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The map label for this gene is bcd [H]

Identifier: 73539841

GI number: 73539841

Start: 160699

End: 161880

Strand: Direct

Name: bcd [H]

Synonym: Reut_A0135

Alternate gene names: 73539841

Gene position: 160699-161880 (Clockwise)

Preceding gene: 73539840

Following gene: 73539842

Centisome position: 4.22

GC content: 64.3

Gene sequence:

>1182_bases
ATGACCGAACTGCCTGGCCTGAAATTCGACCTGGGCGATGACATCGAGATGCTGCGCGGTGCCGTGCGCGACTGGGCGCA
GGCGGAGCTGGCGCCGCGCGCGGGCGAGATCGACCGCACCGACCAGTTTCCGATGGACGCCTGGAAGAAGATGGGCGACC
TCGGCGTGCTCGGCATCACCGTGGCCGAGGAGTACGGCGGCGCCAACATGGGCTACCTGGCCCACATGGTGGCGATGGAG
GAAATCAGCCGTGCCTCGGCGTCGGTCGGCTTGTCCTATGGCGCGCATTCGAACCTGTGCGTGAATCAGATCCACCGCAA
CGGCACCGCCTCGCAGAAGGCGAAGTACCTGCCGAAGCTGGTGTCGGGCGAGTGGATCGGCGCGCTCGCGATGAGCGAGC
CCAATGCCGGCTCCGACGTCGTCAGCATGAAGCTGCGCGCCGATTTCAAAGGCGACCGCTTCGTGCTCAACGGCACCAAG
ATGTGGATCACGAACGGCCCGGATTGCGACGTGCTGGTCGTCTACGCCAAGACGGAACCGGACCTCGGCGCGCGCGGCAT
GACCGCGTTCATCGTCGAGAAGGGCATGAAGGGCTTCTCGGTCGCGCAGAAGCTGGACAAGCTCGGCATGCGGGGGTCGC
ACACCGGCGAACTGGTGTTCGAGGACGTGGAGGTGCCGGTCGAGAACATACTTGGCGGCGAGAACAGCGGCGCCAAGGTA
CTGATGAGCGGTCTCGACTACGAACGCGCGGTGCTGTCGGGCGGCCCGATCGGCATCATGCAGGCGTGCATGGACGTGGT
CACACCGTACATCCACGACCGCAAGCAGTTTGGCCAGAGCATCGGCGAATTCCAGCTGATCCAGGGCAAGGTCGCCGACA
TGTACACGACGCTGCAGGCAGCGCGCAGCTATCTGTACACAGTTGGCAAGAACCTGGATTCGCTCGGCAGCGAGCACGTG
CGCCAGGTGCGCAAGGATTGCGCCGCCGTGATCCTCTACACGGCCGAGAAGGCCACCTGGATGGCCGGCGAAACCGTGCA
GATCCTGGGCGGCAACGGCTATATCAACGAATACCCGGCCGGGCGGCTGTGGCGCGATGCCAAGCTGTACGAGATTGGGG
CCGGGACTTCAGAGATTCGACGGATGCTGATCGGTCGGGAATTGTTTGCCGAGACGATGTGA

Upstream 100 bases:

>100_bases
CGTGGCGACCATGCTGATGACGCTTTGCGTCGTGCGTACGCTCGGACACGTCTGACACGCGCCGAACCGCTGCTGCCAAC
AAGACCCCAAGGAGACCACC

Downstream 100 bases:

>100_bases
TTCTGACCGCGCCTGGTATCGCCGGGTTCCTCCCTCTCCCGTCAGCGGGAGAGGGGGAGCAAACCGGCGGCTATTCGGAA
GGTATTCGCCACTGAGCACC

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTELPGLKFDLGDDIEMLRGAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTASQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRFVLNGTK
MWITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPVENILGGENSGAKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSEHV
RQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM

Sequences:

>Translated_393_residues
MTELPGLKFDLGDDIEMLRGAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTASQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRFVLNGTK
MWITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPVENILGGENSGAKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSEHV
RQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
>Mature_392_residues
TELPGLKFDLGDDIEMLRGAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGITVAEEYGGANMGYLAHMVAMEE
ISRASASVGLSYGAHSNLCVNQIHRNGTASQKAKYLPKLVSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRFVLNGTKM
WITNGPDCDVLVVYAKTEPDLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPVENILGGENSGAKVL
MSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQAARSYLYTVGKNLDSLGSEHVR
QVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPAGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=62.2739018087855, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=65.5172413793103, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=39.2105263157895, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=34.0369393139842, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=36.8956743002545, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=34.025974025974, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=34.025974025974, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=32.3076923076923, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=34.0116279069767, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=34.0116279069767, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=29.6103896103896, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=33.5917312661499, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=34.2696629213483, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=25, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=20.7017543859649, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.720207253886, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=27.5773195876289, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=25, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082384, Length=253, Percent_Identity=23.7154150197628, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=62.015503875969, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=35.0684931506849, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=33.7628865979381, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=34.1968911917098, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=33.0769230769231, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=32.2916666666667, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=30.6068601583113, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.2394366197183, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=37.956204379562, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=30.5699481865285, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.3939393939394, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=36.2676056338028, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=32.8467153284672, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=363, Percent_Identity=29.4765840220386, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=29.5580110497238, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=21.875, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=62.9820051413882, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=39.3700787401575, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=35.9580052493438, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=34.2931937172775, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=33.8501291989664, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI281363737, Length=390, Percent_Identity=33.8461538461538, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=31.1855670103093, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI221473076, Length=327, Percent_Identity=25.0764525993884, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550141, Length=327, Percent_Identity=25.0764525993884, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652780, Length=318, Percent_Identity=22.3270440251572, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42789; Mature: 42657

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELPGLKFDLGDDIEMLRGAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGIT
CCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTASQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRFVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEEECEEEEEECCCCCCEEEEEEECCC
DLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPVENILGGENSGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHH
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGSEHVRQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TELPGLKFDLGDDIEMLRGAVRDWAQAELAPRAGEIDRTDQFPMDAWKKMGDLGVLGIT
CCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTASQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWIGALAMSEPNAGSDVVSMKLRADFKGDRFVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCCEEEEEEEECCCCCEEEEECEEEEEECCCCCCEEEEEEECCC
DLGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPVENILGGENSGAKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHH
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKVADMYTTLQA
EECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
ARSYLYTVGKNLDSLGSEHVRQVRKDCAAVILYTAEKATWMAGETVQILGGNGYINEYPA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCEEEEEECCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETM
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]