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The map label for this gene is ykgC [H]

Identifier: 73540091

GI number: 73540091

Start: 422299

End: 423678

Strand: Direct

Name: ykgC [H]

Synonym: Reut_A0385

Alternate gene names: 73540091

Gene position: 422299-423678 (Clockwise)

Preceding gene: 73540089

Following gene: 73540092

Centisome position: 11.09

GC content: 64.2

Gene sequence:

>1380_bases
ATGGCTCAGGGATTCGACGCGATCATCATCGGAACCGGACAGGCTGGCCCCGCACTTGCCGCGCGGCTGTCCGGCGCGGG
CATGAAGCTGGCCATCATCGAGCGCGCACGTTTCGGCGGCACCTGCGTGAACACCGGCTGCATTCCCACCAAGACCCTCA
TTGCGAGCGCGTATGCAGCCCAACTGGCGCGCCGGGCCGCGGAGTACGGCGTGACCATCGGTGGGCCGGTCGCCGTCGAC
ATGAAACGGGTGAAGGCACGCAAGGACGAGATCTCTGGCCGCTCCAGCAACGGTGTGGAACAGTGGATGCGCGGCCTGGC
CAATATAACGGTCTATCAGGGGCACGCCCGTTTCGAGAACGCGCACAGCGTACAGGTCAACGGTGAACTGCTGGAAGCCA
CGCAGATATTCGTGAACGTCGGCGGCCGGGCCCTGGTTCCTCCCATGCCAGGGCTGGATCAGGTGCCGTACCTCACCAAC
GCGGGGATGATGGATGTGGATTTCCTGCCGGAGCACCTGATCGTGATTGGCGGCAGCTACATCGGCCTCGAGTTTGGCCA
GATGTACCGGCGATTTGGTGCCAGGGTGACCGTCGTCGAAAAAGGCCCGCGCCTGATCCAGCGTGAGGACGAAGATGTCT
CGCAGGCAGTGCGGGAAATTCTGGAAGCCGAAGGCATCGACATCCGGCTCAATGCCAACTGCCTCAGCGCGCGCAGGGAC
GGCGATCATCTTGCCGTCGGGCTGGATTGCGCGTCCGGTGCGCCCGAAGTTCACGGCACGCATCTGCTGATGGCGGTCGG
GCGCGTGCCCAACACGGACGATCTCGGACTCGACAAGGCAGGGGTGGAGACCGACGCCCGCGGCTATATCAAGGTCGACG
AACAGTTGCGCACCAATGTCCCCGGCATCTGGGCGCTTGGCGATTGCAATGGTCGCGGCGCCTTCACGCATACGTCGTAC
AACGACCATGAGATCGTCGCTGCCAATCTCCTCGACAATGACCCGCGCAAGGTGTCGGATCGCATCGCCGCGTATGCCAT
GTTCATCGACCCTCCGCTCGGCCGCGCCGGCATGACGGAGACGGAAGCCCGGCAATCCGGCCGCAAGATACTGGTCGGCA
CCCGCCCGATGAGCCGTGTCGGGCGCGCCGTGGAGCGAGGCGAGAGTCTCGGGTTCATGAAGGTCGTGGTCGACGCGGAC
ACCCGGGTGATCCTTGGAGCGGCGATCCTCGGCCTGACCGGCGACGAGGTGATTCACTCGATCCTTGATGTCATGTATGC
CGGCGCTCCCTATACGGTCATCAGTCGCGCGATGCACATCCATCCCACGGTGTCCGAACTGGTACCGACGCTGCTGCAGG
AGTTGCGGGTACCGGGCTAG

Upstream 100 bases:

>100_bases
GCATATCGCCTAAAGTTTGCTAGTGGCTTTGGCATCCGGCGGTAGCCGCCGAGGCAGCTGTGACCTGCGATGAGCACGGT
ACAAGGCAAGGAGAGTCGTG

Downstream 100 bases:

>100_bases
CCGGCGCCCGTGCGCAAGGATGGGGGAATGGCCATGAATAAGAAGGCACCCGGCGCCAGCCCCGCGTCAGCGGAAGCGCC
GCTCGCAGAGCTGCCGGGCA

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAQGFDAIIIGTGQAGPALAARLSGAGMKLAIIERARFGGTCVNTGCIPTKTLIASAYAAQLARRAAEYGVTIGGPVAVD
MKRVKARKDEISGRSSNGVEQWMRGLANITVYQGHARFENAHSVQVNGELLEATQIFVNVGGRALVPPMPGLDQVPYLTN
AGMMDVDFLPEHLIVIGGSYIGLEFGQMYRRFGARVTVVEKGPRLIQREDEDVSQAVREILEAEGIDIRLNANCLSARRD
GDHLAVGLDCASGAPEVHGTHLLMAVGRVPNTDDLGLDKAGVETDARGYIKVDEQLRTNVPGIWALGDCNGRGAFTHTSY
NDHEIVAANLLDNDPRKVSDRIAAYAMFIDPPLGRAGMTETEARQSGRKILVGTRPMSRVGRAVERGESLGFMKVVVDAD
TRVILGAAILGLTGDEVIHSILDVMYAGAPYTVISRAMHIHPTVSELVPTLLQELRVPG

Sequences:

>Translated_459_residues
MAQGFDAIIIGTGQAGPALAARLSGAGMKLAIIERARFGGTCVNTGCIPTKTLIASAYAAQLARRAAEYGVTIGGPVAVD
MKRVKARKDEISGRSSNGVEQWMRGLANITVYQGHARFENAHSVQVNGELLEATQIFVNVGGRALVPPMPGLDQVPYLTN
AGMMDVDFLPEHLIVIGGSYIGLEFGQMYRRFGARVTVVEKGPRLIQREDEDVSQAVREILEAEGIDIRLNANCLSARRD
GDHLAVGLDCASGAPEVHGTHLLMAVGRVPNTDDLGLDKAGVETDARGYIKVDEQLRTNVPGIWALGDCNGRGAFTHTSY
NDHEIVAANLLDNDPRKVSDRIAAYAMFIDPPLGRAGMTETEARQSGRKILVGTRPMSRVGRAVERGESLGFMKVVVDAD
TRVILGAAILGLTGDEVIHSILDVMYAGAPYTVISRAMHIHPTVSELVPTLLQELRVPG
>Mature_458_residues
AQGFDAIIIGTGQAGPALAARLSGAGMKLAIIERARFGGTCVNTGCIPTKTLIASAYAAQLARRAAEYGVTIGGPVAVDM
KRVKARKDEISGRSSNGVEQWMRGLANITVYQGHARFENAHSVQVNGELLEATQIFVNVGGRALVPPMPGLDQVPYLTNA
GMMDVDFLPEHLIVIGGSYIGLEFGQMYRRFGARVTVVEKGPRLIQREDEDVSQAVREILEAEGIDIRLNANCLSARRDG
DHLAVGLDCASGAPEVHGTHLLMAVGRVPNTDDLGLDKAGVETDARGYIKVDEQLRTNVPGIWALGDCNGRGAFTHTSYN
DHEIVAANLLDNDPRKVSDRIAAYAMFIDPPLGRAGMTETEARQSGRKILVGTRPMSRVGRAVERGESLGFMKVVVDADT
RVILGAAILGLTGDEVIHSILDVMYAGAPYTVISRAMHIHPTVSELVPTLLQELRVPG

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=27.5053304904051, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=27.6824034334764, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI22035672, Length=460, Percent_Identity=26.7391304347826, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI291045266, Length=437, Percent_Identity=24.0274599542334, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI148277065, Length=436, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519430, Length=436, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519428, Length=436, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519426, Length=436, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI148277071, Length=436, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=23.4883720930233, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=36.304347826087, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=29.3064876957494, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=28.6697247706422, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=25.3275109170306, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=28.0701754385965, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=28.1938325991189, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=28.1938325991189, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=25.7383966244726, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17559934, Length=187, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=29.8056155507559, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6325166, Length=476, Percent_Identity=25.8403361344538, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=25.4817987152034, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=29.5652173913043, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=27.2921108742004, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=27.2921108742004, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=27.2921108742004, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=23.454157782516, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 49152; Mature: 49021

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGFDAIIIGTGQAGPALAARLSGAGMKLAIIERARFGGTCVNTGCIPTKTLIASAYAA
CCCCCCEEEEECCCCCHHHHHHHCCCCEEEEEEEHHCCCCEEEECCCCCHHHHHHHHHHH
QLARRAAEYGVTIGGPVAVDMKRVKARKDEISGRSSNGVEQWMRGLANITVYQGHARFEN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCCCC
AHSVQVNGELLEATQIFVNVGGRALVPPMPGLDQVPYLTNAGMMDVDFLPEHLIVIGGSY
CCEEEECCHHHEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCEEHHHCCCEEEEECCCC
IGLEFGQMYRRFGARVTVVEKGPRLIQREDEDVSQAVREILEAEGIDIRLNANCLSARRD
CCHHHHHHHHHHCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCEEEECCHHCCCCCC
GDHLAVGLDCASGAPEVHGTHLLMAVGRVPNTDDLGLDKAGVETDARGYIKVDEQLRTNV
CCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCC
PGIWALGDCNGRGAFTHTSYNDHEIVAANLLDNDPRKVSDRIAAYAMFIDPPLGRAGMTE
CCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHEEEEEECCCCCCCCCCH
TEARQSGRKILVGTRPMSRVGRAVERGESLGFMKVVVDADTRVILGAAILGLTGDEVIHS
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHCCCHHHHHHH
ILDVMYAGAPYTVISRAMHIHPTVSELVPTLLQELRVPG
HHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AQGFDAIIIGTGQAGPALAARLSGAGMKLAIIERARFGGTCVNTGCIPTKTLIASAYAA
CCCCCEEEEECCCCCHHHHHHHCCCCEEEEEEEHHCCCCEEEECCCCCHHHHHHHHHHH
QLARRAAEYGVTIGGPVAVDMKRVKARKDEISGRSSNGVEQWMRGLANITVYQGHARFEN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCCCC
AHSVQVNGELLEATQIFVNVGGRALVPPMPGLDQVPYLTNAGMMDVDFLPEHLIVIGGSY
CCEEEECCHHHEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCEEHHHCCCEEEEECCCC
IGLEFGQMYRRFGARVTVVEKGPRLIQREDEDVSQAVREILEAEGIDIRLNANCLSARRD
CCHHHHHHHHHHCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCEEEECCHHCCCCCC
GDHLAVGLDCASGAPEVHGTHLLMAVGRVPNTDDLGLDKAGVETDARGYIKVDEQLRTNV
CCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCC
PGIWALGDCNGRGAFTHTSYNDHEIVAANLLDNDPRKVSDRIAAYAMFIDPPLGRAGMTE
CCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHEEEEEECCCCCCCCCCH
TEARQSGRKILVGTRPMSRVGRAVERGESLGFMKVVVDADTRVILGAAILGLTGDEVIHS
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHCCCHHHHHHH
ILDVMYAGAPYTVISRAMHIHPTVSELVPTLLQELRVPG
HHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]