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The map label for this gene is mmlH

Identifier: 73541195

GI number: 73541195

Start: 1623073

End: 1624359

Strand: Reverse

Name: mmlH

Synonym: Reut_A1504

Alternate gene names: 73541195

Gene position: 1624359-1623073 (Counterclockwise)

Preceding gene: 73541196

Following gene: 73541194

Centisome position: 42.67

GC content: 63.56

Gene sequence:

>1287_bases
ATGTTTGCTTGGTACAAGGCTGGATCGCCCCAGCAGAAAAAGACATTCTGGGCCTGCTACTCCGGCTGGGCGCTGGATTC
CTTCGACATGCAGATGTTCAGCTTCCTGTTGCCGGCCCTCACACTTACATGGGGCCTGACCAAGGCCGAGGTTGGCGTCC
TCGGGACCGTTGCGCTGGTCGTTACCGCGATTGGCGGCTGGGGCGCCGGGATCCTGAGCGACCGTTACGGCCGCGCACGC
ATCCTGGTGCTGGCAATCATCTGGTTTACCTTGTTCGGCGTGCTCGCCGGCTTCGCCCAGTCTTACCAACAGCTGTTGAT
TGCCCGTACGCTGCAGGGCCTCGGCTTCGGCGGCGAATGGGCGGTCGGGGCGGCATTGATGGCAGAAGTCATCGACTCCA
GGCATCGCGGCAAGGCCATCGGCTTCGTGCAGTCCGGTTTCGCGCTGGGGTGGGCACTAGCGGTCGTCGTCGCCACATTG
CTGCTGGCCTGGCTGCCCAAGGAAATGGCGTGGAGGGTGGCGTTCTGGAGCGGTATCATCCCCGCCCTCATCGTGTTGTT
CATCCGGCGCCATGTCAAGGACTCTTCGATGTTCGAACGGGCACGCCAGAGCCGCGCCCCGCGCGCCTCGCTGTCCTCGG
TGTTCAATCGCAAGTACGCCCGTACGCTAGCGCTGTCCAGCGTGCTGGTCATCGGCCTGCAGGCCGGCTGCTACGCCATC
CTGGTCTGGCTGCCTTCCCTGCTGAACCAGCGGCAGGTCGCGGCCGGTTCGATGATCGTCACCGTATTCATCATGGCCTT
CGGCTCCTTCTGCGGCTTCGCGGTGACGGCTGACCTCTCGGATCGCATCGGAAGGCGCCCTACGCTGATCCTGCTGTCTG
TCTGCGCATGGATCGTGACGGTCAGCTATATGCTTTTGCCGCTGAACACCACGCTGACAGCGATTCTCGGCTTCCTGGTG
GGTTTCTCCGCCATCGGCATGTTCGCCGCGCTTGGCCCGTTCCTGAGCGAACTGTTTCCTACCAATGTGCGCACCACTTG
CATGGGATTCGCGTACAACGTGGGCAAGTCGATTGGAGCGGGGTCCGTCGTCGGCGTCGGCGTGCTGTCCACGCATATCG
GCCTGGCCAACGCCATGGGCACGTTCTGCCTGGTCGCTTACGCCTTTGCGGTATTCGGCATCATGCTGCTGCCCGAGACG
CGCGGCATCGCGATCGAGAACATCGGCGAAGCCGATGCGCACTCTCCCGCCGCACCGCTGGCCCAGCCGGCAAGCGCTCG
ATCCTGA

Upstream 100 bases:

>100_bases
CCGAGCTTGCCTAGCCTTCTCTGCAGGGGCCGGCGGATCGTTCCATCCAATGCCCGGTACCGCACCTACAACGAAAAAAG
ACTCACCTCAGGAGACAACC

Downstream 100 bases:

>100_bases
ATGGCGCCGCGCCAGCACCGGCGGCTGATACAAACGAACACCAACACATCGACAGAGGAGCCAACATGATTCGCTTGCTG
TACCTGCTGGTCAAACCAGC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFAWYKAGSPQQKKTFWACYSGWALDSFDMQMFSFLLPALTLTWGLTKAEVGVLGTVALVVTAIGGWGAGILSDRYGRAR
ILVLAIIWFTLFGVLAGFAQSYQQLLIARTLQGLGFGGEWAVGAALMAEVIDSRHRGKAIGFVQSGFALGWALAVVVATL
LLAWLPKEMAWRVAFWSGIIPALIVLFIRRHVKDSSMFERARQSRAPRASLSSVFNRKYARTLALSSVLVIGLQAGCYAI
LVWLPSLLNQRQVAAGSMIVTVFIMAFGSFCGFAVTADLSDRIGRRPTLILLSVCAWIVTVSYMLLPLNTTLTAILGFLV
GFSAIGMFAALGPFLSELFPTNVRTTCMGFAYNVGKSIGAGSVVGVGVLSTHIGLANAMGTFCLVAYAFAVFGIMLLPET
RGIAIENIGEADAHSPAAPLAQPASARS

Sequences:

>Translated_428_residues
MFAWYKAGSPQQKKTFWACYSGWALDSFDMQMFSFLLPALTLTWGLTKAEVGVLGTVALVVTAIGGWGAGILSDRYGRAR
ILVLAIIWFTLFGVLAGFAQSYQQLLIARTLQGLGFGGEWAVGAALMAEVIDSRHRGKAIGFVQSGFALGWALAVVVATL
LLAWLPKEMAWRVAFWSGIIPALIVLFIRRHVKDSSMFERARQSRAPRASLSSVFNRKYARTLALSSVLVIGLQAGCYAI
LVWLPSLLNQRQVAAGSMIVTVFIMAFGSFCGFAVTADLSDRIGRRPTLILLSVCAWIVTVSYMLLPLNTTLTAILGFLV
GFSAIGMFAALGPFLSELFPTNVRTTCMGFAYNVGKSIGAGSVVGVGVLSTHIGLANAMGTFCLVAYAFAVFGIMLLPET
RGIAIENIGEADAHSPAAPLAQPASARS
>Mature_428_residues
MFAWYKAGSPQQKKTFWACYSGWALDSFDMQMFSFLLPALTLTWGLTKAEVGVLGTVALVVTAIGGWGAGILSDRYGRAR
ILVLAIIWFTLFGVLAGFAQSYQQLLIARTLQGLGFGGEWAVGAALMAEVIDSRHRGKAIGFVQSGFALGWALAVVVATL
LLAWLPKEMAWRVAFWSGIIPALIVLFIRRHVKDSSMFERARQSRAPRASLSSVFNRKYARTLALSSVLVIGLQAGCYAI
LVWLPSLLNQRQVAAGSMIVTVFIMAFGSFCGFAVTADLSDRIGRRPTLILLSVCAWIVTVSYMLLPLNTTLTAILGFLV
GFSAIGMFAALGPFLSELFPTNVRTTCMGFAYNVGKSIGAGSVVGVGVLSTHIGLANAMGTFCLVAYAFAVFGIMLLPET
RGIAIENIGEADAHSPAAPLAQPASARS

Specific function: Probable uptake of 4-methylmuconolactone

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family

Homologues:

Organism=Homo sapiens, GI213021148, Length=447, Percent_Identity=21.923937360179, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24308167, Length=152, Percent_Identity=30.9210526315789, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082404, Length=396, Percent_Identity=25.7575757575758, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87082231, Length=440, Percent_Identity=25.4545454545455, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1790550, Length=374, Percent_Identity=24.8663101604278, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081723, Length=351, Percent_Identity=25.3561253561254, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082159, Length=424, Percent_Identity=25.4716981132075, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786229, Length=442, Percent_Identity=22.1719457013575, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788068, Length=400, Percent_Identity=23.25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788942, Length=410, Percent_Identity=24.390243902439, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789941, Length=421, Percent_Identity=26.603325415677, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922874, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MMLH_CUPPJ (O51798)

Other databases:

- EMBL:   X99639
- EMBL:   CP000090
- RefSeq:   YP_295715.1
- ProteinModelPortal:   O51798
- GeneID:   3609833
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A1504
- NMPDR:   fig|264198.3.peg.1694
- HOGENOM:   HBG757988
- OMA:   VFIMAFG
- ProtClustDB:   CLSK923874
- BioCyc:   REUT264198:REUT_A1504-MONOMER
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 45805; Mature: 45805

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1; PS00217 SUGAR_TRANSPORT_2; PS00306 CASEIN_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf953b50)-; HASH(0xfa7a2a8)-; HASH(0x10795e1c)-; HASH(0x10795d5c)-; HASH(0xffc1d2c)-; HASH(0x10796acc)-; HASH(0x106fe274)-; HASH(0x101a9b64)-; HASH(0xefb6784)-; HASH(0xfb00844)-; HASH(0xff03adc)-; HASH(0xf3535bc)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCH
>Mature Secondary Structure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CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415