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The map label for this gene is rmlA1 [H]

Identifier: 73540420

GI number: 73540420

Start: 773697

End: 774584

Strand: Direct

Name: rmlA1 [H]

Synonym: Reut_A0714

Alternate gene names: 73540420

Gene position: 773697-774584 (Clockwise)

Preceding gene: 73540419

Following gene: 73540421

Centisome position: 20.33

GC content: 57.09

Gene sequence:

>888_bases
GTGGTCAATATGCGCAAAGGCATCATCCTGGCCGGGGGTTCCGGCACGCGGCTCTATCCCATCACGCGGTCTGTATCGAA
GCAGCTGCTGCCGGTATATGACAAGCCGATGATCTACTATCCGCTGTCCACGCTGATGCTCGCGGGGATTCGGGATATTC
TGATTATTTCCACGCCGGAAGATACGCCGCGCTTTTCCGACATGCTCGGTGACGGCAGCAAGTGGGGTCTTAACCTCCAG
TATGCAGTGCAGCCGTCTCCTGACGGCCTGGCCCAGGCGTTCATCATCGGTCGCGATTTCATCGGGAATGACCCGTCGAC
GCTTATCCTCGGCGACAACATCTTTCATGGTCATGATCTCGTGAGCCAGCTGACGCGCTCCTCGGCCCAGTCCCAGGGTG
CAACGGTTTTTGCGTATCACGTGCATGATCCCGAGCGATATGGTGTCGTCGAATTCGACCAGAATTTCCGTGCCCTATCG
CTGGAAGAAAAGCCGCTGAAGCCGCGTTCCAATTATGCGGTGACGGGCCTGTACTTCTACGACAACCAGGTCTGCGATAT
CGCGGCTGACATCAAGCCGTCGGCACGCGGTGAGCTCGAAATCACCGATGTCAACAAGCAGTACCTGTCCCAAAATCAAC
TCGACGTCGAGATCATGGGGCGGGGCTACGCGTGGCTGGATACTGGCACGCATGATTCGTTGCTGGAAGCCGCGAGCTTT
ATTGCAACGTTGCAGAATCGGCAGGGGCTGATGGTGGCGTGTCCTGAGGAGATTGCCTATCGAAGCAAATGGATCTCAGT
GGAACAGGTGGCGGCGCTCGCCCAGCCGCTGGCAAAGAACGGATACGGTCAGTATCTGCAGCGCATCGTATCTGACCCGG
TCAAATAA

Upstream 100 bases:

>100_bases
CGAGACTGGATACCACGCGCCTGCAGGAAACCTTCGGCATCCATCTACCGGACTGGAAGCAGGGCGTGCAGTTCCTGCTC
GATCAGATTCTTCCCTAAGA

Downstream 100 bases:

>100_bases
CCAAGCATCAGGCCTCACCATGAATCTGACTGTCACTCCCACCGCCATCCCGGAGGTGAAGATCATCGAGCCAAAGGTAT
TTGGCGACGACCGAGGATTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MVNMRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFSDMLGDGSKWGLNLQ
YAVQPSPDGLAQAFIIGRDFIGNDPSTLILGDNIFHGHDLVSQLTRSSAQSQGATVFAYHVHDPERYGVVEFDQNFRALS
LEEKPLKPRSNYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKQYLSQNQLDVEIMGRGYAWLDTGTHDSLLEAASF
IATLQNRQGLMVACPEEIAYRSKWISVEQVAALAQPLAKNGYGQYLQRIVSDPVK

Sequences:

>Translated_295_residues
MVNMRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFSDMLGDGSKWGLNLQ
YAVQPSPDGLAQAFIIGRDFIGNDPSTLILGDNIFHGHDLVSQLTRSSAQSQGATVFAYHVHDPERYGVVEFDQNFRALS
LEEKPLKPRSNYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKQYLSQNQLDVEIMGRGYAWLDTGTHDSLLEAASF
IATLQNRQGLMVACPEEIAYRSKWISVEQVAALAQPLAKNGYGQYLQRIVSDPVK
>Mature_295_residues
MVNMRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFSDMLGDGSKWGLNLQ
YAVQPSPDGLAQAFIIGRDFIGNDPSTLILGDNIFHGHDLVSQLTRSSAQSQGATVFAYHVHDPERYGVVEFDQNFRALS
LEEKPLKPRSNYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKQYLSQNQLDVEIMGRGYAWLDTGTHDSLLEAASF
IATLQNRQGLMVACPEEIAYRSKWISVEQVAALAQPLAKNGYGQYLQRIVSDPVK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=252, Percent_Identity=24.2063492063492, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11761619, Length=252, Percent_Identity=24.2063492063492, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788351, Length=291, Percent_Identity=72.8522336769759, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.9122807017544, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=242, Percent_Identity=23.5537190082645, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=280, Percent_Identity=27.1428571428571, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355443, Length=250, Percent_Identity=23.6, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24644084, Length=250, Percent_Identity=23.6, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32725; Mature: 32725

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNMRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPE
CCCCCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCC
DTPRFSDMLGDGSKWGLNLQYAVQPSPDGLAQAFIIGRDFIGNDPSTLILGDNIFHGHDL
CCCHHHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEECHHCCCCCCEEEEECCCCCHHHH
VSQLTRSSAQSQGATVFAYHVHDPERYGVVEFDQNFRALSLEEKPLKPRSNYAVTGLYFY
HHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEE
DNQVCDIAADIKPSARGELEITDVNKQYLSQNQLDVEIMGRGYAWLDTGTHDSLLEAASF
CCCEEEEEECCCCCCCCEEEEEECCHHHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHH
IATLQNRQGLMVACPEEIAYRSKWISVEQVAALAQPLAKNGYGQYLQRIVSDPVK
HHHHHCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVNMRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPE
CCCCCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCC
DTPRFSDMLGDGSKWGLNLQYAVQPSPDGLAQAFIIGRDFIGNDPSTLILGDNIFHGHDL
CCCHHHHHHCCCCCCCEEEEEEECCCCCHHHEEEEEECHHCCCCCCEEEEECCCCCHHHH
VSQLTRSSAQSQGATVFAYHVHDPERYGVVEFDQNFRALSLEEKPLKPRSNYAVTGLYFY
HHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEE
DNQVCDIAADIKPSARGELEITDVNKQYLSQNQLDVEIMGRGYAWLDTGTHDSLLEAASF
CCCEEEEEECCCCCCCCEEEEEECCHHHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHH
IATLQNRQGLMVACPEEIAYRSKWISVEQVAALAQPLAKNGYGQYLQRIVSDPVK
HHHHHCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]