Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 73541066

GI number: 73541066

Start: 1476308

End: 1477525

Strand: Direct

Name: macA [H]

Synonym: Reut_A1372

Alternate gene names: 73541066

Gene position: 1476308-1477525 (Clockwise)

Preceding gene: 73541063

Following gene: 73541067

Centisome position: 38.78

GC content: 69.38

Gene sequence:

>1218_bases
ATGCCAGTGCATTGCCAAGTGCCGGAAGTTGCGGCCGTTCGTCCCGAGATATCCTCCGATTCCCTGTCGCGTCGGCGGCT
TGTCCGTGTTGGCGCCGCCGTGCTCGCGGCAGCGGTCGTGGCGCTGGCGGGGTGTAGCAAGACTAGCGAGCCCGCGCCTG
AAGTGCGGCCCGTCCGCTTGCTGCAGCTGAGCCAGCACACTGGCAAGACGACGTTCGAGTTTTCTGGCGACGTGCGGCCA
CGCGTGGAGTCGCGGCTGGGCTTCCGTGTGGGCGGCAAGATTGCAGCGCGCCTGGTTGACGTGGGTGCGGTCGTACGCAA
GGGCCAGCCGCTGGCGCGCCTCGATCCGACTGACCTGTCGCTGGCCGAGGCGAGCTCGCGCGCCCAGTTCGATGCGGCAC
GCACGGACCGCGATCTGGCGGCCTCCGATCTCAAGCGCTACAACGACCTGTTCGCGAAGGGCTTCATCAGCGCTGCCGAG
CAGCATCGGCGGCAGGCCACGTTCGATGCCGCCGCATCGCGCCTCAAGCAGGCCGAGGCAGGCCTGCGCAGCCAGGCCAA
CCAGACTGCCTATGCCGTGTTGCTGGCTGATGCCGATGGCGTGGTCACGGCGGTGGATGCGGAGGTCGGACAAGTCGTTA
CCCCCGGGCAGGCGGTGATCCGCGTGGCGCAGTCGGCGGAGAAGGAAGTCGCCATCGGGCTGCCCGAAGACCAGGTCGAC
CAGTTGCGCGGTATTACCGATGTGACGGTGCGCACCTGGGCAGATCCGGGCCGCGCGTTGCCCGCGCGCGTACGCGAGAT
TGCCGCCGCAGCCGATCCCGTGACGCGTACCTATGCCACACGTGTGTCGGTGCCGAATCCGCCGGCAGATATCAAGCTCG
GCATGACTGCCGTCGTGACTTTCGTGCGCACGGGCGCCGTGCCGGCGGTACGCGTGCCGCTGACCGCGCTGCTGCAGGAG
CAGGGCCGCAACCAGGTCTGGGTCTATGACGCGGCGGCCGGCACGGTGAAGCCGGTCCAGGTGACGCTGGGTGATCCGGT
CGGCAACGAGATCGAAATACGCCAGGGCCTGGCGCCCGGCCAGACCATTGTCACGGCCGGCGTGCATCTGCTCAAGCCGG
GGCAGAGGGTCAGGCCGATGCAGGCGGTCGTGCCGGCATCGGCGCCGTCCGCCCCATCCCCGGCGCCGACGGCCGCCTCC
GTCCCCCAGCAGGGCTGA

Upstream 100 bases:

>100_bases
TATTAATTCCGGTGCGCACGAATGCTGTTCTGATTGTGCGTAGTAAGCCTCTGAACGGGCCGCATCAGCTTTCCCACGTT
GTTCGATTCGCTGCTTATCC

Downstream 100 bases:

>100_bases
GGGCAAGGCATGGATCATTCTCGTTTCAACCTGTCGCGCTGGGCGCTGGAACACCAGTCGCTGACGCGCTACCTGCTGGT
GGTGTTGCTGCTGGCGGGCC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPVHCQVPEVAAVRPEISSDSLSRRRLVRVGAAVLAAAVVALAGCSKTSEPAPEVRPVRLLQLSQHTGKTTFEFSGDVRP
RVESRLGFRVGGKIAARLVDVGAVVRKGQPLARLDPTDLSLAEASSRAQFDAARTDRDLAASDLKRYNDLFAKGFISAAE
QHRRQATFDAAASRLKQAEAGLRSQANQTAYAVLLADADGVVTAVDAEVGQVVTPGQAVIRVAQSAEKEVAIGLPEDQVD
QLRGITDVTVRTWADPGRALPARVREIAAAADPVTRTYATRVSVPNPPADIKLGMTAVVTFVRTGAVPAVRVPLTALLQE
QGRNQVWVYDAAAGTVKPVQVTLGDPVGNEIEIRQGLAPGQTIVTAGVHLLKPGQRVRPMQAVVPASAPSAPSPAPTAAS
VPQQG

Sequences:

>Translated_405_residues
MPVHCQVPEVAAVRPEISSDSLSRRRLVRVGAAVLAAAVVALAGCSKTSEPAPEVRPVRLLQLSQHTGKTTFEFSGDVRP
RVESRLGFRVGGKIAARLVDVGAVVRKGQPLARLDPTDLSLAEASSRAQFDAARTDRDLAASDLKRYNDLFAKGFISAAE
QHRRQATFDAAASRLKQAEAGLRSQANQTAYAVLLADADGVVTAVDAEVGQVVTPGQAVIRVAQSAEKEVAIGLPEDQVD
QLRGITDVTVRTWADPGRALPARVREIAAAADPVTRTYATRVSVPNPPADIKLGMTAVVTFVRTGAVPAVRVPLTALLQE
QGRNQVWVYDAAAGTVKPVQVTLGDPVGNEIEIRQGLAPGQTIVTAGVHLLKPGQRVRPMQAVVPASAPSAPSPAPTAAS
VPQQG
>Mature_404_residues
PVHCQVPEVAAVRPEISSDSLSRRRLVRVGAAVLAAAVVALAGCSKTSEPAPEVRPVRLLQLSQHTGKTTFEFSGDVRPR
VESRLGFRVGGKIAARLVDVGAVVRKGQPLARLDPTDLSLAEASSRAQFDAARTDRDLAASDLKRYNDLFAKGFISAAEQ
HRRQATFDAAASRLKQAEAGLRSQANQTAYAVLLADADGVVTAVDAEVGQVVTPGQAVIRVAQSAEKEVAIGLPEDQVDQ
LRGITDVTVRTWADPGRALPARVREIAAAADPVTRTYATRVSVPNPPADIKLGMTAVVTFVRTGAVPAVRVPLTALLQEQ
GRNQVWVYDAAAGTVKPVQVTLGDPVGNEIEIRQGLAPGQTIVTAGVHLLKPGQRVRPMQAVVPASAPSAPSPAPTAASV
PQQG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42555; Mature: 42424

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVHCQVPEVAAVRPEISSDSLSRRRLVRVGAAVLAAAVVALAGCSKTSEPAPEVRPVRL
CCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LQLSQHTGKTTFEFSGDVRPRVESRLGFRVGGKIAARLVDVGAVVRKGQPLARLDPTDLS
EEEHHCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LAEASSRAQFDAARTDRDLAASDLKRYNDLFAKGFISAAEQHRRQATFDAAASRLKQAEA
HHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRSQANQTAYAVLLADADGVVTAVDAEVGQVVTPGQAVIRVAQSAEKEVAIGLPEDQVD
HHHHCCCCCEEEEEEECCCCEEEEECCCCCCEECCHHHHHHHHHHCCCEEEECCCHHHHH
QLRGITDVTVRTWADPGRALPARVREIAAAADPVTRTYATRVSVPNPPADIKLGMTAVVT
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCEEHHHHHHHH
FVRTGAVPAVRVPLTALLQEQGRNQVWVYDAAAGTVKPVQVTLGDPVGNEIEIRQGLAPG
HHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCC
QTIVTAGVHLLKPGQRVRPMQAVVPASAPSAPSPAPTAASVPQQG
CHHHHCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVHCQVPEVAAVRPEISSDSLSRRRLVRVGAAVLAAAVVALAGCSKTSEPAPEVRPVRL
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LQLSQHTGKTTFEFSGDVRPRVESRLGFRVGGKIAARLVDVGAVVRKGQPLARLDPTDLS
EEEHHCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LAEASSRAQFDAARTDRDLAASDLKRYNDLFAKGFISAAEQHRRQATFDAAASRLKQAEA
HHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRSQANQTAYAVLLADADGVVTAVDAEVGQVVTPGQAVIRVAQSAEKEVAIGLPEDQVD
HHHHCCCCCEEEEEEECCCCEEEEECCCCCCEECCHHHHHHHHHHCCCEEEECCCHHHHH
QLRGITDVTVRTWADPGRALPARVREIAAAADPVTRTYATRVSVPNPPADIKLGMTAVVT
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCEEHHHHHHHH
FVRTGAVPAVRVPLTALLQEQGRNQVWVYDAAAGTVKPVQVTLGDPVGNEIEIRQGLAPG
HHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCC
QTIVTAGVHLLKPGQRVRPMQAVVPASAPSAPSPAPTAASVPQQG
CHHHHCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]