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The map label for this gene is apt [H]

Identifier: 73540069

GI number: 73540069

Start: 392665

End: 393282

Strand: Direct

Name: apt [H]

Synonym: Reut_A0363

Alternate gene names: 73540069

Gene position: 392665-393282 (Clockwise)

Preceding gene: 73540066

Following gene: 73540070

Centisome position: 10.32

GC content: 65.37

Gene sequence:

>618_bases
ATGCGATGTGCCGGCGCGTGGCGCAACCTTCATTTCAAGATTTCCATGGCAGATTCCCTCATCCAGTCCCCCGATCTCGG
CGATGTCACCGGATACCTGCGCGACCGCATCCGTACCGTGCCGGACTGGCCCATGCCCGGCGTGCAGTTCCGCGACATCA
CGCCGCTGCTGCAGAACCCCAAGACGCTGCGCGTGCTGATCGACGTCTTCGTGCACCGCTACATGGACGCGCAGCTCGAC
CTGGTCGCGGGCATCGACGCGCGCGGTTTCATTCTCGGCGCGATCGTCGCGTACGAACTGAACCTCGGCTTCGTGCCGAT
CCGCAAGAAGGGCAAGCTGCCATTCCAGACCGTGGCCGAGGAATACGAGCTCGAATACGGCAGCGCCACGGTCGAGATCC
ACGCCGACGCCTGCAAGCCCGGCGACCGCGTGCTGCTGATCGACGACCTGATCGCCACCGGCGGCACCATGATGGCCGGC
CGCAAGCTGCTCGAGCGCCTGGGCGCCACCGTGGTGGAAGGCGCGGCGATCGTCGACCTGCCCGAACTGGGCGGTTCGAA
GCTGCTGCAGAATGCGGGTTTGCCTCTGTTCACGGTGTGCCGGTTCGATGGCCACTAA

Upstream 100 bases:

>100_bases
TTACGGGTGCCCGGCCGGCCCGTCGGGCCAGGCGCGGCACCGGCAGGGCCATTTTGCGTGCGGCCCGCGCGGCCCGGGTG
GTAGCCGGTTACCGCAGCCA

Downstream 100 bases:

>100_bases
TATGCCCGTGCGCGCTGCCTGATCCTTTCCGACGGAGATTTTCATGCCCGACCTGCTGCTGTTCCTTGTGACCTCGATCG
CCATCACCCTGGCCCCCGGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRCAGAWRNLHFKISMADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNPKTLRVLIDVFVHRYMDAQLD
LVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAG
RKLLERLGATVVEGAAIVDLPELGGSKLLQNAGLPLFTVCRFDGH

Sequences:

>Translated_205_residues
MRCAGAWRNLHFKISMADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNPKTLRVLIDVFVHRYMDAQLD
LVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAG
RKLLERLGATVVEGAAIVDLPELGGSKLLQNAGLPLFTVCRFDGH
>Mature_205_residues
MRCAGAWRNLHFKISMADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNPKTLRVLIDVFVHRYMDAQLD
LVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAEEYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAG
RKLLERLGATVVEGAAIVDLPELGGSKLLQNAGLPLFTVCRFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=192, Percent_Identity=44.7916666666667, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI71773201, Length=143, Percent_Identity=46.8531468531469, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=49.4252873563218, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=42.7745664739884, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=38.5057471264368, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=30.635838150289, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=39.766081871345, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 22518; Mature: 22518

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCAGAWRNLHFKISMADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNP
CCCCCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCHHHHCC
KTLRVLIDVFVHRYMDAQLDLVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAE
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEECCCEEEECCCCCCCHHHHHH
EYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGAAIVDL
HHCEECCCEEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEEC
PELGGSKLLQNAGLPLFTVCRFDGH
CCCCHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MRCAGAWRNLHFKISMADSLIQSPDLGDVTGYLRDRIRTVPDWPMPGVQFRDITPLLQNP
CCCCCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCHHHHCC
KTLRVLIDVFVHRYMDAQLDLVAGIDARGFILGAIVAYELNLGFVPIRKKGKLPFQTVAE
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEECCCEEEECCCCCCCHHHHHH
EYELEYGSATVEIHADACKPGDRVLLIDDLIATGGTMMAGRKLLERLGATVVEGAAIVDL
HHCEECCCEEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEEC
PELGGSKLLQNAGLPLFTVCRFDGH
CCCCHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA