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The map label for this gene is crp [C]

Identifier: 73539965

GI number: 73539965

Start: 287815

End: 288483

Strand: Reverse

Name: crp [C]

Synonym: Reut_A0259

Alternate gene names: 73539965

Gene position: 288483-287815 (Counterclockwise)

Preceding gene: 73539973

Following gene: 73539964

Centisome position: 7.58

GC content: 62.63

Gene sequence:

>669_bases
ATGCTGAACGATTTTGTCGACCGTTGTGTGTGGGCCGCTGACCTCAGTGCCGAGCAGCGTGATCGCGTCCGCCGCGCGAT
GTTTGTTCGCGAGTACACGCAAGGCGACTACGTTTGTCATAAGGGTGAAATCGCCGAGCACTGGCTGGGCGTGCTCGAAG
GCATCGTCAAGATCACTACCGTGTCGCCGTCCGGCAAGTCGGTCACGTTCACCGGCGTACCGACCGGCGGCTGGTTCGGC
GAGGGCGCGGTGCTCAAGTCGGAGATCCGCAAGTACGACGTGATGGCATTGCGCCGCTCGACCATCGCGTTCCTGCCGCG
CGACACTTTTCAGTGGTTGCTGGATACCAGCCTGCCGTTCACGCGTTTCCTGCTCACGCAGTTCAACGAGCGGCTCGGCC
AGTTCATCGCGGCGGTTGAGTACGAACGCCTGCTCGATATCGACTCGCGCGTGGCGCGCGCAGTCTCGTCGCTGTTCAAT
GAGCATCTCTATCCCGGTATCGGCAACACGCTGGAGATCTCGCAGGAAGAGATCGGCCTGCTCGCCGGCATTTCGCGCCA
GCGCGCCAACCAGGCGCTCAAGGTGCTCGAGCAGCAGGGCCTGGTGCGCGTGGACTATGGCGTGATCGAAGTGCTGGACC
TGGAAGGACTGCGCCAGTACGGCGAGTGA

Upstream 100 bases:

>100_bases
TGCCGGCTCCGTGGTGAACGTAAGATAGCCGATGCCTTCCCCCCCGGTTGTCACGCCGGTGACAATTCCGGGTTAATCCC
TACACAATGATTTTTTCGCC

Downstream 100 bases:

>100_bases
TGCGATGCCAGCGCGCTCCGCGATCGACAACGCCACGCTGCAGGCCTATCGCGAAACCGAGTACCGCGTGCATGGCGATG
CGCCGCTGACACTGAAGATC

Product: cyclic nucleotide-binding protein

Products: NA

Alternate protein names: Transcriptional Regulator Crp/Fnr Family; Transcriptional Regulator; CRP/FNR Family Transcriptional Regulator; Crp Family Transcriptional Regulator; Regulatory Protein; Transcription Regulator Protein; Transcription Regulator Crp Family; Cyclic-Nucleotide-Gated Cation Channel; CNMP Regulatory Protein; HTH Crp Family Transcriptional Regulator; CAMP-Dependent Transcriptional Regulator; Catabolite Gene Activator; Crp/Fnr Family Transcriptional Regulator

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLNDFVDRCVWAADLSAEQRDRVRRAMFVREYTQGDYVCHKGEIAEHWLGVLEGIVKITTVSPSGKSVTFTGVPTGGWFG
EGAVLKSEIRKYDVMALRRSTIAFLPRDTFQWLLDTSLPFTRFLLTQFNERLGQFIAAVEYERLLDIDSRVARAVSSLFN
EHLYPGIGNTLEISQEEIGLLAGISRQRANQALKVLEQQGLVRVDYGVIEVLDLEGLRQYGE

Sequences:

>Translated_222_residues
MLNDFVDRCVWAADLSAEQRDRVRRAMFVREYTQGDYVCHKGEIAEHWLGVLEGIVKITTVSPSGKSVTFTGVPTGGWFG
EGAVLKSEIRKYDVMALRRSTIAFLPRDTFQWLLDTSLPFTRFLLTQFNERLGQFIAAVEYERLLDIDSRVARAVSSLFN
EHLYPGIGNTLEISQEEIGLLAGISRQRANQALKVLEQQGLVRVDYGVIEVLDLEGLRQYGE
>Mature_222_residues
MLNDFVDRCVWAADLSAEQRDRVRRAMFVREYTQGDYVCHKGEIAEHWLGVLEGIVKITTVSPSGKSVTFTGVPTGGWFG
EGAVLKSEIRKYDVMALRRSTIAFLPRDTFQWLLDTSLPFTRFLLTQFNERLGQFIAAVEYERLLDIDSRVARAVSSLFN
EHLYPGIGNTLEISQEEIGLLAGISRQRANQALKVLEQQGLVRVDYGVIEVLDLEGLRQYGE

Specific function: This Protein Complexes With Cyclic AMP And Binds To Specific DNA Sites Near The Promoter To Regulate The Transcription Of Several Catabolite-Sensitive Operons. The Protein Induces A Severe Bend In The DNA. Acts As A Negative Regulator Of Its Own Synthesi

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 25134; Mature: 25134

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDFVDRCVWAADLSAEQRDRVRRAMFVREYTQGDYVCHKGEIAEHWLGVLEGIVKITT
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHEEE
VSPSGKSVTFTGVPTGGWFGEGAVLKSEIRKYDVMALRRSTIAFLPRDTFQWLLDTSLPF
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TRFLLTQFNERLGQFIAAVEYERLLDIDSRVARAVSSLFNEHLYPGIGNTLEISQEEIGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHH
LAGISRQRANQALKVLEQQGLVRVDYGVIEVLDLEGLRQYGE
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNDFVDRCVWAADLSAEQRDRVRRAMFVREYTQGDYVCHKGEIAEHWLGVLEGIVKITT
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHEEE
VSPSGKSVTFTGVPTGGWFGEGAVLKSEIRKYDVMALRRSTIAFLPRDTFQWLLDTSLPF
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TRFLLTQFNERLGQFIAAVEYERLLDIDSRVARAVSSLFNEHLYPGIGNTLEISQEEIGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHH
LAGISRQRANQALKVLEQQGLVRVDYGVIEVLDLEGLRQYGE
HHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA