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The map label for this gene is ctaB [H]

Identifier: 73540029

GI number: 73540029

Start: 352636

End: 353571

Strand: Direct

Name: ctaB [H]

Synonym: Reut_A0323

Alternate gene names: 73540029

Gene position: 352636-353571 (Clockwise)

Preceding gene: 73540028

Following gene: 73540030

Centisome position: 9.26

GC content: 65.06

Gene sequence:

>936_bases
ATGAAAGACAAACTCCCTCCCGTGGTAACCGCAACACACTCCCATCCCGTGGGCCGGGTTCGTCACCTGGCCCGCCAGTA
TGCCGCCCTGACCAAGCCGCGCGTGACGCAGCTCGCGGTGTTCTGCGCCATCATCGGCATGTTCCTGGCTACGCCCGGCA
TGGTGCCGTGGCGCGTGCTGATCGGCGGCGGCGCCGGCATCTGGCTGCTGGCCGGGGCCGCGTTCGCGATCAATTGCCTC
GTCGAGCAGAAGATCGACGCGCTGATGCGCCGTACCGCCTGGCGGCCGTCAGCCACCGGCGAGATCACCACCACGCAGAC
GCTGATCTTCTCGGCCGTCCTCGGTGGCGCCGGCATGTGGCTGCTGCACGTGTTTGCCAACGACCTGACGATGTGGCTGA
CCTTCGCCACATTCCTCGGCTACGCGGTCGTCTACACCATTCTGCTCAAGCCGGCCACGCCGCAGAACATCGTCATCGGA
GGCCTGTCGGGCGCCATGCCGCCGGCGCTGGGCTGGGCGGCTGTTGCCAACGACGTACCTGCCGAAGCGTGGTTCCTGGT
GCTGATCATCTTCACCTGGACGCCGCCGCATTTCTGGGCGCTCGCGCTGTACCGCCGCGCCGACTACGCCAAGTCCGGGC
TGCCGATGCTGCCGATCACGCACGGCGAAAAGTACACGCTGCTCAACATCCTGCTGTACACGCTGGTGATGATCGCCGCG
ACGCTGCTGCCGTTCGTCTACGGCATGAGCGGCTACATCTACCTGGCCAGCGCACTGGTGCTCGGCGCCTGGTTCCTGAA
GTATTCGTGGACGATGTACCGCAACTACTCGGACCAGCTGGCCCAACGCGCCTTCCGCTTCTCGATCCTCTACCTGTCGC
TGCTGTTCGCGGCGCTGCTGATCGATCACTACTTCAAGTTCGTGCCCCAGATCTGA

Upstream 100 bases:

>100_bases
CGGTGCTCCTGCTGCTGTTGGTACGTCTCAACTACAATATAGGGCTCGCGACCCGACCCGCCGGCGCTGCCTCCAGCGTG
CCGACCGCCGCTCGCGCCAC

Downstream 100 bases:

>100_bases
GCGGTCTGGAGCTTCGCGGCCTGCGGCATCTTGTCGCGGCCGCGGTGCCGCACAGCACGAATGGGCGATACTGTGTGCTG
CCCTCGCCATCGCGGCGCCT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKDKLPPVVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVLIGGGAGIWLLAGAAFAINCL
VEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIG
GLSGAMPPALGWAAVANDVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAA
TLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALLIDHYFKFVPQI

Sequences:

>Translated_311_residues
MKDKLPPVVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVLIGGGAGIWLLAGAAFAINCL
VEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIG
GLSGAMPPALGWAAVANDVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAA
TLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALLIDHYFKFVPQI
>Mature_311_residues
MKDKLPPVVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVLIGGGAGIWLLAGAAFAINCL
VEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIG
GLSGAMPPALGWAAVANDVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAA
TLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALLIDHYFKFVPQI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=33.5051546391753, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=31.5412186379928, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71998235, Length=296, Percent_Identity=28.3783783783784, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=274, Percent_Identity=31.021897810219, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921064, Length=314, Percent_Identity=28.0254777070064, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34479; Mature: 34479

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKLPPVVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVL
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
IGGGAGIWLLAGAAFAINCLVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMW
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHH
LLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIGGLSGAMPPALGWAAVANDVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCC
AEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHH
TLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
IDHYFKFVPQI
HHHHHHHHCCC
>Mature Secondary Structure
MKDKLPPVVTATHSHPVGRVRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWRVL
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
IGGGAGIWLLAGAAFAINCLVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMW
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHH
LLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIGGLSGAMPPALGWAAVANDVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCC
AEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLNILLYTLVMIAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHH
TLLPFVYGMSGYIYLASALVLGAWFLKYSWTMYRNYSDQLAQRAFRFSILYLSLLFAALL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
IDHYFKFVPQI
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA