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The map label for this gene is gor [H]

Identifier: 73541178

GI number: 73541178

Start: 1606546

End: 1607895

Strand: Direct

Name: gor [H]

Synonym: Reut_A1485

Alternate gene names: 73541178

Gene position: 1606546-1607895 (Clockwise)

Preceding gene: 73541177

Following gene: 73541179

Centisome position: 42.2

GC content: 61.93

Gene sequence:

>1350_bases
ATGCAGACTTACGATTACGATCTCTTTGTCATTGGAGCAGGCTCCGGTGGCGTTCGGGCAAGCCGCATCGCCGCAGGCTA
CGGTGCGAGAGTTGCTGTCGCCGAGGAGTATCGGACCGGCGGCACCTGCGTCATCCGCGGCTGTGTGCCCAAGAAGCTTC
TGATGTATGCATCCCATTTCGCGCAGGCAGTTGACGACGCAGCGGGGTTCGGGTGGAGGGCCCCAACGCCGGTTCATGAC
TGGGCTTCGCTGATTGCTGCGAAGAACGCGGAGATCGCGCGCCTGGAAGCGATCTACGTGCGCATGCTGCAGAGCGCCGG
CGTTGATGCAATTACGGGACGGGCGCAGATTGTGGGCCCACACCGCGTCGAGGTCAACGGCGTCATTTTCACCGCGAAGG
TCATACTCGTTGCCAGCGGGTCGGTTCCCGTGGAGCCTGCTATCCAGGGTGCGGAACTGATGATCACGTCGAATGAGGCG
TTCTATCTGGATACGTTGCCGAAGCGTATCGCGATAATCGGCGGCGGTTATATAGCGTGCGAGTTCGCAGGCATCTTTAA
CGGGCTCGGCAGCGATGTCACGCAGCTATACCGGGGCCAGCAGATCTTGCGCGGCTTCGACGACGAGTTGCGCAATCACC
TCGGCGCCGAAGTGTCGAAGAGCGGGGTGGATTTGCGCGTCGCGGTCGACGTCGCAGCGGTGGGAAAACGGGGCGATGGC
CTGGTTGTCCATCTGACGACGGGCCAAGCCATCGAAGTCGATGCCGTGATGGCTGCAACCGGAAGACGCAGCAACACGTC
GGGAATGGGGCTGGAGTCCGCGGGGGTCCTACTGGACGAGAGCGGGGCGATCAAGGTCGATGAATACTCGGCAACGTCCA
ATCCGGACATCTATGCGGTCGGTGACGTAACCAACCGGCTGAACCTGACACCGGTTGCGATCCACGAAGGTCATGCGTTC
GCCGACACCGTGTTCGGCGGCAGGAAGCGGGCGAGTGCGCACGACAACGTGCCCTTTGCAGTGTTCAGCCAGCCCCAGGC
GGCATCGGTAGGCCTGACGGAAGCGCAGGCTCGCAGACGGCATGCGAAGGTCGACGTCTATAGCAGCGCGTTTCGGCCGA
TGCGTACCGCGCTGTCGGGTCGCGATGAACGGGCCCTGGTCAAACTTGTCGTGGATGCGTCGACGGATCGGGTGCTAGGC
GCGCATATCGTCGCTGCCGACGCGGCAGAAATCATTCTGGGCATTGCGGTTGCGATCAAGGCGAAGGCGACGAAAGCTGA
TTTCGACGCAACGCTAGGCGTTCATCCCACACTTGCCGAAGAGTTCGTCACGCTGCGCAATCGGCGATGA

Upstream 100 bases:

>100_bases
GTTTATGTTTCAAATGGGTGGTGTCGGACCGATGTTGTCGCGTACGACGGCCTGCGTCCCGATTAACCATTGCCGATTGC
GCGGTCAGTAGCGAACTGCC

Downstream 100 bases:

>100_bases
CGTATGTGCCGGCCAGCGCCGGCAATCCGGCGGCACGCTAACGTCGTAGCCGTATTCAAGATATCGCGCTCCTCGAGCGC
CTAGTCATTCTGGAGAACGA

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQTYDYDLFVIGAGSGGVRASRIAAGYGARVAVAEEYRTGGTCVIRGCVPKKLLMYASHFAQAVDDAAGFGWRAPTPVHD
WASLIAAKNAEIARLEAIYVRMLQSAGVDAITGRAQIVGPHRVEVNGVIFTAKVILVASGSVPVEPAIQGAELMITSNEA
FYLDTLPKRIAIIGGGYIACEFAGIFNGLGSDVTQLYRGQQILRGFDDELRNHLGAEVSKSGVDLRVAVDVAAVGKRGDG
LVVHLTTGQAIEVDAVMAATGRRSNTSGMGLESAGVLLDESGAIKVDEYSATSNPDIYAVGDVTNRLNLTPVAIHEGHAF
ADTVFGGRKRASAHDNVPFAVFSQPQAASVGLTEAQARRRHAKVDVYSSAFRPMRTALSGRDERALVKLVVDASTDRVLG
AHIVAADAAEIILGIAVAIKAKATKADFDATLGVHPTLAEEFVTLRNRR

Sequences:

