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The map label for this gene is fadA [H]

Identifier: 73541262

GI number: 73541262

Start: 1692399

End: 1693604

Strand: Direct

Name: fadA [H]

Synonym: Reut_A1572

Alternate gene names: 73541262

Gene position: 1692399-1693604 (Clockwise)

Preceding gene: 73541261

Following gene: 73541263

Centisome position: 44.46

GC content: 69.98

Gene sequence:

>1206_bases
ATGAATGAAGCAGTCATCGTCGCCGTCGCGCGCACGCCGATCGGCAAGGCCTTCCGCGGCGCCTTCAACGACACCGAAGC
CCCCGTGCTGGGCGGTCATGTGGTGCGTGCGGTGGTCGAGCGCGCGGGCGTGGACCCGGCCGAGGTGGAAGACGTACTGA
TCGGCGCGGCTGCGCAGCAGGGCACCCAGGGCTATAACCTGGGCCGTCTTTGCGCGGTGGCGGCGGGCCTGCCGGACAGC
GTGCCCGGCATGACCTTGGACCGCATGTGCGGCTCCGGCCTGATGACCATTGCCGCGGCGGCGCGTGCGATCCAGTGCGG
CGAGGCCGACATCCTTGTCGCCGGCGGCGTGGAATCCATCTCGCTCACGCAGAACAAGCACAAGAACGCCTTCCGCGCCC
AATCCGAAGCCGTACTGGCGCACCAGCCCGCCGCCTATATGGCGATGATCGAGACCGCCGAAGTGGTCGCGCGCCGTTAC
GGCATCAGCCGCGCCGAGCAGGACGCCTACGCCTGGCGCAGCCAGCAGCGCACGGCCGAGGCACAACGCCGCGGCGCCTT
TGACGACGAGATCGTGCCGCTGGAAACGCGCCGCGCGCTGTTCGACAAGAGCGGCGTGCTGACCGGGCACGAGACCGTGC
GGCTGGAGCGCGACGAATGCAACCGGCCTGACACCACCGCCGAAAGCCTCGCCGCACTGAAGCCGGTCTGGAGCGGCGGA
CAGGCGATCGCTCAAGGCGAATACATCACCGCGGGCAATGCGTCGCAGCTTTCCGATGGCGCGGCCGCCGTACTGCTGAT
GAGCGCCAAAGAGGCACAACGTCGCGGCCTGCGCCCGCTGGGCCGCTACCGCGGCATGGCCGTGGCGGGCTGCGCGCCCG
ACGAGATGGGCATCGGCCCGGTGTTCGCCGTGCCGAAGCTGCTGGAGCGCCACGGCATGACGGTGGCCGACGTGGGCTTG
TGGGAGCTGAACGAGGCGTTTGCGTCGCAGGTGCTGTATTGCCAGCAGAAGCTCGGCATTGCCGATGCGCGCCTGAACGT
CAGCGGCGGGGCGATCTCGGTCGGCCACCCGTTCGGCATGTCGGGTGCGCGCATGACCGCGCACGCGCTGATCGAGGGCC
GCCGCCGCGGTGTGCGGCAAGCGGTGGTGACCATGTGCATCGGCGGCGGCATGGGTGCCGCGGCGCTGTTCGACGTACTG
CCCTGA

Upstream 100 bases:

>100_bases
CAGTCGGTGGTGCGCATGACCGTGGAAATCGAGGGCGAGGACAAGCCGGCCTGCGTGGCCGAGACCATCAGCCGCTACTA
CTTCTGAGAAGGAATCGAGC

Downstream 100 bases:

>100_bases
GCAGCAATCCTGGCATGGAAGCGGCCCGCCACGAGGCCGCCCGCCATGGCTCCATACGGAGGAGACATCATGAAACGACT
GATCGGCATCGCCATGTCGC

Product: thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPAEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTLDRMCGSGLMTIAAAARAIQCGEADILVAGGVESISLTQNKHKNAFRAQSEAVLAHQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKSGVLTGHETVRLERDECNRPDTTAESLAALKPVWSGG
QAIAQGEYITAGNASQLSDGAAAVLLMSAKEAQRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPKLLERHGMTVADVGL
WELNEAFASQVLYCQQKLGIADARLNVSGGAISVGHPFGMSGARMTAHALIEGRRRGVRQAVVTMCIGGGMGAAALFDVL
P

Sequences:

>Translated_401_residues
MNEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPAEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTLDRMCGSGLMTIAAAARAIQCGEADILVAGGVESISLTQNKHKNAFRAQSEAVLAHQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKSGVLTGHETVRLERDECNRPDTTAESLAALKPVWSGG
QAIAQGEYITAGNASQLSDGAAAVLLMSAKEAQRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPKLLERHGMTVADVGL
WELNEAFASQVLYCQQKLGIADARLNVSGGAISVGHPFGMSGARMTAHALIEGRRRGVRQAVVTMCIGGGMGAAALFDVL
P
>Mature_401_residues
MNEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPAEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTLDRMCGSGLMTIAAAARAIQCGEADILVAGGVESISLTQNKHKNAFRAQSEAVLAHQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKSGVLTGHETVRLERDECNRPDTTAESLAALKPVWSGG
QAIAQGEYITAGNASQLSDGAAAVLLMSAKEAQRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPKLLERHGMTVADVGL
WELNEAFASQVLYCQQKLGIADARLNVSGGAISVGHPFGMSGARMTAHALIEGRRRGVRQAVVTMCIGGGMGAAALFDVL
P

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=41.75, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=36.0696517412935, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI148539872, Length=411, Percent_Identity=36.4963503649635, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4557237, Length=409, Percent_Identity=34.2298288508557, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=28.6995515695067, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI194353979, Length=235, Percent_Identity=33.1914893617021, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787663, Length=416, Percent_Identity=42.7884615384615, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=39.8009950248756, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=41.9753086419753, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788554, Length=413, Percent_Identity=38.498789346247, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=29.8076923076923, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=404, Percent_Identity=36.8811881188119, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=34.0050377833753, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=416, Percent_Identity=33.4134615384615, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=28.314606741573, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=29.620253164557, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=39.3034825870647, Blast_Score=245, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=32.4257425742574, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=41.9753086419753, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=34.2364532019704, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=34.1584158415842, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137578, Length=416, Percent_Identity=28.8461538461538, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42119; Mature: 42119

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPAEVEDVLIGAAAQQ
CCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GTQGYNLGRLCAVAAGLPDSVPGMTLDRMCGSGLMTIAAAARAIQCGEADILVAGGVESI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCEE
SLTQNKHKNAFRAQSEAVLAHQPAAYMAMIETAEVVARRYGISRAEQDAYAWRSQQRTAE
EECHHHCCHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRRGAFDDEIVPLETRRALFDKSGVLTGHETVRLERDECNRPDTTAESLAALKPVWSGG
HHHCCCCCCCCCCHHHHHHHHHCCCCEECCCEEEEEHHHCCCCCCHHHHHHHHCCCCCCC
QAIAQGEYITAGNASQLSDGAAAVLLMSAKEAQRRGLRPLGRYRGMAVAGCAPDEMGIGP
CEEECCCEEECCCHHHCCCCCCEEEEECHHHHHHCCCCHHHHHCCEEEECCCCCCCCCCH
VFAVPKLLERHGMTVADVGLWELNEAFASQVLYCQQKLGIADARLNVSGGAISVGHPFGM
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCC
SGARMTAHALIEGRRRGVRQAVVTMCIGGGMGAAALFDVLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MNEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPAEVEDVLIGAAAQQ
CCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GTQGYNLGRLCAVAAGLPDSVPGMTLDRMCGSGLMTIAAAARAIQCGEADILVAGGVESI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCEE
SLTQNKHKNAFRAQSEAVLAHQPAAYMAMIETAEVVARRYGISRAEQDAYAWRSQQRTAE
EECHHHCCHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRRGAFDDEIVPLETRRALFDKSGVLTGHETVRLERDECNRPDTTAESLAALKPVWSGG
HHHCCCCCCCCCCHHHHHHHHHCCCCEECCCEEEEEHHHCCCCCCHHHHHHHHCCCCCCC
QAIAQGEYITAGNASQLSDGAAAVLLMSAKEAQRRGLRPLGRYRGMAVAGCAPDEMGIGP
CEEECCCEEECCCHHHCCCCCCEEEEECHHHHHHCCCCHHHHHCCEEEECCCCCCCCCCH
VFAVPKLLERHGMTVADVGLWELNEAFASQVLYCQQKLGIADARLNVSGGAISVGHPFGM
HHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCC
SGARMTAHALIEGRRRGVRQAVVTMCIGGGMGAAALFDVLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]