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The map label for this gene is guaB [H]

Identifier: 73541545

GI number: 73541545

Start: 2032665

End: 2034128

Strand: Reverse

Name: guaB [H]

Synonym: Reut_A1856

Alternate gene names: 73541545

Gene position: 2034128-2032665 (Counterclockwise)

Preceding gene: 73541548

Following gene: 73541544

Centisome position: 53.44

GC content: 64.96

Gene sequence:

>1464_bases
ATGCGTCTTGTCCAGAAAGCACTCACGTTCGATGATGTGCTGCTCGTGCCGGCCTATTCGGCCGTCCTGCCCCGGGATGT
CTCCCTTCGTACCCGCCTGACCCGTTCGATCGACCTGAACATTCCGCTCGTGTCCGCTGCCATGGATACCGTGACGGAGG
CTCGCCTTGCCATTGCCATGGCGCAGGCCGGCGGCATCGGCATCGTCCACAAGAACTTCAAGCCGGCGGACCAGGCCCGC
GAAGTGGCTCGCGTCAAGCGCTACGAATCGGGCGTGTTGCGTGATCCAATCACCATTTCGCCGGACATGAAGGTGCGGGA
AGTGATCGCGCTGTCGCAACAGCATGGCATTTCGGGTTTCCCGGTGCTGGAAGGCAAGACCGTTGTCGGCATCATCACCA
ACCGCGACCTGCGCTTCGAGGAAGAACTCGACGCACCGGTGCGCGCCAAGATGACGCCGCGCGAGAAGCTCGTGACCGTC
GCCGAAGGCGCTCCGCTTGAAGAAGCCAAGCGCCTGATGAACCGCCACCGCCTTGAGCGCGTGCTGGTGGTCAATGCGGC
ATTCGAGCTGCGCGGCCTGATCACCGTCAAGGACATCCAGAAGGCGGTCGAGAATCCGCTGGCCAGCAAGGACGACCACG
GCCAGCTGCGCGTTGGCGCGGCCGTTGGCGTGGGTCCGGACAACGACGAGCGTGTCGAACTGCTGGTCAAGGCCGGGGTG
GACGTAATCGTCGTCGATACCGCGCACGGCCACAGCCAGGGCGTGCTGGACCGCGTTCGCTGGGTCAAGCAGAACTTCCC
GCAAGTGCAGGTTGTCGGCGGCAACATCGCCACCGGCGATGCCGCGCGCGCGCTGGTCGAGCATGGCGCTGATGGCGTCA
AGGTCGGTATCGGCCCCGGCTCGATCTGCACGACGCGTATCGTGGCTGGCGTCGGCGTGCCGCAGATCACTGCCGTGTCG
AACGTAGCCGAAGCCCTGAAGGGCACCGGCGTGCCGCTGATTGCCGATGGCGGCGTCCGTTATTCGGGCGACGTGGCCAA
GGCGCTCGCAGCCGGCGCGCACACCGTGATGATGGGCGGCATGTTCTCGGGTACCGAGGAAGCGCCGGGCGAGGTATTCC
TGTACCAGGGCCGCTCGTTCAAGAGCTACCGCGGCATGGGTTCGGTGGGTGCGATGAAGGACGGCGCGGCCGACCGCTAC
TTCCAGGAAGACAACACCGCCAACGTCGACAAGCTGGTTCCGGAAGGCATCGAAGGCCGCGTGCCCTACAAGGGCTCGGT
CATGGCGATCATCCACCAGCTCACCGGCGGCGTGCGCGCCTCAATGGGTTACTGCGGCAGCAAGTCGATCGCCGACTGGC
ACGAGAGTGCCCAGTTCGTGCAGATCACGGCAGCCGGCATGCGTGAGTCGCACGTCCACGACGTGCAGATCACCAAGGAA
GCGCCGAACTACCACATCGACTGA

Upstream 100 bases:

>100_bases
AGACATCGAGCATAGCAGAGCCCATTGTGCACGGGCGTTGGCGGCGCGTCAGGGCGCGCGGATTCCTGTATAATTCGCTT
TTGCGCCTAGAGGAATTGCT

Downstream 100 bases:

>100_bases
CCCGCGCGGCAGGCATGCCGGGCCAGATGCCAGGCATCCCGGCAGGCATGTTTGCCGTGCCTGCTGAGGAGCGCTCATGA
AGGTACTGCTGCGAGCCGTG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAIAMAQAGGIGIVHKNFKPADQAR
EVARVKRYESGVLRDPITISPDMKVREVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNAAFELRGLITVKDIQKAVENPLASKDDHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGDAARALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTGVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVMAIIHQLTGGVRASMGYCGSKSIADWHESAQFVQITAAGMRESHVHDVQITKE
APNYHID

Sequences:

>Translated_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAIAMAQAGGIGIVHKNFKPADQAR
EVARVKRYESGVLRDPITISPDMKVREVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNAAFELRGLITVKDIQKAVENPLASKDDHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGDAARALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTGVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVMAIIHQLTGGVRASMGYCGSKSIADWHESAQFVQITAAGMRESHVHDVQITKE
APNYHID
>Mature_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAIAMAQAGGIGIVHKNFKPADQAR
EVARVKRYESGVLRDPITISPDMKVREVIALSQQHGISGFPVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTV
AEGAPLEEAKRLMNRHRLERVLVVNAAFELRGLITVKDIQKAVENPLASKDDHGQLRVGAAVGVGPDNDERVELLVKAGV
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGDAARALVEHGADGVKVGIGPGSICTTRIVAGVGVPQITAVS
NVAEALKGTGVPLIADGGVRYSGDVAKALAAGAHTVMMGGMFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVMAIIHQLTGGVRASMGYCGSKSIADWHESAQFVQITAAGMRESHVHDVQITKE
APNYHID

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=41.6149068322981, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=42.6991150442478, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=42.6991150442478, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=42.6991150442478, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=42.6991150442478, Blast_Score=358, Evalue=7e-99,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=42.6339285714286, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=42.0353982300885, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=39.8230088495575, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI156104880, Length=344, Percent_Identity=32.2674418604651, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=37.5, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=37.5, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=37.5, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=37.5, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=60.3696098562628, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786293, Length=271, Percent_Identity=32.1033210332103, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=38.1856540084388, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.0995260663507, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=280, Percent_Identity=33.9285714285714, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=41.5132924335378, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=40.6185567010309, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=41.4432989690722, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=42.1052631578947, Blast_Score=269, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=40, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.7515527950311, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.7515527950311, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.9092970521542, Blast_Score=312, Evalue=3e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52060; Mature: 52060

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEECCCHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHEE
AQAGGIGIVHKNFKPADQAREVARVKRYESGVLRDPITISPDMKVREVIALSQQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTVAEGAPLEEAKRLMNRHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEECCCCHHHEEEEECCCCHHHHHHHHHHHHHHE
VLVVNAAFELRGLITVKDIQKAVENPLASKDDHGQLRVGAAVGVGPDNDERVELLVKAGV
EEEEEEHHHHCCCEEHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHEEEECCC
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGDAARALVEHGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQITAVSNVAEALKGTGVPLIADGGVRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
CCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVMAIIHQLTGGVRASMGYCGSKSIADWHESAQFVQITAAGMRESHVHDVQITKE
CCCCCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEEC
APNYHID
CCCCCCC
>Mature Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDVSLRTRLTRSIDLNIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEECCCHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHEE
AQAGGIGIVHKNFKPADQAREVARVKRYESGVLRDPITISPDMKVREVIALSQQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVLEGKTVVGIITNRDLRFEEELDAPVRAKMTPREKLVTVAEGAPLEEAKRLMNRHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEECCCCHHHEEEEECCCCHHHHHHHHHHHHHHE
VLVVNAAFELRGLITVKDIQKAVENPLASKDDHGQLRVGAAVGVGPDNDERVELLVKAGV
EEEEEEHHHHCCCEEHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHEEEECCC
DVIVVDTAHGHSQGVLDRVRWVKQNFPQVQVVGGNIATGDAARALVEHGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQITAVSNVAEALKGTGVPLIADGGVRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFSGTEEAPGEVFLYQGRSFKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
CCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVMAIIHQLTGGVRASMGYCGSKSIADWHESAQFVQITAAGMRESHVHDVQITKE
CCCCCHHHHHHHHHHCCHHHHCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEEC
APNYHID
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA