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The map label for this gene is bioA [H]

Identifier: 73539853

GI number: 73539853

Start: 173294

End: 174712

Strand: Direct

Name: bioA [H]

Synonym: Reut_A0147

Alternate gene names: 73539853

Gene position: 173294-174712 (Clockwise)

Preceding gene: 73539852

Following gene: 73539854

Centisome position: 4.55

GC content: 68.5

Gene sequence:

>1419_bases
TTGGAACAACAGTCCCTGCATGCCCCACTGCCCGGTGCCAGCGATTCGCTAGCGCTGCGCAGCAAGCACGCCGTCTGGCA
CCCCTGCACGCGCCTGCGTCCAGACGACATCGCCACGCCGCTCGCCATCGTCCGTGGCGAGGGCCCCTGGCTCCATGACG
CTGACGGCCACCGCTATTTCGACGCTACCAGTTCCTGGTGGGTCAACCTGTTCGGCCACGCCAATCCGAAGATCAACGCC
GCGCTGGCAGACCAGCTCCAGACGCTTGAGCACGTCATGCTCGCCGGCTGTACGCACGCGCCTGCCGTCGAACTTGCCGA
GCGCCTGTCCGCACTGACCGGCGGCGCACTCGGCCACGCGTTCTACGCGTCGGACGGCGCGTCCGCCGTGGAGATCGCGC
TCAAGATGAGCTTCCACTACTGGCGCAACACCGGCCTGCCGGCCAAGCGCGAGTTCGTCTGCCTGGCCAATGGCTACCAC
GGCGAAACCGTGGGCGCGCTGGGCGTGACTGATCTAGATGTCTTCCGCGATGCCTATGACCCGCTGATCCGTCGCGCGCA
TGTGGTGATGTCGCCCGACGCGCGTCAGGCCGCAGATGGCGAGACCGCCGCCGATGTCGCCGTGCGCGCGTTGGCCGCAC
TCGAGACACTGCTGCGCGATCGCACAGGCCAGATTGCCGCGCTGATCGTCGAGCCGCTCGTGCAATGCGCGGCGGGCATG
GCCATGTACGACCCGTCGTATCTGGAGGGCGCGCGCGCGCTGTGCGATCGCTACCGTGTGCACCTGATCGCCGACGAGAT
CGCGGTTGGCTGCGGGCGCACCGGCACGTTCTTCGCGTGGGAGCAATGCCGCGATGCGGACCAGCCGCTGCCCGCGCATG
CATGGCCCGATTTCCTGTGCCTGTCCAAGGGCATCAGCGGTGGCTATCTGCCGCTGTCGCTCGTGCTGTCGCGCCCGGAA
ATCCAGCGCGCCTTCATTGCCGATGAGCTCGCGCGCAGCTTCCTGCATTCGCATTCCTACACCGGCAACCCGCTCGCCTG
CCGCGCCGCCGTGGCAACGCTCGACCTGTTCGCGCAGGACGACGTCATCGCGCAGAACCGCGCCCGGTCGCAGTGGCTGG
CCGACGCGATGGCGCCGTTCGCCCGCGATGCGCGCCTGCACCGCATGCGCCAGCGCGGGCTGATCTGGGCCGTCGATGTC
CGCGAGGAACGGGCTGGCGAAGGCTTCGCCGGGCGCTTCCATCAGGCCGCGCGTGCGCGCGAACTGCTGGTGCGGCCGAT
CGGCAACACGCTGTACGTGATGCCGCCCTACGTATTCGATGCCGAGCAGGCGCGCTGGCTCGCCACGCAACTGCAGGCCA
CGCTGGACGATGTGCTCGGCAACGCCGAGGCTGACAAGGAGGTACGCCATGCTGCTTGA

Upstream 100 bases:

>100_bases
GCCAACCCCAAGGAGACATTCCTAACATGATCCTCCCGAACCATTCCGCAGCGCAGCGAGAAAGTACGCACCGCGAAATG
GTCAACAAAGGAGGACTCCC

Downstream 100 bases:

>100_bases
ACAATTGCGCCGCGCCGCGGACGAACGCCAGGCCCGCGCGCTCACGCGCCGGCGCCGCATTGCGCATACCGCATGCGCGC
CGCACCAGGCCGTGGGCCCG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MEQQSLHAPLPGASDSLALRSKHAVWHPCTRLRPDDIATPLAIVRGEGPWLHDADGHRYFDATSSWWVNLFGHANPKINA
ALADQLQTLEHVMLAGCTHAPAVELAERLSALTGGALGHAFYASDGASAVEIALKMSFHYWRNTGLPAKREFVCLANGYH
GETVGALGVTDLDVFRDAYDPLIRRAHVVMSPDARQAADGETAADVAVRALAALETLLRDRTGQIAALIVEPLVQCAAGM
AMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQCRDADQPLPAHAWPDFLCLSKGISGGYLPLSLVLSRPE
IQRAFIADELARSFLHSHSYTGNPLACRAAVATLDLFAQDDVIAQNRARSQWLADAMAPFARDARLHRMRQRGLIWAVDV
REERAGEGFAGRFHQAARARELLVRPIGNTLYVMPPYVFDAEQARWLATQLQATLDDVLGNAEADKEVRHAA

Sequences:

>Translated_472_residues
MEQQSLHAPLPGASDSLALRSKHAVWHPCTRLRPDDIATPLAIVRGEGPWLHDADGHRYFDATSSWWVNLFGHANPKINA
ALADQLQTLEHVMLAGCTHAPAVELAERLSALTGGALGHAFYASDGASAVEIALKMSFHYWRNTGLPAKREFVCLANGYH
GETVGALGVTDLDVFRDAYDPLIRRAHVVMSPDARQAADGETAADVAVRALAALETLLRDRTGQIAALIVEPLVQCAAGM
AMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQCRDADQPLPAHAWPDFLCLSKGISGGYLPLSLVLSRPE
IQRAFIADELARSFLHSHSYTGNPLACRAAVATLDLFAQDDVIAQNRARSQWLADAMAPFARDARLHRMRQRGLIWAVDV
REERAGEGFAGRFHQAARARELLVRPIGNTLYVMPPYVFDAEQARWLATQLQATLDDVLGNAEADKEVRHAA
>Mature_472_residues
MEQQSLHAPLPGASDSLALRSKHAVWHPCTRLRPDDIATPLAIVRGEGPWLHDADGHRYFDATSSWWVNLFGHANPKINA
ALADQLQTLEHVMLAGCTHAPAVELAERLSALTGGALGHAFYASDGASAVEIALKMSFHYWRNTGLPAKREFVCLANGYH
GETVGALGVTDLDVFRDAYDPLIRRAHVVMSPDARQAADGETAADVAVRALAALETLLRDRTGQIAALIVEPLVQCAAGM
AMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQCRDADQPLPAHAWPDFLCLSKGISGGYLPLSLVLSRPE
IQRAFIADELARSFLHSHSYTGNPLACRAAVATLDLFAQDDVIAQNRARSQWLADAMAPFARDARLHRMRQRGLIWAVDV
REERAGEGFAGRFHQAARARELLVRPIGNTLYVMPPYVFDAEQARWLATQLQATLDDVLGNAEADKEVRHAA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=421, Percent_Identity=28.2660332541568, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI37574042, Length=458, Percent_Identity=25.1091703056769, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI13994255, Length=385, Percent_Identity=26.2337662337662, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI226442705, Length=458, Percent_Identity=24.6724890829694, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI284507298, Length=300, Percent_Identity=28.6666666666667, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=24.3781094527363, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI24119277, Length=461, Percent_Identity=24.9457700650759, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786991, Length=450, Percent_Identity=35.7777777777778, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI145693181, Length=406, Percent_Identity=29.8029556650246, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789759, Length=384, Percent_Identity=26.8229166666667, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=26.3157894736842, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=27.3399014778325, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1787560, Length=427, Percent_Identity=27.4004683840749, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=25.4041570438799, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=26.4775413711584, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=253, Percent_Identity=27.6679841897233, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=468, Percent_Identity=21.7948717948718, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=476, Percent_Identity=28.1512605042017, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=425, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=387, Percent_Identity=26.8733850129199, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=27.1844660194175, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574759, Length=401, Percent_Identity=28.1795511221945, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161085790, Length=401, Percent_Identity=28.1795511221945, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356575, Length=470, Percent_Identity=23.8297872340426, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 51677; Mature: 51677

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQSLHAPLPGASDSLALRSKHAVWHPCTRLRPDDIATPLAIVRGEGPWLHDADGHRYF
CCCCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCCHHCCCEEEEECCCCCCCCCCCCEEE
DATSSWWVNLFGHANPKINAALADQLQTLEHVMLAGCTHAPAVELAERLSALTGGALGHA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHH
FYASDGASAVEIALKMSFHYWRNTGLPAKREFVCLANGYHGETVGALGVTDLDVFRDAYD
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
PLIRRAHVVMSPDARQAADGETAADVAVRALAALETLLRDRTGQIAALIVEPLVQCAAGM
HHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
AMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQCRDADQPLPAHAWPDFLC
HHCCCHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCHHHH
LSKGISGGYLPLSLVLSRPEIQRAFIADELARSFLHSHSYTGNPLACRAAVATLDLFAQD
HHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
DVIAQNRARSQWLADAMAPFARDARLHRMRQRGLIWAVDVREERAGEGFAGRFHQAARAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHH
ELLVRPIGNTLYVMPPYVFDAEQARWLATQLQATLDDVLGNAEADKEVRHAA
HHHHHCCCCEEEECCCEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure
MEQQSLHAPLPGASDSLALRSKHAVWHPCTRLRPDDIATPLAIVRGEGPWLHDADGHRYF
CCCCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCCHHCCCEEEEECCCCCCCCCCCCEEE
DATSSWWVNLFGHANPKINAALADQLQTLEHVMLAGCTHAPAVELAERLSALTGGALGHA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHH
FYASDGASAVEIALKMSFHYWRNTGLPAKREFVCLANGYHGETVGALGVTDLDVFRDAYD
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
PLIRRAHVVMSPDARQAADGETAADVAVRALAALETLLRDRTGQIAALIVEPLVQCAAGM
HHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
AMYDPSYLEGARALCDRYRVHLIADEIAVGCGRTGTFFAWEQCRDADQPLPAHAWPDFLC
HHCCCHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCHHHH
LSKGISGGYLPLSLVLSRPEIQRAFIADELARSFLHSHSYTGNPLACRAAVATLDLFAQD
HHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
DVIAQNRARSQWLADAMAPFARDARLHRMRQRGLIWAVDVREERAGEGFAGRFHQAARAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCHHHHHHHHHHHH
ELLVRPIGNTLYVMPPYVFDAEQARWLATQLQATLDDVLGNAEADKEVRHAA
HHHHHCCCCEEEECCCEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]