>Translated_449_residues
MQTYDYDLFVIGAGSGGVRASRIAAGYGARVAVAEEYRTGGTCVIRGCVPKKLLMYASHFAQAVDDAAGFGWRAPTPVHD
WASLIAAKNAEIARLEAIYVRMLQSAGVDAITGRAQIVGPHRVEVNGVIFTAKVILVASGSVPVEPAIQGAELMITSNEA
FYLDTLPKRIAIIGGGYIACEFAGIFNGLGSDVTQLYRGQQILRGFDDELRNHLGAEVSKSGVDLRVAVDVAAVGKRGDG
LVVHLTTGQAIEVDAVMAATGRRSNTSGMGLESAGVLLDESGAIKVDEYSATSNPDIYAVGDVTNRLNLTPVAIHEGHAF
ADTVFGGRKRASAHDNVPFAVFSQPQAASVGLTEAQARRRHAKVDVYSSAFRPMRTALSGRDERALVKLVVDASTDRVLG
AHIVAADAAEIILGIAVAIKAKATKADFDATLGVHPTLAEEFVTLRNRR
>Mature_449_residues
MQTYDYDLFVIGAGSGGVRASRIAAGYGARVAVAEEYRTGGTCVIRGCVPKKLLMYASHFAQAVDDAAGFGWRAPTPVHD
WASLIAAKNAEIARLEAIYVRMLQSAGVDAITGRAQIVGPHRVEVNGVIFTAKVILVASGSVPVEPAIQGAELMITSNEA
FYLDTLPKRIAIIGGGYIACEFAGIFNGLGSDVTQLYRGQQILRGFDDELRNHLGAEVSKSGVDLRVAVDVAAVGKRGDG
LVVHLTTGQAIEVDAVMAATGRRSNTSGMGLESAGVLLDESGAIKVDEYSATSNPDIYAVGDVTNRLNLTPVAIHEGHAF
ADTVFGGRKRASAHDNVPFAVFSQPQAASVGLTEAQARRRHAKVDVYSSAFRPMRTALSGRDERALVKLVVDASTDRVLG
AHIVAADAAEIILGIAVAIKAKATKADFDATLGVHPTLAEEFVTLRNRR

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=37.9912663755458, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=34.3157894736842, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=34.3157894736842, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=34.3157894736842, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=34.3157894736842, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=34.3157894736842, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=34.1772151898734, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=35.244161358811, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI291045268, Length=471, Percent_Identity=32.6963906581741, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.0393013100437, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=39.2523364485981, Blast_Score=284, Evalue=8e-78,
Organism=Escherichia coli, GI1786307, Length=444, Percent_Identity=27.9279279279279, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=27.3522975929978, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=29.0748898678414, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1789065, Length=178, Percent_Identity=33.1460674157303, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=39.5089285714286, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=39.5089285714286, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=32.9059829059829, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=32.2981366459627, Blast_Score=211, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=31.140350877193, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=37.6344086021505, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6321091, Length=460, Percent_Identity=29.1304347826087, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=29.4623655913978, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=32.9787234042553, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=32.9787234042553, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=32.9787234042553, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=33.1210191082803, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=30.6167400881057, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 47382; Mature: 47382

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTYDYDLFVIGAGSGGVRASRIAAGYGARVAVAEEYRTGGTCVIRGCVPKKLLMYASHF
CCCEEEEEEEEECCCCCCCHHEEECCCCCEEEEEHHHCCCCEEEEECCCHHHHHHHHHHH
AQAVDDAAGFGWRAPTPVHDWASLIAAKNAEIARLEAIYVRMLQSAGVDAITGRAQIVGP
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCEEEECC
HRVEVNGVIFTAKVILVASGSVPVEPAIQGAELMITSNEAFYLDTLPKRIAIIGGGYIAC
CEEEEEEEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCEEEE
EFAGIFNGLGSDVTQLYRGQQILRGFDDELRNHLGAEVSKSGVDLRVAVDVAAVGKRGDG
EHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCC
LVVHLTTGQAIEVDAVMAATGRRSNTSGMGLESAGVLLDESGAIKVDEYSATSNPDIYAV
EEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEE
GDVTNRLNLTPVAIHEGHAFADTVFGGRKRASAHDNVPFAVFSQPQAASVGLTEAQARRR
CCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
HAKVDVYSSAFRPMRTALSGRDERALVKLVVDASTDRVLGAHIVAADAAEIILGIAVAIK
HCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHEEE
AKATKADFDATLGVHPTLAEEFVTLRNRR
ECCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTYDYDLFVIGAGSGGVRASRIAAGYGARVAVAEEYRTGGTCVIRGCVPKKLLMYASHF
CCCEEEEEEEEECCCCCCCHHEEECCCCCEEEEEHHHCCCCEEEEECCCHHHHHHHHHHH
AQAVDDAAGFGWRAPTPVHDWASLIAAKNAEIARLEAIYVRMLQSAGVDAITGRAQIVGP
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCEEEECC
HRVEVNGVIFTAKVILVASGSVPVEPAIQGAELMITSNEAFYLDTLPKRIAIIGGGYIAC
CEEEEEEEEEEEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCEEEE
EFAGIFNGLGSDVTQLYRGQQILRGFDDELRNHLGAEVSKSGVDLRVAVDVAAVGKRGDG
EHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCC
LVVHLTTGQAIEVDAVMAATGRRSNTSGMGLESAGVLLDESGAIKVDEYSATSNPDIYAV
EEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEEE
GDVTNRLNLTPVAIHEGHAFADTVFGGRKRASAHDNVPFAVFSQPQAASVGLTEAQARRR
CCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHH
HAKVDVYSSAFRPMRTALSGRDERALVKLVVDASTDRVLGAHIVAADAAEIILGIAVAIK
HCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHEEE
AKATKADFDATLGVHPTLAEEFVTLRNRR
ECCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]