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The map label for this gene is ubiE [H]

Identifier: 73540137

GI number: 73540137

Start: 474535

End: 475266

Strand: Direct

Name: ubiE [H]

Synonym: Reut_A0431

Alternate gene names: 73540137

Gene position: 474535-475266 (Clockwise)

Preceding gene: 73540136

Following gene: 73540138

Centisome position: 12.47

GC content: 60.79

Gene sequence:

>732_bases
ATGAGCGAAACCCACTTCGGGTTCGAGAAGGTCGACGAAACGGAAAAGGCCGGCAAAGTTGCCGGCGTGTTCCATTCGGT
CGCCAGCAAGTATGACGTGATGAACGACCTGATGTCGGGCGGCATGCACCGGTTGTGGAAGATGTTCACCATCGCCCAGG
CCAACGTGCGGCCCGGCCACAAGGTGCTGGACATTGCCGGCGGCACGGGCGACCTGGCCAAGGCGTTCGCGAAGCAGGCC
GGCCCGACCGGCCAGGTCTGGCTCACGGACATCAACGAGTCGATGCTGCGCGTGGGCCGCGACCGCCTGCTCGACAAGGG
CGTCGTCACACCGGTGGCGCTGTGCGACGCCGAGCACATTCCGTTTCCGGACAACTACTTCGATCTGGTCACCGTTGCAT
TCGGCCTGCGCAACATGACCCACAAGGACGCTGCACTGGCCGAGATGCGCCGCGTGGTGAAGCCTGGCGGCAAGGTCATG
GTTCTGGAATTCTCCAAGGTGTGGAAGCCGCTGGAAAAGGCATACGATGTCTATTCGTTCCAGGTGCTGCCGTGGCTCGG
CCAGAAGGTGGCCGGGGATGCCGCGAGCTATCGTTATCTGGCAGAATCGATCAGAATGCATCCAGACCAGACTTCACTTG
TACGCTTGATGGAACAAGTTGGGCTGGAGAAGGTCGAATACTTCAATCTGACGGCCGGAGTAGTGGCGCTCCACGTCGGG
CGCAAGTATTAA

Upstream 100 bases:

>100_bases
AGCTGCCGGCGCCGACCGTGACACGCCCATGGCGGCGCCGGGCGGCCATGGCTGCGGCCATCACCACTGATCTGTACCCT
CTGTACCTGGAGTCCGAGAT

Downstream 100 bases:

>100_bases
ATCGCCATTCCTGGCTTGAATTCCGGCGGCTCAGCCTGAATTTGAGCGGACACTGACAGGGGATCACTGAATATGTCATC
ACTTCGCGGAAAATTCCTGG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSETHFGFEKVDETEKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQANVRPGHKVLDIAGGTGDLAKAFAKQA
GPTGQVWLTDINESMLRVGRDRLLDKGVVTPVALCDAEHIPFPDNYFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVM
VLEFSKVWKPLEKAYDVYSFQVLPWLGQKVAGDAASYRYLAESIRMHPDQTSLVRLMEQVGLEKVEYFNLTAGVVALHVG
RKY

Sequences:

>Translated_243_residues
MSETHFGFEKVDETEKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQANVRPGHKVLDIAGGTGDLAKAFAKQA
GPTGQVWLTDINESMLRVGRDRLLDKGVVTPVALCDAEHIPFPDNYFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVM
VLEFSKVWKPLEKAYDVYSFQVLPWLGQKVAGDAASYRYLAESIRMHPDQTSLVRLMEQVGLEKVEYFNLTAGVVALHVG
RKY
>Mature_242_residues
SETHFGFEKVDETEKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQANVRPGHKVLDIAGGTGDLAKAFAKQAG
PTGQVWLTDINESMLRVGRDRLLDKGVVTPVALCDAEHIPFPDNYFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVMV
LEFSKVWKPLEKAYDVYSFQVLPWLGQKVAGDAASYRYLAESIRMHPDQTSLVRLMEQVGLEKVEYFNLTAGVVALHVGR
KY

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=45.8483754512635, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=62.1399176954732, Blast_Score=306, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17557039, Length=244, Percent_Identity=47.1311475409836, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=257, Percent_Identity=38.1322957198444, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24641702, Length=255, Percent_Identity=45.0980392156863, Blast_Score=213, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27020; Mature: 26888

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
SETHFGFEKVDETEKAGKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQANVRPGH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KVLDIAGGTGDLAKAFAKQAGPTGQVWLTDINESMLRVGRDRLLDKGVVTPVALCDAEHI
EEEEECCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCC
PFPDNYFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVMVLEFSKVWKPLEKAYDVYSF
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
QVLPWLGQKVAGDAASYRYLAESIRMHPDQTSLVRLMEQVGLEKVEYFNLTAGVVALHVG
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
RKY
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA