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The map label for this gene is nodT [H]

Identifier: 73539942

GI number: 73539942

Start: 260139

End: 261605

Strand: Reverse

Name: nodT [H]

Synonym: Reut_A0236

Alternate gene names: 73539942

Gene position: 261605-260139 (Counterclockwise)

Preceding gene: 73539946

Following gene: 73539940

Centisome position: 6.87

GC content: 70.48

Gene sequence:

>1467_bases
ATGACGCAAGGGCAACCCTTCCCTCCGGCACGGCGCTTTGGGCGCAGCCTCGCGGTACTCGCCGCCACAGCCATGGCCGC
GAGCCTGGCCGCGTGCGCGTTCGGTCCCGATTACCATGCCCCCGCGCCGGACTTGCCGGCGGCATACGCGCACGCCGCCG
CATTGCAGGCCCAGGAAGCAGCGCCTGCGGCGCCCGCGCTCGATAGCTGGTGGAAGGGATTCGACGATCCCGCGCTGACC
CGGATCATCGAGCGCGCGCTGGCGCAGAACCTGGACCTTGCTGCATCGGTAGCCCGTGTCGACCAAGCGCGTGCGGCCGC
CGACTACGCCGGCGCGGCATTGCTGCCGGAGGGATCGCTGTCCGGCAGCGTCGCGCGGCAACGGCAGTCACTCGAAAGCC
CGCTGGGCAAGATCGCCAGCAAGTCGCCTGGCTTCGAGCGCAACAACACGCTGTACAACGCCGGTGCGGGGGCCAGTTGG
GAGATCGACATCGCCGGCGGCCTGCGGCGCGGGGCCGAGGCGGCCGACGCGGAAGCCCAGGCGGCCGAGGCCGAACACCT
CGGCGTGCGCGTGCTGGTGGCAGCGGAAGCCGCCGACGCCTACTTCCGCGTGCGCGGTGCGCAGCAGCGCATCACCATCG
CGCAGCAGCAGGTGCAGACCAATGCGCGGCTGCTGGATCTGGTGAAGCTGCGCCTGGCCGACGGCATCGGCGCCGAGCGC
GAACGCGCGCAGGCCGAAGCGCGGCTCGCACAGACCCGCGTCACCATCCCGCCGCTCCAGATCGAGCTCGACACGCAGCT
CAACCGACTCGACGTGCTGATGGGCGCGGCGCCGGGCACCTATGCCGCCGAACTCGCCACGCCGGGTGCGCGTACCGGCG
TTCCGCAGATTCCGCTCGCACAGGGTCCTGCCGCGCTGCTCGAACGCCGCCCCGACGTCATTGCCGCCGAACGCCGGCTG
GCCGCGTCCAGCGCGCGCATCGGCGTGGCTACGGCGGAGTACTACCCCAAGCTATCGCTCGCGGCATTGCTCGGCTTCGA
AAGCCTGTCGGCGAGCAAGATGTTCACGGCCGCCACGTTCCAGCCCGCAGCCATGGCCGGCCTGCGCTGGCGTCTGTTCG
ATTTCGGCCGTGTGGACGCCGAAGTCGCCCAGGCACGCGGCGCGAATGCAGAGGCACTCGCCACCTATCGGAAGTCCATG
CTGCGCGCGACCGAGGATGTAGAAAACGCAATCGTCACGCTGACCCAGCTGCAACTGCAGAGCCAGGACCTGACCGTGGA
AGTCGATGCTCAGGCCCGATCGCGCGGCGCGGCCGAAGAGGCCTACAAGGGCGGCGCTGTCAGCCTGTTCGAAGTGCTTG
AGGAAGACCGCCAGTTATTGGCCGCGCGCGACCAGCAGGCACGCGCGGGCACCGATAACGCACGCGCCGCAGTGGCGGCG
TTCCGCGCGCTGGGTGGCGGCTGGTAA

Upstream 100 bases:

>100_bases
GGGTTGCTATCAAGTTGAAAGTTAGTCTAGAGTAGTGACTATCATGTTGCAAGTTAATTTGGCAACATGCAGTACGACTC
ACGAACGAGAGGTGCATGAC

Downstream 100 bases:

>100_bases
GAATCAGGGGAGAAAGCGCCGCGTCGCCTTAGTCGGCTTCGGCCTTTTCCGTGGTCGACAGGTAGGCGGCGGCATCGGCC
AGGCGCCGGCGCACGCCTTC

Product: RND efflux system, outer membrane lipoprotein, NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTQGQPFPPARRFGRSLAVLAATAMAASLAACAFGPDYHAPAPDLPAAYAHAAALQAQEAAPAAPALDSWWKGFDDPALT
RIIERALAQNLDLAASVARVDQARAAADYAGAALLPEGSLSGSVARQRQSLESPLGKIASKSPGFERNNTLYNAGAGASW
EIDIAGGLRRGAEAADAEAQAAEAEHLGVRVLVAAEAADAYFRVRGAQQRITIAQQQVQTNARLLDLVKLRLADGIGAER
ERAQAEARLAQTRVTIPPLQIELDTQLNRLDVLMGAAPGTYAAELATPGARTGVPQIPLAQGPAALLERRPDVIAAERRL
AASSARIGVATAEYYPKLSLAALLGFESLSASKMFTAATFQPAAMAGLRWRLFDFGRVDAEVAQARGANAEALATYRKSM
LRATEDVENAIVTLTQLQLQSQDLTVEVDAQARSRGAAEEAYKGGAVSLFEVLEEDRQLLAARDQQARAGTDNARAAVAA
FRALGGGW

Sequences:

>Translated_488_residues
MTQGQPFPPARRFGRSLAVLAATAMAASLAACAFGPDYHAPAPDLPAAYAHAAALQAQEAAPAAPALDSWWKGFDDPALT
RIIERALAQNLDLAASVARVDQARAAADYAGAALLPEGSLSGSVARQRQSLESPLGKIASKSPGFERNNTLYNAGAGASW
EIDIAGGLRRGAEAADAEAQAAEAEHLGVRVLVAAEAADAYFRVRGAQQRITIAQQQVQTNARLLDLVKLRLADGIGAER
ERAQAEARLAQTRVTIPPLQIELDTQLNRLDVLMGAAPGTYAAELATPGARTGVPQIPLAQGPAALLERRPDVIAAERRL
AASSARIGVATAEYYPKLSLAALLGFESLSASKMFTAATFQPAAMAGLRWRLFDFGRVDAEVAQARGANAEALATYRKSM
LRATEDVENAIVTLTQLQLQSQDLTVEVDAQARSRGAAEEAYKGGAVSLFEVLEEDRQLLAARDQQARAGTDNARAAVAA
FRALGGGW
>Mature_487_residues
TQGQPFPPARRFGRSLAVLAATAMAASLAACAFGPDYHAPAPDLPAAYAHAAALQAQEAAPAAPALDSWWKGFDDPALTR
IIERALAQNLDLAASVARVDQARAAADYAGAALLPEGSLSGSVARQRQSLESPLGKIASKSPGFERNNTLYNAGAGASWE
IDIAGGLRRGAEAADAEAQAAEAEHLGVRVLVAAEAADAYFRVRGAQQRITIAQQQVQTNARLLDLVKLRLADGIGAERE
RAQAEARLAQTRVTIPPLQIELDTQLNRLDVLMGAAPGTYAAELATPGARTGVPQIPLAQGPAALLERRPDVIAAERRLA
ASSARIGVATAEYYPKLSLAALLGFESLSASKMFTAATFQPAAMAGLRWRLFDFGRVDAEVAQARGANAEALATYRKSML
RATEDVENAIVTLTQLQLQSQDLTVEVDAQARSRGAAEEAYKGGAVSLFEVLEEDRQLLAARDQQARAGTDNARAAVAAF
RALGGGW

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=475, Percent_Identity=25.8947368421053, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI2367348, Length=429, Percent_Identity=26.3403263403263, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51349; Mature: 51218

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGQPFPPARRFGRSLAVLAATAMAASLAACAFGPDYHAPAPDLPAAYAHAAALQAQEA
CCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
APAAPALDSWWKGFDDPALTRIIERALAQNLDLAASVARVDQARAAADYAGAALLPEGSL
CCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCC
SGSVARQRQSLESPLGKIASKSPGFERNNTLYNAGAGASWEIDIAGGLRRGAEAADAEAQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHH
AAEAEHLGVRVLVAAEAADAYFRVRGAQQRITIAQQQVQTNARLLDLVKLRLADGIGAER
HHHHHHCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ERAQAEARLAQTRVTIPPLQIELDTQLNRLDVLMGAAPGTYAAELATPGARTGVPQIPLA
HHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCC
QGPAALLERRPDVIAAERRLAASSARIGVATAEYYPKLSLAALLGFESLSASKMFTAATF
CCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCHHHHHHCC
QPAAMAGLRWRLFDFGRVDAEVAQARGANAEALATYRKSMLRATEDVENAIVTLTQLQLQ
CHHHHHCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQDLTVEVDAQARSRGAAEEAYKGGAVSLFEVLEEDRQLLAARDQQARAGTDNARAAVAA
CCCCEEEECCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FRALGGGW
HHHHCCCC
>Mature Secondary Structure 
TQGQPFPPARRFGRSLAVLAATAMAASLAACAFGPDYHAPAPDLPAAYAHAAALQAQEA
CCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
APAAPALDSWWKGFDDPALTRIIERALAQNLDLAASVARVDQARAAADYAGAALLPEGSL
CCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCC
SGSVARQRQSLESPLGKIASKSPGFERNNTLYNAGAGASWEIDIAGGLRRGAEAADAEAQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCHHH
AAEAEHLGVRVLVAAEAADAYFRVRGAQQRITIAQQQVQTNARLLDLVKLRLADGIGAER
HHHHHHCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ERAQAEARLAQTRVTIPPLQIELDTQLNRLDVLMGAAPGTYAAELATPGARTGVPQIPLA
HHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCC
QGPAALLERRPDVIAAERRLAASSARIGVATAEYYPKLSLAALLGFESLSASKMFTAATF
CCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCHHHHHHCC
QPAAMAGLRWRLFDFGRVDAEVAQARGANAEALATYRKSMLRATEDVENAIVTLTQLQLQ
CHHHHHCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQDLTVEVDAQARSRGAAEEAYKGGAVSLFEVLEEDRQLLAARDQQARAGTDNARAAVAA
CCCCEEEECCHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FRALGGGW
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]