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The map label for this gene is nhaK [H]

Identifier: 73540085

GI number: 73540085

Start: 414407

End: 416002

Strand: Direct

Name: nhaK [H]

Synonym: Reut_A0379

Alternate gene names: 73540085

Gene position: 414407-416002 (Clockwise)

Preceding gene: 73540084

Following gene: 73540087

Centisome position: 10.89

GC content: 65.85

Gene sequence:

>1596_bases
ATGTCGCCTGTCCTGGCATTCAAGCTGGTACTGCTGTCACTGATCGCCATCATCGCGCTGGAGTTGCTGGCGGCAAAGCT
GCGGCTGCCGCCGGCGGCGGCCTTTCTGGTCGGTGGCATTGCCATGGCATTCGTGCCGGGCCTGCCGGCGGTCGAGCTCA
GTCCGGACCTGGTGTTGCTGGTCTTCCTGCCGCCGCTGCTGACGGACGGCGCGTACTTTTCAGTGTGGGACGAGTTCCGG
CGCAATCTCAGCGGCATCCTGATGCTGGCGATCGGAGCCGTGTTGTTCACGACGCTGGTCGTTGGCGTGGCCGTCCACAT
GGTGGTTCCGGGCCTGCCGTGGGCGGCGTGCTTTGCGCTCGGCGCGATCGTGTCGCCGCCCGACGCCGTCGCGGCCAAGG
CCGTGCTCGAGCGGGTCGCGCTGCCGCGGCGGCTCATGACCTTGCTGGAGGGCGAAAGCCTGCTCAATGACGCAACCGGG
CTGGTGCTCTACCGCTTCGCCGTCGCGGCCGCGCTGACCGGTGCGTTCAGCCTCGAACATGCCACCGTGGATTTCTTCGT
GCTCGCACTGGGCGGGGTTGCCGTGGGGATCGCCATCGGCTTTGCGCTGGTGCGCGTGCTGCGGCGGCTGGCCGACGAAT
ATCTTCTGATCACCGCAGCCATACTGTCCTCCTGGGTCAGCTACATCGTCGGCGAATGGCTGGAAGTCTCCGGCGTCATC
GCGACGGTGACCACCGGCATGATCCTTGGCTGGCACCAGCACCAGGTGTTCTCGGCGTCGACAAGAATCCGTGGCACGGC
GTTCTGGCAGGTCATGGTGTTCCTGCTCGAGGCGCTGGTGTTCATACTGATCGGGCTATCGCTGCGCGGCGTGATTGCGC
GGCACGGTGGCACCGCTGATGTGATGGCGTCGCTGGCCCTGCCGGTTGGCATGGTGATCGTCTCGGTCGTGCTCTCGCGC
TTCGCATGGGTGTTCGGGTCGGAGGCGCTGAAGTCGGCGTGGCAGCGCGTGGTACGCCGTCAGGCTCGCGCGGACTGGCG
TTCGGCCACCATCGTCAGCTGGGCCGGGATGCGCGGCGTCGTGACCCTCGCCATTGCGCTGGCGCTTCCGGAGCAGATGC
CGGGCCGCGACCTGATCCTCGTCGCATCGTTCGCGGTGATCCTCGTCACCGTGCTGTTGCAGGGCACGACCATTGGGCCG
CTGATCCGCCTGCTGGATATCCGGCGCATCGAAGATGCCTCGGGCCGTAAACTGACCGAAGCGCAGGCATGGGCCCGTCT
CGAAGCGGTGCAGCGCGATGCGATCCGCCCGCTGGTGTTCGACGCAGACGGTGCGCTGCGGCATCCGCGGCTATGGGAAC
AGGTCAACTACCGCGCGCAGATTACCGAGAGTTTCAAGGACAACATCATTCCCGACGAAGAGCGCACTTCCCACTATGGT
GTGATCCTGGCGGGCCTTGCCGCAGCGCGGGAGGAGTTGCTGCGGATGCATCGTGCGGGGCAGCTTCATGACGAACTGCT
GCGTCATCTTGAATACGATCTGGATCTGCAGGAGATCGCGGCGTTGCATGGGAGTGCAGGCGTGGGGGCGGATTGA

Upstream 100 bases:

>100_bases
TGACCGCCGATCGAACCTTCCTGCATGGCGAGCTACCGGCTCGACGCGTTGAACCACCCCTGGTAATAATCGCTGCAACG
CCAAACTTCAGGGGTGGTGC

Downstream 100 bases:

>100_bases
AGCGCCCGGCCCACAGCTGCCCCACAGCTGCTCCCGTCACCGACCCGCTTCGCCACTACCGCGAAATTCGGACGGACTGA
CGCCATTGGCCCGGCGAAAG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSPVLAFKLVLLSLIAIIALELLAAKLRLPPAAAFLVGGIAMAFVPGLPAVELSPDLVLLVFLPPLLTDGAYFSVWDEFR
RNLSGILMLAIGAVLFTTLVVGVAVHMVVPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMTLLEGESLLNDATG
LVLYRFAVAAALTGAFSLEHATVDFFVLALGGVAVGIAIGFALVRVLRRLADEYLLITAAILSSWVSYIVGEWLEVSGVI
ATVTTGMILGWHQHQVFSASTRIRGTAFWQVMVFLLEALVFILIGLSLRGVIARHGGTADVMASLALPVGMVIVSVVLSR
FAWVFGSEALKSAWQRVVRRQARADWRSATIVSWAGMRGVVTLAIALALPEQMPGRDLILVASFAVILVTVLLQGTTIGP
LIRLLDIRRIEDASGRKLTEAQAWARLEAVQRDAIRPLVFDADGALRHPRLWEQVNYRAQITESFKDNIIPDEERTSHYG
VILAGLAAAREELLRMHRAGQLHDELLRHLEYDLDLQEIAALHGSAGVGAD

Sequences:

>Translated_531_residues
MSPVLAFKLVLLSLIAIIALELLAAKLRLPPAAAFLVGGIAMAFVPGLPAVELSPDLVLLVFLPPLLTDGAYFSVWDEFR
RNLSGILMLAIGAVLFTTLVVGVAVHMVVPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMTLLEGESLLNDATG
LVLYRFAVAAALTGAFSLEHATVDFFVLALGGVAVGIAIGFALVRVLRRLADEYLLITAAILSSWVSYIVGEWLEVSGVI
ATVTTGMILGWHQHQVFSASTRIRGTAFWQVMVFLLEALVFILIGLSLRGVIARHGGTADVMASLALPVGMVIVSVVLSR
FAWVFGSEALKSAWQRVVRRQARADWRSATIVSWAGMRGVVTLAIALALPEQMPGRDLILVASFAVILVTVLLQGTTIGP
LIRLLDIRRIEDASGRKLTEAQAWARLEAVQRDAIRPLVFDADGALRHPRLWEQVNYRAQITESFKDNIIPDEERTSHYG
VILAGLAAAREELLRMHRAGQLHDELLRHLEYDLDLQEIAALHGSAGVGAD
>Mature_530_residues
SPVLAFKLVLLSLIAIIALELLAAKLRLPPAAAFLVGGIAMAFVPGLPAVELSPDLVLLVFLPPLLTDGAYFSVWDEFRR
NLSGILMLAIGAVLFTTLVVGVAVHMVVPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMTLLEGESLLNDATGL
VLYRFAVAAALTGAFSLEHATVDFFVLALGGVAVGIAIGFALVRVLRRLADEYLLITAAILSSWVSYIVGEWLEVSGVIA
TVTTGMILGWHQHQVFSASTRIRGTAFWQVMVFLLEALVFILIGLSLRGVIARHGGTADVMASLALPVGMVIVSVVLSRF
AWVFGSEALKSAWQRVVRRQARADWRSATIVSWAGMRGVVTLAIALALPEQMPGRDLILVASFAVILVTVLLQGTTIGPL
IRLLDIRRIEDASGRKLTEAQAWARLEAVQRDAIRPLVFDADGALRHPRLWEQVNYRAQITESFKDNIIPDEERTSHYGV
ILAGLAAAREELLRMHRAGQLHDELLRHLEYDLDLQEIAALHGSAGVGAD

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=431, Percent_Identity=26.6821345707657, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI148727259, Length=396, Percent_Identity=26.2626262626263, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI41872703, Length=437, Percent_Identity=25.4004576659039, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI194239733, Length=424, Percent_Identity=26.1792452830189, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI27777632, Length=393, Percent_Identity=26.2086513994911, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4759144, Length=384, Percent_Identity=27.34375, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI27734935, Length=431, Percent_Identity=22.737819025522, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI14211919, Length=518, Percent_Identity=24.1312741312741, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI294997330, Length=518, Percent_Identity=23.1660231660232, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI110227626, Length=518, Percent_Identity=23.1660231660232, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI5454070, Length=515, Percent_Identity=23.1067961165049, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1790501, Length=507, Percent_Identity=28.5996055226824, Blast_Score=163, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71999817, Length=403, Percent_Identity=24.5657568238213, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71999819, Length=403, Percent_Identity=24.5657568238213, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71999821, Length=403, Percent_Identity=24.5657568238213, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI71980847, Length=458, Percent_Identity=21.8340611353712, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71987535, Length=409, Percent_Identity=23.2273838630807, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71987537, Length=409, Percent_Identity=22.4938875305623, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25150332, Length=416, Percent_Identity=23.3173076923077, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147678, Length=506, Percent_Identity=22.9249011857708, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71990924, Length=387, Percent_Identity=23.7726098191214, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71990932, Length=387, Percent_Identity=23.7726098191214, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71987559, Length=420, Percent_Identity=21.9047619047619, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71987545, Length=420, Percent_Identity=21.9047619047619, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71993590, Length=374, Percent_Identity=25.4010695187166, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993582, Length=374, Percent_Identity=25.4010695187166, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71992101, Length=384, Percent_Identity=22.3958333333333, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71992107, Length=384, Percent_Identity=22.3958333333333, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320663, Length=341, Percent_Identity=24.3401759530792, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221510734, Length=391, Percent_Identity=26.3427109974425, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221510738, Length=400, Percent_Identity=26, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI221510736, Length=391, Percent_Identity=26.3427109974425, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221510732, Length=391, Percent_Identity=26.3427109974425, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585580, Length=391, Percent_Identity=26.3427109974425, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585578, Length=391, Percent_Identity=26.3427109974425, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221510740, Length=391, Percent_Identity=26.3427109974425, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281364513, Length=406, Percent_Identity=24.1379310344828, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI221473222, Length=406, Percent_Identity=24.1379310344828, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221473212, Length=415, Percent_Identity=23.855421686747, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221473215, Length=390, Percent_Identity=24.1025641025641, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360447, Length=469, Percent_Identity=23.2409381663113, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 57326; Mature: 57194

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVLAFKLVLLSLIAIIALELLAAKLRLPPAAAFLVGGIAMAFVPGLPAVELSPDLVLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEH
VFLPPLLTDGAYFSVWDEFRRNLSGILMLAIGAVLFTTLVVGVAVHMVVPGLPWAACFAL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GAIVSPPDAVAAKAVLERVALPRRLMTLLEGESLLNDATGLVLYRFAVAAALTGAFSLEH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVDFFVLALGGVAVGIAIGFALVRVLRRLADEYLLITAAILSSWVSYIVGEWLEVSGVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVTTGMILGWHQHQVFSASTRIRGTAFWQVMVFLLEALVFILIGLSLRGVIARHGGTAD
HHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VMASLALPVGMVIVSVVLSRFAWVFGSEALKSAWQRVVRRQARADWRSATIVSWAGMRGV
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHH
VTLAIALALPEQMPGRDLILVASFAVILVTVLLQGTTIGPLIRLLDIRRIEDASGRKLTE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHH
AQAWARLEAVQRDAIRPLVFDADGALRHPRLWEQVNYRAQITESFKDNIIPDEERTSHYG
HHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHH
VILAGLAAAREELLRMHRAGQLHDELLRHLEYDLDLQEIAALHGSAGVGAD
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPVLAFKLVLLSLIAIIALELLAAKLRLPPAAAFLVGGIAMAFVPGLPAVELSPDLVLL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEH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HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA