGTTCT
TCACGCCCGCCGAAGCGGCGCGCGGCGCGAGCGTCGTGTTCACCAACGTGACCTCGTCCGAGGACGTGCGCGAGGTGCTT
CTCGGCGAGAACGGCGTGATCCACGGCGCCGCGCCCGGAACCGTATGCGTCGACCACAGCACCATCTCGCCGATTGTCAC
GCGCGAGATCGCCACGGCGCTGGCCGCGCGCGGCATCGACGCACTGGACTGCCCGGTGTCGGGCGGCACGGCCGGCGCCG
AGGCTGCCACGCTGACCATCATGGTCGGCGGCAAGCCGGAAGTGCTGGAGCGCGTGCGCCCGCTGCTGGCGCTGCTCGGC
AAGAGCATCACCTACATCGGCGGCAACGGCGCGGGCCAGGTGGCCAAGCTGTGCAACCAGATCGTGCAGGTGGTCAATAT
CGAAGGCATCGCGGAGGCGATGCATTTTGCCGCTGCACAGCAGGTCGACACCGGACGGGTGCTTCAGGCGATCTCCACGG
GCTTTGCGGGCAGCCGCATGCTGGACCTGATGGGCCCGAAGATGGTCGAGCGCGAGTTCGCAGCCGGCATCGAGGCGCGG
CTGCACGACAAGGACTTCGGGCTCGCGCGCGATATCGCGCAGGAAATCGGCCTGAAACTGCCGGCCATGCAGGCAACTTC
AGCGCAGCTGAAGTCGCTGATGGAACACGGCTGGGGCAAGGACGATACCTCGTCCCTGCTGCGCGTGCTGGAAAACTGA

Upstream 100 bases:

>100_bases
GCGCGTGATGGGGGTCATCCGCAACGGCAAGTTCGCCTACGCGCCGGACCAGTGATCCGGTGCGAGGCGGCTGCCGGATT
CGCAACAAGGAAGTTCTGAC

Downstream 100 bases:

>100_bases
GAGCGATTACGTCCTGACGCCCGTCAGTGTCAGGACAGCGCGCAGCAGCGTGCTGTCGGGATTGGCCAGGTCGTCCATCA
CGTTGAAATGGTGCCGGCCC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTATQSTTVAFIGLGAMGSHMVRHLLAAGHTVRAFVRRPEAAEAARALGAEPFFTPAEAARGASVVFTNVTSSEDVREVL
LGENGVIHGAAPGTVCVDHSTISPIVTREIATALAARGIDALDCPVSGGTAGAEAATLTIMVGGKPEVLERVRPLLALLG
KSITYIGGNGAGQVAKLCNQIVQVVNIEGIAEAMHFAAAQQVDTGRVLQAISTGFAGSRMLDLMGPKMVEREFAAGIEAR
LHDKDFGLARDIAQEIGLKLPAMQATSAQLKSLMEHGWGKDDTSSLLRVLEN

Sequences:

>Translated_292_residues
MTATQSTTVAFIGLGAMGSHMVRHLLAAGHTVRAFVRRPEAAEAARALGAEPFFTPAEAARGASVVFTNVTSSEDVREVL
LGENGVIHGAAPGTVCVDHSTISPIVTREIATALAARGIDALDCPVSGGTAGAEAATLTIMVGGKPEVLERVRPLLALLG
KSITYIGGNGAGQVAKLCNQIVQVVNIEGIAEAMHFAAAQQVDTGRVLQAISTGFAGSRMLDLMGPKMVEREFAAGIEAR
LHDKDFGLARDIAQEIGLKLPAMQATSAQLKSLMEHGWGKDDTSSLLRVLEN
>Mature_291_residues
TATQSTTVAFIGLGAMGSHMVRHLLAAGHTVRAFVRRPEAAEAARALGAEPFFTPAEAARGASVVFTNVTSSEDVREVLL
GENGVIHGAAPGTVCVDHSTISPIVTREIATALAARGIDALDCPVSGGTAGAEAATLTIMVGGKPEVLERVRPLLALLGK
SITYIGGNGAGQVAKLCNQIVQVVNIEGIAEAMHFAAAQQVDTGRVLQAISTGFAGSRMLDLMGPKMVEREFAAGIEARL
HDKDFGLARDIAQEIGLKLPAMQATSAQLKSLMEHGWGKDDTSSLLRVLEN

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=30.952380952381, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=41.696113074205, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI145693186, Length=278, Percent_Identity=41.3669064748201, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1790315, Length=281, Percent_Identity=32.0284697508897, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789092, Length=223, Percent_Identity=30.0448430493274, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=249, Percent_Identity=33.7349397590361, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=30.5841924398625, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=30.5841924398625, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=23.8434163701068, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30387; Mature: 30256

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATQSTTVAFIGLGAMGSHMVRHLLAAGHTVRAFVRRPEAAEAARALGAEPFFTPAEAA
CCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHC
RGASVVFTNVTSSEDVREVLLGENGVIHGAAPGTVCVDHSTISPIVTREIATALAARGID
CCCEEEEEECCCHHHHHHHHHCCCCEEECCCCCCEEECCCCCCHHHHHHHHHHHHHCCCC
ALDCPVSGGTAGAEAATLTIMVGGKPEVLERVRPLLALLGKSITYIGGNGAGQVAKLCNQ
CCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
IVQVVNIEGIAEAMHFAAAQQVDTGRVLQAISTGFAGSRMLDLMGPKMVEREFAAGIEAR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHH
LHDKDFGLARDIAQEIGLKLPAMQATSAQLKSLMEHGWGKDDTSSLLRVLEN
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TATQSTTVAFIGLGAMGSHMVRHLLAAGHTVRAFVRRPEAAEAARALGAEPFFTPAEAA
CCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHC
RGASVVFTNVTSSEDVREVLLGENGVIHGAAPGTVCVDHSTISPIVTREIATALAARGID
CCCEEEEEECCCHHHHHHHHHCCCCEEECCCCCCEEECCCCCCHHHHHHHHHHHHHCCCC
ALDCPVSGGTAGAEAATLTIMVGGKPEVLERVRPLLALLGKSITYIGGNGAGQVAKLCNQ
CCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
IVQVVNIEGIAEAMHFAAAQQVDTGRVLQAISTGFAGSRMLDLMGPKMVEREFAAGIEAR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHH
LHDKDFGLARDIAQEIGLKLPAMQATSAQLKSLMEHGWGKDDTSSLLRVLEN
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]