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The map label for this gene is tmk

Identifier: 73541128

GI number: 73541128

Start: 1549499

End: 1550110

Strand: Direct

Name: tmk

Synonym: Reut_A1434

Alternate gene names: 73541128

Gene position: 1549499-1550110 (Clockwise)

Preceding gene: 73541127

Following gene: 73541129

Centisome position: 40.71

GC content: 66.34

Gene sequence:

>612_bases
ATGCGCGGAAAATTCATTACCTTCGAAGGCATCGACGGCGCCGGCAAGAGCACCCATATCGGCGCGGTGGCGGCGCGGCT
GCGCGAGCGCAAGGACATCCCGGCCGTTGTCACCACGCGCGAGCCGGGCGGTACGCCGCTGGGAGAGGACCTGCGACAGA
TCCTGCTGCACCGCAAGATGCACCTGGAAACCGAAGCGCTGCTGATGTTCGCGGCGCGCCGCGAACACATCGCGGAGGTC
ATCGAACCGGCGCTGGCACGTGGCGACTGGGTGATCTCGGACCGATTCACCGATGCCACGTTTGCTTACCAGGGCGGCGG
AAGAGGGCTGGCCACGTCCCGGCTCGAAACGCTGGAAACGTGGGTACAGGACGGCCTGCAGCCGGACCTGACGCTGCTGT
TCGATGTGCCGCTGGAAACCGCGAGCGAGCGCCTGGCCGGCGCGCGCGAGCCCGACAAGTTCGAGGCGGAATCGCGCGCG
TTCTTCGAGCGTACGCGGGCCGAGTACCTGCGCCGCGCCGCGCAGGCGCCCGAACGCTTCCGCGTGATCGACGCCACGCA
GAGCATTGAAGCCATTCGCGTCGAACTTGAAAAGATCATCTCAACGCTTTGA

Upstream 100 bases:

>100_bases
GTATTTCGTGGCGCGCGGCGACGGTACCAGCCATTTCTCCAATACGCTTCCCGAACACAACCGCGCGGTAGATCAGTACC
AGCGCGGCAAATAAGCATCC

Downstream 100 bases:

>100_bases
TTTTCCAGCTTTATATTGATCGATAATAATGGACCGACGCTGTGCCGTTACGTCATCGGCAGCGGCACGGTTGTAAAGGT
GACCCCTCGGCTTTCGCGGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRGKFITFEGIDGAGKSTHIGAVAARLRERKDIPAVVTTREPGGTPLGEDLRQILLHRKMHLETEALLMFAARREHIAEV
IEPALARGDWVISDRFTDATFAYQGGGRGLATSRLETLETWVQDGLQPDLTLLFDVPLETASERLAGAREPDKFEAESRA
FFERTRAEYLRRAAQAPERFRVIDATQSIEAIRVELEKIISTL

Sequences:

>Translated_203_residues
MRGKFITFEGIDGAGKSTHIGAVAARLRERKDIPAVVTTREPGGTPLGEDLRQILLHRKMHLETEALLMFAARREHIAEV
IEPALARGDWVISDRFTDATFAYQGGGRGLATSRLETLETWVQDGLQPDLTLLFDVPLETASERLAGAREPDKFEAESRA
FFERTRAEYLRRAAQAPERFRVIDATQSIEAIRVELEKIISTL
>Mature_203_residues
MRGKFITFEGIDGAGKSTHIGAVAARLRERKDIPAVVTTREPGGTPLGEDLRQILLHRKMHLETEALLMFAARREHIAEV
IEPALARGDWVISDRFTDATFAYQGGGRGLATSRLETLETWVQDGLQPDLTLLFDVPLETASERLAGAREPDKFEAESRA
FFERTRAEYLRRAAQAPERFRVIDATQSIEAIRVELEKIISTL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=198, Percent_Identity=45.959595959596, Blast_Score=144, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CUPPJ (Q471X9)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_295648.1
- HSSP:   P65248
- GeneID:   3609537
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A1434
- NMPDR:   fig|264198.3.peg.2026
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   REUT264198:REUT_A1434-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22744; Mature: 22744

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKFITFEGIDGAGKSTHIGAVAARLRERKDIPAVVTTREPGGTPLGEDLRQILLHRKM
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
HLETEALLMFAARREHIAEVIEPALARGDWVISDRFTDATFAYQGGGRGLATSRLETLET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHH
WVQDGLQPDLTLLFDVPLETASERLAGAREPDKFEAESRAFFERTRAEYLRRAAQAPERF
HHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHE
RVIDATQSIEAIRVELEKIISTL
EEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGKFITFEGIDGAGKSTHIGAVAARLRERKDIPAVVTTREPGGTPLGEDLRQILLHRKM
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
HLETEALLMFAARREHIAEVIEPALARGDWVISDRFTDATFAYQGGGRGLATSRLETLET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHH
WVQDGLQPDLTLLFDVPLETASERLAGAREPDKFEAESRAFFERTRAEYLRRAAQAPERF
HHHCCCCCCEEEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHE
RVIDATQSIEAIRVELEKIISTL
EEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA