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The map label for this gene is hslU [H]

Identifier: 73539874

GI number: 73539874

Start: 195384

End: 196715

Strand: Direct

Name: hslU [H]

Synonym: Reut_A0168

Alternate gene names: 73539874

Gene position: 195384-196715 (Clockwise)

Preceding gene: 73539873

Following gene: 73539875

Centisome position: 5.13

GC content: 63.14

Gene sequence:

>1332_bases
ATGTCGCATACCATGACCCCGTCGGAAATCGTTTCCGAACTCGACAAGCACATCATCGGCCAGAACAAGGCCAAGAAGGC
CGTCGCCGTCGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTGGCCGAGCCGCTGCGCCAGGAAATCACGCCCAAGAACA
TCCTGATGATCGGCCCGACCGGCGTCGGCAAGACCGAGATCGCGCGCCGCCTGGCCAAGCTGGCCGACGCGCCCTTCATC
AAGATCGAGGCGACCAAGTTCACTGAAGTGGGCTACGTCGGCCGCGACGTGGACACCATCGTGCGCGACCTGGCCGAGAT
GGCCATCAAGCAGACGCGCGAATCCGAGATGAAGAAGGTGCGCACCAAGGCCGAAGAGGCGGCCGAGGATCGCCTGCTCG
ACGTGCTGCTGCCGCCGCCGCGCGATATCGGCTTCTCGCAGCCTGAAGAGAAGGATTCCAACACGCGTCAGGTGTTCCGC
AAGAAGCTGCGCGAAGGCCAGCTGGACGACAAGGACATCGAACTCGAAGTTGCCGCCGGCCTGCCGAGCATGGACATCAT
GGGGCCGCCGGGCATGGAGGAAATGACTGAGCAGATCCGCTCGATGTTCGCCGGCATGGGCCAGGGCAAGAAGCATCGCC
GCAAGATGAAGGTGAAGGAAGCCTTCAAGCTGCTGATCGATGAAGAGGCCGCCAAGCTCGTCAACGACGAGGAGCTCAAG
CACAAGGCCATCGCCAATGTCGAGCAGAACGGCATCGTGTTCCTGGACGAGATCGACAAGATCGCCAACCGCAGCGAACT
GGGTGGCGGCGAGGTGTCGCGCCAGGGCGTGCAGCGCGACCTGCTGCCGCTCGTGGAAGGCACCACGGTGAGCACGAAGT
ACGGGATGATCAAGACCGACCACATCCTGTTCATCGCCTCGGGCGCGTTCCACCTGTCCAAGCCGAGCGACCTGATCCCC
GAACTGCAGGGCCGCTTCCCGATCCGCGTGGAGCTGGAATCGCTGTCCGTGCAGGACTTCGAGGCCATCCTGACGCAGAC
CGATGCGAGCCTGACCAAGCAGTATCAGGCGCTGCTCAAGACCGAAGAGGTCGAACTGCAGTTCGCGCCGGACGGCATCC
GCCGCTTGGCCGAGATCGCGTTCTCGGTCAACGAGAAGGTCGAGAACATCGGTGCGCGCCGGCTGTACACGGTGATGGAG
CGCCTGCTCGAAGACCTGTCATTCCACGCGAGCAAGTCGTCGGGCGAGACGGTGACAATCGATGCCGCCTATGTGAACGA
ACGGCTGGGTGATCTTGCCGTCAACGAGGACCTGTCACGCTACGTGCTGTAA

Upstream 100 bases:

>100_bases
GCATCTACACCAACACCAACTTCGTCATCGAAACGCTGGAATGAGCGCTGGCCGGCCCGCGCACGGGCCGGCGTGCTTCA
CTGAACGCTGAACGGACACC

Downstream 100 bases:

>100_bases
GCGGTAGCGCGATCGCAATTGGGAAGGGTGCACAGGAGTGCACCCTTTCTTGCTTCTGGGGCCCGCGCGAAAAACGAACC
GGGCACCGACGAGTTCCACC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFI
KIEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKVRTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFR
KKLREGQLDDKDIELEVAAGLPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELK
HKAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFHLSKPSDLIP
ELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVME
RLLEDLSFHASKSSGETVTIDAAYVNERLGDLAVNEDLSRYVL

Sequences:

>Translated_443_residues
MSHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFI
KIEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKVRTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFR
KKLREGQLDDKDIELEVAAGLPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELK
HKAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFHLSKPSDLIP
ELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVME
RLLEDLSFHASKSSGETVTIDAAYVNERLGDLAVNEDLSRYVL
>Mature_442_residues
SHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKVRTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFRK
KLREGQLDDKDIELEVAAGLPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELKH
KAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFHLSKPSDLIPE
LQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLKTEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVMER
LLEDLSFHASKSSGETVTIDAAYVNERLGDLAVNEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=440, Percent_Identity=65.4545454545455, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=48, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24648289, Length=108, Percent_Identity=39.8148148148148, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648291, Length=108, Percent_Identity=39.8148148148148, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49688; Mature: 49557

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPT
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKV
CCCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFRKKLREGQLDDKDIELEVAAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
LPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELK
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HKAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTD
HHHHHCCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLSKPSDLIPELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLK
CEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHASKSSGETVTI
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DAAYVNERLGDLAVNEDLSRYVL
EHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SHTMTPSEIVSELDKHIIGQNKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPT
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAIKQTRESEMKKV
CCCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTKAEEAAEDRLLDVLLPPPRDIGFSQPEEKDSNTRQVFRKKLREGQLDDKDIELEVAAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
LPSMDIMGPPGMEEMTEQIRSMFAGMGQGKKHRRKMKVKEAFKLLIDEEAAKLVNDEELK
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HKAIANVEQNGIVFLDEIDKIANRSELGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTD
HHHHHCCCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLSKPSDLIPELQGRFPIRVELESLSVQDFEAILTQTDASLTKQYQALLK
CEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TEEVELQFAPDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHASKSSGETVTI
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DAAYVNERLGDLAVNEDLSRYVL
EHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA