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The map label for this gene is argH [H]

Identifier: 73540401

GI number: 73540401

Start: 752336

End: 753748

Strand: Reverse

Name: argH [H]

Synonym: Reut_A0695

Alternate gene names: 73540401

Gene position: 753748-752336 (Counterclockwise)

Preceding gene: 73540402

Following gene: 73540400

Centisome position: 19.8

GC content: 67.45

Gene sequence:

>1413_bases
ATGACGACCTCCCAACTTGCCAAGAAAGGCGAAGCCTGGTCCGCCCGCTTCTCCGAACCGATGTCCGACCTGGTGAAGCG
CTACACCGCTTCGGTGTTCTTCGACAAGCGCCTGGCCCTGTTCGACATCCAGGGCTCGCTGGCGCATGCGGCCATGCTGG
CCAAGCAAGGCATCATCGCCGAGGCCGACCGCGCCGAGATCGAGCGCGGCATGGCACAGATCAAGGGCGAGATCGAAGCC
GGCGGCTTCGAATGGAAGCTGGATCTCGAAGACGTCCACCTGAACATCGAAGCGCGCCTGACCGCGCTGGTCGGCGATGC
CGGCAAGCGCCTGCATACGGGCCGCTCGCGCAACGACCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCAGCGAGATCG
ACAACATCATCGCCCTGCTCGGCGCGCTGCGCGGGTCGCTGCTGGACCTGGCCGACCAGAACGCCGACACGATCCTGCCG
GGCTTCACGCACCTGCAGGTCGCGCAGCCCGTGACCTTCGGCCACCACCTGCTGGCCTACGTGGAAATGTTCACGCGCGA
TGCCGAGCGCATGGCCGACTGCCGCAAGCGCGTCAACCGCCTGCCGCTGGGCGCCGCCGCGCTCGCCGGCACGAGCTACC
CGATCGACCGCGAATTCGTCGCGCAGCAGCTCGGCTTCGACGGCGTGTGCCGCAATTCGCTGGATGCGGTGTCGGACCGC
GACTTCGCGATCGAATTCTGCGCAGCCGCCGCGCTGGTGATGACCCACGTGTCGCGCTTCTCGGAAGAACTGGTGCTGTG
GATGAGCCCGCGCGTCGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACC
CCGACGTGCCGGAACTGGCCCGCGGCAAGACCGGCCGCGTCAACGGCCACCTGATCGGCCTGCTGACGCTGATGAAGGGC
CAGCCGCTCGCATACAACAAGGACAACCAGGAAGACAAGGAACCGCTGTTCGATACGGTCGATACCGTCGTGGACACGCT
GCGCATCTTCGCTGACATGGTGCCTGGCATCACCGTCAAGCCCGAAGCCATGCGCGCCGCCGCGCTGCAGGGCTACGCCA
CGGCCACCGACCTGGCCGACTACCTCGTCAAGAAGGGCCTGCCGTTCCGCGACGCGCACGAAGCCGTGGCCCACGCCGTG
CGCGCGTGCGACAGCCGCAACTGCGACCTGGCCGACCTTACCGTGGCCGAACTGCGTGAAGTCTCGGGCCTCGGCGACAA
GTCCGCGCTGATCGGCGATGACGTGCACACCGTCCTGACGCTCGAAGGTTCGGTCGCTGCGCGTAACCACATCGGCGGCA
CCGCACCGGACCAGGTGCGCGCGGCGATCGCCGCCGCACGCGCAGCGCTCTGA

Upstream 100 bases:

>100_bases
TATAATCCCCGTTTCTCCGAAATCCGCTCGCGTCCGCCCCGCATGGTCATGCACCGGCCGCACGCCGCGCGAGCCATAGA
GCCACATAGCCCTGACGTCC

Downstream 100 bases:

>100_bases
GTTGACGCTGTAAGTTCCGCGTAAGTTTCAAGCAAGAAAAAGCCACGATGGGCCGGCCATCGTGGCTTTTTTCATTTACA
AGACGGATTTTTGCGCAATG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMAQIKGEIEA
GGFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILP
GFTHLQVAQPVTFGHHLLAYVEMFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDR
DFAIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKG
QPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKPEAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAV
RACDSRNCDLADLTVAELREVSGLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQVRAAIAAARAAL

Sequences:

>Translated_470_residues
MTTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMAQIKGEIEA
GGFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILP
GFTHLQVAQPVTFGHHLLAYVEMFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDR
DFAIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKG
QPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKPEAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAV
RACDSRNCDLADLTVAELREVSGLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQVRAAIAAARAAL
>Mature_469_residues
TTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMAQIKGEIEAG
GFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILPG
FTHLQVAQPVTFGHHLLAYVEMFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRD
FAIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKPEAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVR
ACDSRNCDLADLTVAELREVSGLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQVRAAIAAARAAL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=40.7327586206897, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=40.7327586206897, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=38.3620689655172, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI68303549, Length=464, Percent_Identity=37.9310344827586, Blast_Score=318, Evalue=9e-87,
Organism=Escherichia coli, GI1790398, Length=459, Percent_Identity=46.4052287581699, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=41.648590021692, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=38.4787472035794, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=38.4787472035794, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51087; Mature: 50956

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIA
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCC
EADRAEIERGMAQIKGEIEAGGFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQ
CCHHHHHHHHHHHHCCCEECCCEEEEEEHHHEEEEHHHHHHHHHHCCHHHHCCCCCCCCH
VATDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILPGFTHLQVAQPVTFGHHLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
VEMFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCCHHHCCCC
DFAIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELA
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHH
RGKTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVK
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PEAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRACDSRNCDLADLTVAELRE
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VSGLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQVRAAIAAARAAL
HHCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIA
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCC
EADRAEIERGMAQIKGEIEAGGFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQ
CCHHHHHHHHHHHHCCCEECCCEEEEEEHHHEEEEHHHHHHHHHHCCHHHHCCCCCCCCH
VATDIRLWLRSEIDNIIALLGALRGSLLDLADQNADTILPGFTHLQVAQPVTFGHHLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
VEMFTRDAERMADCRKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDR
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCCHHHCCCC
DFAIEFCAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELA
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHH
RGKTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVK
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PEAMRAAALQGYATATDLADYLVKKGLPFRDAHEAVAHAVRACDSRNCDLADLTVAELRE
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VSGLGDKSALIGDDVHTVLTLEGSVAARNHIGGTAPDQVRAAIAAARAAL
HHCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA