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The map label for this gene is upp [H]

Identifier: 73542204

GI number: 73542204

Start: 2762242

End: 2762892

Strand: Direct

Name: upp [H]

Synonym: Reut_A2519

Alternate gene names: 73542204

Gene position: 2762242-2762892 (Clockwise)

Preceding gene: 73542203

Following gene: 73542205

Centisome position: 72.57

GC content: 64.06

Gene sequence:

>651_bases
ATGAAACAAGATCCGCGTTTCCCCAGCCTGTACATCCTCGACCACCCGCTGATCCAGCACAAGCTCTCGCATATGCGCGA
CAAGGACACGTCCACGCGCACCTTCCGCGAATTGCTGCGCGAGATCACGCTGCTGATGGGCTACGAGATCACGCGCCACC
TGCCGCTCACCACGCGGCATATCGAGACGCCGCTGGTGCCGCTGGAAGCGCCGGTGATCGCAGGCAAGAAGCTCACGATC
GTGCCAGTGCTGCGCGCGGGCGTAGGCATGAGCGATGGCCTGGTCGAACTGATCCCGTCGGCACGCATCGGCCATATCGG
CGTGTATCGTGACGAGCAGCACCGCCCGGTGGAATACCTGGTGCGCCTGCCCGACGTGGAAGACCGCAGCTTTATCCTGT
GCGATCCGATGGTGGCCACCGGTTACTCGGCCGCACATGCCGTGGACGTGCTAAAGCGCCGCGGCGTGAAGGACGAAGCC
ATCACTTTCGTCGCACTGGTCGCTGCGCCCGAAGGCGTGGAGGTATTCCACAAGGCGCATCCGAACGTGAAGCTGTACGT
GGCGTCGCTCGACAGCCACCTGGACGACCACGCGTACATCGTGCCGGGCCTCGGCGACGCGGGCGACCGGCTGTTCGGTA
CCAAGAACTGA

Upstream 100 bases:

>100_bases
TCGGCTTCCATTACAATCCCGCTACAACGGCGCGGCGCCCCGGTCCACAAGATCGGGGCCGCCCGCTTCCCCCTCCTGCC
GCCGAGCCATCGCCGCCGCC

Downstream 100 bases:

>100_bases
TATTGCGGCGGGCCGGAAAGGCCCGCCTGATTTTTTTCCCATGCCGGCGTGGCTTGATCCTACTCAATAGCCCACCCGGT
GCGGCTCCCTACACTCGACG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKQDPRFPSLYILDHPLIQHKLSHMRDKDTSTRTFRELLREITLLMGYEITRHLPLTTRHIETPLVPLEAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDEQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDEA
ITFVALVAAPEGVEVFHKAHPNVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN

Sequences:

>Translated_216_residues
MKQDPRFPSLYILDHPLIQHKLSHMRDKDTSTRTFRELLREITLLMGYEITRHLPLTTRHIETPLVPLEAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDEQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDEA
ITFVALVAAPEGVEVFHKAHPNVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN
>Mature_216_residues
MKQDPRFPSLYILDHPLIQHKLSHMRDKDTSTRTFRELLREITLLMGYEITRHLPLTTRHIETPLVPLEAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDEQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDEA
ITFVALVAAPEGVEVFHKAHPNVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=33.160621761658, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=33.160621761658, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=48.780487804878, Blast_Score=200, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17539892, Length=219, Percent_Identity=27.8538812785388, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=219, Percent_Identity=27.8538812785388, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=217, Percent_Identity=37.7880184331797, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45550449, Length=223, Percent_Identity=33.6322869955157, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573516, Length=223, Percent_Identity=33.6322869955157, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573514, Length=223, Percent_Identity=33.6322869955157, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573512, Length=223, Percent_Identity=33.6322869955157, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005765 [H]

Pfam domain/function: NA

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24117; Mature: 24117

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDPRFPSLYILDHPLIQHKLSHMRDKDTSTRTFRELLREITLLMGYEITRHLPLTTRH
CCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IETPLVPLEAPVIAGKKLTIVPVLRAGVGMSDGLVELIPSARIGHIGVYRDEQHRPVEYL
CCCCCCCCCCCEECCCCEEEEEEHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDEAITFVALVAAPEGVEVFHKAH
EECCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCCCHHHHHHCC
PNVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQDPRFPSLYILDHPLIQHKLSHMRDKDTSTRTFRELLREITLLMGYEITRHLPLTTRH
CCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IETPLVPLEAPVIAGKKLTIVPVLRAGVGMSDGLVELIPSARIGHIGVYRDEQHRPVEYL
CCCCCCCCCCCEECCCCEEEEEEHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDEAITFVALVAAPEGVEVFHKAH
EECCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCHHHEEEEEEEECCCCHHHHHHCC
PNVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA